LOCUS       NM_001385193            1924 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens C-type lectin domain family 18 member B (CLEC18B),
            transcript variant 2, mRNA.
ACCESSION   NM_001385193 XM_005255976
VERSION     NM_001385193.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Guo,R.M., Zhao,C.B., Li,P., Zhang,L., Zang,S.H. and Yang,B.
  TITLE     Overexpression of CLEC18B Associates With the Proliferation,
            Migration, and Prognosis of Glioblastoma
  JOURNAL   ASN Neuro 10, 1759091418781949 (2018)
   PUBMED   29914265
  REMARK    GeneRIF: The results from this study showed that CLEC18B was
            markedly elevated in both GBM tissues and cells, and exhibited
            strong inverse correlation with overall survival in GBM patients
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Huang,Y.L., Pai,F.S., Tsou,Y.T., Mon,H.C., Hsu,T.L., Wu,C.Y.,
            Chou,T.Y., Yang,W.B., Chen,C.H., Wong,C.H. and Hsieh,S.L.
  TITLE     Human CLEC18 Gene Cluster Contains C-type Lectins with Differential
            Glycan-binding Specificity
  JOURNAL   J Biol Chem 290 (35), 21252-21263 (2015)
   PUBMED   26170455
  REMARK    GeneRIF: The human C-type lectin 18 (clec18) gene cluster, which
            contains three clec18a, clec18b, and clec18c loci, is located in
            human chromosome 16q22.
REFERENCE   3  (bases 1 to 1924)
  AUTHORS   Zelensky,A.N. and Gready,J.E.
  TITLE     The C-type lectin-like domain superfamily
  JOURNAL   FEBS J 272 (24), 6179-6217 (2005)
   PUBMED   16336259
  REMARK    Review article
REFERENCE   4  (bases 1 to 1924)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009053.7.
            
            On Jul 10, 2020 this sequence version replaced XM_005255976.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.185720.1,
                                           SRR1803615.348841.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682950.1/ ENSP00000507367.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-332               AC009053.7         42831-43162
            333-424             AC009053.7         43717-43808
            425-664             AC009053.7         46011-46250
            665-762             AC009053.7         50633-50730
            763-884             AC009053.7         51151-51272
            885-992             AC009053.7         51429-51536
            993-1085            AC009053.7         52063-52155
            1086-1192           AC009053.7         52534-52640
            1193-1322           AC009053.7         53275-53404
            1323-1419           AC009053.7         53677-53773
            1420-1511           AC009053.7         54668-54759
            1512-1924           AC009053.7         55266-55678
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..1924
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /note="C-type lectin domain family 18 member B"
                     /db_xref="GeneID:497190"
                     /db_xref="HGNC:HGNC:33849"
                     /db_xref="MIM:616572"
     exon            1..332
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1549
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; mannose receptor-like 2; secretory protein
                     LOC497190; mannose receptor-like protein 1"
                     /codon_start=1
                     /product="C-type lectin domain family 18 member B isoform
                     1 precursor"
                     /protein_id="NP_001372122.1"
                     /db_xref="CCDS:CCDS92195.1"
                     /db_xref="GeneID:497190"
                     /db_xref="HGNC:HGNC:33849"
                     /db_xref="MIM:616572"
                     /translation="MLHPETSPGRGHLLAVLLALLGTTWAEVWPPQLQEQAPMAGALN
                     RKESFLLLSLHNRLRSWVQPPAADMRRLDWSDSLAQLAQARAALCGIPTPSLASGLWR
                     TLQVGWNMQLLPAGLASFVEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQ
                     LGCGRHLCSAGQTAIEAFVCAYSPGGNWEVNGKTIIPYKKGAWCSLCTASVSGCFKAW
                     DHAGGLCEVPRNPCRMSCQNHGRLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREE
                     ECSCVCDIGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVL
                     AQIKSQKVQDILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAF
                     TSFAFGQPDNHGFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWGPGS"
     exon            333..424
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            425..664
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            665..762
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..884
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            885..992
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1085
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1192
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1322
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1419
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1511
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1924
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1903..1908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /note="hexamer: ATTAAA"
     polyA_site      1924
                     /gene="CLEC18B"
                     /gene_synonym="MRCL2"
                     /note="major polyA site"
ORIGIN      
        1 ctcttttcat gccagcgcca acaggaggct gtctggacac actgattact cactcaccag
       61 cctccttctt ttgttcacca gcccccctct tttgtccacc agcccagcct gactcctgga
      121 gattgtgaat agctccatcc agcctgagaa acaagccggg tggctgagcc aggctgtgca
      181 cggagcgcct gacgggccca acagacccat gctgcatcca gagacctccc ctggccgggg
      241 gcatctcctg gctgtgctcc tggccctcct tggcaccacc tgggcagagg tgtggccacc
      301 ccagctgcag gagcaggctc cgatggccgg agccctgaac aggaaggaga gtttcttgct
      361 cctctccctg cacaaccgcc tgcgcagctg ggtccagccc cctgcggctg acatgcggag
      421 gctggactgg agtgacagcc tggcccaact ggctcaagcc agggcagccc tctgtggaat
      481 cccaaccccg agcctggcgt ccggcctgtg gcgcaccctg caagtgggct ggaacatgca
      541 gctgctgccc gcgggcttgg cgtcctttgt tgaagtggtc agcctgtggt ttgcagaggg
      601 gcagcggtac agccacgcgg caggagagtg tgctcgcaac gccacctgca cccactacac
      661 gcagctcgtg tgggccacct caagccagct gggctgtggg cggcacctgt gctctgcagg
      721 ccagacagcg atagaagcct ttgtctgtgc ctactccccc ggaggcaact gggaggtcaa
      781 cgggaagaca atcatcccct ataagaaggg tgcctggtgt tcgctctgca cagccagtgt
      841 ctcaggctgc ttcaaagcct gggaccatgc aggggggctc tgtgaggtcc ccaggaatcc
      901 ttgtcgcatg agctgccaga accatggacg tctcaacatc agcacctgcc actgccactg
      961 tccccctggc tacacgggca gatactgcca agtgaggtgc agcctgcagt gtgtgcacgg
     1021 ccggttccgg gaggaggagt gctcgtgcgt ctgtgacatc ggctacgggg gagcccagtg
     1081 tgccaccaag gtgcattttc ccttccacac ctgtgacctg aggatcgacg gagactgctt
     1141 catggtgtct tcagaggcag acacctatta cagagccagg atgaaatgtc agaggaaagg
     1201 cggggtgctg gcccagatca agagccagaa agtgcaggac atcctcgcct tctatctggg
     1261 ccgcctggag accaccaacg aggtgattga cagtgacttc gagaccagga acttctggat
     1321 cgggctcacc tacaagaccg ccaaggactc cttccgctgg gccacagggg agcaccaggc
     1381 cttcaccagt tttgcctttg ggcagcctga caaccacggg tttggcaact gcgtggagct
     1441 gcaggcttca gctgccttca actggaacga ccagcgctgc aaaacccgaa accgttacat
     1501 ctgccagttt gcccaggagc acatctcccg gtggggccca gggtcctgag gcctgaccac
     1561 atggctccct cgcctgccct gggagcaccg gctctgctta cctgtctgcc cacctgtctg
     1621 gaacaagggc caggttaaga ccacatgcct catgtccaaa gaggtctcag accttgcaca
     1681 atgccagaag ttgggcagag agaggcaggg aggccagtga gggccaggga gtgagtgtta
     1741 gaagaagctg gggcccttcg cctgcttttg attgggaaga tgggcttcaa ttagatggcg
     1801 aaggagagga caccgccagt ggtccaaaaa ggctgctctc ttccacctgg cccagaccct
     1861 gtggggcagc ggagcttccc tgtggcatga accccacggg gtattaaatt atgaatcagc
     1921 tgaa
//
