LOCUS       NM_020982               1583 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens claudin 9 (CLDN9), mRNA.
ACCESSION   NM_020982 XM_001715692
VERSION     NM_020982.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1583)
  AUTHORS   Du,Q., Lin,Y., Ding,C., Wu,L., Xu,Y. and Feng,Q.
  TITLE     Pharmacological Activity of Matrine in Inhibiting Colon Cancer
            Cells VM Formation, Proliferation, and Invasion by Downregulating
            Claudin-9 Mediated EMT Process and MAPK Signaling Pathway
  JOURNAL   Drug Des Devel Ther 17, 2787-2804 (2023)
   PUBMED   37719361
  REMARK    GeneRIF: Pharmacological Activity of Matrine in Inhibiting Colon
            Cancer Cells VM Formation, Proliferation, and Invasion by
            Downregulating Claudin-9 Mediated EMT Process and MAPK Signaling
            Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1583)
  AUTHORS   Endo,Y., Sugimoto,K., Kobayashi,M., Kobayashi,Y., Kojima,M.,
            Furukawa,S., Soeda,S., Watanabe,T., Higashi,A.Y., Higashi,T.,
            Hashimoto,Y., Fujimori,K. and Chiba,H.
  TITLE     Claudin-9 is a novel prognostic biomarker for endometrial cancer
  JOURNAL   Int J Oncol 61 (5) (2022)
   PUBMED   36129146
  REMARK    GeneRIF: Claudin9 is a novel prognostic biomarker for endometrial
            cancer.
REFERENCE   3  (bases 1 to 1583)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1583)
  AUTHORS   Sineni,C.J., Yildirim-Baylan,M., Guo,S., Camarena,V., Wang,G.,
            Tokgoz-Yilmaz,S., Duman,D., Bademci,G. and Tekin,M.
  TITLE     A truncating CLDN9 variant is associated with autosomal recessive
            nonsyndromic hearing loss
  JOURNAL   Hum Genet 138 (10), 1071-1075 (2019)
   PUBMED   31175426
  REMARK    GeneRIF: We conclude that CLDN9 is essential for proper audition in
            humans and its disruption leads to SNHL in humans.
REFERENCE   5  (bases 1 to 1583)
  AUTHORS   Chavarria-Velazquez,C.O., Torres-Martinez,A.C., Montano,L.F. and
            Rendon-Huerta,E.P.
  TITLE     TLR2 activation induced by H. pylori LPS promotes the differential
            expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2
            in AGS cells
  JOURNAL   Immunobiology 223 (1), 38-48 (2018)
   PUBMED   29031421
  REMARK    GeneRIF: these results suggest that Helicobacter pylori
            lipopolysaccharide induces TLR2 expression in the gastric
            adenocarcinoma cells, and that the longer the exposure to
            lipopolysaccharide, the greater the expression of TLR2 in the cell
            membrane; consequently the expression of claudin-4, -6, -7 and -9
            also increases
REFERENCE   6  (bases 1 to 1583)
  AUTHORS   Tsukita,S., Furuse,M. and Itoh,M.
  TITLE     Multifunctional strands in tight junctions
  JOURNAL   Nat Rev Mol Cell Biol 2 (4), 285-293 (2001)
   PUBMED   11283726
  REMARK    Review article
REFERENCE   7  (bases 1 to 1583)
  AUTHORS   Heiskala,M., Peterson,P.A. and Yang,Y.
  TITLE     The roles of claudin superfamily proteins in paracellular transport
  JOURNAL   Traffic 2 (2), 93-98 (2001)
   PUBMED   11247307
  REMARK    Review article
REFERENCE   8  (bases 1 to 1583)
  AUTHORS   Yi,X., Wang,Y. and Yu,F.S.
  TITLE     Corneal epithelial tight junctions and their response to
            lipopolysaccharide challenge
  JOURNAL   Invest Ophthalmol Vis Sci 41 (13), 4093-4100 (2000)
   PUBMED   11095601
REFERENCE   9  (bases 1 to 1583)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell Mol Neurobiol 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
REFERENCE   10 (bases 1 to 1583)
  AUTHORS   Peacock,R.E., Keen,T.J. and Inglehearn,C.F.
  TITLE     Analysis of a human gene homologous to rat ventral prostate.1
            protein
  JOURNAL   Genomics 46 (3), 443-449 (1997)
   PUBMED   9441748
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK091002.1, BC051870.1 and
            AI791760.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020982.3.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. This protein is one of the entry cofactors
            for hepatitis C virus. Mouse studies revealed that this gene is
            required for the preservation of sensory cells in the hearing organ
            and the gene deficiency is associated with deafness. [provided by
            RefSeq, Jun 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK091002.1, BC065830.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000445369.3/ ENSP00000398017.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-770               AK091002.1         468-1237
            771-1136            BC051870.1         903-1268
            1137-1450           AI791760.1         162-475
            1451-1583           BC051870.1         1583-1715
FEATURES             Location/Qualifiers
     source          1..1583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1583
                     /gene="CLDN9"
                     /gene_synonym="DFNB116"
                     /note="claudin 9"
                     /db_xref="GeneID:9080"
                     /db_xref="HGNC:HGNC:2051"
                     /db_xref="MIM:615799"
     exon            1..1583
                     /gene="CLDN9"
                     /gene_synonym="DFNB116"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..1094
                     /gene="CLDN9"
                     /gene_synonym="DFNB116"
                     /codon_start=1
                     /product="claudin-9"
                     /protein_id="NP_066192.1"
                     /db_xref="CCDS:CCDS10487.1"
                     /db_xref="GeneID:9080"
                     /db_xref="HGNC:HGNC:2051"
                     /db_xref="MIM:615799"
                     /translation="MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQ
                     VVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGA
                     QCTTCVEDEGAKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKREL
                     GASLYLGWAAAALLMLGGGLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV"
     regulatory      1562..1567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN9"
                     /gene_synonym="DFNB116"
                     /note="hexamer: AATAAA"
     polyA_site      1583
                     /gene="CLDN9"
                     /gene_synonym="DFNB116"
                     /note="major polyA site"
ORIGIN      
        1 agagtcccca ggtggcactg tcagagtcgc tcagtgggaa cctgcgccag ccggcaggag
       61 acgtggctgt cctcagcctg gcagtgcgtc tggagggcct gtgcgagctc agcccaggtg
      121 tgacagcggg gtggtaagag cagcagcacc ctcagggcat ccgatgggcg gaggcccctc
      181 gaggtgacac ccaccactca gccgagcggg actacgagtc tgctttgtgc tccgcgagga
      241 ccagaaacac ctgcaagagg cacggagagg aggcgccttt caagaggcgc ctttcatgga
      301 actgaggact ggcctggctt ggggacacca acaagccttc cccctcctgc tggacacaga
      361 gacacccacc cagcacacca gacacaccct ctgagtcacc taggccgcct ggggctgaga
      421 agacctaacc gaggggccag atggcttcga ccggcttaga actgctgggc atgaccctgg
      481 ctgtgctggg ctggctgggg accctggtgt cctgcgccct gcccctgtgg aaggtgaccg
      541 ccttcatcgg caacagcatc gtggtggccc aggtggtgtg ggagggcctg tggatgtcct
      601 gcgtggtgca gagcacgggc cagatgcagt gcaaggtgta cgactcactg ctggctctgc
      661 cgcaggacct gcaggccgca cgtgccctct gtgtcattgc cctcctgctg gccctgcttg
      721 gcctcctggt ggccatcaca ggtgcccagt gtaccacgtg tgtggaggac gaaggtgcca
      781 aggcccgtat cgtgctcacc gcgggggtca tcctcctcct cgccggcatc ctggtgctca
      841 tccctgtgtg ctggacggcg cacgccatca tccaggactt ctacaacccc ctggtggctg
      901 aggccctcaa gcgggagctg ggggcctccc tctacctggg ctgggcggcg gctgcactgc
      961 ttatgctggg cggggggctc ctctgctgca cgtgcccccc gccccaggtc gagcggcccc
     1021 gcggacctcg gctgggctac tccatcccct cccgctcggg tgcatctgga ctggacaaga
     1081 gggactacgt gtgaggcgga ggtttcccct gggagcccac tgctccccac tgccccgccc
     1141 tttcgacctt ggcctgatga ccagatgccc tgctccatca caacctcctt ccccaggaaa
     1201 acccactttc caaaagccca agctacacct ggctgcaggg ctgggtcagc tggcctggct
     1261 gagctcttct cagtggggtc ccctttgatg ttctccccca agttgggcag cctagaggtg
     1321 ttgggaaccc tggcctgccc ccacctcccc agtaattgtt tccttccgtt gcccaggaca
     1381 ctggctggcc ttccttctct tctgagccct cccctgcccc aggaaccctg gcctcaccaa
     1441 aacagcagca gctcgttggc tccaaaacca gggagcagac catgccctcc caaccctgga
     1501 gttgtcaggg agggcctgcc catcacctcc ctctccccaa catccccacc ctcgagttgg
     1561 aaataaagag catttgtaac tgg
//
