LOCUS       NM_001130711             905 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens C-type lectin domain family 2 member A (CLEC2A),
            transcript variant 1, mRNA.
ACCESSION   NM_001130711
VERSION     NM_001130711.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 905)
  AUTHORS   Goncalves-Maia,M., Gache,Y., Basante,M., Cosson,E., Salavagione,E.,
            Muller,M., Bernerd,F., Avril,M.F., Schaub,S., Sarasin,A.,
            Braud,V.M. and Magnaldo,T.
  TITLE     NK Cell and Fibroblast-Mediated Regulation of Skin Squamous Cell
            Carcinoma Invasion by CLEC2A Is Compromised in Xeroderma
            Pigmentosum
  JOURNAL   J Invest Dermatol 140 (9), 1723-1732 (2020)
   PUBMED   32061658
  REMARK    GeneRIF: NK Cell and Fibroblast-Mediated Regulation of Skin
            Squamous Cell Carcinoma Invasion by CLEC2A Is Compromised in
            Xeroderma Pigmentosum.
REFERENCE   2  (bases 1 to 905)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 905)
  AUTHORS   Izquierdo,I., Barrachina,M.N., Hermida-Nogueira,L., Casas,V.,
            Moran,L.A., Lacerenza,S., Pinto-Llorente,R., Eble,J.A., de Los
            Rios,V., Dominguez,E., Loza,M.I., Casal,J.I., Carrascal,M.,
            Abian,J. and Garcia,A.
  TITLE     A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel
            Components of the Platelet CLEC-2 Signaling Cascade
  JOURNAL   Thromb Haemost 120 (2), 262-276 (2020)
   PUBMED   31901221
  REMARK    GeneRIF: A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals
            Novel Components of the Platelet CLEC-2 Signaling Cascade.
REFERENCE   4  (bases 1 to 905)
  AUTHORS   Suzuki-Inoue,K., Osada,M. and Ozaki,Y.
  TITLE     Physiologic and pathophysiologic roles of interaction between
            C-type lectin-like receptor 2 and podoplanin: partners from in
            utero to adulthood
  JOURNAL   J Thromb Haemost 15 (2), 219-229 (2017)
   PUBMED   27960039
  REMARK    GeneRIF: Review of C-type lectin-like receptor 2 and podoplanin
            interactions [review]
            Review article
REFERENCE   5  (bases 1 to 905)
  AUTHORS   Agrawal,S., Ganguly,S., Hajian,P., Cao,J.N. and Agrawal,A.
  TITLE     PDGF upregulates CLEC-2 to induce T regulatory cells
  JOURNAL   Oncotarget 6 (30), 28621-28632 (2015)
   PUBMED   26416420
  REMARK    GeneRIF: PDGF upregulates the expression of CLEC-2 on dendritic
            cells to induce T regulatory cells.
REFERENCE   6  (bases 1 to 905)
  AUTHORS   Spreu,J., Kuttruff,S., Stejfova,V., Dennehy,K.M., Schittek,B. and
            Steinle,A.
  TITLE     Interaction of C-type lectin-like receptors NKp65 and KACL
            facilitates dedicated immune recognition of human keratinocytes
  JOURNAL   Proc Natl Acad Sci U S A 107 (11), 5100-5105 (2010)
   PUBMED   20194751
  REMARK    GeneRIF: Keratinocytes express KACL and are capable of stimulating
            NKp65-expressing cells in a KACL-dependent manner.
REFERENCE   7  (bases 1 to 905)
  AUTHORS   Ozaki,Y., Suzuki-Inoue,K. and Inoue,O.
  TITLE     Novel interactions in platelet biology: CLEC-2/podoplanin and
            laminin/GPVI
  JOURNAL   J Thromb Haemost 7 Suppl 1, 191-194 (2009)
   PUBMED   19630798
  REMARK    GeneRIF: CLEC-2 is the receptor for podoplanin, a sialoglycoprotein
            implicated in tumor-induced platelet aggregation and tumor
            metastasis[review]
            Review article
REFERENCE   8  (bases 1 to 905)
  AUTHORS   Huarte,E., Cubillos-Ruiz,J.R., Nesbeth,Y.C., Scarlett,U.K.,
            Martinez,D.G., Engle,X.A., Rigby,W.F., Pioli,P.A., Guyre,P.M. and
            Conejo-Garcia,J.R.
  TITLE     PILAR is a novel modulator of human T-cell expansion
  JOURNAL   Blood 112 (4), 1259-1268 (2008)
   PUBMED   18550855
  REMARK    GeneRIF: T-cell PILAR signaling through CD161 supports CD3
            antibody-dependent and antigen-specific T-cell proliferation by
            increasing the expression of antiapoptotic Bcl-xL and induces
            secretion of T helper type 1 cytokines
REFERENCE   9  (bases 1 to 905)
  AUTHORS   Spreu,J., Kienle,E.C., Schrage,B. and Steinle,A.
  TITLE     CLEC2A: a novel, alternatively spliced and skin-associated member
            of the NKC-encoded AICL-CD69-LLT1 family
  JOURNAL   Immunogenetics 59 (12), 903-912 (2007)
   PUBMED   18046548
REFERENCE   10 (bases 1 to 905)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EF127467.1.
            
            On May 17, 2019 this sequence version replaced NM_001130711.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF127467.1, EU095394.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455827.2/ ENSP00000396163.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-905               EF127467.1         12-916
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..905
                     /gene="CLEC2A"
                     /gene_synonym="INPE5792; KACL; PILAR; UNQ5792"
                     /note="C-type lectin domain family 2 member A"
                     /db_xref="GeneID:387836"
                     /db_xref="HGNC:HGNC:24191"
                     /db_xref="MIM:612087"
     exon            1..96
                     /gene="CLEC2A"
                     /gene_synonym="INPE5792; KACL; PILAR; UNQ5792"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..566
                     /gene="CLEC2A"
                     /gene_synonym="INPE5792; KACL; PILAR; UNQ5792"
                     /note="isoform 1 is encoded by transcript variant 1;
                     keratinocyte-associated C-type lectin;
                     proliferation-induced lymphocyte-associated receptor"
                     /codon_start=1
                     /product="C-type lectin domain family 2 member A isoform
                     1"
                     /protein_id="NP_001124183.1"
                     /db_xref="CCDS:CCDS44829.1"
                     /db_xref="GeneID:387836"
                     /db_xref="HGNC:HGNC:24191"
                     /db_xref="MIM:612087"
                     /translation="MINPELRDGRADGFIHRIVPKLIQNWKIGLMCFLSIIITTVCII
                     MIATWSKHAKPVACSGDWLGVRDKCFYFSDDTRNWTASKIFCSLQKAELAQIDTQEDM
                     EFLKRYAGTDMHWIGLSRKQGDSWKWTNGTTFNGWFEIIGNGSFAFLSADGVHSSRGF
                     IDIKWICSKPKYFL"
     exon            97..180
                     /gene="CLEC2A"
                     /gene_synonym="INPE5792; KACL; PILAR; UNQ5792"
                     /inference="alignment:Splign:2.1.0"
     exon            181..347
                     /gene="CLEC2A"
                     /gene_synonym="INPE5792; KACL; PILAR; UNQ5792"
                     /inference="alignment:Splign:2.1.0"
     exon            348..451
                     /gene="CLEC2A"
                     /gene_synonym="INPE5792; KACL; PILAR; UNQ5792"
                     /inference="alignment:Splign:2.1.0"
     exon            452..905
                     /gene="CLEC2A"
                     /gene_synonym="INPE5792; KACL; PILAR; UNQ5792"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagtcctct cctactgatc tccatcggtt agcgccttgc catgattaat ccagagctgc
       61 gggatggcag agctgatggc ttcatacatc ggatagttcc caagttgata caaaactgga
      121 agattggcct tatgtgcttc ctgagtatta ttattactac agtttgcatt attatgatag
      181 ccacatggtc caagcatgct aaacctgtgg catgttcagg ggactggctt ggagtgagag
      241 ataagtgttt ctatttttct gatgatacca gaaattggac agccagtaaa atattttgta
      301 gtttgcagaa agcagaactt gctcagattg atacacaaga agacatggaa tttttgaaga
      361 ggtacgcagg aactgatatg cactggattg gactaagcag gaaacaagga gattcttgga
      421 aatggacaaa tggcaccaca ttcaatggtt ggtttgaaat tatagggaac ggatcctttg
      481 ctttcttgag tgctgatgga gtccatagtt ccagaggatt tattgatatc aagtggattt
      541 gcagcaaacc taaatatttt ttatagagca gaaaaaactt gaaaatgatt atcacacttc
      601 aagattgaaa gaagagctaa ttatgcaaaa gtggctttct cacttattct gttacagaat
      661 acggaacctc tggtgagggc ccattttcta gtttatagat ggaaacttct tgctgtgccc
      721 tgccatggtt aaagagacaa ggccgttctc tggagccttt tataagggca caatcacatt
      781 tactatggct ccatcctcat gaactaatca cctcctgatg gatggctcca tcccctaata
      841 ccatcacact ggtgattagc tttcaattta tgagttttgg gaggacccaa atactcagaa
      901 catag
//
