LOCUS       NM_152353                974 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens claudin domain containing 2 (CLDND2), mRNA.
ACCESSION   NM_152353
VERSION     NM_152353.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 974)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008750.9 and BC029518.1.
            
            On May 17, 2019 this sequence version replaced NM_152353.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029518.1, AI337031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291715.5/ ENSP00000291715.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               AC008750.9         41606-41953         c
            349-974             BC029518.1         349-974
FEATURES             Location/Qualifiers
     source          1..974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..974
                     /gene="CLDND2"
                     /note="claudin domain containing 2"
                     /db_xref="GeneID:125875"
                     /db_xref="HGNC:HGNC:28511"
     exon            1..595
                     /gene="CLDND2"
                     /inference="alignment:Splign:2.1.0"
     CDS             427..930
                     /gene="CLDND2"
                     /codon_start=1
                     /product="claudin domain-containing protein 2"
                     /protein_id="NP_689566.1"
                     /db_xref="CCDS:CCDS12829.1"
                     /db_xref="GeneID:125875"
                     /db_xref="HGNC:HGNC:28511"
                     /translation="MGVKRSLQSGGILLSLVANVLMVLSTATNYWTRQQEGHSGLWQE
                     CNHGICSSIPCQTTLAVTVACMVLAVGVGVVGMVMGLRIRCDEGESLRGQTTSAFLFL
                     GGLLLLTALIGYTVKNAWKNNVFFSWSYFSGWLALPFSILAGFCFLLADMIMQSTDAI
                     SGFPVCL"
     exon            596..736
                     /gene="CLDND2"
                     /inference="alignment:Splign:2.1.0"
     exon            737..856
                     /gene="CLDND2"
                     /inference="alignment:Splign:2.1.0"
     exon            857..974
                     /gene="CLDND2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      951..956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDND2"
                     /note="hexamer: AATAAA"
     polyA_site      974
                     /gene="CLDND2"
                     /note="major polyA site"
ORIGIN      
        1 gtctctctgg gctctgtgtc taaggagccc tagggcactg ggtgtgagtc acttaggtgg
       61 gcctgtgtgg aggggtgtct ggggaggaca ttgaacaggc tgggctgaaa gggcgttcgg
      121 ctgtcggggg aggtctctgg gaagacaggt tcctcacagc aaagcctgtg gtgaaggtct
      181 cagaggcctc tcaggggaag tctcaaggtc tccagtaagg ggaacgaggt ctggagggag
      241 gaggttgtgg atcctcaggc agggttgttg agggaggggg gtctccaggt ccccagaagc
      301 agggacctca ggcaggagta ccaggggagg agtgtggagg aagcgggctc ctcagctggg
      361 ggcctcgggg taggaaaggc ctgggcccat cctgcccttg tggcccccgg ctgcagcctc
      421 agtggcatgg gggtgaagcg gagcctccag agtgggggca ttctgctcag cctcgtggcc
      481 aacgtcctca tggtgctctc cacggccacc aactactgga cccgccaaca agagggccac
      541 agtggcctgt ggcaggaatg caaccacggc atctgctcca gcatcccctg ccagaccacg
      601 ctggcggtga ctgtggcgtg catggtgctg gcggtgggtg tcggcgtggt gggcatggtg
      661 atgggactgc ggattcggtg cgacgagggc gagtcgctgc ggggccagac cacgagcgcc
      721 ttcctcttcc tcggcggact gctgctgctg accgccttga taggctacac cgtgaagaat
      781 gcgtggaaga acaacgtctt cttctcttgg tcctattttt ctgggtggct ggccttaccc
      841 ttctcaattc tcgcgggctt ctgctttctg ctggcagaca tgatcatgca gagcaccgac
      901 gccatcagtg gattccccgt gtgtctgtga ctgcagcctg cctggggcag aataaaggaa
      961 cggctttttt tagc
//
