LOCUS       NM_001370523            1749 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens C-type lectin domain family 18 member A (CLEC18A),
            transcript variant 4, mRNA.
ACCESSION   NM_001370523 XM_005255934
VERSION     NM_001370523.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Hsu,Y.W., Wong,H.S., Huang,W.C., Yeh,Y.H., Hsiao,C.D., Chang,W.C.
            and Hsieh,S.L.
  TITLE     Human rs75776403 polymorphism links differential phenotypic and
            clinical outcomes to a CLEC18A p.T151M-driven multiomics
  JOURNAL   J Biomed Sci 29 (1), 43 (2022)
   PUBMED   35717171
  REMARK    GeneRIF: Human rs75776403 polymorphism links differential
            phenotypic and clinical outcomes to a CLEC18A p.T151M-driven
            multiomics.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1749)
  AUTHORS   Huang,Y.L., Huang,M.T., Sung,P.S., Chou,T.Y., Yang,R.B., Yang,A.S.,
            Yu,C.M., Hsu,Y.W., Chang,W.C. and Hsieh,S.L.
  TITLE     Endosomal TLR3 co-receptor CLEC18A enhances host immune response to
            viral infection
  JOURNAL   Commun Biol 4 (1), 229 (2021)
   PUBMED   33603190
  REMARK    GeneRIF: Endosomal TLR3 co-receptor CLEC18A enhances host immune
            response to viral infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1749)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1749)
  AUTHORS   Liao,T.L., Huang,Y.L., Chen,Y.M., Lee,H.C., Chen,D.Y. and
            Hsieh,S.L.
  TITLE     Association of C-type lectin 18 levels with extrahepatic
            manifestations in chronic HCV infection
  JOURNAL   Sci Rep 8 (1), 17287 (2018)
   PUBMED   30470801
  REMARK    GeneRIF: High CLEC18 serum levels were associated with chronic HCV
            infection in rheumatic diseases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1749)
  AUTHORS   Tsai,T.Y., Peng,C.Y., Yang,H.I., Huang,Y.L., Tao,M.H., Yuan,S.S.,
            Lai,H.C. and Hsieh,S.L.
  TITLE     The human C-type lectin 18 is a potential biomarker in patients
            with chronic hepatitis B virus infection
  JOURNAL   J Biomed Sci 25 (1), 59 (2018)
   PUBMED   30055605
  REMARK    GeneRIF: Plasma CLEC18 levels were correlated with the stage of HBV
            infection and could predict HBeAg loss and seroconversion in the
            patients with chronic hepatitis B (CHB) undergoing NUC therapy
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1749)
  AUTHORS   Huang,Y.L., Pai,F.S., Tsou,Y.T., Mon,H.C., Hsu,T.L., Wu,C.Y.,
            Chou,T.Y., Yang,W.B., Chen,C.H., Wong,C.H. and Hsieh,S.L.
  TITLE     Human CLEC18 Gene Cluster Contains C-type Lectins with Differential
            Glycan-binding Specificity
  JOURNAL   J Biol Chem 290 (35), 21252-21263 (2015)
   PUBMED   26170455
  REMARK    GeneRIF: The human C-type lectin 18 (clec18) gene cluster, which
            contains three clec18a, clec18b, and clec18c loci, is located in
            human chromosome 16q22.
REFERENCE   7  (bases 1 to 1749)
  AUTHORS   Zelensky,A.N. and Gready,J.E.
  TITLE     The C-type lectin-like domain superfamily
  JOURNAL   FEBS J 272 (24), 6179-6217 (2005)
   PUBMED   16336259
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026468.7.
            
            On Feb 4, 2021 this sequence version replaced NM_001370523.3.
            
            Summary: This is one of three closely related paralogous genes on
            chromosome 16 encoding secreted proteins containing C-type lectin
            domains. These domains bind to carbohydrates in the presence of
            calcium, and may be involved in cell adhesion, immune response and
            apoptosis. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Sep 2012].
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF428259.1, AK074773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288040.11/ ENSP00000288040.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC026468.7         49402-49558         c
            158-249             AC026468.7         48766-48857         c
            250-489             AC026468.7         46319-46558         c
            490-587             AC026468.7         41853-41950         c
            588-709             AC026468.7         41311-41432         c
            710-817             AC026468.7         41046-41153         c
            818-910             AC026468.7         40427-40519         c
            911-1017            AC026468.7         39941-40047         c
            1018-1147           AC026468.7         39177-39306         c
            1148-1244           AC026468.7         38808-38904         c
            1245-1336           AC026468.7         37825-37916         c
            1337-1749           AC026468.7         36906-37318         c
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1749
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /note="C-type lectin domain family 18 member A"
                     /db_xref="GeneID:348174"
                     /db_xref="HGNC:HGNC:30388"
                     /db_xref="MIM:616571"
     exon            1..157
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1374
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /note="mannose receptor-like 1; mannose receptor-like
                     protein 2; mannose receptor-like protein 3"
                     /codon_start=1
                     /product="C-type lectin domain family 18 member A
                     precursor"
                     /protein_id="NP_001357452.1"
                     /db_xref="CCDS:CCDS10886.1"
                     /db_xref="GeneID:348174"
                     /db_xref="HGNC:HGNC:30388"
                     /db_xref="MIM:616571"
                     /translation="MLHPETSPGRGHLLAVLLALLGTAWAEVWPPQLQEQAPMAGALN
                     RKESFLLLSLHNRLRSWVQPPAADMRRLDWSDSLAQLAQARAALCGTPTPSLASGLWR
                     TLQVGWNMQLLPAGLVSFVEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQ
                     LGCGRHLCSAGQAAIEAFVCAYSPRGNWEVNGKTIVPYKKGAWCSLCTASVSGCFKAW
                     DHAGGLCEVPRNPCRMSCQNHGRLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREE
                     ECSCVCDIGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVL
                     AQIKSQKVQDILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAF
                     TSFAFGQPDNHGFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWGPGS"
     exon            158..249
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            250..489
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            490..587
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..709
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            710..817
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..910
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1017
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1147
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1244
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1336
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1749
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1728..1733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /note="hexamer: ATTAAA"
     polyA_site      1749
                     /gene="CLEC18A"
                     /gene_synonym="MRCL; MRCL1; MRLP2"
                     /note="major polyA site"
ORIGIN      
        1 gtgcacggag cgcctgacgg gcccaacaga cccatgctgc atccagagac ctcccctggc
       61 cgggggcatc tcctggctgt gctcctggcc ctccttggca ccgcctgggc agaggtgtgg
      121 ccaccccagc tgcaggagca ggctccgatg gccggagccc tgaacaggaa ggagagtttc
      181 ttgctcctct ccctgcacaa ccgcctgcgc agctgggtcc agccccctgc ggctgacatg
      241 cggaggctgg actggagtga cagcctggcc cagctggctc aagccagggc agccctctgt
      301 ggaaccccaa ccccgagcct ggcgtccggc ctgtggcgca ccctgcaagt gggctggaac
      361 atgcagctgc tacccgcggg cttggtgtcc tttgtcgaag tggtcagcct atggtttgca
      421 gaggggcagc ggtacagcca cgcggcagga gagtgtgctc gcaacgccac ctgcacccac
      481 tacacgcagc tcgtgtgggc cacctcaagc cagctgggct gtgggcggca cctgtgctct
      541 gcaggccagg cagcgataga agcctttgtc tgtgcctact cccccagagg caactgggag
      601 gtcaacggga agacaatcgt cccctataag aagggtgcct ggtgttcgct ctgcacagcc
      661 agtgtctcag gctgcttcaa agcctgggac catgcagggg ggctctgtga ggtccccagg
      721 aatccttgtc gcatgagctg ccagaaccat ggacgtctca acatcagcac ctgccactgc
      781 cactgtcccc ctggctacac gggcagatac tgccaagtga ggtgcagcct gcagtgtgtg
      841 cacggccggt tccgggagga ggagtgctcg tgcgtctgtg acatcggcta cgggggagcc
      901 cagtgtgcca ccaaggtgca ttttcccttc cacacctgtg acctgaggat cgacggagac
      961 tgcttcatgg tgtcttcaga ggcagacacc tattacagag ccaggatgaa atgtcagagg
     1021 aaaggcgggg tgctggccca gatcaagagc cagaaagtgc aggacatcct cgccttctat
     1081 ctgggccgcc tggagaccac caacgaggtg attgacagtg acttcgagac caggaacttc
     1141 tggatcgggc tcacctacaa gaccgccaag gactccttcc gctgggccac aggggagcac
     1201 caggccttca ccagttttgc ctttgggcag cctgacaacc acgggtttgg caactgcgtg
     1261 gagctgcagg cttcagctgc cttcaactgg aacgaccagc gctgcaaaac ccgaaaccgt
     1321 tacatctgcc agtttgccca ggagcacatc tcccggtggg gcccagggtc ctgaggcctg
     1381 accacatggc tccctcgcct gccctgggag caccggctct gcttacctgt ctgcccacct
     1441 gtctggaaca agggccaggt taagatcaca tgcctcatgt ccaaagaggt ctcagacctt
     1501 gcacaatgcc agaagttggg cagagagagg cagggaggcc agtgagggcc agggagtgag
     1561 tgttagaaga agctggggcc cttcgcctgc ttttgattgg gaagatgggc ttcaattaga
     1621 tggcgaagga gaggacaccg ccagtggtcc aaaaaggctg ctctcttcca cctggcccag
     1681 accctgtggg gcagcggagc ttccctgtgg catgaacccc acagggtatt aaattatgaa
     1741 tcagctgaa
//
