LOCUS       NM_194284               2160 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens claudin 23 (CLDN23), mRNA.
ACCESSION   NM_194284 XM_059895
VERSION     NM_194284.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2160)
  AUTHORS   Raya-Sandino,A., Lozada-Soto,K.M., Rajagopal,N.,
            Garcia-Hernandez,V., Luissint,A.C., Brazil,J.C., Cui,G., Koval,M.,
            Parkos,C.A., Nangia,S. and Nusrat,A.
  TITLE     Claudin-23 reshapes epithelial tight junction architecture to
            regulate barrier function
  JOURNAL   Nat Commun 14 (1), 6214 (2023)
   PUBMED   37798277
  REMARK    GeneRIF: Claudin-23 reshapes epithelial tight junction architecture
            to regulate barrier function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2160)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2160)
  AUTHORS   Chen,W., Zhu,X.N., Wang,J., Wang,Y.P. and Yang,J.L.
  TITLE     [The Expression and Biological Function of claudin-23 in Colorectal
            Cancer]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 49 (3), 331-336 (2018)
   PUBMED   30014629
  REMARK    GeneRIF: claudin-23 facilitates the migration ability of colorectal
            cancer cells and may participate in the metastasis of colorectal
            cancer
REFERENCE   4  (bases 1 to 2160)
  AUTHORS   Lu,Y., Jing,J., Sun,L., Gong,Y., Chen,M., Wang,Z., Sun,M. and
            Yuan,Y.
  TITLE     Expression of claudin-11, -23 in different gastric tissues and its
            relationship with the risk and prognosis of gastric cancer
  JOURNAL   PLoS One 12 (3), e0174476 (2017)
   PUBMED   28350854
  REMARK    GeneRIF: The expression of claudin-11, -23 was remarkably
            downregulated in gastric cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2160)
  AUTHORS   Maryan,N., Statkiewicz,M., Mikula,M., Goryca,K., Paziewska,A.,
            Strzalkowska,A., Dabrowska,M., Bujko,M. and Ostrowski,J.
  TITLE     Regulation of the expression of claudin 23 by the enhancer of zeste
            2 polycomb group protein in colorectal cancer
  JOURNAL   Mol Med Rep 12 (1), 728-736 (2015)
   PUBMED   25695204
  REMARK    GeneRIF: The present study demonstrated an epigenetic link between
            the activity of the EZH2 methyltransferase at the CLDN23 locus and
            the expression of CLDN23 in CRC tissue.
REFERENCE   6  (bases 1 to 2160)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   7  (bases 1 to 2160)
  AUTHORS   Ballana,E., Mercader,J.M., Fischel-Ghodsian,N. and Estivill,X.
  TITLE     MRPS18CP2 alleles and DEFA3 absence as putative chromosome 8p23.1
            modifiers of hearing loss due to mtDNA mutation A1555G in the 12S
            rRNA gene
  JOURNAL   BMC Med Genet 8, 81 (2007)
   PUBMED   18154640
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2160)
  AUTHORS   Katoh,M.
  TITLE     Epithelial-mesenchymal transition in gastric cancer (Review)
  JOURNAL   Int J Oncol 27 (6), 1677-1683 (2005)
   PUBMED   16273224
  REMARK    Review article
REFERENCE   9  (bases 1 to 2160)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     CLDN23 gene, frequently down-regulated in intestinal-type gastric
            cancer, is a novel member of CLAUDIN gene family
  JOURNAL   Int J Mol Med 11 (6), 683-689 (2003)
   PUBMED   12736707
  REMARK    GeneRIF: characterization of CLDN23 gene, a candidate tumor
            suppressor gene implicated in intestinal-type gastric cancer
            GeneRIF: Human CLDN23, showing 79.5% total-amino-acid identity with
            mouse Cldn23, is a four-transmembrane protein with WWCC motif,
            defined by W-X(17-22)-W-X(2)-C-X(8-10)-C.
REFERENCE   10 (bases 1 to 2160)
  AUTHORS   Gress,T.M., Muller-Pillasch,F., Geng,M., Zimmerhackl,F.,
            Zehetner,G., Friess,H., Buchler,M., Adler,G. and Lehrach,H.
  TITLE     A pancreatic cancer-specific expression profile
  JOURNAL   Oncogene 13 (8), 1819-1830 (1996)
   PUBMED   8895530
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087269.5, BC125149.1 and
            BC016047.1.
            
            On May 17, 2019 this sequence version replaced NM_194284.2.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. This gene is expressed in germinal center
            B-cells, placenta and stomach as well as in colon tumor. This gene
            is down-regulated in intestinal type gastric cancer. [provided by
            RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR6380200.29125.21,
                                        SRR7346977.1094289.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000519106.2/ ENSP00000428780.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AC087269.5         80646-80864         c
            220-239             AC087269.5         80626-80645         c
            240-1372            BC125149.1         1-1133
            1373-2160           BC016047.1         841-1628
FEATURES             Location/Qualifiers
     source          1..2160
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..2160
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /note="claudin 23"
                     /db_xref="GeneID:137075"
                     /db_xref="HGNC:HGNC:17591"
                     /db_xref="MIM:609203"
     exon            1..2160
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /inference="alignment:Splign:2.1.0"
     CDS             463..1341
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /note="2310014B08Rik"
                     /codon_start=1
                     /product="claudin-23"
                     /protein_id="NP_919260.2"
                     /db_xref="CCDS:CCDS55195.1"
                     /db_xref="GeneID:137075"
                     /db_xref="HGNC:HGNC:17591"
                     /db_xref="MIM:609203"
                     /translation="MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVE
                     LYQGLWDMCREQSSRERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGV
                     RCWQDEPNFVLAGLSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSL
                     VLGYLGSCLLLLGGFSLALSFAPWCDERCRRRRKGPSAGPRRSSVSTIQVEWPEPDLA
                     PAIKYYSDGQHRPPPAQHRKPKPKPKVGFPMPRPRPKAYTNSVDVLDGEGWESQDAPS
                     CSTHPCDSSLPCDSDL"
     regulatory      2141..2146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /note="hexamer: AATAAA"
     polyA_site      2160
                     /gene="CLDN23"
                     /gene_synonym="CLDNL; hCG1646163"
                     /note="major polyA site"
ORIGIN      
        1 aggcgtggcc cagccgcccg gctgcaaggt ggggtgtccc cgccgctcgg atccccatct
       61 cacctgccgc gggcgaggtg gccccgccgc ttcctgcgct cacctcgggt ccctccctcc
      121 cgggccaggt ttggccgcgg cagccgcccc tgggcgcccg cgcccggacc cgcggtttcg
      181 gtcagacccg cccgcgggct ggtttcgatt agggccagta ggagggcgga gcggccggga
      241 cgccaggagg gaactagcct aagtggggac ggtccccgtg caggagacaa agagcgtccc
      301 tggagcgatc agggctcagg agcccgaccc ggagcccggg gcgtccgcgc tgacttcggg
      361 tccccggagc ctggggcacg gcagggagaa gacgacggcg gagaaggcga cagcggagaa
      421 ggaaggcagg ctgcaggggc gccgtcggcg cggcgggccg ggatgcggac gccggtggtg
      481 atgacgctgg gcatggtgtt ggcgccctgc gggctcctgc tcaacctgac cggcaccctg
      541 gcgcccggct ggcggctggt gaagggcttc ctgaaccagc cagtggacgt ggagttgtac
      601 cagggcctgt gggacatgtg tcgcgagcag agcagccgcg agcgcgagtg cggccagacg
      661 gaccagtggg gctacttcga ggcccagccc gtgctggtgg cgcgggcact catggtcacc
      721 tcgctggccg ccacggtcct ggggcttctg ctggcgtcgc tgggcgtgcg ctgctggcag
      781 gacgagccca acttcgtgct ggcagggctc tcgggcgtcg tgctcttcgt cgctggcctc
      841 ctcggcctca tcccggtgtc ctggtacaac cacttcttgg gggaccgcga cgtgctgccc
      901 gccccggcca gcccggtcac ggtgcaggtc agctacagcc tggtcctggg ctacctgggc
      961 agctgcctcc tgctgctggg cggcttctcg ctggcgctca gcttcgcgcc ctggtgcgac
     1021 gagcgttgtc gccgccgccg caagggaccc tccgccgggc ctcgccgcag cagcgtcagc
     1081 accatccaag tggagtggcc cgagcccgac ctggcgcccg ccatcaagta ctacagcgac
     1141 ggccagcacc gaccgccgcc tgcccagcac cgcaagccca agcccaagcc caaggtcggc
     1201 ttccccatgc cgcggccgcg gcccaaggcc tacaccaact cggtggacgt cctcgacggg
     1261 gaggggtggg agtcccagga cgctccctcg tgcagcaccc acccctgcga cagctcgctg
     1321 ccctgcgact ccgacctcta gacgcttgta gagcctgggg ggcgccgggt ggcaaaggac
     1381 tcacccccgc acaggcccgc ctggcttcga gttggaaccc ggacacttgc ccctcactgg
     1441 tgtggatgga aatctgcctt tcgtgggacc aaacaggact ccttggacga ttagttcagg
     1501 ttgggtttgg ttttcttctt aaagagttta gttttcctct ccagagggat cagggtcctc
     1561 ttagggagtg acgggctttt catatatttt tgctgaagaa tatatggaaa gggtggcatt
     1621 tgcgtcacgt ggaccaggga cagtgctgaa atcagcagtg ctcagaaaca atttaacatg
     1681 ttgaaacgac aatattctaa aatactgatg aatcttgcat caatataatt attgggtttt
     1741 ttttcttttt cctgctgtat aactccttgc catgcaaact ctcaagaggc caatatattc
     1801 ctggccatgt ttgaatgagc ctcttaaaat aaacttagag ccatgcaaat gccagcagct
     1861 taatggattt catggaatga aataccgtga ttaactcata gctacatatc attgcataaa
     1921 tgggatttat cttttttctc acttattttt gcggtgaaag tcgagggcat gcaagagttt
     1981 ctcttccaga agccaagagg agaacaaagg tcctaatgct gtactattcc accctttgga
     2041 cgcctcatcc aggacgcaga ggactctagg tttaacattt tgtacaaaat ggaacctgtt
     2101 aatcatatta aagcacatat gtatatatct tttatttata aataaaattt taaaacaata
//
