LOCUS       NM_005127               1533 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens C-type lectin domain family 2 member B (CLEC2B), mRNA.
ACCESSION   NM_005127
VERSION     NM_005127.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1533)
  AUTHORS   Zhang,X., Yuan,J.R., Wang,X., Fu,S., Wang,R.T. and Wang,G.Y.
  TITLE     Association between c-type lectin-like receptor 2 and
            microsatellite instability in colorectal cancer: a cross-sectional
            study
  JOURNAL   BMC Cancer 22 (1), 823 (2022)
   PUBMED   35902826
  REMARK    GeneRIF: Association between c-type lectin-like receptor 2 and
            microsatellite instability in colorectal cancer: a cross-sectional
            study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1533)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1533)
  AUTHORS   Fei,M., Xiang,L., Chai,X., Jin,J., You,T., Zhao,Y., Ruan,C., Hao,Y.
            and Zhu,L.
  TITLE     Plasma soluble C-type lectin-like receptor-2 is associated with the
            risk of coronary artery disease
  JOURNAL   Front Med 14 (1), 81-90 (2020)
   PUBMED   31280468
  REMARK    GeneRIF: Plasma soluble C-type lectin-like receptor-2 is associated
            with the risk of coronary artery disease.
REFERENCE   4  (bases 1 to 1533)
  AUTHORS   Neuss,S., Bartel,Y., Born,C., Weil,S., Koch,J., Behrends,C.,
            Hoffmeister,M. and Steinle,A.
  TITLE     Cellular Mechanisms Controlling Surfacing of AICL Glycoproteins,
            Cognate Ligands of the Activating NK Receptor NKp80
  JOURNAL   J Immunol 201 (4), 1275-1286 (2018)
   PUBMED   29980609
  REMARK    GeneRIF: our data demonstrate that AICL expression and surfacing
            are tightly controlled by several independent cellular
            posttranslational mechanisms.
REFERENCE   5  (bases 1 to 1533)
  AUTHORS   Suzuki-Inoue,K., Osada,M. and Ozaki,Y.
  TITLE     Physiologic and pathophysiologic roles of interaction between
            C-type lectin-like receptor 2 and podoplanin: partners from in
            utero to adulthood
  JOURNAL   J Thromb Haemost 15 (2), 219-229 (2017)
   PUBMED   27960039
  REMARK    GeneRIF: Review of C-type lectin-like receptor 2 and podoplanin
            interactions [review]
            Review article
REFERENCE   6  (bases 1 to 1533)
  AUTHORS   Ebner,S., Sharon,N. and Ben-Tal,N.
  TITLE     Evolutionary analysis reveals collective properties and specificity
            in the C-type lectin and lectin-like domain superfamily
  JOURNAL   Proteins 53 (1), 44-55 (2003)
   PUBMED   12945048
REFERENCE   7  (bases 1 to 1533)
  AUTHORS   Renedo,M., Arce,I., Montgomery,K., Roda-Navarro,P., Lee,E.,
            Kucherlapati,R. and Fernandez-Ruiz,E.
  TITLE     A sequence-ready physical map of the region containing the human
            natural killer gene complex on chromosome 12p12.3-p13.2
  JOURNAL   Genomics 65 (2), 129-136 (2000)
   PUBMED   10783260
REFERENCE   8  (bases 1 to 1533)
  AUTHORS   Drickamer,K.
  TITLE     C-type lectin-like domains
  JOURNAL   Curr Opin Struct Biol 9 (5), 585-590 (1999)
   PUBMED   10508765
  REMARK    Review article
REFERENCE   9  (bases 1 to 1533)
  AUTHORS   Yokoyama-Kobayashi,M., Yamaguchi,T., Sekine,S. and Kato,S.
  TITLE     Selection of cDNAs encoding putative type II membrane proteins on
            the cell surface from a human full-length cDNA bank
  JOURNAL   Gene 228 (1-2), 161-167 (1999)
   PUBMED   10072769
REFERENCE   10 (bases 1 to 1533)
  AUTHORS   Hamann,J., Montgomery,K.T., Lau,S., Kucherlapati,R. and van
            Lier,R.A.
  TITLE     AICL: a new activation-induced antigen encoded by the human NK gene
            complex
  JOURNAL   Immunogenetics 45 (5), 295-300 (1997)
   PUBMED   9038101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313916.1, AC007068.17 and
            BM973072.1.
            
            On Aug 11, 2020 this sequence version replaced NM_005127.2.
            
            Summary: This gene encodes a member of the C-type lectin/C-type
            lectin-like domain (CTL/CTLD) superfamily. Members of this family
            share a common protein fold and have diverse functions, such as
            cell adhesion, cell-cell signalling, glycoprotein turnover, and
            roles in inflammation and immune response. The encoded type 2
            transmembrane protein may function as a cell activation antigen. An
            alternative splice variant has been described but its full-length
            sequence has not been determined. This gene is closely linked to
            other CTL/CTLD superfamily members on chromosome 12p13 in the
            natural killer gene complex region. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2593122.1, AV758319.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228438.3/ ENSP00000228438.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AK313916.1         9-157
            150-602             AK313916.1         159-611
            603-1502            AC007068.17        10214-11113
            1503-1533           BM973072.1         15-45               c
FEATURES             Location/Qualifiers
     source          1..1533
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1533
                     /gene="CLEC2B"
                     /gene_synonym="AICL; CLECSF2; HP10085; IFNRG1"
                     /note="C-type lectin domain family 2 member B"
                     /db_xref="GeneID:9976"
                     /db_xref="HGNC:HGNC:2053"
                     /db_xref="MIM:603242"
     exon            1..150
                     /gene="CLEC2B"
                     /gene_synonym="AICL; CLECSF2; HP10085; IFNRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            151..225
                     /gene="CLEC2B"
                     /gene_synonym="AICL; CLECSF2; HP10085; IFNRG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..602
                     /gene="CLEC2B"
                     /gene_synonym="AICL; CLECSF2; HP10085; IFNRG1"
                     /note="C-type (calcium dependent, carbohydrate-recognition
                     domain) lectin, superfamily member 2 (activation-induced);
                     IFN-alpha2b-inducing related protein 1; activation-induced
                     C-type lectin; C-type lectin superfamily member 2;
                     IFN-alpha-2b-inducing-related protein 1"
                     /codon_start=1
                     /product="C-type lectin domain family 2 member B"
                     /protein_id="NP_005118.2"
                     /db_xref="CCDS:CCDS8605.1"
                     /db_xref="GeneID:9976"
                     /db_xref="HGNC:HGNC:2053"
                     /db_xref="MIM:603242"
                     /translation="MMTKHKKCFIIVGVLITTNIITLIVKLTRDSQSLCPYDWIGFQN
                     KCYYFSKEEGDWNSSKYNCSTQHADLTIIDNIEEMNFLRRYKCSSDHWIGLKMAKNRT
                     GQWVDGATFTKSFGMRGSEGCAYLSDDGAATARCYTERKWICRKRIH"
     exon            226..389
                     /gene="CLEC2B"
                     /gene_synonym="AICL; CLECSF2; HP10085; IFNRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..493
                     /gene="CLEC2B"
                     /gene_synonym="AICL; CLECSF2; HP10085; IFNRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..1533
                     /gene="CLEC2B"
                     /gene_synonym="AICL; CLECSF2; HP10085; IFNRG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      675..680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC2B"
                     /gene_synonym="AICL; CLECSF2; HP10085; IFNRG1"
                     /note="hexamer: ATTAAA"
     polyA_site      695
                     /gene="CLEC2B"
                     /gene_synonym="AICL; CLECSF2; HP10085; IFNRG1"
                     /note="major polyA site"
     regulatory      1510..1515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC2B"
                     /gene_synonym="AICL; CLECSF2; HP10085; IFNRG1"
                     /note="hexamer: AATAAA"
     polyA_site      1533
                     /gene="CLEC2B"
                     /gene_synonym="AICL; CLECSF2; HP10085; IFNRG1"
ORIGIN      
        1 ggtatacctc tagtttggag ctgtgctgta aaaacaagag taacattttt atattaaagt
       61 taaataaagt tacaactttg aagagagttt ctgcaagaca tgacacaaag ctgctagcag
      121 aaaatcaaaa cgctgattaa aagaagcacg gtatgatgac caaacataaa aagtgtttta
      181 taattgttgg tgttttaata acaactaata ttattactct gatagttaaa ctaactcgag
      241 attctcagag tttatgcccc tatgattgga ttggtttcca aaacaaatgc tattatttct
      301 ctaaagaaga aggagattgg aattcaagta aatacaactg ttccactcaa catgccgacc
      361 taactataat tgacaacata gaagaaatga attttcttag gcggtataaa tgcagttctg
      421 atcactggat tggactgaag atggcaaaaa atcgaacagg acaatgggta gatggagcta
      481 catttaccaa atcgtttggc atgagaggga gtgaaggatg tgcctacctc agcgatgatg
      541 gtgcagcaac agctagatgt tacaccgaaa gaaaatggat ttgcaggaaa agaatacact
      601 aagttaatgt ctaagataat ggggaaaata gaaaataaca ttattaagtg taaaaccagc
      661 aaagtacttt tttaattaaa caaagttcga gttttgtacc tgtctggtta attctgctta
      721 cgtgtcaggc tacacataaa agccacttca aagattggca aaaaatggtt acaggtattc
      781 tgctgagttt ttttctttct ttctttctct ctctctcttt ctttctttct ttctttcttt
      841 ctttttttaa ctgtaaacca gaaaacaatt gtggggatca aggacagaca tagcacttag
      901 acaggacttt catgacccaa tatggaacaa tttgagtacc agaataggag attatggcct
      961 attgaacaaa atgtgaaact gggagtccac aaagacataa atggaaagat gaagtacctc
     1021 ctgacagagc aagaatggca ctgaacaatg ttatatggac aatggctatt ttattcaaga
     1081 ctattacaat agggaaaaga gactaggact cagtctgaac tgaaatctgt caaaacaaag
     1141 gggggtgggg ctttaagagt gaaggtgagg aggagatcac acaccgtatg tgtttgctaa
     1201 ctggctttac ccaaaagaaa attaaacttt ctttgatctg tacaagttga tcaaacaaat
     1261 ggggtcattc ttgtcatatg caactaaaac agggtagaca ggccagggga aaaaggcact
     1321 cagggcacac agcattgctt caaaatataa ttctctacaa acctagttgc taaaactacc
     1381 tgttgtaacc taaaaccagt tttatctaac agctattaaa acaacctact gtgactgcaa
     1441 aactggtttt acccaccact gtcacacacc aatcagaact tgccagctcc tcaaaacttt
     1501 actagggcca ataaactttc tttcaaaaca ata
//
