LOCUS       NM_001129998            1279 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens C-type lectin domain family 12 member B (CLEC12B),
            transcript variant 1, mRNA.
ACCESSION   NM_001129998
VERSION     NM_001129998.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1279)
  AUTHORS   Sormani,L., Montaudie,H., Blot,L., Heim,M., Cardot Leccia,N.,
            Mhaidly,R., Verhoeyen,E., Regazzetti,C., Nottet,N., Cheli,Y., De
            Donatis,G.M., Dabert Gay,A.S., Debayle,D., Taquin Martin,H.,
            Gesbert,F., Rocchi,S., Tulic,M.K. and Passeron,T.
  TITLE     CLEC12B Is a Melanocytic Gene Regulating the Color of the Skin
  JOURNAL   J Invest Dermatol 142 (7), 1858-1868 (2022)
   PUBMED   34896119
  REMARK    GeneRIF: CLEC12B Is a Melanocytic Gene Regulating the Color of the
            Skin.
REFERENCE   2  (bases 1 to 1279)
  AUTHORS   Montaudie,H., Sormani,L., Dadone-Montaudie,B., Heim,M.,
            Cardot-Leccia,N., Tulic,M.K., Beranger,G., Gay,A.S., Debayle,D.,
            Cheli,Y., Raymond,J.H., Sohier,P., Petit,V., Rocchi,S., Gesbert,F.,
            Larue,L. and Passeron,T.
  TITLE     CLEC12B Decreases Melanoma Proliferation by Repressing Signal
            Transducer and Activator of Transcription 3
  JOURNAL   J Invest Dermatol 142 (2), 425-434 (2022)
   PUBMED   34310951
  REMARK    GeneRIF: CLEC12B Decreases Melanoma Proliferation by Repressing
            Signal Transducer and Activator of Transcription 3.
REFERENCE   3  (bases 1 to 1279)
  AUTHORS   Chi,D., Wang,D., Zhang,M., Ma,H., Chen,F. and Sun,Y.
  TITLE     CLEC12B suppresses lung cancer progression by inducing SHP-1
            expression and inactivating the PI3K/AKT signaling pathway
  JOURNAL   Exp Cell Res 409 (2), 112914 (2021)
   PUBMED   34780782
  REMARK    GeneRIF: CLEC12B suppresses lung cancer progression by inducing
            SHP-1 expression and inactivating the PI3K/AKT signaling pathway.
REFERENCE   4  (bases 1 to 1279)
  AUTHORS   Iijima,A., Kanemaru,K., Wang,Y., Nabekura,T., Nakamura,Y.,
            Fujisawa,Y., Mori,D., Ohmuraya,M., Yamasaki,S., Tahara-Hanaoka,S.
            and Shibuya,A.
  TITLE     Selective expression of a C-type lectin receptor, Clec12b, on skin
            mast cells
  JOURNAL   Biochem Biophys Res Commun 561, 101-105 (2021)
   PUBMED   34020140
  REMARK    GeneRIF: Selective expression of a C-type lectin receptor, Clec12b,
            on skin mast cells.
            Erratum:[Biochem Biophys Res Commun. 2021 Sep 3;568:193-194. doi:
            10.1016/j.bbrc.2021.07.009.. PMID: 34246465]
REFERENCE   5  (bases 1 to 1279)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1279)
  AUTHORS   Derpoorter,C., Vandepoele,K., Diez-Fraile,A., Vandemeulebroecke,K.,
            De Wilde,B., Speleman,F., Van Roy,N., Lammens,T. and Laureys,G.
  TITLE     Pinpointing a potential role for CLEC12B in cancer predisposition
            through familial exome sequencing
  JOURNAL   Pediatr Blood Cancer 66 (2), e27513 (2019)
   PUBMED   30350915
  REMARK    GeneRIF: we identified a potential deleterious, missense mutation
            in CLEC12B in two children affected by ganglioneuroma and
            neuroblastoma
REFERENCE   7  (bases 1 to 1279)
  AUTHORS   Kulkarni,Y.M., Liu,C., Qi,Q., Zhu,Y., Klinke,D.J. 2nd and Liu,J.
  TITLE     Differential proteomic analysis of caveolin-1 KO cells reveals
            Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and
            Capns1 as a potential mediator of caveolin-1-induced apoptosis
  JOURNAL   Analyst 138 (22), 6986-6996 (2013)
   PUBMED   24091439
REFERENCE   8  (bases 1 to 1279)
  AUTHORS   Hoffmann,S.C., Schellack,C., Textor,S., Konold,S., Schmitz,D.,
            Cerwenka,A., Pflanz,S. and Watzl,C.
  TITLE     Identification of CLEC12B, an inhibitory receptor on myeloid cells
  JOURNAL   J Biol Chem 282 (31), 22370-22375 (2007)
   PUBMED   17562706
  REMARK    GeneRIF: CLEC12B is an inhibitory receptor on myeloid cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024224.33.
            
            On Sep 24, 2020 this sequence version replaced NM_001129998.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005550.1, DQ368812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338896.11/ ENSP00000344563.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               AC024224.33        1204-1427
            225-323             AC024224.33        3362-3460
            324-542             AC024224.33        5100-5318
            543-697             AC024224.33        5829-5983
            698-813             AC024224.33        6189-6304
            814-1279            AC024224.33        8908-9373
FEATURES             Location/Qualifiers
     source          1..1279
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1279
                     /gene="CLEC12B"
                     /gene_synonym="UNQ5782"
                     /note="C-type lectin domain family 12 member B"
                     /db_xref="GeneID:387837"
                     /db_xref="HGNC:HGNC:31966"
                     /db_xref="MIM:617573"
     exon            1..224
                     /gene="CLEC12B"
                     /gene_synonym="UNQ5782"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..964
                     /gene="CLEC12B"
                     /gene_synonym="UNQ5782"
                     /note="isoform 1 is encoded by transcript variant 1;
                     macrophage antigen h; testis secretory sperm-binding
                     protein Li 205a"
                     /codon_start=1
                     /product="C-type lectin domain family 12 member B isoform
                     1"
                     /protein_id="NP_001123470.1"
                     /db_xref="CCDS:CCDS44830.1"
                     /db_xref="GeneID:387837"
                     /db_xref="HGNC:HGNC:31966"
                     /db_xref="MIM:617573"
                     /translation="MSEEVTYATLTFQDSAGARNNRDGNNLRKRGHPAPSPIWRHAAL
                     GLVTLCLMLLIGLVTLGMMFLQISNDINSDSEKLSQLQKTIQQQQDNLSQQLGNSNNL
                     SMEEEFLKSQISSVLKRQEQMAIKLCQELIIHTSDHRCNPCPKMWQWYQNSCYYFTTN
                     EEKTWANSRKDCIDKNSTLVKIDSLEEKDFLMSQPLLMFSFFWLGLSWDSSGRSWFWE
                     DGSVPSPSLFSTKELDQINGSKGCAYFQKGNIYISRCSAEIFWICEKTAAPVKTEDLD
                     "
     exon            225..323
                     /gene="CLEC12B"
                     /gene_synonym="UNQ5782"
                     /inference="alignment:Splign:2.1.0"
     exon            324..542
                     /gene="CLEC12B"
                     /gene_synonym="UNQ5782"
                     /inference="alignment:Splign:2.1.0"
     exon            543..697
                     /gene="CLEC12B"
                     /gene_synonym="UNQ5782"
                     /inference="alignment:Splign:2.1.0"
     exon            698..813
                     /gene="CLEC12B"
                     /gene_synonym="UNQ5782"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1279
                     /gene="CLEC12B"
                     /gene_synonym="UNQ5782"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1090..1095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC12B"
                     /gene_synonym="UNQ5782"
                     /note="hexamer: AATGAA"
     polyA_site      1109
                     /gene="CLEC12B"
                     /gene_synonym="UNQ5782"
     regulatory      1253..1258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC12B"
                     /gene_synonym="UNQ5782"
                     /note="hexamer: AATAAA"
     polyA_site      1279
                     /gene="CLEC12B"
                     /gene_synonym="UNQ5782"
                     /note="major polyA site"
ORIGIN      
        1 ggggcagtag agtgtgtctg ggtcagctga gtgactacat caaagctccc agccttgaaa
       61 aacacatgct gttcccaggc ctcaagatat tgaaacatta attagataat ttaaagtagc
      121 gttttcttct acaatgtctg aagaagtgac ctacgcgaca ctcacatttc aggattctgc
      181 tggagcaagg aataaccgag atggaaataa cctaagaaaa agagggcatc cagctccatc
      241 tcccatttgg cgtcatgctg ctctgggtct ggtaactctt tgcctgatgt tgctgattgg
      301 gctggtgaca ttggggatga tgtttttgca gatatctaat gacattaact cagattcaga
      361 gaaattgagt caacttcaga aaaccatcca acagcagcag gataacttat cccagcaact
      421 gggcaactcc aacaacttgt ccatggagga ggaatttctc aagtcacaga tctccagtgt
      481 actgaagagg caggaacaaa tggccatcaa actgtgccaa gagctaatca ttcatacttc
      541 agaccacaga tgtaatccat gtcctaagat gtggcaatgg taccaaaata gttgctacta
      601 ttttacaaca aatgaggaga aaacctgggc taacagtaga aaggactgca tagacaagaa
      661 ctccacccta gtgaagatag acagtttgga agaaaaggat tttcttatgt cacagccatt
      721 actcatgttt tcgttctttt ggctgggatt atcatgggac tcctctggca gaagttggtt
      781 ctgggaagat ggctctgttc cctctccatc cttatttagt actaaagaac ttgaccagat
      841 caatggatcc aaaggatgtg cttattttca aaaaggaaat atttatattt ctcgctgtag
      901 tgctgaaatt ttttggattt gcgagaagac agctgcccca gtgaagactg aggatttgga
      961 ttagtatgct tcttccaaat tctccaagaa gtaagagact tgtgagtaag ctcatatgag
     1021 gaaagaggaa actacggtac cagagccaaa ccagctttta aaatgactgt gtatttacat
     1081 tatcagacaa atgaacttgt ttaacagaac attctccagt tccttgtctg acgtcttctg
     1141 atttgatgtt attattcggt cttaaaatta tacctgggga caaaggggaa tagccatact
     1201 atggccctat gattgtctca gaatcatttc actgaatttc tttgctttct caaataaaga
     1261 ctcctttctt tcattatta
//
