LOCUS       NM_001001346            1209 bp    mRNA    linear   PRI 04-JUN-2024
DEFINITION  Homo sapiens claudin 20 (CLDN20), mRNA.
ACCESSION   NM_001001346
VERSION     NM_001001346.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1209)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1209)
  AUTHORS   Berndt,P., Winkler,L., Cording,J., Breitkreuz-Korff,O., Rex,A.,
            Dithmer,S., Rausch,V., Blasig,R., Richter,M., Sporbert,A.,
            Wolburg,H., Blasig,I.E. and Haseloff,R.F.
  TITLE     Tight junction proteins at the blood-brain barrier: far more than
            claudin-5
  JOURNAL   Cell Mol Life Sci 76 (10), 1987-2002 (2019)
   PUBMED   30734065
REFERENCE   3  (bases 1 to 1209)
  AUTHORS   Lal-Nag,M. and Morin,P.J.
  TITLE     The claudins
  JOURNAL   Genome Biol 10 (8), 235 (2009)
   PUBMED   19706201
  REMARK    Review article
REFERENCE   4  (bases 1 to 1209)
  AUTHORS   Angelow,S., Ahlstrom,R. and Yu,A.S.
  TITLE     Biology of claudins
  JOURNAL   Am J Physiol Renal Physiol 295 (4), F867-F876 (2008)
   PUBMED   18480174
  REMARK    Review article
REFERENCE   5  (bases 1 to 1209)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   6  (bases 1 to 1209)
  AUTHORS   Tsukita,S. and Furuse,M.
  TITLE     Claudin-based barrier in simple and stratified cellular sheets
  JOURNAL   Curr Opin Cell Biol 14 (5), 531-536 (2002)
   PUBMED   12231346
  REMARK    Review article
REFERENCE   7  (bases 1 to 1209)
  AUTHORS   Tsukita,S., Furuse,M. and Itoh,M.
  TITLE     Multifunctional strands in tight junctions
  JOURNAL   Nat Rev Mol Cell Biol 2 (4), 285-293 (2001)
   PUBMED   11283726
  REMARK    Review article
REFERENCE   8  (bases 1 to 1209)
  AUTHORS   Heiskala,M., Peterson,P.A. and Yang,Y.
  TITLE     The roles of claudin superfamily proteins in paracellular transport
  JOURNAL   Traffic 2 (2), 93-98 (2001)
   PUBMED   11247307
  REMARK    Review article
REFERENCE   9  (bases 1 to 1209)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell Mol Neurobiol 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
REFERENCE   10 (bases 1 to 1209)
  AUTHORS   Berg,M., Geisel,A. and Necheles,H.
  TITLE     The influence of carbenoxolone on steroid-induced ulcer and mucus
            secretion in the rat
  JOURNAL   Am J Dig Dis 20 (2), 134-137 (1975)
   PUBMED   1124737
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC020838.1 and AL139101.13.
            
            On Jun 5, 2010 this sequence version replaced NM_001001346.2.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. [provided by RefSeq, Jun 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005642.1, BC020838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367165.3/ ENSP00000356133.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1206              BC020838.1         2-1207
            1207-1209           AL139101.13        20674-20676
FEATURES             Location/Qualifiers
     source          1..1209
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..1209
                     /gene="CLDN20"
                     /note="claudin 20"
                     /db_xref="GeneID:49861"
                     /db_xref="HGNC:HGNC:2042"
     exon            1..276
                     /gene="CLDN20"
                     /inference="alignment:Splign:2.1.0"
     exon            277..1209
                     /gene="CLDN20"
                     /inference="alignment:Splign:2.1.0"
     CDS             381..1040
                     /gene="CLDN20"
                     /note="testis secretory sperm-binding protein Li 229n"
                     /codon_start=1
                     /product="claudin-20 precursor"
                     /protein_id="NP_001001346.1"
                     /db_xref="CCDS:CCDS5249.1"
                     /db_xref="GeneID:49861"
                     /db_xref="HGNC:HGNC:2042"
                     /translation="MASAGLQLLAFILALSGVSGVLTATLLPNWKVNVDVDSNIITAI
                     VQLHGLWMDCTWYSTGMFSCALKHSILSLPIHVQAARATMVLACVLSALGICTSTVGM
                     KCTRLGGDRETKSHASFAGGVCFMSAGISSLISTVWYTKEIIANFLDLTVPESNKHEP
                     GGAIYIGFISAMLLFISGMIFCTSCIKRNPEARLDPPTQQPISNTQLENNSTHNLKDY
                     V"
     regulatory      1187..1192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN20"
                     /note="hexamer: AATAAA"
     polyA_site      1209
                     /gene="CLDN20"
                     /note="major polyA site"
ORIGIN      
        1 aaagttcgaa gtgggatgat cacgggcaga cctgggtggt tgggaacagg aagcatatgg
       61 catcttgcag gctataggca ccacaaaatg gaacgcagga ggacaggggc ttgggagagc
      121 cacttcactg tcgggtaaaa caacggagca agatgagtgc ctccggatgc ttggtttccc
      181 caccctccag tgtctgcttg ctcttcaagt acctccacca agctaatgac agtccacttt
      241 aggacatcac gggcctcgag gttacaactt tcccaggctt tgttatttgg ttctctactg
      301 cacagaaata gatagaattc tgacagccat cattgttaaa catcaggatt ttctaagagg
      361 acagacttaa cagtaacatc atggcctcag caggactcca gctccttgct ttcatcctgg
      421 ccttatctgg ggtctctgga gtgctcacag ccactctgct gcccaactgg aaggtgaatg
      481 tggatgtgga ctccaacatc ataacagcca ttgtacagct gcacgggctc tggatggact
      541 gtacgtggta cagcactggg atgttcagct gtgccctgaa acactccatt ctgtccctcc
      601 ccatccacgt gcaggctgcg agagccacca tggtcctggc gtgtgttctg tctgctttgg
      661 ggatctgcac ttccacagta ggaatgaaat gtactcgctt aggaggggac agagaaacca
      721 agagccatgc ttcctttgct ggaggagtct gtttcatgtc tgcaggaatc tctagtttaa
      781 tctcgacagt gtggtacaca aaggagatca tagcaaactt tctggatctg acagttccag
      841 aaagcaacaa acatgaacct ggaggagcta tctatatcgg attcatttct gcaatgctgt
      901 tgtttatctc tggcatgatt ttctgcacct cctgtataaa aaggaatcca gaagctagac
      961 tcgacccacc cacacagcag cctatctcta acacacagct cgagaacaat tccacacaca
     1021 atctgaagga ttatgtgtaa ataactgagt aatgcatatg aaatggaact tttgggtgcc
     1081 aaatgggact tttagattaa aaaaaaatca gaattatgct taactttccc tacaaagaaa
     1141 gtagaatgta aaatacttta acaactacaa agtagtttaa aatgccaata aaactatcat
     1201 atacaatta
//
