LOCUS       NM_175060               2094 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens C-type lectin domain containing 14A (CLEC14A), mRNA.
ACCESSION   NM_175060
VERSION     NM_175060.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2094)
  AUTHORS   Yan,L., Li,X. and Yuan,Y.
  TITLE     CLEC14A was up-regulated in hepatocellular carcinoma and may
            function as a potential diagnostic biomarker
  JOURNAL   Clinics (Sao Paulo) 77, 100029 (2022)
   PUBMED   35576868
  REMARK    GeneRIF: CLEC14A was up-regulated in hepatocellular carcinoma and
            may function as a potential diagnostic biomarker.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2094)
  AUTHORS   Robinson,J., Whitworth,K., Jinks,E., Nagy,Z., Bicknell,R. and
            Lee,S.P.
  TITLE     An evaluation of the tumour endothelial marker CLEC14A as a
            therapeutic target in solid tumours
  JOURNAL   J Pathol Clin Res 6 (4), 308-319 (2020)
   PUBMED   32696621
  REMARK    GeneRIF: An evaluation of the tumour endothelial marker CLEC14A as
            a therapeutic target in solid tumours.
REFERENCE   3  (bases 1 to 2094)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2094)
  AUTHORS   Sandoval,D.R., Gomez Toledo,A., Painter,C.D., Tota,E.M.,
            Sheikh,M.O., West,A.M.V., Frank,M.M., Wells,L., Xu,D., Bicknell,R.,
            Corbett,K.D. and Esko,J.D.
  TITLE     Proteomics-based screening of the endothelial heparan sulfate
            interactome reveals that C-type lectin 14a (CLEC14A) is a
            heparin-binding protein
  JOURNAL   J Biol Chem 295 (9), 2804-2821 (2020)
   PUBMED   31964714
  REMARK    GeneRIF: Proteomics-based screening of the endothelial heparan
            sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a
            heparin-binding protein.
REFERENCE   5  (bases 1 to 2094)
  AUTHORS   Marg,A., Escobar,H., Karaiskos,N., Grunwald,S.A., Metzler,E.,
            Kieshauer,J., Sauer,S., Pasemann,D., Malfatti,E., Mompoint,D.,
            Quijano-Roy,S., Boltengagen,A., Schneider,J., Schulke,M., Kunz,S.,
            Carlier,R., Birchmeier,C., Amthor,H., Spuler,A., Kocks,C.,
            Rajewsky,N. and Spuler,S.
  TITLE     Human muscle-derived CLEC14A-positive cells regenerate muscle
            independent of PAX7
  JOURNAL   Nat Commun 10 (1), 5776 (2019)
   PUBMED   31852888
  REMARK    GeneRIF: Study identified PAX7-negative human muscle-derived cell
            colonies also positive for the myogenic markers desmin and MYF5 and
            reveal the endothelial cell marker CLEC14A to be highly expressed
            in PAX7null cells. Transplanted PAX7neg cells repopulate the
            satellite cell niche where they re-express PAX7, or, strikingly,
            CLEC14A. In conclusion, transplanted human cells do not depend on
            PAX7 for muscle regeneration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2094)
  AUTHORS   Luykx,J.J., Bakker,S.C., Lentjes,E., Neeleman,M., Strengman,E.,
            Mentink,L., DeYoung,J., de Jong,S., Sul,J.H., Eskin,E., van
            Eijk,K., van Setten,J., Buizer-Voskamp,J.E., Cantor,R.M., Lu,A.,
            van Amerongen,M., van Dongen,E.P., Keijzers,P., Kappen,T.,
            Borgdorff,P., Bruins,P., Derks,E.M., Kahn,R.S. and Ophoff,R.A.
  TITLE     Genome-wide association study of monoamine metabolite levels in
            human cerebrospinal fluid
  JOURNAL   Mol Psychiatry 19 (2), 228-234 (2014)
   PUBMED   23319000
REFERENCE   7  (bases 1 to 2094)
  AUTHORS   Ki,M.K., Jeoung,M.H., Choi,J.R., Rho,S.S., Kwon,Y.G., Shim,H.,
            Chung,J., Hong,H.J., Song,B.D. and Lee,S.
  TITLE     Human antibodies targeting the C-type lectin-like domain of the
            tumor endothelial cell marker clec14a regulate angiogenic
            properties in vitro
  JOURNAL   Oncogene 32 (48), 5449-5457 (2013)
   PUBMED   23644659
  REMARK    GeneRIF: clec14a-CTLD may be a key domain in angiogenesis
REFERENCE   8  (bases 1 to 2094)
  AUTHORS   Mura,M., Swain,R.K., Zhuang,X., Vorschmitt,H., Reynolds,G.,
            Durant,S., Beesley,J.F., Herbert,J.M., Sheldon,H., Andre,M.,
            Sanderson,S., Glen,K., Luu,N.T., McGettrick,H.M., Antczak,P.,
            Falciani,F., Nash,G.B., Nagy,Z.S. and Bicknell,R.
  TITLE     Identification and angiogenic role of the novel tumor endothelial
            marker CLEC14A
  JOURNAL   Oncogene 31 (3), 293-305 (2012)
   PUBMED   21706054
  REMARK    GeneRIF: In this study, they identify and characterize a novel
            tumor endothelial marker, CLEC14A, which has properties that
            suggest it is a candidate for tumor vascular targeting and
            anti-angiogenic approaches.
REFERENCE   9  (bases 1 to 2094)
  AUTHORS   Zhuang,X., Cross,D., Heath,V.L. and Bicknell,R.
  TITLE     Shear stress, tip cells and regulators of endothelial migration
  JOURNAL   Biochem Soc Trans 39 (6), 1571-1575 (2011)
   PUBMED   22103489
  REMARK    Review article
REFERENCE   10 (bases 1 to 2094)
  AUTHORS   Rho,S.S., Choi,H.J., Min,J.K., Lee,H.W., Park,H., Park,H., Kim,Y.M.
            and Kwon,Y.G.
  TITLE     Clec14a is specifically expressed in endothelial cells and mediates
            cell to cell adhesion
  JOURNAL   Biochem Biophys Res Commun 404 (1), 103-108 (2011)
   PUBMED   21095181
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358395.1 and AY606132.1.
            
            On May 17, 2019 this sequence version replaced NM_175060.2.
            
            Summary: This gene encodes a member of the C-type lectin/C-type
            lectin-like domain (CTL/CTLD) superfamily. Members of this family
            share a common protein fold and have diverse functions, such as
            cell adhesion, cell-cell signalling, glycoprotein turnover, and
            roles in inflammation and immune response. This family member plays
            a role in cell-cell adhesion and angiogenesis. It functions in
            filopodia formation, cell migration and tube formation. Due to its
            presence at higher levels in tumor endothelium than in normal
            tissue endothelium, it is considered to be a candidate for tumor
            vascular targeting. [provided by RefSeq, Jan 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY606132.1, SRR1660803.154150.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342213.3/ ENSP00000353013.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1984              AY358395.1         243-2226
            1985-2094           AY606132.1         1987-2096
FEATURES             Location/Qualifiers
     source          1..2094
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.1"
     gene            1..2094
                     /gene="CLEC14A"
                     /gene_synonym="C14orf27; CEG1; EGFR-5"
                     /note="C-type lectin domain containing 14A"
                     /db_xref="GeneID:161198"
                     /db_xref="HGNC:HGNC:19832"
                     /db_xref="MIM:616845"
     exon            1..2094
                     /gene="CLEC14A"
                     /gene_synonym="C14orf27; CEG1; EGFR-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1544
                     /gene="CLEC14A"
                     /gene_synonym="C14orf27; CEG1; EGFR-5"
                     /note="ClECT and EGF-like domain containing protein;
                     epidermal growth factor receptor 5; C-type lectin domain
                     family 14 member A"
                     /codon_start=1
                     /product="C-type lectin domain family 14 member A
                     precursor"
                     /protein_id="NP_778230.1"
                     /db_xref="CCDS:CCDS9667.1"
                     /db_xref="GeneID:161198"
                     /db_xref="HGNC:HGNC:19832"
                     /db_xref="MIM:616845"
                     /translation="MRPAFALCLLWQALWPGPGGGEHPTADRAGCSASGACYSLHHAT
                     MKRQAAEEACILRGGALSTVRAGAELRAVLALLRAGPGPGGGSKDLLFWVALERRRSH
                     CTLENEPLRGFSWLSSDPGGLESDTLQWVEEPQRSCTARRCAVLQATGGVEPAGWKEM
                     RCHLRANGYLCKYQFEVLCPAPRPGAASNLSYRAPFQLHSAALDFSPPGTEVSALCRG
                     QLPISVTCIADEIGARWDKLSGDVLCPCPGRYLRAGKCAELPNCLDDLGGFACECATG
                     FELGKDGRSCVTSGEGQPTLGGTGVPTRRPPATATSPVPQRTWPIRVDEKLGETPLVP
                     EQDNSVTSIPEIPRWGSQSTMSTLQMSLQAESKATITPSGSVISKFNSTTSSATPQAF
                     DSSSAVVFIFVSTAVVVLVILTMTVLGLVKLCFHESPSSQPRKESMGPPGLESDPEPA
                     ALGSSSAHCTNNGVKVGDCDLRDRAEGALLAESPLGSSDA"
     regulatory      1873..1878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC14A"
                     /gene_synonym="C14orf27; CEG1; EGFR-5"
                     /note="hexamer: AATAAT"
     polyA_site      1889
                     /gene="CLEC14A"
                     /gene_synonym="C14orf27; CEG1; EGFR-5"
                     /note="major polyA site"
     regulatory      1968..1973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC14A"
                     /gene_synonym="C14orf27; CEG1; EGFR-5"
                     /note="hexamer: ATTAAA"
     polyA_site      1986
                     /gene="CLEC14A"
                     /gene_synonym="C14orf27; CEG1; EGFR-5"
ORIGIN      
        1 agacacagct ctgcgtcctc gagcgggaca gatccaagtt gggagcagct ctgcgtgcgg
       61 ggcctcagag aatgaggccg gcgttcgccc tgtgcctcct ctggcaggcg ctctggcccg
      121 ggccgggcgg cggcgaacac cccactgccg accgtgctgg ctgctcggcc tcgggggcct
      181 gctacagcct gcaccacgct accatgaagc ggcaggcggc cgaggaggcc tgcatcctgc
      241 gaggtggggc gctcagcacc gtgcgtgcgg gcgccgagct gcgcgctgtg ctcgcgctcc
      301 tgcgggcagg cccagggccc ggagggggct ccaaagacct gctgttctgg gtcgcactgg
      361 agcgcaggcg ttcccactgc accctggaga acgagccttt gcggggtttc tcctggctgt
      421 cctccgaccc cggcggtctc gaaagcgaca cgctgcagtg ggtggaggag ccccaacgct
      481 cctgcaccgc gcggagatgc gcggtactcc aggccaccgg tggggtcgag cccgcaggct
      541 ggaaggagat gcgatgccac ctgcgcgcca acggctacct gtgcaagtac cagtttgagg
      601 tcttgtgtcc tgcgccgcgc cccggggccg cctctaactt gagctatcgc gcgcccttcc
      661 agctgcacag cgccgctctg gacttcagtc cacctgggac cgaggtgagt gcgctctgcc
      721 ggggacagct cccgatctca gttacttgca tcgcggacga aatcggcgct cgctgggaca
      781 aactctcggg cgatgtgttg tgtccctgcc ccgggaggta cctccgtgct ggcaaatgcg
      841 cagagctccc taactgccta gacgacttgg gaggctttgc ctgcgaatgt gctacgggct
      901 tcgagctggg gaaggacggc cgctcttgtg tgaccagtgg ggaaggacag ccgacccttg
      961 gggggaccgg ggtgcccacc aggcgcccgc cggccactgc aaccagcccc gtgccgcaga
     1021 gaacatggcc aatcagggtc gacgagaagc tgggagagac accacttgtc cctgaacaag
     1081 acaattcagt aacatctatt cctgagattc ctcgatgggg atcacagagc acgatgtcta
     1141 cccttcaaat gtcccttcaa gccgagtcaa aggccactat caccccatca gggagcgtga
     1201 tttccaagtt taattctacg acttcctctg ccactcctca ggctttcgac tcctcctctg
     1261 ccgtggtctt catatttgtg agcacagcag tagtagtgtt ggtgatcttg accatgacag
     1321 tactggggct tgtcaagctc tgctttcacg aaagcccctc ttcccagcca aggaaggagt
     1381 ctatgggccc gccgggcctg gagagtgatc ctgagcccgc tgctttgggc tccagttctg
     1441 cacattgcac aaacaatggg gtgaaagtcg gggactgtga tctgcgggac agagcagagg
     1501 gtgccttgct ggcggagtcc cctcttggct ctagtgatgc atagggaaac aggggacatg
     1561 ggcactcctg tgaacagttt ttcacttttg atgaaacggg gaaccaagag gaacttactt
     1621 gtgtaactga caatttctgc agaaatcccc cttcctctaa attcccttta ctccactgag
     1681 gagctaaatc agaactgcac actccttccc tgatgataga ggaagtggaa gtgcctttag
     1741 gatggtgata ctgggggacc gggtagtgct ggggagagat attttcttat gtttattcgg
     1801 agaatttgga gaagtgattg aacttttcaa gacattggaa acaaatagaa cacaatataa
     1861 tttacattaa aaaataattt ctaccaaaat ggaaaggaaa tgttctatgt tgttcaggct
     1921 aggagtatat tggttcgaaa tcccagggaa aaaaataaaa ataaaaaatt aaaggattgt
     1981 tgataaccca gactcaaata tcattgcctt cctccaggag taattaggaa cagctgaggg
     2041 catgctggga gtaagcagca agagtgcatt ctgcttttag attgagggag aggt
//
