LOCUS       NM_015226               6812 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens C-type lectin domain containing 16A (CLEC16A),
            transcript variant 1, mRNA.
ACCESSION   NM_015226 XM_497484
VERSION     NM_015226.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6812)
  AUTHORS   Pandey,R., Bakay,M. and Hakonarson,H.
  TITLE     CLEC16A-An Emerging Master Regulator of Autoimmunity and
            Neurodegeneration
  JOURNAL   Int J Mol Sci 24 (9), 8224 (2023)
   PUBMED   37175930
  REMARK    GeneRIF: CLEC16A-An Emerging Master Regulator of Autoimmunity and
            Neurodegeneration.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6812)
  AUTHORS   Vandewalle,J., Desouter,A.K., Van der Auwera,B.J., Tenoutasse,S.,
            Gillard,P., De Block,C., Keymeulen,B., Gorus,F.K. and Van de
            Casteele,M.
  CONSRTM   Belgian Diabetes Registry
  TITLE     CTLA4, SH2B3, and CLEC16A diversely affect the progression of early
            islet autoimmunity in relatives of Type 1 diabetes patients
  JOURNAL   Clin Exp Immunol 211 (3), 224-232 (2023)
   PUBMED   36622793
  REMARK    GeneRIF: CTLA4, SH2B3, and CLEC16A diversely affect the progression
            of early islet autoimmunity in relatives of Type 1 diabetes
            patients.
REFERENCE   3  (bases 1 to 6812)
  AUTHORS   Smits,D.J., Dekker,J., Schot,R., Tabarki,B., Alhashem,A.,
            Demmers,J.A.A., Dekkers,D.H.W., Romito,A., van der Spek,P.J., van
            Ham,T.J., Bertoli-Avella,A.M. and Mancini,G.M.S.
  TITLE     CLEC16A interacts with retromer and TRIM27, and its loss impairs
            endosomal trafficking and neurodevelopment
  JOURNAL   Hum Genet 142 (3), 379-397 (2023)
   PUBMED   36538041
  REMARK    GeneRIF: CLEC16A interacts with retromer and TRIM27, and its loss
            impairs endosomal trafficking and neurodevelopment.
REFERENCE   4  (bases 1 to 6812)
  AUTHORS   Gingerich,M.A., Liu,X., Chai,B., Pearson,G.L., Vincent,M.P.,
            Stromer,T., Zhu,J., Sidarala,V., Renberg,A., Sahu,D.,
            Klionsky,D.J., Schnell,S. and Soleimanpour,S.A.
  TITLE     An intrinsically disordered protein region encoded by the human
            disease gene CLEC16A regulates mitophagy
  JOURNAL   Autophagy 19 (2), 525-543 (2023)
   PUBMED   35604110
  REMARK    GeneRIF: An intrinsically disordered protein region encoded by the
            human disease gene CLEC16A regulates mitophagy.
REFERENCE   5  (bases 1 to 6812)
  AUTHORS   Eriksson,A.M., Leikfoss,I.S., Abrahamsen,G., Sundvold,V.,
            Isom,M.M., Keshari,P.K., Rognes,T., Landsverk,O.J.B., Bos,S.D.,
            Harbo,H.F., Spurkland,A. and Berge,T.
  TITLE     Exploring the role of the multiple sclerosis susceptibility gene
            CLEC16A in T cells
  JOURNAL   Scand J Immunol 94 (1), e13050 (2021)
   PUBMED   34643957
  REMARK    GeneRIF: Exploring the role of the multiple sclerosis
            susceptibility gene CLEC16A in T cells.
REFERENCE   6  (bases 1 to 6812)
  AUTHORS   Skinningsrud,B., Husebye,E.S., Pearce,S.H., McDonald,D.O.,
            Brandal,K., Wolff,A.B., Lovas,K., Egeland,T. and Undlien,D.E.
  TITLE     Polymorphisms in CLEC16A and CIITA at 16p13 are associated with
            primary adrenal insufficiency
  JOURNAL   J Clin Endocrinol Metab 93 (9), 3310-3317 (2008)
   PUBMED   18593762
  REMARK    GeneRIF: Two alleles at 16p13 are independently associated with the
            risk of Addison's disease in the Norwegian population, suggesting
            this chromosomal region to harbor common autoimmunity gene(s),
            CLEC16A and CIITA being possible independent candidates.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6812)
  AUTHORS   Hafler,D.A., Compston,A., Sawcer,S., Lander,E.S., Daly,M.J., De
            Jager,P.L., de Bakker,P.I., Gabriel,S.B., Mirel,D.B., Ivinson,A.J.,
            Pericak-Vance,M.A., Gregory,S.G., Rioux,J.D., McCauley,J.L.,
            Haines,J.L., Barcellos,L.F., Cree,B., Oksenberg,J.R. and
            Hauser,S.L.
  CONSRTM   International Multiple Sclerosis Genetics Consortium
  TITLE     Risk alleles for multiple sclerosis identified by a genomewide
            study
  JOURNAL   N Engl J Med 357 (9), 851-862 (2007)
   PUBMED   17660530
REFERENCE   8  (bases 1 to 6812)
  AUTHORS   Hakonarson,H., Grant,S.F., Bradfield,J.P., Marchand,L., Kim,C.E.,
            Glessner,J.T., Grabs,R., Casalunovo,T., Taback,S.P.,
            Frackelton,E.C., Lawson,M.L., Robinson,L.J., Skraban,R., Lu,Y.,
            Chiavacci,R.M., Stanley,C.A., Kirsch,S.E., Rappaport,E.F.,
            Orange,J.S., Monos,D.S., Devoto,M., Qu,H.Q. and Polychronakos,C.
  TITLE     A genome-wide association study identifies KIAA0350 as a type 1
            diabetes gene
  JOURNAL   Nature 448 (7153), 591-594 (2007)
   PUBMED   17632545
  REMARK    GeneRIF: results indicate that KIAA0350 might be involved in the
            pathogenesis of type 1 diabetes and demonstrate the utility of the
            genome-wide association approach in the identification of
            previously unsuspected genetic determinants of complex traits
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 6812)
  AUTHORS   Todd,J.A., Walker,N.M., Cooper,J.D., Smyth,D.J., Downes,K.,
            Plagnol,V., Bailey,R., Nejentsev,S., Field,S.F., Payne,F.,
            Lowe,C.E., Szeszko,J.S., Hafler,J.P., Zeitels,L., Yang,J.H.,
            Vella,A., Nutland,S., Stevens,H.E., Schuilenburg,H., Coleman,G.,
            Maisuria,M., Meadows,W., Smink,L.J., Healy,B., Burren,O.S.,
            Lam,A.A., Ovington,N.R., Allen,J., Adlem,E., Leung,H.T.,
            Wallace,C., Howson,J.M., Guja,C., Ionescu-Tirgoviste,C.,
            Simmonds,M.J., Heward,J.M., Gough,S.C., Dunger,D.B., Wicker,L.S.
            and Clayton,D.G.
  CONSRTM   Genetics of Type 1 Diabetes in Finland; Wellcome Trust Case Control
            Consortium
  TITLE     Robust associations of four new chromosome regions from genome-wide
            analyses of type 1 diabetes
  JOURNAL   Nat Genet 39 (7), 857-864 (2007)
   PUBMED   17554260
REFERENCE   10 (bases 1 to 6812)
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study of 14,000 cases of seven common
            diseases and 3,000 shared controls
  JOURNAL   Nature 447 (7145), 661-678 (2007)
   PUBMED   17554300
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB069341.1, AB002348.3 and
            AW072095.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015226.2.
            
            Summary: This gene encodes a member of the C-type lectin domain
            containing family. Single nucleotide polymorphisms in introns of
            this gene have been associated with diabetes mellitus, multiple
            sclerosis and rheumatoid arthritis. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002348.3, SRR1803614.203490.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409790.6/ ENSP00000387122.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DB069341.1         77-97
            22-6807             AB002348.3         1-6786
            6808-6812           AW072095.1         4-8                 c
FEATURES             Location/Qualifiers
     source          1..6812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..6812
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /note="C-type lectin domain containing 16A"
                     /db_xref="GeneID:23274"
                     /db_xref="HGNC:HGNC:29013"
                     /db_xref="MIM:611303"
     exon            1..234
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..3316
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein CLEC16A; C-type lectin domain family 16 member A"
                     /codon_start=1
                     /product="protein CLEC16A isoform 1"
                     /protein_id="NP_056041.1"
                     /db_xref="CCDS:CCDS45409.1"
                     /db_xref="GeneID:23274"
                     /db_xref="HGNC:HGNC:29013"
                     /db_xref="MIM:611303"
                     /translation="MFGRSRSWVGGGHGKTSRNIHSLDHLKYLYHVLTKNTTVTEQNR
                     NLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLN
                     ILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHF
                     FYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVSLDNQAMLHYIRDKTAVP
                     YFSNLVWFIGSHVIELDDCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLN
                     DVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLA
                     EVILNGDLSEMYAKTEQDIQRSSAKPSIRCFIKPTETLERSLEMNKHKGKRRVQKRPN
                     YKNVGEEEDEEKGPTEDAQEDAEKAKGTEGGSKGIKTSGESEEIEMVIMERSKLSELA
                     ASTSVQEQNTTDEEKSAAATCSESTQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAM
                     SHNKGMDPEKLERIQLPVPNAAEKTTYNHPLAERLIRIMNNAAQPDGKIRLATLELSC
                     LLLKQQVLMSAGCIMKDVHLACLEGAREESVHLVRHFYKGEDIFLDMFEDEYRSMTMK
                     PMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLRG
                     EPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQRFLAVDIYQMSLVEPD
                     VSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDH
                     IRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSTSTQHLPFRFY
                     DQGRRGSSDPTVQRSVFASVDKVPGFAVAQCINQHSSPSLSSQSPPSASGSPSGSGST
                     SHCDSGGTSSSSTPSTAQSPADAPMSPELPKPHLPDQLVIVNETEADSKPSKNVARSA
                     AVETASLSPSLVPARQPTISLLCEDTADTLSVESLTLVPPVDPHSLRSLTGMPPLSTP
                     AAACTEPVGEEAACAEPVGTAED"
     exon            235..363
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            364..497
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            498..646
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            647..752
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            753..758
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            759..882
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1057
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1111
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1225
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1457
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1590
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1691
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1814
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1924
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..1969
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2020
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2149
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2270
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2422
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2627
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2795
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2960
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..6812
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6527..6532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /note="hexamer: AATAAA"
     regulatory      6531..6536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /note="hexamer: AATAAA"
     polyA_site      6545
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /note="major polyA site"
     polyA_site      6564
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
     regulatory      6788..6793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /note="hexamer: AATAAA"
     polyA_site      6812
                     /gene="CLEC16A"
                     /gene_synonym="Gop-1; KIAA0350"
                     /note="major polyA site"
ORIGIN      
        1 agtgctgggc tgtgggccgg ggaggaaggc ggctcgcggt tcctccaccg cctccgccgc
       61 cgcatcctcc gcttgtgcta ccgccgcggg cgctgggccg ctctgctggt ccggcatgag
      121 accgtgagac gagagacggg tcggggccgc cgacatgttt ggccgctcgc ggagctgggt
      181 gggcgggggc catggcaaga cttcccgcaa catccactcc ttggaccacc tcaagtatct
      241 gtaccacgtt ttgaccaaaa acaccacagt cacagaacag aaccggaacc tgctagtgga
      301 gaccatccgt tccatcactg agatcctgat ctggggagat caaaatgaca gctctgtatt
      361 tgacttcttc ctggagaaga atatgtttgt tttcttcttg aacatcttgc ggcaaaagtc
      421 gggccgttac gtgtgcgttc agctgctgca gaccttgaac atcctctttg agaacatcag
      481 tcacgagacc tcactttatt atttgctctc aaataactac gtaaattcta tcatcgttca
      541 taaatttgac ttttctgatg aggagattat ggcctattat atatcgttcc tgaaaacact
      601 ttcgttaaaa ctcaacaacc acactgtcca tttcttttat aatgagcaca ccaatgactt
      661 tgccctgtac acagaagcca tcaagttttt caaccaccct gaaagcatgg ttagaattgc
      721 tgtaagaacc ataactttga atgtctataa agtgtcattg gataaccagg ccatgctgca
      781 ctacatccga gataaaactg ctgttcctta cttctccaat ttggtctggt tcattgggag
      841 ccatgtgatc gaactcgatg actgcgtgca gactgatgag gagcatcgga atcggggtaa
      901 actgagtgat ctggtggcag agcacctaga ccacctgcac tatctcaatg acatcctgat
      961 catcaactgt gagttcctca acgatgtgct cactgaccac ctgctcaaca ggctcttcct
     1021 gcccctctac gtgtactcac tggagaacca ggacaaggga ggagaacggc cgaaaattag
     1081 cctgccggtg tctctttatc ttctgtcaca ggtcttctta attatacatc atgcaccgct
     1141 ggtgaactcg ttagctgaag tcattctgaa tggtgatctg tctgagatgt acgctaagac
     1201 tgaacaggat attcagagaa gttctgccaa gcccagcatt cggtgcttca ttaaacccac
     1261 cgagacactc gagcggtccc ttgagatgaa caagcacaag ggcaagaggc gggtgcaaaa
     1321 gagacccaac tacaaaaacg ttggggaaga agaagatgag gagaaagggc ccaccgagga
     1381 tgcccaagaa gacgccgaga aggctaaagg tacagagggt ggttcaaaag gcatcaagac
     1441 gagtggggag agtgaagaga tcgagatggt gatcatggag cgtagcaagc tctcagagct
     1501 ggccgccagc acctccgtgc aggagcagaa caccacggac gaggagaaaa gcgccgccgc
     1561 cacctgctct gagagcacgc aatggagcag acccttcctg gatatggtgt accacgcgct
     1621 ggacagcccg gatgatgatt accatgccct gttcgtgctc tgcctcctct atgccatgtc
     1681 tcataataaa ggcatggatc ctgaaaaatt agagcgaatc cagctccccg tgccaaatgc
     1741 ggccgagaag accacctaca accacccgct agctgaaaga ctcatcagga tcatgaacaa
     1801 cgctgcccag ccagatggga agatccggct ggcgacgctg gagctgagct gcctgcttct
     1861 gaagcagcaa gtcctgatga gtgctggctg catcatgaag gacgtgcacc tggcctgcct
     1921 ggagggtgcg agagaagaaa gtgttcacct tgtacgacat ttttataagg gagaagacat
     1981 ttttttggac atgtttgaag atgagtatag gagcatgaca atgaagccca tgaacgtgga
     2041 atatctcatg atggacgcct ccatcctgct gcccccaaca ggcacgccac tgacgggcat
     2101 tgacttcgtg aagcggctgc cgtgtggcga tgtggagaag acccggcggg ccatccgggt
     2161 gttcttcatg ctgcgttccc tgtcactgca attgcgaggg gagcctgaga cacagttgcc
     2221 gctgactcgg gaggaggacc tgatcaagac tgatgatgtc ctggatctga ataacagcga
     2281 cttgattgca tgtacagtga tcaccaagga tggcggcatg gtccagcgat tcctggctgt
     2341 ggatatttac cagatgagtt tggtggagcc tgatgtgtcc aggcttggct ggggagtggt
     2401 caagtttgca ggcctattgc aggacatgca ggtgactggc gtggaggacg acagccgtgc
     2461 cctgaacatc accatccaca agcctgcgtc cagcccccat tccaagccct tccccatcct
     2521 ccaggccacc ttcatcttct cagaccacat ccgctgcatc atcgccaagc agcgcctggc
     2581 caaaggccgc atccaggcaa ggcgcatgaa gatgcagaga atagctgccc tcctggacct
     2641 cccaatccag cccaccactg aagtcctggg gtttggactc ggctcctcca cctccactca
     2701 gcacctgcct ttccgcttct acgaccaggg gcgccggggc agcagcgacc ccacagtgca
     2761 gcgctccgtg tttgcatcgg tggacaaggt gccaggcttc gccgtggccc agtgcataaa
     2821 ccagcacagc tccccgtccc tgtcctcaca gtcgccaccc tccgccagcg ggagccccag
     2881 cggcagcggg agcaccagcc actgcgactc tggaggcacc agctcgtcct ccaccccctc
     2941 cacagcccag agtccagcag atgcccccat gagtccagaa ctgcctaagc ctcaccttcc
     3001 tgaccagttg gtaatcgtca acgaaacgga agcagactct aagcccagca agaacgtggc
     3061 caggagcgca gccgtggaga cagccagcct gtcccccagc ctcgtccctg cccggcagcc
     3121 caccatttcc ctgctctgcg aggacacggc tgacacgctg agcgtcgaat cgctgaccct
     3181 tgtcccccca gttgaccccc acagcctccg cagcctcacc ggcatgcccc cgctgtccac
     3241 gccggctgcc gcctgcacag agcccgtggg cgaagaggct gcatgtgctg agcctgtggg
     3301 caccgctgag gactgagtca gtgccggggc ctccctttgt gtgtgtggcc ccgctggtag
     3361 ggaccccagt gccgctgact ggcaagacac actgggagca cccaccattc tgtgcggccc
     3421 ccagcagcca tctcaaccac ctatccctgc gctcccttga atgggaagaa gccccacgtt
     3481 gtccttgaat tcctttttca ctttgcatct cttcacgtgc aggctgggac cagcggagac
     3541 accgcggcga atgcagatga ctgcaccggc cactcaggga gctgcctggg ctccgtgtct
     3601 ctgagccccg ggtggcagga cccaccggca cctctttctt cctctgtcat atggctcctc
     3661 tgtcaccagc cccagtgtgc acagaagaat tggaccaggt cactgtacgt agaaatttgt
     3721 agaaaagcag acttagataa acatctcctt tggatattta tttccgcttt tggcagcagg
     3781 tgaacattta tttttaaaac ttctatttaa aagaagtcca aaaacatcaa cactaaggtt
     3841 tgatgtcatg tgaaaagtgt aataataaca gttaagattt catgatcatt ttcactggac
     3901 ctttcctgat attttgtttc agagttctta gtgtggcttt ttccatttat ttaagtgatt
     3961 ctttgttact cactaactct gcaagcctgt ggaataatga agtaccttcc tggaaagttt
     4021 ggattatttt ttaaacaaaa acaagggaga tacatgtatt ctcaggtaca cacagagctg
     4081 agagggctga atggttttct gctatagcag ccgagaggcc tcccatcatg gaaagatttc
     4141 tccaggaaaa ggaggaatgt agccagctcc ccactcagga cgcttcctca tttctcttca
     4201 ccaaaaccaa acagagacag cttccagcac cttcttcagt gttaccatct ctaagaagga
     4261 accagttggg accgtgaaga ctcccgaccc tgtggccatg atggaaatca aaggaagaca
     4321 ccctctacgt cacctgccct cgactgtgtg tgcccacatg tgccgagaga tggcccagag
     4381 ccagttcccc tccagctgca agggcatggt gtccccagag ctctgagtct gtcactctcc
     4441 ctctgctact gctgctgatc tgaatatgga aaccccatgg ttcccttccc cattcggact
     4501 gggtgtgtac aagcaaggac ccagatgcat cagacacagc ccccaagatg ttcctttcta
     4561 ctcggccagc tcgggagcca gacacagcac tcacagccca ggccgtgatc caccctcccc
     4621 aagtccacca gggccagcgg cccctcacct ctctggtcac tggtgagacc ttccacaact
     4681 ttcctccaga cctgccagca gatgtgccca ccaggggcat taggtatccg ccggagcctg
     4741 gccatagggt agtctcggga gccgcgctga gatcttttgc cacctgcatt ttagaagaac
     4801 atggtctctg tctcctcggc ccagccagct gtcccggcaa ggcctgccga gggcagtttt
     4861 caacctcatg aaggaaacac agtcctgcca aggaggggga gtggcgccca tggggacagg
     4921 cctcagtcct tagaagccct ctgggtagct gtgcccaccc agccttcatg gctgcaggta
     4981 caaggacctt tgcttccata gagaaaacgc acagctcaga aagggggcca catgggcaga
     5041 aacccaaagg aaggacaaac cacgaccacc gtggccatct gcagaatccc tggaagagaa
     5101 ggaaggcagg gtggagcggg gggaagacca tcatggagag aaggaccaca gcatcaggag
     5161 acgggacacg ccacacccag caggcagcct gtgtgttgct taatttttta agagcaagag
     5221 gggtagagag gatcaagctg gccctggctg gagatggcta gcccctgaga catgcacttc
     5281 tggttttgaa atgactctgt ctgtggggca gcagaaacta gagaaggcaa gtggctgccc
     5341 caccccaagg cgtgaccagg aggaacagcc tgcagctcac tccatgccac acgggtgggc
     5401 caccagcctg ctgtcagaag tctctgggct ccaactggtc ttgtaaccac tgagcactga
     5461 aggagagagg tcttggtcag ggctggacag catgcccggg aggaccagca gaggattaaa
     5521 ggtgactggg aggaccagcg gaggataaaa gacactgctc agggcagggc ttctaccctg
     5581 catccctggc caagaaaagg gcagtcccca tgtgggcttg cagggtcact ctcaggggcc
     5641 tctttcagct ggggctggca acttgcgtct gggggacacc tccaggtgtg tggggtgagg
     5701 atttcctata accagggctc ccagaagctt tgcttatgta aggaggtctg ggagccagcc
     5761 cattggaggc caccagccat tttggcttca aaggacccca cctcacccag gtctcagcgg
     5821 cagtgggcac agctatgtct tcaggagctc ccgtcaaacc tcatagctgg ggcgctccca
     5881 gacaggccag tccagacagg acacgctggg cccctggcat ccagaggaag agccaggagt
     5941 gtgggaaggc ccacagtggg ggctgtggct tctgacactc aggtcatagc ctcagaggtc
     6001 tgaggtcagc ccccacagac ccatccggcc cgccccccaa gtccctgcag agagcactta
     6061 gagttatggc ccaggccctg gtccaccctt cccctgtgca cctccggctg ggtttgccaa
     6121 gtcagggagc agggctggcc gcaggaactc ccaaaccttg gctttgaata ttgttgtgga
     6181 ggtgtgctcg tccctttctg gacgtgcaag gtacctgtcc cagcaggtca gatggggcca
     6241 gctgaggcgc tcccccaggc aggaagggcc agccttcacc atcgcgtggg attgggagga
     6301 ggggcctccg tgagcagccc ctcctctgcc gctgtcccag cccagtccct ctcccggagc
     6361 cttggcagcc tcccacaacc cagacacttg cgttcacaag caacctaagg ggcaggtgaa
     6421 gaagcgcagc cctgccagac gcgctagatt cctctaaggt ctctgagatg caccgttttt
     6481 taaaaaggcg tggggtgaac tgattttgat cttcttgtct agatgcaata aataaatctg
     6541 aagcatttaa tgtagtcatc ttgacattgg gcctacactg tacgagttcc ttatgtttcc
     6601 ttgagctaaa aatatgtaaa taatttttgt cccagtgaga accgagggtt agaaaacctc
     6661 gatgcctctg agcctcggga ccgctctagg gaagtacctg ctttcgccag catgactcat
     6721 gcttcgtggg tactgaacac gagggtggaa atgaaaactg gaacttcctt gtaaatttaa
     6781 acttggcaat aaaagagaaa aaaagttacc aa
//
