LOCUS       NM_001101389             690 bp    mRNA    linear   PRI 04-JUN-2024
DEFINITION  Homo sapiens claudin 25 (CLDN25), mRNA.
ACCESSION   NM_001101389 XM_927777 XM_938396
VERSION     NM_001101389.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 690)
  AUTHORS   Berndt,P., Winkler,L., Cording,J., Breitkreuz-Korff,O., Rex,A.,
            Dithmer,S., Rausch,V., Blasig,R., Richter,M., Sporbert,A.,
            Wolburg,H., Blasig,I.E. and Haseloff,R.F.
  TITLE     Tight junction proteins at the blood-brain barrier: far more than
            claudin-5
  JOURNAL   Cell Mol Life Sci 76 (10), 1987-2002 (2019)
   PUBMED   30734065
REFERENCE   2  (bases 1 to 690)
  AUTHORS   Lal-Nag,M. and Morin,P.J.
  TITLE     The claudins
  JOURNAL   Genome Biol 10 (8), 235 (2009)
   PUBMED   19706201
  REMARK    Review article
REFERENCE   3  (bases 1 to 690)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   4  (bases 1 to 690)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     CLDN23 gene, frequently down-regulated in intestinal-type gastric
            cancer, is a novel member of CLAUDIN gene family
  JOURNAL   Int J Mol Med 11 (6), 683-689 (2003)
   PUBMED   12736707
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from CH471065.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_927777.1, XM_938396.1.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. [provided by RefSeq, Jun 2010].
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no transcript was available for the gene. The extent
            of this transcript is supported by orthologous data.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000453129.3/ ENSP00000396304.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.2"
     gene            1..690
                     /gene="CLDN25"
                     /note="claudin 25"
                     /db_xref="GeneID:644672"
                     /db_xref="HGNC:HGNC:37218"
                     /db_xref="MIM:620812"
     CDS             1..690
                     /gene="CLDN25"
                     /codon_start=1
                     /product="putative claudin-25"
                     /protein_id="NP_001094859.1"
                     /db_xref="CCDS:CCDS44736.1"
                     /db_xref="GeneID:644672"
                     /db_xref="HGNC:HGNC:37218"
                     /db_xref="MIM:620812"
                     /translation="MAWSFRAKVQLGGLLLSLLGWVCSCVTTILPQWKTLNLELNEME
                     TWIMGIWEVCVDREEVATVCKAFESFLSLPQELQVARILMVASHGLGLLGLLLCSFGS
                     ECFQFHRIRWVFKRRLGLLGRTLEASASATTLLPVSWVAHATIQDFWDDSIPDIIPRW
                     EFGGALYLGWAAGIFLALGGLLLIFSACLGKEDVPFPLMAGPTVPLSCAPVEESDGSF
                     HLMLRPRNLVI"
     exon            1..690
                     /gene="CLDN25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcctgga gtttccgtgc aaaagtccag ctcggggggc tacttctctc cctccttggc
       61 tgggtctgct cctgtgttac caccatcctg ccccagtgga agactcttaa tctggaactg
      121 aacgagatgg agacctggat catggggatt tgggaggtct gcgtggatcg agaggaagtc
      181 gccactgtgt gcaaggcctt tgaatccttc ttgtctctgc cccaggagct ccaggtagcc
      241 cgcatcctca tggtagcctc ccatgggctg ggcctattgg ggcttttgct ctgcagcttt
      301 gggtctgaat gcttccagtt tcacaggatc agatgggtat tcaagaggcg gcttggtctc
      361 ctgggaagga ctttggaggc atccgcttca gccactaccc tccttccagt ctcctgggtg
      421 gcccatgcca caatccaaga cttctgggat gacagcatcc ctgacatcat acctcggtgg
      481 gagtttggag gtgccctcta cttgggctgg gctgctggta ttttcctggc tcttggtggg
      541 ctactcctca tcttctcggc ctgcctggga aaagaagatg tgccttttcc tttgatggct
      601 ggtcccacag tccccctatc ctgtgctcca gtggaggagt cagatggctc cttccacctc
      661 atgctaagac ctaggaacct ggtcatctag
//
