LOCUS       NM_002975               1375 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens C-type lectin domain containing 11A (CLEC11A), mRNA.
ACCESSION   NM_002975
VERSION     NM_002975.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1375)
  AUTHORS   Swanson,A.J., Rogowski,V.J., Bishop,J.A., Walker,D.M., Roxas,G.M.
            and Raimondi,S.L.
  TITLE     CLEC11A methylation is correlated to AML subtypes and cytogenetic
            risk factors but not patient demographics
  JOURNAL   PLoS One 19 (3), e0300477 (2024)
   PUBMED   38466706
  REMARK    GeneRIF: CLEC11A methylation is correlated to AML subtypes and
            cytogenetic risk factors but not patient demographics.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1375)
  AUTHORS   Zheng,Q., Gong,Z., Li,B., Cheng,R., Luo,W., Huang,C. and Wang,H.
  TITLE     Identification and characterization of CLEC11A and its derived
            immune signature in gastric cancer
  JOURNAL   Front Immunol 15, 1324959 (2024)
   PUBMED   38348052
  REMARK    GeneRIF: Identification and characterization of CLEC11A and its
            derived immune signature in gastric cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1375)
  AUTHORS   Zhang,J., Cohen,A., Shen,B., Du,L., Tasdogan,A., Zhao,Z.,
            Shane,E.J. and Morrison,S.J.
  TITLE     The effect of parathyroid hormone on osteogenesis is mediated
            partly by osteolectin
  JOURNAL   Proc Natl Acad Sci U S A 118 (25) (2021)
   PUBMED   34140410
  REMARK    GeneRIF: The effect of parathyroid hormone on osteogenesis is
            mediated partly by osteolectin.
REFERENCE   4  (bases 1 to 1375)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1375)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1375)
  AUTHORS   Bannwarth,S., Giordanengo,V., Grosgeorge,J., Turc-Carel,C. and
            Lefebvre,J.C.
  TITLE     Cloning, mapping, and genomic organization of the LSLCL gene,
            encoding a new lymphocytic secreted mucin-like protein with a
            C-type lectin domain: A new model of exon shuffling
  JOURNAL   Genomics 57 (2), 316-317 (1999)
   PUBMED   10198175
REFERENCE   7  (bases 1 to 1375)
  AUTHORS   Mio,H., Kagami,N., Yokokawa,S., Kawai,H., Nakagawa,S., Takeuchi,K.,
            Sekine,S. and Hiraoka,A.
  TITLE     Isolation and characterization of a cDNA for human mouse, and rat
            full-length stem cell growth factor, a new member of C-type lectin
            superfamily
  JOURNAL   Biochem Biophys Res Commun 249 (1), 124-130 (1998)
   PUBMED   9705843
REFERENCE   8  (bases 1 to 1375)
  AUTHORS   Bannwarth,S., Giordanengo,V., Lesimple,J. and Lefebvre,J.C.
  TITLE     Molecular cloning of a new secreted sulfated mucin-like protein
            with a C-type lectin domain that is expressed in lymphoblastic
            cells
  JOURNAL   J Biol Chem 273 (4), 1911-1916 (1998)
   PUBMED   9442024
REFERENCE   9  (bases 1 to 1375)
  AUTHORS   Hiraoka,A., Sugimura,A., Seki,T., Nagasawa,T., Ohta,N.,
            Shimonishi,M., Hagiya,M. and Shimizu,S.
  TITLE     Cloning, expression, and characterization of a cDNA encoding a
            novel human growth factor for primitive hematopoietic progenitor
            cells
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7577-7582 (1997)
   PUBMED   9207134
REFERENCE   10 (bases 1 to 1375)
  AUTHORS   Hiraoka,A., Ohkubo,T. and Fukuda,M.
  TITLE     Production of human hematopoietic survival and growth factor by a
            myeloid leukemia cell line (KPB-M15) and placenta as detected by a
            monoclonal antibody
  JOURNAL   Cancer Res 47 (19), 5025-5030 (1987)
   PUBMED   3304620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF020044.1 and BQ014793.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002975.2.
            
            Summary: This gene encodes a member of the C-type lectin
            superfamily. The encoded protein is a secreted sulfated
            glycoprotein and functions as a growth factor for primitive
            hematopoietic progenitor cells. An alternative splice variant has
            been described but its biological nature has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF020044.1, SRR3476690.182083.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250340.9/ ENSP00000250340.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1155              AF020044.1         18-1172
            1156-1375           BQ014793.1         18-237              c
FEATURES             Location/Qualifiers
     source          1..1375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1375
                     /gene="CLEC11A"
                     /gene_synonym="CLECSF3; LSLCL; P47; SCGF"
                     /note="C-type lectin domain containing 11A"
                     /db_xref="GeneID:6320"
                     /db_xref="HGNC:HGNC:10576"
                     /db_xref="MIM:604713"
     exon            1..309
                     /gene="CLEC11A"
                     /gene_synonym="CLECSF3; LSLCL; P47; SCGF"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1134
                     /gene="CLEC11A"
                     /gene_synonym="CLECSF3; LSLCL; P47; SCGF"
                     /note="stem cell growth factor; lymphocyte secreted C-type
                     lectin; C-type (calcium dependent,
                     carbohydrate-recognition domain) lectin, superfamily
                     member 3; lymphocyte secreted long form of C-type lectin;
                     C-type lectin superfamily member 3; osteolectin; C-type
                     lectin domain family 11 member A"
                     /codon_start=1
                     /product="C-type lectin domain family 11 member A
                     precursor"
                     /protein_id="NP_002966.1"
                     /db_xref="CCDS:CCDS12800.1"
                     /db_xref="GeneID:6320"
                     /db_xref="HGNC:HGNC:10576"
                     /db_xref="MIM:604713"
                     /translation="MQAAWLLGALVVPQLLGFGHGARGAEREWEGGWGGAQEEERERE
                     ALMLKHLQEALGLPAGRGDENPAGTVEGKEDWEMEEDQGEEEEEEATPTPSSGPSPSP
                     TPEDIVTYILGRLAGLDAGLHQLHVRLHALDTRVVELTQGLRQLRNAAGDTRDAVQAL
                     QEAQGRAEREHGRLEGCLKGLRLGHKCFLLSRDFEAQAAAQARCTARGGSLAQPADRQ
                     QMEALTRYLRAALAPYNWPVWLGVHDRRAEGLYLFENGQRVSFFAWHRSPRPELGAQP
                     SASPHPLSPDQPNGGTLENCVAQASDDGSWWDHDCQRRLYYVCEFPF"
     exon            310..496
                     /gene="CLEC11A"
                     /gene_synonym="CLECSF3; LSLCL; P47; SCGF"
                     /inference="alignment:Splign:2.1.0"
     exon            497..688
                     /gene="CLEC11A"
                     /gene_synonym="CLECSF3; LSLCL; P47; SCGF"
                     /inference="alignment:Splign:2.1.0"
     exon            689..1375
                     /gene="CLEC11A"
                     /gene_synonym="CLECSF3; LSLCL; P47; SCGF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1354..1359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLEC11A"
                     /gene_synonym="CLECSF3; LSLCL; P47; SCGF"
                     /note="hexamer: AATAAA"
     polyA_site      1375
                     /gene="CLEC11A"
                     /gene_synonym="CLECSF3; LSLCL; P47; SCGF"
                     /note="major polyA site"
ORIGIN      
        1 agagacgagg agaggaacag gaagagagaa gctgggagaa tcgggaacct gggggctagt
       61 gacctgcaca cagggcaggg gcactcggca gttcccagag gccacccctc ccaccccaga
      121 catccagaca tctggaactt tgggtgccaa gagtccagct taatgcaggc agcctggctt
      181 ttgggggctt tggtggtccc ccagctcttg ggctttggcc atggggctcg gggagcagag
      241 agggagtggg agggaggctg gggaggtgcc caggaggagg agcgggagag ggaggccctg
      301 atgctgaagc atctgcagga agccctagga ctgcctgctg ggagggggga tgagaatcct
      361 gccggaactg ttgagggaaa agaggactgg gagatggagg aggaccaggg ggaggaagag
      421 gaggaggaag caacgccaac cccatcctcc ggccccagcc cctctcccac ccctgaggac
      481 atcgtcactt acatcctggg ccgcctggcc ggcctggacg caggcctgca ccagctgcac
      541 gtccgtctgc acgcgttgga cacccgcgtg gtcgagctga cccaggggct gcggcagctg
      601 cggaacgcgg caggcgacac ccgcgatgcc gtgcaagccc tgcaggaggc gcagggtcgc
      661 gccgagcgcg agcacggccg cttggagggc tgcctgaagg ggctgcgcct gggccacaag
      721 tgcttcctgc tctcgcgcga cttcgaagct caggcggcgg cgcaggcgcg gtgcacggcg
      781 cggggcggga gcctggcgca gccggcagac cgccagcaga tggaggcgct cactcggtac
      841 ctgcgcgcgg cgctcgctcc ctacaactgg cccgtgtggc tgggcgtgca cgatcggcgc
      901 gccgagggcc tctacctctt cgaaaacggc cagcgcgtgt ccttcttcgc ctggcatcgc
      961 tcaccccgcc ccgagctcgg cgcccagccc agcgcctcgc cgcatccgct cagcccggac
     1021 cagcccaacg gtggcacgct cgagaactgc gtggcgcagg cctctgacga cggctcctgg
     1081 tgggaccacg actgccagcg gcgtctctac tacgtctgcg agttcccctt ctagcggggc
     1141 cggtaccccg cctccctgcc catcccacca cccggccttt ccctgcgccg tgcccaccct
     1201 cctccggaat ctcccttccc ttcctggcca cgaatggcag cgtcctcccc gacccccagt
     1261 ctgggcgctt ctgggagggc tcttgcggtg ccggcactcc tccttgttag tgtctttcct
     1321 tgaaggggcg ggcaccaggc taggtccggt gccaataaat ccttgtggaa tctga
//
