LOCUS       NM_001111319            2177 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens claudin 22 (CLDN22), mRNA.
ACCESSION   NM_001111319 XM_001723535 XM_926796 XM_940253
VERSION     NM_001111319.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2177)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2177)
  AUTHORS   Lal-Nag,M. and Morin,P.J.
  TITLE     The claudins
  JOURNAL   Genome Biol 10 (8), 235 (2009)
   PUBMED   19706201
  REMARK    Review article
REFERENCE   3  (bases 1 to 2177)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   4  (bases 1 to 2177)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     CLDN23 gene, frequently down-regulated in intestinal-type gastric
            cancer, is a novel member of CLAUDIN gene family
  JOURNAL   Int J Mol Med 11 (6), 683-689 (2003)
   PUBMED   12736707
  REMARK    GeneRIF: CLDN21, clustered with CLDN22 at human chromosome 4q35.1,
            is a four-transmembrane protein with WWCC motif, defined by
            W-X(17-22)-W-X(2)-C-X(8-10)-C.
REFERENCE   5  (bases 1 to 2177)
  AUTHORS   Gonzalez-Mariscal,L., Betanzos,A., Nava,P. and Jaramillo,B.E.
  TITLE     Tight junction proteins
  JOURNAL   Prog Biophys Mol Biol 81 (1), 1-44 (2003)
   PUBMED   12475568
  REMARK    Review article
REFERENCE   6  (bases 1 to 2177)
  AUTHORS   Tsukita,S. and Furuse,M.
  TITLE     Claudin-based barrier in simple and stratified cellular sheets
  JOURNAL   Curr Opin Cell Biol 14 (5), 531-536 (2002)
   PUBMED   12231346
  REMARK    Review article
REFERENCE   7  (bases 1 to 2177)
  AUTHORS   Tsukita,S., Furuse,M. and Itoh,M.
  TITLE     Multifunctional strands in tight junctions
  JOURNAL   Nat Rev Mol Cell Biol 2 (4), 285-293 (2001)
   PUBMED   11283726
  REMARK    Review article
REFERENCE   8  (bases 1 to 2177)
  AUTHORS   Heiskala,M., Peterson,P.A. and Yang,Y.
  TITLE     The roles of claudin superfamily proteins in paracellular transport
  JOURNAL   Traffic 2 (2), 93-98 (2001)
   PUBMED   11247307
  REMARK    Review article
REFERENCE   9  (bases 1 to 2177)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell Mol Neurobiol 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093844.3.
            
            On Jan 10, 2020 this sequence version replaced NM_001111319.2.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. This gene is intronless and overlaps the 3'
            UTR of the WWC2 gene (GeneID: 80014) on the opposite strand.
            [provided by RefSeq, Aug 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK098064.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323319.7/ ENSP00000318113.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2177              AC093844.3         110408-112584       c
FEATURES             Location/Qualifiers
     source          1..2177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..2177
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="claudin 22"
                     /db_xref="GeneID:53842"
                     /db_xref="HGNC:HGNC:2044"
                     /db_xref="MIM:620566"
     exon            1..2177
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..721
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /codon_start=1
                     /product="claudin-22"
                     /protein_id="NP_001104789.1"
                     /db_xref="CCDS:CCDS43286.1"
                     /db_xref="GeneID:53842"
                     /db_xref="HGNC:HGNC:2044"
                     /db_xref="MIM:620566"
                     /translation="MALVFRTVAQLAGVSLSLLGWVLSCLTNYLPHWKNLNLDLNEME
                     NWTMGLWQTCVIQEEVGMQCKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGL
                     DCLRIGESQRDLKRRLLILGGILSWASGVTALVPVSWVAHKTVQEFWDENVPDFVPRW
                     EFGEALFLGWFAGLSLLLGGCLLHCAACSSHAPLASGHYAVAQTQDHHQELETRNTNL
                     KH"
     regulatory      845..850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="hexamer: ATTAAA"
     polyA_site      867
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
     regulatory      1872..1877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="hexamer: AACAAG"
     polyA_site      1890
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="major polyA site"
     regulatory      2154..2159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="hexamer: AATAAA"
     polyA_site      2177
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
ORIGIN      
        1 cttttcacag caaccgaagg gcaggagtta gtttggctaa agctctcagg acattataat
       61 ggctttagta tttagaactg tagctcaact agctggagtt tcattatctt tgctgggatg
      121 ggttttatcc tgtcttacaa actacctgcc acactggaag aacctcaacc tggacttaaa
      181 tgaaatggaa aactggacca tgggactctg gcaaacctgt gtcatccaag aggaagtggg
      241 gatgcaatgc aaggactttg actccttcct ggctttgcct gctgaactca gggtctccag
      301 gatcttaatg tttctgtcaa atgggctggg atttctgggc ctgctggtct ctgggtttgg
      361 cctggactgt ttgagaattg gagagagtca gagagatctc aagaggcgac tgctgatcct
      421 gggaggaatt ctgtcctggg cctcgggagt cacagccctg gttcccgtct cttgggttgc
      481 ccacaagacg gttcaggagt tctgggatga gaacgtccca gactttgtcc ccaggtggga
      541 gtttggggag gccctgtttc tgggctggtt tgctggactt tctcttctgc taggagggtg
      601 tctgctccac tgtgcagcct gctccagcca cgctccccta gcttcgggcc actacgcagt
      661 ggcacaaaca caagatcatc atcaagaact ggagacgaga aacaccaacc tgaaacacta
      721 agccagaaag gacaagcgtc tgctgttcag gagacgcttg ctcaacactg gatttggtag
      781 gatgtcccgc tctagtcatc tcactgtgct tttgattttt gaaaatgcat cttttcctgt
      841 ggctattaaa ctatagtttc tttccaagac tggtaaacca tttttatctt ctagtctgag
      901 accaaaatca atcaagactg aatagtaatg acacccatta ctgtggatga gttttctcaa
      961 ttttaaaata gcgattgcac agaagtggta aataaaacat taatctctat gtatctttga
     1021 aggtattatt catatggagc ggaatcattt ggcaaatcat ttacttattt caggtgttta
     1081 agataaccta gtataataag cctgaggtct tgttgcatat ttatttaaaa tgcatgacgt
     1141 cttattatat aaaataatta ctagctcttt agaagcttca gaggtgaaag gtgtagacac
     1201 atcatctcct tctgaatcag agacctcagt gtctctatgg aacctttttc aaaaggcagc
     1261 cacattcagt cacgccttct atactgtcag aggcaggagg gcgatcttgg gttttggatg
     1321 attcaagtag actctgccac acaaacgtgc ttctgcatcc tgtgttctgt atttcacggg
     1381 cagcgtttct ggcttcccag gcactgagca gcctgtgggg ggcacggcag ggcaggactg
     1441 gggtgtgtgg gtagataacc tcctgggacg gctgcctctc tgtggagcac actgccagcc
     1501 caggcgcagc gaccacagag cacatattct ggagcccttc attttatttg ctcaatgaaa
     1561 atacttcgtc cttttttatc agcaatacat atagttccaa caagaactat tcatcacaaa
     1621 ctgccagcct ggggatttct tcatgaaata ttttgtattt gcttggtaca tggttcaagg
     1681 aaactcttgt gtttgtgcca atcagggaaa taaactgaac aataaacgac actgaaatag
     1741 agtattaggc aatatgtagc tttgtttttg cttttttttt taaaaaaaac cactgaattt
     1801 ttttccaccc acaaacacat ggaaagtgca gaaaccagtt aatctatgtg atgtatttgc
     1861 atacgtttac aaacaagaca aattaaaaca gaaacatgtt cagaatttaa cctgattaaa
     1921 tattaagttc agtcctgagc ttttgatatt taagacaata tagataaagc aatagcaaaa
     1981 aattttaatt tatttgattt gcatgctaca gagatttagc taaactttgt tcatttggct
     2041 agcaatattc tttttgtacc tgtaacactt aagattctga tatacaaaat tgtaataata
     2101 tactgataat tcaaacttga gaactaaata ttacattctt tttaccctgt gcgaataaat
     2161 tctacctttt aaaaata
//
