LOCUS       NM_021195               1366 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens claudin 6 (CLDN6), mRNA.
ACCESSION   NM_021195
VERSION     NM_021195.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1366)
  AUTHORS   Jin,Q., Qi,D., Zhang,M., Qu,H., Dong,Y., Sun,M. and Quan,C.
  TITLE     CLDN6 inhibits breast cancer growth and metastasis through
            SREBP1-mediated RAS palmitoylation
  JOURNAL   Cell Mol Biol Lett 29 (1), 112 (2024)
   PUBMED   39169280
  REMARK    GeneRIF: CLDN6 inhibits breast cancer growth and metastasis through
            SREBP1-mediated RAS palmitoylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1366)
  AUTHORS   Dong,Y., Xu,W., Qi,D., Qu,H., Jin,Q., Sun,M., Wang,X. and Quan,C.
  TITLE     CLDN6 inhibits colorectal cancer proliferation dependent on
            restraining p53 ubiquitination via ZO-1/PTEN axis
  JOURNAL   Cell Signal 112, 110930 (2023)
   PUBMED   37852424
  REMARK    GeneRIF: CLDN6 inhibits colorectal cancer proliferation dependent
            on restraining p53 ubiquitination via ZO-1/PTEN axis.
REFERENCE   3  (bases 1 to 1366)
  AUTHORS   Romero-Estrada,J.H., Montano,L.F. and Rendon-Huerta,E.P.
  TITLE     Binding of YY1/CREB to an Enhancer Region Triggers Claudin 6
            Expression in H. pylori LPS-Stimulated AGS Cells
  JOURNAL   Int J Mol Sci 24 (18), 13974 (2023)
   PUBMED   37762277
  REMARK    GeneRIF: Binding of YY1/CREB to an Enhancer Region Triggers Claudin
            6 Expression in H. pylori LPS-Stimulated AGS Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1366)
  AUTHORS   Liu,T., Jiang,L., Bai,Q., Wu,S., Yu,X., Wu,T., Wang,J., Zhang,X.,
            Li,H., Zhao,K. and Wang,L.
  TITLE     CLDN6 Suppresses Migration and Invasion of MCF-7 and SKBR-3 Breast
            Cancer Cells by Blocking the SMAD/Snail/MMP-2/9 Axis
  JOURNAL   Bull Exp Biol Med 175 (3), 376-381 (2023)
   PUBMED   37566248
  REMARK    GeneRIF: CLDN6 Suppresses Migration and Invasion of MCF-7 and
            SKBR-3 Breast Cancer Cells by Blocking the SMAD/Snail/MMP-2/9 Axis.
REFERENCE   5  (bases 1 to 1366)
  AUTHORS   Dong,Y., Jin,Q., Sun,M., Qi,D., Qu,H., Wang,X. and Quan,C.
  TITLE     CLDN6 inhibits breast cancer metastasis through WIP-dependent actin
            cytoskeleton-mediated autophagy
  JOURNAL   J Exp Clin Cancer Res 42 (1), 68 (2023)
   PUBMED   36935496
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1366)
  AUTHORS   Heiskala,M., Peterson,P.A. and Yang,Y.
  TITLE     The roles of claudin superfamily proteins in paracellular transport
  JOURNAL   Traffic 2 (2), 93-98 (2001)
   PUBMED   11247307
  REMARK    Review article
REFERENCE   7  (bases 1 to 1366)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell Mol Neurobiol 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
REFERENCE   8  (bases 1 to 1366)
  AUTHORS   Itoh,M., Furuse,M., Morita,K., Kubota,K., Saitou,M. and Tsukita,S.
  TITLE     Direct binding of three tight junction-associated MAGUKs, ZO-1,
            ZO-2, and ZO-3, with the COOH termini of claudins
  JOURNAL   J Cell Biol 147 (6), 1351-1363 (1999)
   PUBMED   10601346
REFERENCE   9  (bases 1 to 1366)
  AUTHORS   Morita,K., Sasaki,H., Furuse,M. and Tsukita,S.
  TITLE     Endothelial claudin: claudin-5/TMVCF constitutes tight junction
            strands in endothelial cells
  JOURNAL   J Cell Biol 147 (1), 185-194 (1999)
   PUBMED   10508865
REFERENCE   10 (bases 1 to 1366)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX444798.2, CN420342.1 and
            BC008934.2.
            
            On Nov 22, 2018 this sequence version replaced NM_021195.4.
            
            Summary: Tight junctions represent one mode of cell-to-cell
            adhesion in epithelial or endothelial cell sheets, forming
            continuous seals around cells and serving as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space. These junctions are comprised of sets of
            continuous networking strands in the outwardly facing cytoplasmic
            leaflet, with complementary grooves in the inwardly facing
            extracytoplasmic leaflet. This gene encodes a component of tight
            junction strands, which is a member of the claudin family. The
            protein is an integral membrane protein and is one of the entry
            cofactors for hepatitis C virus. The gene methylation may be
            involved in esophageal tumorigenesis. This gene is adjacent to
            another family member CLDN9 on chromosome 16.[provided by RefSeq,
            Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA733985.1, AK075329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328796.5/ ENSP00000328674.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BX444798.2         5-50
            47-561              CN420342.1         12-526
            562-1366            BC008934.2         540-1344
FEATURES             Location/Qualifiers
     source          1..1366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1366
                     /gene="CLDN6"
                     /note="claudin 6"
                     /db_xref="GeneID:9074"
                     /db_xref="HGNC:HGNC:2048"
                     /db_xref="MIM:615798"
     exon            1..35
                     /gene="CLDN6"
                     /inference="alignment:Splign:2.1.0"
     exon            36..1366
                     /gene="CLDN6"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..719
                     /gene="CLDN6"
                     /note="skullin"
                     /codon_start=1
                     /product="claudin-6"
                     /protein_id="NP_067018.2"
                     /db_xref="CCDS:CCDS10488.1"
                     /db_xref="GeneID:9074"
                     /db_xref="HGNC:HGNC:2048"
                     /db_xref="MIM:615798"
                     /translation="MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQ
                     VVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGA
                     KCTTCVEEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKREL
                     GASLYLGWAASGLLLLGGGLLCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKN
                     YV"
     regulatory      1343..1348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN6"
                     /note="hexamer: AATAAA"
     polyA_site      1366
                     /gene="CLDN6"
                     /note="major polyA site"
ORIGIN      
        1 actcggccta ggaatttccc ttatctcctt cgcagtgcag ctccttcaac ctcgccatgg
       61 cctctgccgg aatgcagatc ctgggagtcg tcctgacact gctgggctgg gtgaatggcc
      121 tggtctcctg tgccctgccc atgtggaagg tgaccgcttt catcggcaac agcatcgtgg
      181 tggcccaggt ggtgtgggag ggcctgtgga tgtcctgcgt ggtgcagagc accggccaga
      241 tgcagtgcaa ggtgtacgac tcactgctgg cgctgccaca ggacctgcag gctgcacgtg
      301 ccctctgtgt catcgccctc cttgtggccc tgttcggctt gctggtctac cttgctgggg
      361 ccaagtgtac cacctgtgtg gaggagaagg attccaaggc ccgcctggtg ctcacctctg
      421 ggattgtctt tgtcatctca ggggtcctga cgctaatccc cgtgtgctgg acggcgcatg
      481 ccatcatccg ggacttctat aaccccctgg tggctgaggc ccaaaagcgg gagctggggg
      541 cctccctcta cttgggctgg gcggcctcag gccttttgtt gctgggtggg gggttgctgt
      601 gctgcacttg cccctcgggg gggtcccagg gccccagcca ttacatggcc cgctactcaa
      661 catctgcccc tgccatctct cgggggccct ctgagtaccc taccaagaat tacgtctgac
      721 gtggagggga atgggggctc cgctggcgct agagccatcc agaagtggca gtgcccaaca
      781 gctttgggat gggttcgtac cttttgtttc tgcctcctgc tatttttctt ttgactgagg
      841 atatttaaaa ttcatttgaa aactgagcca aggtgttgac tcagactctc acttaggctc
      901 tgctgtttct cacccttgga tgatggagcc aaagagggga tgctttgaga ttctggatct
      961 tgacatgccc atcttagaag ccagtcaagc tatggaacta atgcggaggc tgcttgctgt
     1021 gctggctttg caacaagaca gactgtcccc aagagttcct gctgctgctg ggggctgggc
     1081 ttccctagat gtcactggac agctgccccc catcctactc aggtctctgg agctcctctc
     1141 ttcacccctg gaaaaacaaa tgatctgtta acaaaggact gcccacctcc ggaacttctg
     1201 acctctgttt cctccgtcct gataagacgt ccacccccca gggccaggtc ccagctatgt
     1261 agacccccgc ccccacctcc aacactgcac ccttctgccc tgcccccctc gtctcacccc
     1321 ctttacactc acatttttat caaataaagc atgttttgtt agtgca
//
