LOCUS       NM_001204118            3053 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens C-type lectin domain containing 17A (CLEC17A),
            transcript variant 1, mRNA.
ACCESSION   NM_001204118
VERSION     NM_001204118.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3053)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3053)
  AUTHORS   Breiman,A., Lopez Robles,M.D., de Carne Trecesson,S.,
            Echasserieau,K., Bernardeau,K., Drickamer,K., Imberty,A.,
            Barille-Nion,S., Altare,F. and Le Pendu,J.
  TITLE     Carcinoma-associated fucosylated antigens are markers of the
            epithelial state and can contribute to cell adhesion through
            CLEC17A (Prolectin)
  JOURNAL   Oncotarget 7 (12), 14064-14082 (2016)
   PUBMED   26908442
  REMARK    GeneRIF: High CLEC17A expression is associated with breast cancer.
REFERENCE   3  (bases 1 to 3053)
  CONSRTM   Cross-Disorder Group of the Psychiatric Genomics Consortium
  TITLE     Identification of risk loci with shared effects on five major
            psychiatric disorders: a genome-wide analysis
  JOURNAL   Lancet 381 (9875), 1371-1379 (2013)
   PUBMED   23453885
  REMARK    Erratum:[Lancet. 2013 Apr 20;381(9875):1360]
REFERENCE   4  (bases 1 to 3053)
  AUTHORS   Graham,S.A., Jegouzo,S.A., Yan,S., Powlesland,A.S., Brady,J.P.,
            Taylor,M.E. and Drickamer,K.
  TITLE     Prolectin, a glycan-binding receptor on dividing B cells in
            germinal centers
  JOURNAL   J Biol Chem 284 (27), 18537-18544 (2009)
   PUBMED   19419970
  REMARK    GeneRIF: this novel receptor has the potential to function in
            carbohydrate-mediated communication between cells in the germinal
            center
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010527.5, BC140848.1, AC140008.2 and AC135052.2.
            
            On Nov 30, 2019 this sequence version replaced NM_001204118.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140848.1, SRR18074968.925797.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417570.6/ ENSP00000393719.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC010527.5         10124-10173         c
            51-1224             BC140848.1         12-1185
            1225-1962           AC140008.2         19025-19762
            1963-3053           AC135052.2         3523-4613
FEATURES             Location/Qualifiers
     source          1..3053
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..3053
                     /gene="CLEC17A"
                     /note="C-type lectin domain containing 17A"
                     /db_xref="GeneID:388512"
                     /db_xref="HGNC:HGNC:34520"
                     /db_xref="MIM:616838"
     exon            1..120
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1214
                     /gene="CLEC17A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     prolectin; C-type lectin domain family 17 member A"
                     /codon_start=1
                     /product="C-type lectin domain family 17, member A isoform
                     1"
                     /protein_id="NP_001191047.1"
                     /db_xref="CCDS:CCDS56087.1"
                     /db_xref="GeneID:388512"
                     /db_xref="HGNC:HGNC:34520"
                     /db_xref="MIM:616838"
                     /translation="MHNLYSITGYPDPPGTMEEEEEDDDYENSTPPYKDLPPKPGTME
                     EEEEDDDYENSTPPYKDLPPKPGTMEEEEEDDDYENSTPPYKDLPPKPGSSAPPRPPR
                     AAKETEKPPLPCKPRNMTGLDLAAVTCPPPQLAVNLEPSPLQPSLAATPVPWLNQRSG
                     GPGCCQKRWMVYLCLLVVTSLFLGCLGLTVTLIKYQELMEELRMLSFQQMTWRTNMTG
                     MAGLAGLKHDIARVRADTNQSLVELWGLLDCRRITCPEGWLPFEGKCYYFSPSTKSWD
                     EARMFCQENYSHLVIINSFAEHNFVAKAHGSPRVYWLGLNDRAQEGDWRWLDGSPVTL
                     SFWEPEEPNNIHDEDCATMNKGGTWNDLSCYKTTYWICERKCSC"
     exon            121..198
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     exon            199..276
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     exon            277..354
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     exon            355..387
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     exon            388..438
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     exon            439..480
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     exon            481..522
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     exon            523..660
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     exon            661..723
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     exon            724..819
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     exon            820..971
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1081
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..3053
                     /gene="CLEC17A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3031..3036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC17A"
                     /note="hexamer: AATAAA"
     regulatory      3037..3042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC17A"
                     /note="hexamer: AATAAA"
     polyA_site      3048
                     /gene="CLEC17A"
     polyA_site      3053
                     /gene="CLEC17A"
                     /note="major polyA site"
ORIGIN      
        1 agacgcctga gtcggagaga cagggggcag aggttgccaa gccctggctg ccacttgtca
       61 ggttccctgt gctagacatg cataatctgt attccatcac tgggtacccg gacccaccag
      121 ggaccatgga ggaggaggag gaggatgatg actatgagaa ctcaacacct ccctacaagg
      181 accttcctcc caagccaggg accatggagg aggaggagga ggatgatgac tatgagaact
      241 caacacctcc ctacaaggac cttcctccca agccagggac catggaggag gaggaggagg
      301 atgatgacta tgagaactca acacctccct acaaggacct tcctcccaag ccaggttcaa
      361 gtgctccacc aagacctcca agggcagcaa aggaaacaga gaaaccccca cttccttgca
      421 agccccggaa catgacaggc ctggacctcg ccgctgtcac ctgtccacct cctcaactgg
      481 ctgtgaatct tgagccttct ccattgcagc catccctggc cgcaactcca gtcccctggc
      541 tcaatcagag gtctggaggt cctggctgct gccagaagag gtggatggtg tacctgtgtc
      601 tgctggtggt gacttccctg ttcctgggct gccttggtct cactgtgacc ctgattaagt
      661 accaggagtt gatggaagaa ctgagaatgt taagctttca gcagatgacg tggcgaacaa
      721 atatgactgg catggcaggg ctagctggcc tgaagcatga cattgcccgt gtaagagctg
      781 acaccaacca gtccctggtg gaactttggg gcttattaga ctgccgccga attacctgtc
      841 ctgaaggctg gctgcccttt gagggcaagt gttactactt ctccccaagc accaagtcat
      901 gggatgaggc ccggatgttc tgccaggaga attactctca cttggtcatc atcaatagct
      961 ttgctgagca caattttgtg gccaaggccc atggctctcc acgggtgtac tggctggggc
     1021 tgaatgacag ggcccaggaa ggggactgga ggtggctgga tgggtctcct gtgacattaa
     1081 gcttctggga gccagaggaa cccaataaca tccacgatga ggactgtgct accatgaaca
     1141 aaggtggcac ctggaatgat ctctcttgct acaaaactac gtattggatt tgtgagcgga
     1201 aatgttcctg ttgaagccca gggccgaggc tgggggtcca tatctgagtg tctctttgag
     1261 atgagaatct cctgcccttt cgtggacggc cttgcctctt cgtgagtgga cacacagatg
     1321 tgcctcaaac aggattggca ccctggatgc agcaagttcc caggggtgca agtcaggctg
     1381 tttctagagt gaggacttgg gcttgcccta gtagatggtg agctgggagg atgctcagag
     1441 cttggtggtg ggaggtctcc cacttctggg gttgaaagga tcttcactaa gttcctgatc
     1501 atgactcttg ggaagtgata ctagccctga ggaccctggg gctggtgttg aacctgggat
     1561 gaaatatcct ggcgcctgtg aaccacaaag agctgggact gggctccttt tcctgcagcc
     1621 tcaaacttct gggctcaggt gatcctccca tctcagcctc ctgagtagct gggactacac
     1681 atgcgcacca ccatgcctgg ccaatttttt gtagcattta aagagaggga gtctcactat
     1741 gttgcccagg ccagtctcaa actccttgcc tcaatggatc ctcctacttg ggcttcccaa
     1801 attgtgagga ttacaggtgt gagccactgt gcctggctca aaattattat tattattttt
     1861 atagagatga ggtctcactc tgttgccgag gctggtctca aactcctggg gtcaagcaat
     1921 ccttccgtga tggcctccca aagtgctggg attacaggca tgtgtcaccg tacctggccg
     1981 atatttttat ttttattttt actttcccca tcttttcctt tttttttttt ttccaaacaa
     2041 aagctttgaa agtggtgaca gaaaaatttc cctttgagct agacctctag atctgcctcg
     2101 cacagaaata cattaagtgg gctggtctca tgtagtcccc acatcattgc aaattacaaa
     2161 cctaaaaata cagaacatca gcggagaaga caggagagct tctatattca ccccatgtcg
     2221 tcctctccag acactgcttc cttcctggtc tcaaacagca caaataaccc agaaaccatc
     2281 aaaattattt ttgaccagca actttctcaa tgtcttgggt gaggtttgca caagctaagt
     2341 ggcagaatca gacttttgcc agaagacttg gcccgtggaa cttctatcct tttttttttt
     2401 tttttttttt tttgagatag ggtttcattc tactacccag gctggagtgc agtggcacaa
     2461 tcatagctta ctgcaccctc tgcctcctgg gctcgagtga tcctcctgcc tcagcctccc
     2521 aagtagctgg gactacaggc gttcaccctc acacctggct ggcccatgga acttctagaa
     2581 aggcatacca gctgaaaagc aagaccccta catagtgtgg ccaggcaggc cataacctgg
     2641 tcatatccac acaggacaac gatggaccta tctgccagca cgtgcccttg agctatctgt
     2701 gggttgtaac gtctttgatg atataattca ctttacttgc caggcacagt ggctcacgcc
     2761 tgtaatccca gcactctggg agactgaggt gggctgatca cctggggtca ggatttcgag
     2821 accagcctgg ccaacatggt aaaatcctat ctctactaaa aatacaaaaa aattagctgg
     2881 gcgtggtggc atgtgcctgt aatcccagct actcaggaga ctaaggcacg agaattgctt
     2941 gaacccagga ggcggaggtt gcagtgagcc gagattgtgc cactgcactc cagcctgggt
     3001 gacagagcaa gactccatct caaataaata aataaaaata aaaattcact tta
//
