LOCUS       NM_001307               1542 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens claudin 7 (CLDN7), transcript variant 1, mRNA.
ACCESSION   NM_001307
VERSION     NM_001307.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Markey,G.E., Ryan,S., Furuta,G.T., Menard-Katcher,C., McNamee,E.N.
            and Masterson,J.C.
  TITLE     Hypoxia-inducible microRNA-155 negatively regulates epithelial
            barrier in eosinophilic esophagitis by suppressing tight junction
            claudin-7
  JOURNAL   FASEB J 38 (1), e23358 (2024)
   PUBMED   38050671
  REMARK    GeneRIF: Hypoxia-inducible microRNA-155 negatively regulates
            epithelial barrier in eosinophilic esophagitis by suppressing tight
            junction claudin-7.
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Xiao,Y., Lian,H., Zhong,X.S., Krishnachaitanya,S.S., Cong,Y.,
            Dashwood,R.H., Savidge,T.C., Powell,D.W., Liu,X. and Li,Q.
  TITLE     Matrix metalloproteinase 7 contributes to intestinal barrier
            dysfunction by degrading tight junction protein Claudin-7
  JOURNAL   Front Immunol 13, 1020902 (2022)
   PUBMED   36275703
  REMARK    GeneRIF: Matrix metalloproteinase 7 contributes to intestinal
            barrier dysfunction by degrading tight junction protein Claudin-7.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1542)
  AUTHORS   Kamble,P.R., Patkar,S.R., Breed,A.A. and Pathak,B.R.
  TITLE     N-glycosylation status of Trop2 impacts its surface density,
            interaction with claudin-7 and exosomal release
  JOURNAL   Arch Biochem Biophys 714, 109084 (2021)
   PUBMED   34774484
  REMARK    GeneRIF: N-glycosylation status of Trop2 impacts its surface
            density, interaction with claudin-7 and exosomal release.
REFERENCE   4  (bases 1 to 1542)
  AUTHORS   Kuwatsuka,S., Koike,Y., Kuwatsuka,Y., Yamaoka,T. and Murota,H.
  TITLE     Claudin-7 in keratinocytes is downregulated by the inhibition of
            HMG-CoA reductase and is highly expressed in the stratum granulosum
            of the psoriatic epidermis
  JOURNAL   J Dermatol Sci 104 (2), 132-137 (2021)
   PUBMED   34763991
  REMARK    GeneRIF: Claudin-7 in keratinocytes is downregulated by the
            inhibition of HMG-CoA reductase and is highly expressed in the
            stratum granulosum of the psoriatic epidermis.
REFERENCE   5  (bases 1 to 1542)
  AUTHORS   Gowrikumar,S., Primeaux,M., Pravoverov,K., Wu,C., Szeglin,B.C.,
            Sauve,C.G., Thapa,I., Bastola,D., Chen,X.S., Smith,J.J., Singh,A.B.
            and Dhawan,P.
  TITLE     A Claudin-Based Molecular Signature Identifies High-Risk,
            Chemoresistant Colorectal Cancer Patients
  JOURNAL   Cells 10 (9), 2211 (2021)
   PUBMED   34571860
  REMARK    GeneRIF: A Claudin-Based Molecular Signature Identifies High-Risk,
            Chemoresistant Colorectal Cancer Patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1542)
  AUTHORS   Heiskala,M., Peterson,P.A. and Yang,Y.
  TITLE     The roles of claudin superfamily proteins in paracellular transport
  JOURNAL   Traffic 2 (2), 93-98 (2001)
   PUBMED   11247307
  REMARK    Review article
REFERENCE   7  (bases 1 to 1542)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell Mol Neurobiol 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
REFERENCE   8  (bases 1 to 1542)
  AUTHORS   Itoh,M., Furuse,M., Morita,K., Kubota,K., Saitou,M. and Tsukita,S.
  TITLE     Direct binding of three tight junction-associated MAGUKs, ZO-1,
            ZO-2, and ZO-3, with the COOH termini of claudins
  JOURNAL   J Cell Biol 147 (6), 1351-1363 (1999)
   PUBMED   10601346
REFERENCE   9  (bases 1 to 1542)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
REFERENCE   10 (bases 1 to 1542)
  AUTHORS   Peacock,R.E., Keen,T.J. and Inglehearn,C.F.
  TITLE     Analysis of a human gene homologous to rat ventral prostate.1
            protein
  JOURNAL   Genomics 46 (3), 443-449 (1997)
   PUBMED   9441748
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CV575841.1, AC003688.1 and
            BC071844.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001307.5.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. Differential expression of this gene has been
            observed in different types of malignancies, including breast
            cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors,
            prostate cancer, lung cancer, head and neck cancers, thyroid
            carcinomas, etc.. Alternatively spliced transcript variants
            encoding different isoforms have been found.[provided by RefSeq,
            May 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071844.1, ERR279844.320.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360325.11/ ENSP00000353475.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 CV575841.1         468-468
            2-658               AC003688.1         64217-64873         c
            659-823             AC003688.1         63217-63381         c
            824-1542            BC071844.1         629-1347
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1542
                     /gene="CLDN7"
                     /gene_synonym="CEPTRL2; claudin-1; CLDN-7; CPETRL2;
                     Hs.84359"
                     /note="claudin 7"
                     /db_xref="GeneID:1366"
                     /db_xref="HGNC:HGNC:2049"
                     /db_xref="MIM:609131"
     exon            1..658
                     /gene="CLDN7"
                     /gene_synonym="CEPTRL2; claudin-1; CLDN-7; CPETRL2;
                     Hs.84359"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..1071
                     /gene="CLDN7"
                     /gene_synonym="CEPTRL2; claudin-1; CLDN-7; CPETRL2;
                     Hs.84359"
                     /note="isoform 1 is encoded by transcript variant 1;
                     clostridium perfringens enterotoxin receptor-like 2;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="claudin-7 isoform 1"
                     /protein_id="NP_001298.3"
                     /db_xref="CCDS:CCDS11096.1"
                     /db_xref="GeneID:1366"
                     /db_xref="HGNC:HGNC:2049"
                     /db_xref="MIM:609131"
                     /translation="MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQ
                     AMYKGLWMDCVTQSTGMMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGM
                     KCTRCGGDDKVKKARIAMGGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYE
                     FGPAIFIGWAGSALVILGGALLSCSCPGNESKAGYRVPRSYPKSNSSKEYV"
     exon            659..823
                     /gene="CLDN7"
                     /gene_synonym="CEPTRL2; claudin-1; CLDN-7; CPETRL2;
                     Hs.84359"
                     /inference="alignment:Splign:2.1.0"
     exon            824..908
                     /gene="CLDN7"
                     /gene_synonym="CEPTRL2; claudin-1; CLDN-7; CPETRL2;
                     Hs.84359"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1542
                     /gene="CLDN7"
                     /gene_synonym="CEPTRL2; claudin-1; CLDN-7; CPETRL2;
                     Hs.84359"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1285..1290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN7"
                     /gene_synonym="CEPTRL2; claudin-1; CLDN-7; CPETRL2;
                     Hs.84359"
                     /note="hexamer: AATAAA"
     polyA_site      1306
                     /gene="CLDN7"
                     /gene_synonym="CEPTRL2; claudin-1; CLDN-7; CPETRL2;
                     Hs.84359"
                     /note="major polyA site"
     regulatory      1514..1519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN7"
                     /gene_synonym="CEPTRL2; claudin-1; CLDN-7; CPETRL2;
                     Hs.84359"
                     /note="hexamer: AATAAA"
     polyA_site      1542
                     /gene="CLDN7"
                     /gene_synonym="CEPTRL2; claudin-1; CLDN-7; CPETRL2;
                     Hs.84359"
                     /note="major polyA site"
ORIGIN      
        1 gcccgcacct gctggctcac ctccgagcca cctctgctgc gcaccgcagc ctcggaccta
       61 cagcccagga tactttggga cttgccggcg ctcagaaacg cgcccagacg gcccctccac
      121 cttttgtttg cctagggtcg ccgagagcgc ccggagggaa ccgcctggcc ttcggggacc
      181 accaattttg tctggaacca ccctcccggc gtatcctact ccctgtgccg cgaggccatc
      241 gcttcactgg aggggtcgat ttgtgtgtag tttggtgaca agatttgcat tcacctggcc
      301 caaacccttt ttgtctcttt gggtgaccgg aaaactccac ctcaagtttt cttttgtggg
      361 gctgcccccc aagtgtcgtt tgttttactg tagggtctcc ccgcccggcg cccccagtgt
      421 tttctgaggg cggaaatggc caattcgggc ctgcagttgc tgggcttctc catggccctg
      481 ctgggctggg tgggtctggt ggcctgcacc gccatcccgc agtggcagat gagctcctat
      541 gcgggtgaca acatcatcac ggcccaggcc atgtacaagg ggctgtggat ggactgcgtc
      601 acgcagagca cggggatgat gagctgcaaa atgtacgact cggtgctcgc cctgtccgcg
      661 gccttgcagg ccactcgagc cctaatggtg gtctccctgg tgctgggctt cctggccatg
      721 tttgtggcca cgatgggcat gaagtgcacg cgctgtgggg gagacgacaa agtgaagaag
      781 gcccgtatag ccatgggtgg aggcataatt ttcatcgtgg caggtcttgc cgccttggta
      841 gcttgctcct ggtatggcca tcagattgtc acagactttt ataacccttt gatccctacc
      901 aacattaagt atgagtttgg ccctgccatc tttattggct gggcagggtc tgccctagtc
      961 atcctgggag gtgcactgct ctcctgttcc tgtcctggga atgagagcaa ggctgggtac
     1021 cgtgtacccc gctcttaccc taagtccaac tcttccaagg agtatgtgtg acctgggatc
     1081 tccttgcccc agcctgacag gctatgggag tgtctagatg cctgaaaggg cctggggctg
     1141 agctcagcct gtgggcaggg tgccggacaa aggcctcctg gtcactctgt ccctgcactc
     1201 catgtatagt cctcttgggt tgggggtggg ggggtgccgt tggtgggaga gacaaaaaga
     1261 gggagagtgt gctttttgta cagtaataaa aaataagtat tgggaagcag gcttttttcc
     1321 cttcagggcc tctgctttcc tcccgtccag atccttgcag ggagcttgga accttagtgc
     1381 acctacttca gttcagaaca cttagcaccc cactgactcc actgacaatt gactaaaaga
     1441 tgcaggtgct cgtatctcga cattcattcc cacccccctc ttatttaaat agctaccaaa
     1501 gtacttcttt tttaataaaa aaataaagat ttttattagg ta
//
