LOCUS       NM_016509                779 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens C-type lectin domain family 1 member B (CLEC1B),
            transcript variant 1, mRNA.
ACCESSION   NM_016509
VERSION     NM_016509.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 779)
  AUTHORS   Yamazaki,E., Ikeda,K., Urata,R., Ueno,D., Katayama,A., Ito,F.,
            Ikegaya,H. and Matoba,S.
  TITLE     Endothelial CLEC-1b plays a protective role against cancer
            hematogenous metastasis
  JOURNAL   Biochem Biophys Res Commun 708, 149819 (2024)
   PUBMED   38531221
  REMARK    GeneRIF: Endothelial CLEC-1b plays a protective role against cancer
            hematogenous metastasis.
REFERENCE   2  (bases 1 to 779)
  AUTHORS   Bourne,J.H., Colicchia,M., Di,Y., Martin,E., Slater,A.,
            Roumenina,L.T., Dimitrov,J.D., Watson,S.P. and Rayes,J.
  TITLE     Heme induces human and mouse platelet activation through
            C-type-lectin-like receptor-2
  JOURNAL   Haematologica 106 (2), 626-629 (2021)
   PUBMED   32354867
  REMARK    GeneRIF: Heme induces human and mouse platelet activation through
            C-type-lectin-like receptor-2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 779)
  AUTHORS   Jin,J.C. and Hao,Y.W.
  TITLE     [Expression of Clec2 in Patients with Myelodysplastic Syndrome and
            Its Correlation with TPO]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 28 (5), 1643-1647 (2020)
   PUBMED   33067967
  REMARK    GeneRIF: [Expression of Clec2 in Patients with Myelodysplastic
            Syndrome and Its Correlation with TPO].
REFERENCE   4  (bases 1 to 779)
  AUTHORS   Martyanov,A.A., Balabin,F.A., Dunster,J.L., Panteleev,M.A.,
            Gibbins,J.M. and Sveshnikova,A.N.
  TITLE     Control of Platelet CLEC-2-Mediated Activation by Receptor
            Clustering and Tyrosine Kinase Signaling
  JOURNAL   Biophys J 118 (11), 2641-2655 (2020)
   PUBMED   32396849
  REMARK    GeneRIF: Control of Platelet CLEC-2-Mediated Activation by Receptor
            Clustering and Tyrosine Kinase Signaling.
REFERENCE   5  (bases 1 to 779)
  AUTHORS   Suzuki-Inoue,K.
  TITLE     Platelets and cancer-associated thrombosis: focusing on the
            platelet activation receptor CLEC-2 and podoplanin
  JOURNAL   Blood 134 (22), 1912-1918 (2019)
   PUBMED   31778548
  REMARK    GeneRIF: Platelets and cancer-associated thrombosis: focusing on
            the platelet activation receptor CLEC-2 and podoplanin.
            Review article
REFERENCE   6  (bases 1 to 779)
  AUTHORS   Chaipan,C., Soilleux,E.J., Simpson,P., Hofmann,H., Gramberg,T.,
            Marzi,A., Geier,M., Stewart,E.A., Eisemann,J., Steinkasserer,A.,
            Suzuki-Inoue,K., Fuller,G.L., Pearce,A.C., Watson,S.P., Hoxie,J.A.,
            Baribaud,F. and Pohlmann,S.
  TITLE     DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1
            capture by platelets
  JOURNAL   J Virol 80 (18), 8951-8960 (2006)
   PUBMED   16940507
  REMARK    GeneRIF: platelets capture and transfer infectious HIV-1 via
            DC-SIGN and CLEC-2, thereby possibly facilitating HIV-1
            dissemination in infected patients
REFERENCE   7  (bases 1 to 779)
  AUTHORS   Suzuki-Inoue,K., Fuller,G.L., Garcia,A., Eble,J.A., Pohlmann,S.,
            Inoue,O., Gartner,T.K., Hughan,S.C., Pearce,A.C., Laing,G.D.,
            Theakston,R.D., Schweighoffer,E., Zitzmann,N., Morita,T.,
            Tybulewicz,V.L., Ozaki,Y. and Watson,S.P.
  TITLE     A novel Syk-dependent mechanism of platelet activation by the
            C-type lectin receptor CLEC-2
  JOURNAL   Blood 107 (2), 542-549 (2006)
   PUBMED   16174766
REFERENCE   8  (bases 1 to 779)
  AUTHORS   Watson,A.A. and O'Callaghan,C.A.
  TITLE     Crystallization and X-ray diffraction analysis of human CLEC-2
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 61 (Pt 12),
            1094-1096 (2005)
   PUBMED   16511244
  REMARK    GeneRIF: X-ray diffraction analysis of human CLEC-2
REFERENCE   9  (bases 1 to 779)
  AUTHORS   Sobanov,Y., Bernreiter,A., Derdak,S., Mechtcheriakova,D.,
            Schweighofer,B., Duchler,M., Kalthoff,F. and Hofer,E.
  TITLE     A novel cluster of lectin-like receptor genes expressed in
            monocytic, dendritic and endothelial cells maps close to the NK
            receptor genes in the human NK gene complex
  JOURNAL   Eur J Immunol 31 (12), 3493-3503 (2001)
   PUBMED   11745369
REFERENCE   10 (bases 1 to 779)
  AUTHORS   Colonna,M., Samaridis,J. and Angman,L.
  TITLE     Molecular characterization of two novel C-type lectin-like
            receptors, one of which is selectively expressed in human dendritic
            cells
  JOURNAL   Eur J Immunol 30 (2), 697-704 (2000)
   PUBMED   10671229
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091814.10.
            
            On Feb 4, 2021 this sequence version replaced NM_016509.3.
            
            Summary: Natural killer (NK) cells express multiple
            calcium-dependent (C-type) lectin-like receptors, such as CD94
            (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact
            with major histocompatibility complex class I molecules and either
            inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a
            C-type lectin-like receptor expressed in myeloid cells and NK cells
            (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF124841.1, AY358599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162895 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298527.11/ ENSP00000298527.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC091814.10        11327-11411
            86-184              AC091814.10        12068-12166
            185-304             AC091814.10        13169-13288
            305-459             AC091814.10        13448-13602
            460-566             AC091814.10        15202-15308
            567-779             AC091814.10        17161-17373
FEATURES             Location/Qualifiers
     source          1..779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31-p13.2"
     gene            1..779
                     /gene="CLEC1B"
                     /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
                     QDED721"
                     /note="C-type lectin domain family 1 member B"
                     /db_xref="GeneID:51266"
                     /db_xref="HGNC:HGNC:24356"
                     /db_xref="MIM:606783"
     exon            1..85
                     /gene="CLEC1B"
                     /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
                     QDED721"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..711
                     /gene="CLEC1B"
                     /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
                     QDED721"
                     /note="isoform a is encoded by transcript variant 1;
                     C-type lectin-like receptor 2"
                     /codon_start=1
                     /product="C-type lectin domain family 1 member B isoform
                     a"
                     /protein_id="NP_057593.3"
                     /db_xref="CCDS:CCDS41752.1"
                     /db_xref="GeneID:51266"
                     /db_xref="HGNC:HGNC:24356"
                     /db_xref="MIM:606783"
                     /translation="MQDEDGYITLNIKTRKPALISVGSASSSWWRVMALILLILCVGM
                     VVGLVALGIWSVMQRNYLQGENENRTGTLQQLAKRFCQYVVKQSELKGTFKGHKCSPC
                     DTNWRYYGDSCYGFFRHNLTWEESKQYCTDMNATLLKIDNRNIVEYIKARTHLIRWVG
                     LSRQKSNEVWKWEDGSVISENMFEFLEDGKGNMNCAYFHNGKMHPTFCENKHYLMCER
                     KAGMTKVDQLP"
     exon            86..184
                     /gene="CLEC1B"
                     /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
                     QDED721"
                     /inference="alignment:Splign:2.1.0"
     exon            185..304
                     /gene="CLEC1B"
                     /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
                     QDED721"
                     /inference="alignment:Splign:2.1.0"
     exon            305..459
                     /gene="CLEC1B"
                     /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
                     QDED721"
                     /inference="alignment:Splign:2.1.0"
     exon            460..566
                     /gene="CLEC1B"
                     /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
                     QDED721"
                     /inference="alignment:Splign:2.1.0"
     exon            567..779
                     /gene="CLEC1B"
                     /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
                     QDED721"
                     /inference="alignment:Splign:2.1.0"
     regulatory      757..762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC1B"
                     /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
                     QDED721"
                     /note="hexamer: AATAAA"
     polyA_site      779
                     /gene="CLEC1B"
                     /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
                     QDED721"
                     /note="major polyA site"
ORIGIN      
        1 agttgcagta ctcgggaagc catgcaggat gaagatggat acatcacctt aaatattaaa
       61 actcggaaac cagctctcat ctccgttggc tctgcatcct cctcctggtg gcgtgtgatg
      121 gctttgattc tgctgatcct gtgcgtgggg atggttgtcg ggctggtggc tctggggatt
      181 tggtctgtca tgcagcgcaa ttacctacaa ggtgagaatg aaaatcgcac aggaactctg
      241 caacaattag caaagcgctt ctgtcaatat gtggtaaaac aatcagaact aaagggcact
      301 ttcaaaggtc ataaatgcag cccctgtgac acaaactgga gatattatgg agatagctgc
      361 tatgggttct tcaggcacaa cttaacatgg gaagagagta agcagtactg cactgacatg
      421 aatgctactc tcctgaagat tgacaaccgg aacattgtgg agtacatcaa agccaggact
      481 catttaattc gttgggtcgg attatctcgc cagaagtcga atgaggtctg gaagtgggag
      541 gatggctcgg ttatctcaga aaatatgttt gagtttttgg aagatggaaa aggaaatatg
      601 aattgtgctt attttcataa tgggaaaatg caccctacct tctgtgagaa caaacattat
      661 ttaatgtgtg agaggaaggc tggcatgacc aaggtggacc aactacctta atgcaaagag
      721 gtggacagga taacacagat aagggcttta ttgtacaata aaagatatgt atgaatgca
//
