LOCUS       NM_138337               1555 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens C-type lectin domain family 12 member A (CLEC12A),
            transcript variant 1, mRNA.
ACCESSION   NM_138337
VERSION     NM_138337.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Malamud,M., Whitehead,L., McIntosh,A., Colella,F., Roelofs,A.J.,
            Kusakabe,T., Dambuza,I.M., Phillips-Brookes,A., Salazar,F.,
            Perez,F., Shoesmith,R., Zakrzewski,P., Sey,E.A., Rodrigues,C.,
            Morvay,P.L., Redelinghuys,P., Bedekovic,T., Fernandes,M.J.G.,
            Almizraq,R., Branch,D.R., Amulic,B., Harvey,J., Stewart,D.,
            Yuecel,R., Reid,D.M., McConnachie,A., Pickering,M.C., Botto,M.,
            Iliev,I.D., McInnes,I.B., De Bari,C., Willment,J.A. and Brown,G.D.
  TITLE     Recognition and control of neutrophil extracellular trap formation
            by MICL
  JOURNAL   Nature 633 (8029), 442-450 (2024)
   PUBMED   39143217
  REMARK    GeneRIF: Recognition and control of neutrophil extracellular trap
            formation by MICL.
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Mori,S., Nagae,M. and Yamasaki,S.
  TITLE     Crystal structure of the complex of CLEC12A and an antibody that
            interferes with binding of diverse ligands
  JOURNAL   Int Immunol 36 (6), 279-290 (2024)
   PUBMED   38386511
  REMARK    GeneRIF: Crystal structure of the complex of CLEC12A and an
            antibody that interferes with binding of diverse ligands.
REFERENCE   3  (bases 1 to 1555)
  AUTHORS   Tang,H., Xiao,Y., Qian,L., Wang,Z., Lu,M., Yao,N., Zhou,T.,
            Tian,F., Cao,L., Zheng,P. and Dong,X.
  TITLE     Mechanistic insights into the C-type lectin receptor
            CLEC12A-mediated immune recognition of monosodium urate crystal
  JOURNAL   J Biol Chem 300 (3), 105765 (2024)
   PUBMED   38367667
  REMARK    GeneRIF: Mechanistic insights into the C-type lectin receptor
            CLEC12A-mediated immune recognition of monosodium urate crystal.
REFERENCE   4  (bases 1 to 1555)
  AUTHORS   Oguz,A.K., Oygur,C.S., Tasir,S., Ozdag,H. and Akar,M.N.
  TITLE     Behcet syndrome: The disturbed balance between anti- (CLEC12A, CLC)
            and proinflammatory (IFI27) gene expressions
  JOURNAL   Immun Inflamm Dis 11 (4), e836 (2023)
   PUBMED   37102643
  REMARK    GeneRIF: Behcet syndrome: The disturbed balance between anti-
            (CLEC12A, CLC) and proinflammatory (IFI27) gene expressions.
REFERENCE   5  (bases 1 to 1555)
  AUTHORS   Kattner,S., Muller,J., Glanz,K., Manoochehri,M., Sylvester,C.,
            Vainshtein,Y., Berger,M.M., Brenner,T. and Sohn,K.
  TITLE     Identification of two early blood biomarkers ACHE and CLEC12A for
            improved risk stratification of critically ill COVID-19 patients
  JOURNAL   Sci Rep 13 (1), 4388 (2023)
   PUBMED   36928077
  REMARK    GeneRIF: Identification of two early blood biomarkers ACHE and
            CLEC12A for improved risk stratification of critically ill COVID-19
            patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1555)
  AUTHORS   Marshall,A.S., Willment,J.A., Pyz,E., Dennehy,K.M., Reid,D.M.,
            Dri,P., Gordon,S., Wong,S.Y. and Brown,G.D.
  TITLE     Human MICL (CLEC12A) is differentially glycosylated and is
            down-regulated following cellular activation
  JOURNAL   Eur J Immunol 36 (8), 2159-2169 (2006)
   PUBMED   16838277
  REMARK    GeneRIF: human MICL may be involved in the control of myeloid cell
            activation during inflammation
REFERENCE   7  (bases 1 to 1555)
  AUTHORS   Han,Y., Zhang,M., Li,N., Chen,T., Zhang,Y., Wan,T. and Cao,X.
  TITLE     KLRL1, a novel killer cell lectinlike receptor, inhibits natural
            killer cell cytotoxicity
  JOURNAL   Blood 104 (9), 2858-2866 (2004)
   PUBMED   15238421
  REMARK    GeneRIF: the molecular cloning, tissue distribution, and functional
            characterization of a novel NK cell receptor, KLRL1, from human and
            mouse dendritic cells [KLRL1]
REFERENCE   8  (bases 1 to 1555)
  AUTHORS   Marshall,A.S., Willment,J.A., Lin,H.H., Williams,D.L., Gordon,S.
            and Brown,G.D.
  TITLE     Identification and characterization of a novel human myeloid
            inhibitory C-type lectin-like receptor (MICL) that is predominantly
            expressed on granulocytes and monocytes
  JOURNAL   J Biol Chem 279 (15), 14792-14802 (2004)
   PUBMED   14739280
  REMARK    GeneRIF: MICL is a negative regulator of granulocyte and monocyte
            function
REFERENCE   9  (bases 1 to 1555)
  AUTHORS   Ebner,S., Sharon,N. and Ben-Tal,N.
  TITLE     Evolutionary analysis reveals collective properties and specificity
            in the C-type lectin and lectin-like domain superfamily
  JOURNAL   Proteins 53 (1), 44-55 (2003)
   PUBMED   12945048
REFERENCE   10 (bases 1 to 1555)
  AUTHORS   Drickamer,K.
  TITLE     C-type lectin-like domains
  JOURNAL   Curr Opin Struct Biol 9 (5), 585-590 (1999)
   PUBMED   10508765
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD642076.1, BC126289.1 and
            AY547296.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_138337.5.
            
            Summary: This gene encodes a member of the C-type lectin/C-type
            lectin-like domain (CTL/CTLD) superfamily. Members of this family
            share a common protein fold and have diverse functions, such as
            cell adhesion, cell-cell signaling, glycoprotein turnover, and
            roles in inflammation and immune response. The protein encoded by
            this gene is a negative regulator of granulocyte and monocyte
            function. Several alternatively spliced transcript variants of this
            gene have been described, but the full-length nature of some of
            these variants has not been determined. This gene is closely linked
            to other CTL/CTLD superfamily members in the natural killer gene
            complex region on chromosome 12p13. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1, also referred to as alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF247788.1, BC126289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304361.9/ ENSP00000302804.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 CD642076.1         4-9
            7-917               BC126289.1         1-911
            918-1555            AY547296.1         791-1428
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31-p13.2"
     gene            1..1555
                     /gene="CLEC12A"
                     /gene_synonym="CD371; CLL-1; CLL1; DCAL-2; hKLRL1; MICL"
                     /note="C-type lectin domain family 12 member A"
                     /db_xref="GeneID:160364"
                     /db_xref="HGNC:HGNC:31713"
                     /db_xref="MIM:612088"
     exon            1..279
                     /gene="CLEC12A"
                     /gene_synonym="CD371; CLL-1; CLL1; DCAL-2; hKLRL1; MICL"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..986
                     /gene="CLEC12A"
                     /gene_synonym="CD371; CLL-1; CLL1; DCAL-2; hKLRL1; MICL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myeloid inhibitory C-type lectin-like receptor; C-type
                     lectin protein CLL-1; C-type lectin-like molecule-1;
                     dendritic cell-associated lectin 2; killer cell C-type
                     lectin-like receptor L1"
                     /codon_start=1
                     /product="C-type lectin domain family 12 member A isoform
                     1"
                     /protein_id="NP_612210.4"
                     /db_xref="CCDS:CCDS8608.1"
                     /db_xref="GeneID:160364"
                     /db_xref="HGNC:HGNC:31713"
                     /db_xref="MIM:612088"
                     /translation="MSEEVTYADLQFQNSSEMEKIPEIGKFGEKAPPAPSHVWRPAAL
                     FLTLLCLLLLIGLGVLASMFHVTLKIEMKKMNKLQNISEELQRNISLQLMSNMNISNK
                     IRNLSTTLQTIATKLCRELYSKEQEHKCKPCPRRWIWHKDSCYFLSDDVQTWQESKMA
                     CAAQNASLLKINNKNALEFIKSQSRSYDYWLGLSPEEDSTRGMRVDNIINSSAWVIRN
                     APDLNNMYCGYINRLYVQYYHCTYKKRMICEKMANPVQLGSTYFREA"
     exon            280..378
                     /gene="CLEC12A"
                     /gene_synonym="CD371; CLL-1; CLL1; DCAL-2; hKLRL1; MICL"
                     /inference="alignment:Splign:2.1.0"
     exon            379..567
                     /gene="CLEC12A"
                     /gene_synonym="CD371; CLL-1; CLL1; DCAL-2; hKLRL1; MICL"
                     /inference="alignment:Splign:2.1.0"
     exon            568..719
                     /gene="CLEC12A"
                     /gene_synonym="CD371; CLL-1; CLL1; DCAL-2; hKLRL1; MICL"
                     /inference="alignment:Splign:2.1.0"
     exon            720..829
                     /gene="CLEC12A"
                     /gene_synonym="CD371; CLL-1; CLL1; DCAL-2; hKLRL1; MICL"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1555
                     /gene="CLEC12A"
                     /gene_synonym="CD371; CLL-1; CLL1; DCAL-2; hKLRL1; MICL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1537..1542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC12A"
                     /gene_synonym="CD371; CLL-1; CLL1; DCAL-2; hKLRL1; MICL"
                     /note="hexamer: AACAAA"
     polyA_site      1555
                     /gene="CLEC12A"
                     /gene_synonym="CD371; CLL-1; CLL1; DCAL-2; hKLRL1; MICL"
                     /note="major polyA site"
ORIGIN      
        1 ggctcatttg cagacatatg ggtgattggt acagtaggtt tataaacaga agtttaaact
       61 tgtaagctta agcttccgtt tataaacaga agtttaaaat tataggtcct gtttaacatt
      121 cagctctgtt aactcactca tctttttgtg tttttacact ttgtcaagat ttctttacat
      181 attcatcaat gtctgaagaa gttacttatg cagatcttca attccagaac tccagtgaga
      241 tggaaaaaat cccagaaatt ggcaaatttg gggaaaaagc acctccagct ccctctcatg
      301 tatggcgtcc agcagccttg tttctgactc ttctgtgcct tctgttgctc attggattgg
      361 gagtcttggc aagcatgttt cacgtaactt tgaagataga aatgaaaaaa atgaacaaac
      421 tacaaaacat cagtgaagag ctccagagaa atatttctct acaactgatg agtaacatga
      481 atatctccaa caagatcagg aacctctcca ccacactgca aacaatagcc accaaattat
      541 gtcgtgagct atatagcaaa gaacaagagc acaaatgtaa gccttgtcca aggagatgga
      601 tttggcataa ggacagctgt tatttcctaa gtgatgatgt ccaaacatgg caggagagta
      661 aaatggcctg tgctgctcag aatgccagcc tgttgaagat aaacaacaaa aatgcattgg
      721 aatttataaa atcccagagt agatcatatg actattggct gggattatct cctgaagaag
      781 attccactcg tggtatgaga gtggataata taatcaactc ctctgcctgg gttataagaa
      841 acgcacctga cttaaataac atgtattgtg gatatataaa tagactatat gttcaatatt
      901 atcactgcac ttataaaaaa agaatgatat gtgagaagat ggccaatcca gtgcagcttg
      961 gttctacata ttttagggag gcatgaggca tcaatcaaat acatttaagg agtgtagggg
     1021 gtgggggttc taggctatag gtaaatttaa atattttctg gttgacaatt agttgagttt
     1081 gtctgaagac ctgggatttt atcatgcaga tgaaacatcc aggtagcaag cttcagagag
     1141 aatagactgt gaatgttaat gccagagagg tataatgaag catgtcccac ctcccacttt
     1201 ccatcatggc ctgaaccctg gaggaagagg aagtccattc agatagttgt ggggggcctt
     1261 cgaattttca ttttcattta cgttcttccc cttctggcca agatttgcca gaggcaacat
     1321 caaaaaccag caaattttaa ttttgtccca cagcgttgct agggtggcat ggctccccat
     1381 ctcgggtcca tcctatactt ccatgggact ccctatggct gaaggcctta tgagtcaaag
     1441 gacttatagc caattgattg ttctaggcca ggtaagaatg gatatggaca tgcatttatt
     1501 acctcttaaa attattattt taagtaaaag ccaataaaca aaaacgaaaa ggcaa
//
