LOCUS       NM_001305               1695 bp    mRNA    linear   PRI 30-APR-2025
DEFINITION  Homo sapiens claudin 4 (CLDN4), mRNA.
ACCESSION   NM_001305
VERSION     NM_001305.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1695)
  AUTHORS   Elsayed,A.M., Mahmoud,E.I., Salem,M.M. and Khairy,R.A.
  TITLE     Immunohistochemical Expression of Claudin-1 and Claudin-4 in
            Urothelial Carcinoma of the Urinary Bladder
  JOURNAL   Asian Pac J Cancer Prev 25 (2), 637-646 (2024)
   PUBMED   38415551
  REMARK    GeneRIF: Immunohistochemical Expression of Claudin-1 and Claudin-4
            in Urothelial Carcinoma of the Urinary Bladder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1695)
  AUTHORS   Hu,P., Lei,L., Wang,Y., Tian,X., Wei,X., Jiang,N. and Liu,L.
  TITLE     CLDN4 as a Novel Diagnostic and Prognostic Biomarker and Its
            Association with Immune Infiltrates in Ovarian Cancer
  JOURNAL   Mediators Inflamm 2023, 1075265 (2023)
   PUBMED   37057131
  REMARK    GeneRIF: CLDN4 as a Novel Diagnostic and Prognostic Biomarker and
            Its Association with Immune Infiltrates in Ovarian Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1695)
  AUTHORS   Yang,C.L., Yang,M., Wang,Y.F., Song,C.C., DU,G.H. and Tang,G.Y.
  TITLE     [Effects of Fusobacterium nucleus derived outer membrane vesicles
            on claudin-4 expression in oral epithelial cells]
  JOURNAL   Shanghai Kou Qiang Yi Xue 32 (2), 126-131 (2023)
   PUBMED   37153991
  REMARK    GeneRIF: [Effects of Fusobacterium nucleus derived outer membrane
            vesicles on claudin-4 expression in oral epithelial cells].
REFERENCE   4  (bases 1 to 1695)
  AUTHORS   Kabra,H., Mohanty,N.R., Tripathy,S., Mohanty,M., Senapati,U. and
            Rath,J.
  TITLE     Expression of Claudin-4 and D2-40 and their significance in
            prostatic adenocarcinoma
  JOURNAL   J Cancer Res Ther 19 (Suppl 2), S800-S806 (2023)
   PUBMED   38384059
  REMARK    GeneRIF: Expression of Claudin-4 and D2-40 and their significance
            in prostatic adenocarcinoma.
REFERENCE   5  (bases 1 to 1695)
  AUTHORS   Mangla,G., Bakshi,P., Agarwal,P. and Verma,K.
  TITLE     Diagnostic Utility of Claudin4 and Comparison with BerEp4 as a
            Marker for Metastatic Adenocarcinoma in Serous Effusions
  JOURNAL   Acta Cytol 67 (5), 564-572 (2023)
   PUBMED   37331346
  REMARK    GeneRIF: Diagnostic Utility of Claudin4 and Comparison with BerEp4
            as a Marker for Metastatic Adenocarcinoma in Serous Effusions.
REFERENCE   6  (bases 1 to 1695)
  AUTHORS   Itoh,M., Furuse,M., Morita,K., Kubota,K., Saitou,M. and Tsukita,S.
  TITLE     Direct binding of three tight junction-associated MAGUKs, ZO-1,
            ZO-2, and ZO-3, with the COOH termini of claudins
  JOURNAL   J Cell Biol 147 (6), 1351-1363 (1999)
   PUBMED   10601346
REFERENCE   7  (bases 1 to 1695)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
REFERENCE   8  (bases 1 to 1695)
  AUTHORS   Paperna,T., Peoples,R., Wang,Y.K., Kaplan,P. and Francke,U.
  TITLE     Genes for the CPE receptor (CPETR1) and the human homolog of RVP1
            (CPETR2) are localized within the Williams-Beuren syndrome deletion
  JOURNAL   Genomics 54 (3), 453-459 (1998)
   PUBMED   9878248
REFERENCE   9  (bases 1 to 1695)
  AUTHORS   Katahira,J., Sugiyama,H., Inoue,N., Horiguchi,Y., Matsuda,M. and
            Sugimoto,N.
  TITLE     Clostridium perfringens enterotoxin utilizes two structurally
            related membrane proteins as functional receptors in vivo
  JOURNAL   J Biol Chem 272 (42), 26652-26658 (1997)
   PUBMED   9334247
REFERENCE   10 (bases 1 to 1695)
  AUTHORS   Katahira,J., Inoue,N., Horiguchi,Y., Matsuda,M. and Sugimoto,N.
  TITLE     Molecular cloning and functional characterization of the receptor
            for Clostridium perfringens enterotoxin
  JOURNAL   J Cell Biol 136 (6), 1239-1247 (1997)
   PUBMED   9087440
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093168.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 15, 2020 this sequence version replaced NM_001305.4.
            
            Summary: The protein encoded by this intronless gene belongs to the
            claudin family. Claudins are integral membrane proteins that are
            components of the epithelial cell tight junctions, which regulate
            movement of solutes and ions through the paracellular space. This
            protein is a high-affinity receptor for Clostridium perfringens
            enterotoxin (CPE) and may play a role in internal organ development
            and function during pre- and postnatal life. This gene is deleted
            in Williams-Beuren syndrome, a neurodevelopmental disorder
            affecting multiple systems. [provided by RefSeq, Sep 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK026651.1, BC000671.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340958.4/ ENSP00000342445.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1695              AC093168.3         66053-67747
FEATURES             Location/Qualifiers
     source          1..1695
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..1695
                     /gene="CLDN4"
                     /gene_synonym="CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8"
                     /note="claudin 4"
                     /db_xref="GeneID:1364"
                     /db_xref="HGNC:HGNC:2046"
                     /db_xref="MIM:602909"
     exon            1..1695
                     /gene="CLDN4"
                     /gene_synonym="CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..836
                     /gene="CLDN4"
                     /gene_synonym="CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8"
                     /note="Clostridium perfringens enterotoxin receptor 1;
                     Williams-Beuren syndrome chromosomal region 8 protein;
                     CPE-receptor"
                     /codon_start=1
                     /product="claudin-4"
                     /protein_id="NP_001296.1"
                     /db_xref="CCDS:CCDS5560.1"
                     /db_xref="GeneID:1364"
                     /db_xref="HGNC:HGNC:2046"
                     /db_xref="MIM:602909"
                     /translation="MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQ
                     TIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGG
                     KCTNCLEDESAKAKTMIVAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREM
                     GASLYVGWAASGLLLLGGGLLCCNCPPRTDKPYSAKYSAARSAAASNYV"
     regulatory      1667..1672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN4"
                     /gene_synonym="CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8"
                     /note="hexamer: AATAAA"
     polyA_site      1695
                     /gene="CLDN4"
                     /gene_synonym="CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8"
                     /note="major polyA site"
ORIGIN      
        1 agagtgccct ggcagctgtc ggctggaagg aactggtctg ctcacacttg ctggcttgcg
       61 catcaggact ggctttatct cctgactcac ggtgcaaagg tgcactctgc gaacgttaag
      121 tccgtcccca gcgcttggaa tcctacggcc cccacagccg gatcccctca gccttccagg
      181 tcctcaactc ccgtggacgc tgaacaatgg cctccatggg gctacaggta atgggcatcg
      241 cgctggccgt cctgggctgg ctggccgtca tgctgtgctg cgcgctgccc atgtggcgcg
      301 tgacggcctt catcggcagc aacattgtca cctcgcagac catctgggag ggcctatgga
      361 tgaactgcgt ggtgcagagc accggccaga tgcagtgcaa ggtgtacgac tcgctgctgg
      421 cactgccgca ggacctgcag gcggcccgcg ccctcgtcat catcagcatc atcgtggctg
      481 ctctgggcgt gctgctgtcc gtggtggggg gcaagtgtac caactgcctg gaggatgaaa
      541 gcgccaaggc caagaccatg atcgtggcgg gcgtggtgtt cctgttggcc ggccttatgg
      601 tgatagtgcc ggtgtcctgg acggcccaca acatcatcca agacttctac aatccgctgg
      661 tggcctccgg gcagaagcgg gagatgggtg cctcgctcta cgtcggctgg gccgcctccg
      721 gcctgctgct ccttggcggg gggctgcttt gctgcaactg tccaccccgc acagacaagc
      781 cttactccgc caagtattct gctgcccgct ctgctgctgc cagcaactac gtgtaaggtg
      841 ccacggctcc actctgttcc tctctgcttt gttcttccct ggactgagct cagcgcaggc
      901 tgtgacccca ggagggccct gccacgggcc actggctgct ggggactggg gactgggcag
      961 agactgagcc aggcaggaag gcagcagcct tcagcctctc tggcccactc ggacaacttc
     1021 ccaaggccgc ctcctgctag caagaacaga gtccaccctc ctctggatat tggggaggga
     1081 cggaagtgac agggtgtggt ggtggagtgg ggagctggct tctgctggcc aggatagctt
     1141 aaccctgact ttgggatctg cctgcatcgg cgttggccac tgtccccatt tacattttcc
     1201 ccactctgtc tgcctgcatc tcctctgttc cgggtaggcc ttgatatcac ctctgggact
     1261 gtgccttgct caccgaaacc cgcgcccagg agtatggctg aggccttgcc cacccacctg
     1321 cctgggaagt gcagagtgga tggacgggtt tagaggggag gggcgaaggt gctgtaaaca
     1381 ggtttgggca gtggtggggg agggggccag agaggcggct caggttgccc agctctgtgg
     1441 cctcaggact ctctgcctca cccgcttcag cccagggccc ctggagactg atcccctctg
     1501 agtcctctgc cccttccaag gacactaatg agcctgggag ggtggcaggg aggaggggac
     1561 agcttcaccc ttggaagtcc tggggttttt cctcttcctt ctttgtggtt tctgttttgt
     1621 aatttaagaa gagctattca tcactgtaat tattattatt ttctacaata aatgggacct
     1681 gtgcacagga ggaaa
//
