LOCUS       NM_001256720            2546 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens C-type lectin domain containing 19A (CLEC19A), mRNA.
ACCESSION   NM_001256720
VERSION     NM_001256720.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2546)
  AUTHORS   Mohajerani,F., Tehrankhah,Z.M., Rahmani,S., Afsordeh,N.,
            Shafiee,S., Pourgholami,M.H., Soltani,B.M. and Sadeghizadeh,M.
  TITLE     CLEC19A overexpression inhibits tumor cell proliferation/migration
            and promotes apoptosis concomitant suppression of
            PI3K/AKT/NF-kappaB signaling pathway in glioblastoma multiforme
  JOURNAL   BMC Cancer 24 (1), 19 (2024)
   PUBMED   38167030
  REMARK    GeneRIF: CLEC19A overexpression inhibits tumor cell
            proliferation/migration and promotes apoptosis concomitant
            suppression of PI3K/AKT/NF-kappaB signaling pathway in glioblastoma
            multiforme.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2546)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2546)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AC003003.1, BC119018.1 and
            BX640722.1.
            
            On May 17, 2019 this sequence version replaced NM_001256720.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. There are no human mRNAs or ESTs
            supporting the full-length exon combination of this RefSeq; it is
            predicted based on partial human and homologous transcript
            alignments from zebrafish and chicken, and on human RNA-Seq
            alignments from the ENCODE project.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000636231.2/ ENSP00000490375.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC003003.1         102533-102584
            53-166              BC119018.1         1-114
            167-167             AC003003.1         102699-102699
            168-306             BC119018.1         116-254
            307-307             AC003003.1         115572-115572
            308-469             BC119018.1         256-417
            470-621             BX640722.1         305-456
            622-2495            AC003003.1         125825-127698
            2496-2546           BX640722.1         2332-2382
FEATURES             Location/Qualifiers
     source          1..2546
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..2546
                     /gene="CLEC19A"
                     /note="C-type lectin domain containing 19A"
                     /db_xref="GeneID:728276"
                     /db_xref="HGNC:HGNC:34522"
     exon            1..209
                     /gene="CLEC19A"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..682
                     /gene="CLEC19A"
                     /note="C-type lectin domain family 19 member A"
                     /codon_start=1
                     /product="C-type lectin domain family 19 member A
                     precursor"
                     /protein_id="NP_001243649.1"
                     /db_xref="CCDS:CCDS81953.1"
                     /db_xref="GeneID:728276"
                     /db_xref="HGNC:HGNC:34522"
                     /translation="MQRWTLWAAAFLTLHSAQAFPQTDISISPALPELPLPSLCPLFW
                     MEFKGHCYRFFPLNKTWAEADLYCSEFSVGRKSAKLASIHSWEENVFVYDLVNSCVPG
                     IPADVWTGLHDHRQEGQFEWTDGSSYDYSYWDGSQPDDGVHADPEEEDCVQIWYRPTS
                     ALRSWNDNTCSRKFPFVCKIPSLTIH"
     exon            210..375
                     /gene="CLEC19A"
                     /inference="alignment:Splign:2.1.0"
     exon            376..469
                     /gene="CLEC19A"
                     /inference="alignment:Splign:2.1.0"
     exon            470..602
                     /gene="CLEC19A"
                     /inference="alignment:Splign:2.1.0"
     exon            603..2546
                     /gene="CLEC19A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1193..1198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC19A"
                     /note="hexamer: AATAAT"
     polyA_site      1215
                     /gene="CLEC19A"
                     /note="major polyA site"
ORIGIN      
        1 agtctgtccc agctcctgcc aggctccatc tgaccctagg agagcaatcc tggacccaag
       61 ctccagccaa aaagcctctc tcctccactc aggctgggag gttgctttct aggagctcag
      121 gatgcaaagg tggacactgt gggctgcagc cttcctgacc ctccactctg cacaggcctt
      181 tccacaaaca gacatcagta tcagtccagc cctgccagag ctgcccctgc cttccctgtg
      241 ccccctgttc tggatggagt tcaaaggcca ctgctatcga ttcttccctc tcaataagac
      301 ctgggctgag gccgacctct actgttctga gttctctgtg ggcaggaagt ccgccaagct
      361 ggcctccatc cacagctggg aggagaatgt ctttgtatat gacctcgtga acagctgtgt
      421 tcccggcatc ccagctgacg tctggacagg ccttcatgat cacagacagg aagggcagtt
      481 tgaatggact gatggctcat cctatgacta cagctactgg gatggcagcc agccagatga
      541 tggcgtccac gcggacccag aagaagagga ctgcgtgcag atatggtaca ggcctaccag
      601 tgctctgagg tcatggaatg ataacacctg cagccggaag ttcccctttg tctgcaaaat
      661 cccatctctg accattcatt gatcctgtct tgtcctactg gtgtgagctc aactctagta
      721 tcatcttgta gctgtaacca gtgtagaatt gacattgaat acatgtaaaa catacatagg
      781 aagtaaatct cttggacaga gattttaaac aagcagatct taattataca gggtggtcac
      841 ttggccaagt gtcaggaaag ccagctcaaa ttggcttaat tttttaaagt gttttttttt
      901 ttaaattgac ccaagtaaca aaaatccagg ggttgttctg attcagagtt gaatctcact
      961 ggcctggctc gggtcacgtg cccatccctg aagcaatcac tttggcatat gctaagtggc
     1021 tagctcctgc ttagctgtac atctttggac aaaatggggt ggaagtcaca ttatcagagg
     1081 cgctgggagt gggggaaaat gcgggggggt gttggtcaaa gcatacaaac ttttggaaat
     1141 aagattaata agtttgggag gcttaatgta cagcgtgatg actatagtta ataataatgt
     1201 attgtattcc tgaaatttgc tacgagagta attttttttt ttgagacaga gtctcactct
     1261 gttgcccagg ctgaagtgca atgatgcaat cacagctcac tgcagcctca acctcctggg
     1321 ctcaggtgat ccttccacct ccagtcccca gagtaggtgg gactacagga cgctacaggc
     1381 gcatgccacc acatctagct aacttttgta tttttttttt taaatagaga cgaggtttca
     1441 tcatgtcatc caagctggtt tcgaactcct gggctcaagg gatccaccca cctcagcctc
     1501 ccaaagtact gggattacag gcatgagcca ctgcgcctag ccaagaatac atcttaaata
     1561 ttcccgtcaa cacatgggct caaagatgag gctggttctt caaaggaaaa caaaaagatt
     1621 accaaactca taaattgctg gtgggaatgt aaaatagtga agccactgtg gaaaagtttg
     1681 gcagttcctc aaaaagttaa acatagaatt acatctaagc cagcaattcc actcctagat
     1741 ctcgacctaa gagaatcgga aacaggtatt taaatataag tggtcggcca ggtgtagtgg
     1801 ctcatgcctg taatcccagc actttgggaa gctgaggaga gaggatcact tgagcccagg
     1861 agttgaagat cagcctgggc aacatagtaa gaccccatct ccataagaaa aattttttaa
     1921 ttagccaagc atggtgatgc acatctgtag tcccagctgt ttgggaggct gagatgggag
     1981 gatcacttga gcccaggata tcaaggctgc aatggaccat gattgtgctt ctgcactcca
     2041 gcctgggtga cagagcaaga ccctgtctca aaaaacaaaa acaaaaaaat gtgatcacag
     2101 cagcattatt gataaaaacc acaaaaaaaa tgaagacaac ccaagtgctc accaacagat
     2161 gaatgactaa acaaatgtgg tctattcata gggtggaata ttattcaagc ataaaaagga
     2221 atgaagtaac gatagatact acaacctgaa tgaacctgaa aaacattatg cttccagtca
     2281 caaaagacca catgttgtat gattccatat atatgaaata tccagaatag gcaagtctat
     2341 agagatggaa agtggattag tggttgccag gggatgtgtg gagggggaat agaaagtgag
     2401 tgctaatagg tatgggatta ctttgtgagg tgacaaaaat tatctgcaat tagatagtgg
     2461 taatggctgc acaatattgt aaatgtacaa gaagccactg aactgtacat tttaaaataa
     2521 tagttaaaat gataaatttt acatta
//
