LOCUS       NM_001306               1274 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens claudin 3 (CLDN3), mRNA.
ACCESSION   NM_001306
VERSION     NM_001306.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1274)
  AUTHORS   Ahmad,R., Kumar,B., Thapa,I., Talmon,G.A., Salomon,J.,
            Ramer-Tait,A.E., Bastola,D.K., Dhawan,P. and Singh,A.B.
  TITLE     Loss of claudin-3 expression increases colitis risk by promoting
            Gut Dysbiosis
  JOURNAL   Gut Microbes 15 (2), 2282789 (2023)
   PUBMED   38010872
  REMARK    GeneRIF: Loss of claudin-3 expression increases colitis risk by
            promoting Gut Dysbiosis.
REFERENCE   2  (bases 1 to 1274)
  AUTHORS   Sun,Z., Yan,T., Jiang,H., Cai,J., Zhu,X. and Chen,Q.
  TITLE     Claudin-3 facilitates the progression and mediates the tumorigenic
            effects of TGF-beta in glioblastoma multiforme
  JOURNAL   Med Oncol 40 (9), 268 (2023)
   PUBMED   37578554
  REMARK    GeneRIF: Claudin-3 facilitates the progression and mediates the
            tumorigenic effects of TGF-beta in glioblastoma multiforme.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1274)
  AUTHORS   Rafik,D., Younis,I., Atef,R. and Eid,H.
  TITLE     Claudin-3 is a novel intestinal integrity marker in patients with
            alopecia areata: Correlation with the disease severity
  JOURNAL   J Cosmet Dermatol 22 (4), 1377-1381 (2023)
   PUBMED   36606388
  REMARK    GeneRIF: Claudin-3 is a novel intestinal integrity marker in
            patients with alopecia areata: Correlation with the disease
            severity.
REFERENCE   4  (bases 1 to 1274)
  AUTHORS   Fujiwara,S., Nguyen,T.P., Furuse,K., Fukazawa,Y., Otani,T. and
            Furuse,M.
  TITLE     Tight junction formation by a claudin mutant lacking the
            COOH-terminal PDZ domain-binding motif
  JOURNAL   Ann N Y Acad Sci 1516 (1), 85-94 (2022)
   PUBMED   35945631
  REMARK    GeneRIF: Tight junction formation by a claudin mutant lacking the
            COOH-terminal PDZ domain-binding motif.
REFERENCE   5  (bases 1 to 1274)
  AUTHORS   Gonschior,H., Schmied,C., Van der Veen,R.E., Eichhorst,J.,
            Himmerkus,N., Piontek,J., Gunzel,D., Bleich,M., Furuse,M.,
            Haucke,V. and Lehmann,M.
  TITLE     Nanoscale segregation of channel and barrier claudins enables
            paracellular ion flux
  JOURNAL   Nat Commun 13 (1), 4985 (2022)
   PUBMED   36008380
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1274)
  AUTHORS   Itoh,M., Furuse,M., Morita,K., Kubota,K., Saitou,M. and Tsukita,S.
  TITLE     Direct binding of three tight junction-associated MAGUKs, ZO-1,
            ZO-2, and ZO-3, with the COOH termini of claudins
  JOURNAL   J Cell Biol 147 (6), 1351-1363 (1999)
   PUBMED   10601346
REFERENCE   7  (bases 1 to 1274)
  AUTHORS   Furuse,M., Sasaki,H. and Tsukita,S.
  TITLE     Manner of interaction of heterogeneous claudin species within and
            between tight junction strands
  JOURNAL   J Cell Biol 147 (4), 891-903 (1999)
   PUBMED   10562289
REFERENCE   8  (bases 1 to 1274)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
REFERENCE   9  (bases 1 to 1274)
  AUTHORS   Peacock,R.E., Keen,T.J. and Inglehearn,C.F.
  TITLE     Analysis of a human gene homologous to rat ventral prostate.1
            protein
  JOURNAL   Genomics 46 (3), 443-449 (1997)
   PUBMED   9441748
REFERENCE   10 (bases 1 to 1274)
  AUTHORS   Katahira,J., Sugiyama,H., Inoue,N., Horiguchi,Y., Matsuda,M. and
            Sugimoto,N.
  TITLE     Clostridium perfringens enterotoxin utilizes two structurally
            related membrane proteins as functional receptors in vivo
  JOURNAL   J Biol Chem 272 (42), 26652-26658 (1997)
   PUBMED   9334247
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM764277.1 and BC016056.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001306.3.
            
            Summary: Tight junctions represent one mode of cell-to-cell
            adhesion in epithelial or endothelial cell sheets, forming
            continuous seals around cells and serving as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space. These junctions are comprised of sets of
            continuous networking strands in the outwardly facing cytoplasmic
            leaflet, with complementary grooves in the inwardly facing
            extracytoplasmic leaflet. The protein encoded by this intronless
            gene, a member of the claudin family, is an integral membrane
            protein and a component of tight junction strands. It is also a
            low-affinity receptor for Clostridium perfringens enterotoxin, and
            shares aa sequence similarity with a putative apoptosis-related
            protein found in rat. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC016056.1, SRR3476690.663362.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395145.3/ ENSP00000378577.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BM764277.1         1-24
            25-1274             BC016056.1         1-1250
FEATURES             Location/Qualifiers
     source          1..1274
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..1274
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /note="claudin 3"
                     /db_xref="GeneID:1365"
                     /db_xref="HGNC:HGNC:2045"
                     /db_xref="MIM:602910"
     exon            1..1274
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..884
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /note="Clostridium perfringens enterotoxin receptor 2;
                     CPE-receptor 2; ventral prostate.1-like protein; CPE-R 2;
                     ventral prostate.1 protein homolog"
                     /codon_start=1
                     /product="claudin-3"
                     /protein_id="NP_001297.1"
                     /db_xref="CCDS:CCDS5559.1"
                     /db_xref="GeneID:1365"
                     /db_xref="HGNC:HGNC:2045"
                     /db_xref="MIM:602910"
                     /translation="MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQN
                     IWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQ
                     CTNCVQDDTAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMG
                     AGLYVGWAAAALQLLGGALLCCSCPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKD
                     YV"
     regulatory      1253..1258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /note="hexamer: AATAAA"
     polyA_site      1274
                     /gene="CLDN3"
                     /gene_synonym="C7orf1; CPE-R2; CPETR2; HRVP1; RVP1"
                     /note="major polyA site"
ORIGIN      
        1 agcccagtcg ccgccgcccg cccacaaagc cacaggcagg tgcaggcgca gccgcggcga
       61 gagcgtatgg agccgagccg ttagcgcgcg ccgtcggtga gtcagtccgt ccgtccgtcc
      121 gtccgtcggg gcgccgcagc tcccgccagg cccagcggcc ccggcccctc gtctccccgc
      181 acccggagcc acccggtgga gcgggccttg ccgcggcagc catgtccatg ggcctggaga
      241 tcacgggcac cgcgctggcc gtgctgggct ggctgggcac catcgtgtgc tgcgcgttgc
      301 ccatgtggcg cgtgtcggcc ttcatcggca gcaacatcat cacgtcgcag aacatctggg
      361 agggcctgtg gatgaactgc gtggtgcaga gcaccggcca gatgcagtgc aaggtgtacg
      421 actcgctgct ggcactgcca caggaccttc aggcggcccg cgccctcatc gtggtggcca
      481 tcctgctggc cgccttcggg ctgctagtgg cgctggtggg cgcccagtgc accaactgcg
      541 tgcaggacga cacggccaag gccaagatca ccatcgtggc aggcgtgctg ttccttctcg
      601 ccgccctgct caccctcgtg ccggtgtcct ggtcggccaa caccattatc cgggacttct
      661 acaaccccgt ggtgcccgag gcgcagaagc gcgagatggg cgcgggcctg tacgtgggct
      721 gggcggccgc ggcgctgcag ctgctggggg gcgcgctgct ctgctgctcg tgtcccccac
      781 gcgagaagaa gtacacggcc accaaggtcg tctactccgc gccgcgctcc accggcccgg
      841 gagccagcct gggcacaggc tacgaccgca aggactacgt ctaagggaca gacgcaggga
      901 gaccccacca ccaccaccac caccaacacc accaccacca ccgcgagctg gagcgcgcac
      961 caggccatcc agcgtgcagc cttgcctcgg aggccagccc acccccagaa gccaggaagc
     1021 ccccgcgctg gactggggca gcttccccag cagccacggc tttgcgggcc gggcagtcga
     1081 cttcggggcc cagggaccaa cctgcatgga ctgtgaaacc tcacccttct ggagcacggg
     1141 gcctgggtga ccgccaatac ttgaccaccc cgtcgagccc catcgggccg ctgcccccat
     1201 gctcgcgctg ggcagggacc ggcagccctg gaaggggcac ttgatatttt tcaataaaag
     1261 cctttcgttt tgca
//
