LOCUS       NM_199328               2092 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens claudin 8 (CLDN8), mRNA.
ACCESSION   NM_199328
VERSION     NM_199328.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2092)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2092)
  AUTHORS   Nattramilarasu,P.K., Bucker,R., Lobo de Sa,F.D., Fromm,A.,
            Nagel,O., Lee,I.M., Butkevych,E., Mousavi,S., Genger,C., Klove,S.,
            Heimesaat,M.M., Bereswill,S., Schweiger,M.R., Nielsen,H.L.,
            Troeger,H. and Schulzke,J.D.
  TITLE     Campylobacter concisus Impairs Sodium Absorption in Colonic
            Epithelium via ENaC Dysfunction and Claudin-8 Disruption
  JOURNAL   Int J Mol Sci 21 (2), 373 (2020)
   PUBMED   31936044
  REMARK    GeneRIF: Campylobacter concisus Impairs Sodium Absorption in
            Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2092)
  AUTHORS   Wang,Z., Zhu,J., Liu,C. and Ma,L.
  TITLE     Identification of key genes and pathways associated with Crohn's
            disease by bioinformatics analysis
  JOURNAL   Scand J Gastroenterol 54 (10), 1205-1213 (2019)
   PUBMED   31526198
  REMARK    GeneRIF: MMP1 and CLDN8 were two key genes screened from the
            differentially expressed genes involved in the pathogenesis of
            Crohn's disease.
REFERENCE   4  (bases 1 to 2092)
  AUTHORS   Liu,B., Lu,B., Wang,X., Jiang,H. and Kuang,W.
  TITLE     MiR-361-5p inhibits cell proliferation and induces cell apoptosis
            in retinoblastoma by negatively regulating CLDN8
  JOURNAL   Childs Nerv Syst 35 (8), 1303-1311 (2019)
   PUBMED   31161266
  REMARK    GeneRIF: MiR-361-5p inhibits cell proliferation and induces cell
            apoptosis in retinoblastoma by negatively regulating CLDN8.
REFERENCE   5  (bases 1 to 2092)
  AUTHORS   Zhou,S., Piao,X., Wang,C., Wang,R. and Song,Z.
  TITLE     Identification of claudin-1, -3, -7 and -8 as prognostic markers in
            human laryngeal carcinoma
  JOURNAL   Mol Med Rep 20 (1), 393-400 (2019)
   PUBMED   31115553
  REMARK    GeneRIF: the findings of the present study demonstrated that the
            expression levels of CLDN1, 3, 7 and 8 varied between laryngeal
            squamous carcinoma tissues and nonneoplastic tissues
REFERENCE   6  (bases 1 to 2092)
  AUTHORS   Tsukita,S., Furuse,M. and Itoh,M.
  TITLE     Multifunctional strands in tight junctions
  JOURNAL   Nat Rev Mol Cell Biol 2 (4), 285-293 (2001)
   PUBMED   11283726
  REMARK    Review article
REFERENCE   7  (bases 1 to 2092)
  AUTHORS   Heiskala,M., Peterson,P.A. and Yang,Y.
  TITLE     The roles of claudin superfamily proteins in paracellular transport
  JOURNAL   Traffic 2 (2), 93-98 (2001)
   PUBMED   11247307
  REMARK    Review article
REFERENCE   8  (bases 1 to 2092)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell Mol Neurobiol 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
REFERENCE   9  (bases 1 to 2092)
  AUTHORS   Itoh,M., Furuse,M., Morita,K., Kubota,K., Saitou,M. and Tsukita,S.
  TITLE     Direct binding of three tight junction-associated MAGUKs, ZO-1,
            ZO-2, and ZO-3, with the COOH termini of claudins
  JOURNAL   J Cell Biol 147 (6), 1351-1363 (1999)
   PUBMED   10601346
REFERENCE   10 (bases 1 to 2092)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA629490.1, AY358707.1,
            AL049977.1 and AW235670.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_199328.2.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. This protein plays important roles in the
            paracellular cation barrier of the distal renal tubule, and in the
            paracellular barrier to prevent sodium back-leakage in distal
            colon. Differential expression of this gene has been observed in
            colorectal carcinoma and renal cell tumors, and along with
            claudin-7, is an immunohistochemical marker for the differential
            diagnosis of chromophobe renal cell carcinoma and renal
            oncocytoma.[provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY358707.1, BC058004.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399899.2/ ENSP00000382783.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                DA629490.1         55-130
            77-1532             AY358707.1         1-1456
            1533-2081           AL049977.1         522-1070
            2082-2092           AW235670.1         2-12                c
FEATURES             Location/Qualifiers
     source          1..2092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..2092
                     /gene="CLDN8"
                     /gene_synonym="HEL-S-79"
                     /note="claudin 8"
                     /db_xref="GeneID:9073"
                     /db_xref="HGNC:HGNC:2050"
                     /db_xref="MIM:611231"
     exon            1..2092
                     /gene="CLDN8"
                     /gene_synonym="HEL-S-79"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..850
                     /gene="CLDN8"
                     /gene_synonym="HEL-S-79"
                     /note="epididymis secretory protein Li 79"
                     /codon_start=1
                     /product="claudin-8"
                     /protein_id="NP_955360.1"
                     /db_xref="CCDS:CCDS13587.1"
                     /db_xref="GeneID:9073"
                     /db_xref="HGNC:HGNC:2050"
                     /db_xref="MIM:611231"
                     /translation="MATHALEIAGLFLGGVGMVGTVAVTVMPQWRVSAFIENNIVVFE
                     NFWEGLWMNCVRQANIRMQCKIYDSLLALSPDLQAARGLMCAASVMSFLAFMMAILGM
                     KCTRCTGDNEKVKAHILLTAGIIFIITGMVVLIPVSWVANAIIRDFYNSIVNVAQKRE
                     LGEALYLGWTTALVLIVGGALFCCVFCCNEKSSSYRYSIPSHRTTQKSYHTGKKSPSV
                     YSRSQYV"
     regulatory      2063..2068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN8"
                     /gene_synonym="HEL-S-79"
                     /note="hexamer: AATAAA"
     polyA_site      2092
                     /gene="CLDN8"
                     /gene_synonym="HEL-S-79"
                     /note="major polyA site"
ORIGIN      
        1 actggatact atctggccag aagtagcaaa gcagctctta tttgaaaaac cactgggttc
       61 cgagttcatt actacaggaa aaactgttct cttctgtggc acagagaacc ctgcttcaaa
      121 gcagaagtag cagttccgga gtccagctgg ctaaaactca tcccagagga taatggcaac
      181 ccatgcctta gaaatcgctg ggctgtttct tggtggtgtt ggaatggtgg gcacagtggc
      241 tgtcactgtc atgcctcagt ggagagtgtc ggccttcatt gaaaacaaca tcgtggtttt
      301 tgaaaacttc tgggaaggac tgtggatgaa ttgcgtgagg caggctaaca tcaggatgca
      361 gtgcaaaatc tatgattccc tgctggctct ttctccggac ctacaggcag ccagaggact
      421 gatgtgtgct gcttccgtga tgtccttctt ggctttcatg atggccatcc ttggcatgaa
      481 atgcaccagg tgcacggggg acaatgagaa ggtgaaggct cacattctgc tgacggctgg
      541 aatcatcttc atcatcacgg gcatggtggt gctcatccct gtgagctggg ttgccaatgc
      601 catcatcaga gatttctata actcaatagt gaatgttgcc caaaaacgtg agcttggaga
      661 agctctctac ttaggatgga ccacggcact ggtgctgatt gttggaggag ctctgttctg
      721 ctgcgttttt tgttgcaacg aaaagagcag tagctacaga tactcgatac cttcccatcg
      781 cacaacccaa aaaagttatc acaccggaaa gaagtcaccg agcgtctact ccagaagtca
      841 gtatgtgtag ttgtgtatgt ttttttaact ttactataaa gccatgcaaa tgacaaaaat
      901 ctatattact ttctcaaaat ggaccccaaa gaaactttga tttactgttc ttaactgcct
      961 aatcttaatt acaggaactg tgcatcagct atttatgatt ctataagcta tttcagcaga
     1021 atgagatatt aaacccaatg ctttgattgt tctagaaagt atagtaattt gttttctaag
     1081 gtggttcaag catctactct ttttatcatt tacttcaaaa tgacattgct aaagactgca
     1141 ttattttact actgtaattt ctccacgaca tagcattatg tacatagatg agtgtaacat
     1201 ttatatctca catagagaca tgcttatatg gttttattta aaatgaaatg ccagtccatt
     1261 acactgaata aatagaactc aactattgct tttcagggaa atcatggata gggttgaaga
     1321 aggttactat taattgttta aaaacagctt agggattaat gtcctccatt tataatgaag
     1381 attaaaatga aggctttaat cagcattgta aaggaaattg aatggctttc tgatatgctg
     1441 ttttttagcc taggagttag aaatcctaac ttctttatcc tcttctccca gaggcttttt
     1501 ttttcttgtg tattaaatta acatttttaa aaagcagata ttttgtcaag gggctttgca
     1561 ttcaaactgc ttttccaggg ctatactcag aagaaagata aaagtgtgat ctaagaaaaa
     1621 gtgatggttt taggaaagtg aaaatatttt tgtttttgta tttgaagaag aatgatgcat
     1681 tttgacaaga aatcatatat gtatggatat attttaataa gtatttgagt acagactttg
     1741 aggtttcatc aatataaata aaagagcaga aaaatatgtc ttggttttca tttgcttacc
     1801 aaaaaaacaa caacaaaaaa agttgtcctt tgagaacttc acctgctcct atgtgggtac
     1861 ctgagtcaaa attgtcattt ttgttctgtg aaaaataaat ttccttcttg taccatttct
     1921 gtttagtttt actaaaatct gtaaatactg tatttttctg tttattccaa atttgatgaa
     1981 actgacaatc caatttgaaa gtttgtgtcg acgtctgtct agcttaaatg aatgtgttct
     2041 atttgcttta tacatttata ttaataaatt gtacattttt ctaattattt ga
//
