LOCUS       NM_020384               2961 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens claudin 2 (CLDN2), transcript variant 1, mRNA.
ACCESSION   NM_020384
VERSION     NM_020384.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2961)
  AUTHORS   Eguchi,H., Yu,Y., Yoshino,Y., Hara,H., Tanaka,H. and Ikari,A.
  TITLE     Plasma-activated medium ameliorates the chemoresistance of human
            lung adenocarcinoma cells mediated via downregulation of claudin-2
            expression
  JOURNAL   Arch Biochem Biophys 751, 109846 (2024)
   PUBMED   38056686
  REMARK    GeneRIF: Plasma-activated medium ameliorates the chemoresistance of
            human lung adenocarcinoma cells mediated via downregulation of
            claudin-2 expression.
REFERENCE   2  (bases 1 to 2961)
  AUTHORS   Telgenhoff,D.
  TITLE     Claudin-2 in hyperproliferative migrating keratinocytes and
            migration inhibition via siRNA knockdown
  JOURNAL   Anat Histol Embryol 52 (5), 723-731 (2023)
   PUBMED   37147871
  REMARK    GeneRIF: Claudin-2 in hyperproliferative migrating keratinocytes
            and migration inhibition via siRNA knockdown.
REFERENCE   3  (bases 1 to 2961)
  AUTHORS   Ahmad,R., Kumar,B., Tamang,R.L., Talmon,G.A., Dhawan,P. and
            Singh,A.B.
  TITLE     P62/SQSTM1 binds with claudin-2 to target for selective autophagy
            in stressed intestinal epithelium
  JOURNAL   Commun Biol 6 (1), 740 (2023)
   PUBMED   37460613
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2961)
  AUTHORS   Arai,W., Konno,T., Kohno,T., Kodera,Y., Tsujiwaki,M., Shindo,Y.,
            Chiba,H., Miyajima,M., Sakuma,Y., Watanabe,A. and Kojima,T.
  TITLE     Downregulation of angulin-1/LSR induces malignancy via upregulation
            of EGF-dependent claudin-2 and TGF-beta-dependent cell metabolism
            in human lung adenocarcinoma A549 cells
  JOURNAL   Oncotarget 14, 261-275 (2023)
   PUBMED   36961882
  REMARK    GeneRIF: Downregulation of angulin-1/LSR induces malignancy via
            upregulation of EGF-dependent claudin-2 and TGF-beta-dependent cell
            metabolism in human lung adenocarcinoma A549 cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2961)
  AUTHORS   Gonschior,H., Schmied,C., Van der Veen,R.E., Eichhorst,J.,
            Himmerkus,N., Piontek,J., Gunzel,D., Bleich,M., Furuse,M.,
            Haucke,V. and Lehmann,M.
  TITLE     Nanoscale segregation of channel and barrier claudins enables
            paracellular ion flux
  JOURNAL   Nat Commun 13 (1), 4985 (2022)
   PUBMED   36008380
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2961)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell Mol Neurobiol 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
REFERENCE   7  (bases 1 to 2961)
  AUTHORS   Itoh,M., Furuse,M., Morita,K., Kubota,K., Saitou,M. and Tsukita,S.
  TITLE     Direct binding of three tight junction-associated MAGUKs, ZO-1,
            ZO-2, and ZO-3, with the COOH termini of claudins
  JOURNAL   J Cell Biol 147 (6), 1351-1363 (1999)
   PUBMED   10601346
REFERENCE   8  (bases 1 to 2961)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
REFERENCE   9  (bases 1 to 2961)
  AUTHORS   Furuse,M., Fujita,K., Hiiragi,T., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin-1 and -2: novel integral membrane proteins localizing at
            tight junctions with no sequence similarity to occludin
  JOURNAL   J Cell Biol 141 (7), 1539-1550 (1998)
   PUBMED   9647647
REFERENCE   10 (bases 1 to 2961)
  AUTHORS   Shelton,C., LaRusch,J. and Whitcomb,D.C.
  TITLE     Pancreatitis Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24624459
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA743944.1, AK075405.1 and
            AA973123.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_020384.3.
            
            Summary: This gene product belongs to the claudin protein family
            whose members have been identified as major integral membrane
            proteins localized exclusively at tight junctions. Claudins are
            expressed in an organ-specific manner and regulate tissue-specific
            physiologic properties of tight junctions. This protein is
            expressed in the intestine. Alternatively spliced transcript
            variants with different 5' untranslated region have been found for
            this gene.[provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant represents the predominant
            transcript. Variants 1-3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075405.1, SRR1803611.186626.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267767, SAMN03267768
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336803.2/ ENSP00000336571.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-541               DA743944.1         39-579
            542-2524            AK075405.1         540-2522
            2525-2961           AA973123.1         12-448              c
FEATURES             Location/Qualifiers
     source          1..2961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.3"
     gene            1..2961
                     /gene="CLDN2"
                     /gene_synonym="claudin-2; OAZON"
                     /note="claudin 2"
                     /db_xref="GeneID:9075"
                     /db_xref="HGNC:HGNC:2041"
                     /db_xref="MIM:300520"
     exon            1..150
                     /gene="CLDN2"
                     /gene_synonym="claudin-2; OAZON"
                     /inference="alignment:Splign:2.1.0"
     exon            151..2961
                     /gene="CLDN2"
                     /gene_synonym="claudin-2; OAZON"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..1021
                     /gene="CLDN2"
                     /gene_synonym="claudin-2; OAZON"
                     /note="SP82"
                     /codon_start=1
                     /product="claudin-2"
                     /protein_id="NP_065117.1"
                     /db_xref="CCDS:CCDS14524.1"
                     /db_xref="GeneID:9075"
                     /db_xref="HGNC:HGNC:2041"
                     /db_xref="MIM:300520"
                     /translation="MASLGLQLVGYILGLLGLLGTLVAMLLPSWKTSSYVGASIVTAV
                     GFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIISVVGM
                     RCTVFCQESRAKDRVAVAGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEI
                     GEALYLGIISSLFSLIAGIILCFSCSSQRNRSNYYDAYQAQPLATRSSPRPGQPPKVK
                     SEFNSYSLTGYV"
     regulatory      2941..2946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN2"
                     /gene_synonym="claudin-2; OAZON"
                     /note="hexamer: AATAAA"
     polyA_site      2961
                     /gene="CLDN2"
                     /gene_synonym="claudin-2; OAZON"
                     /note="major polyA site"
ORIGIN      
        1 gcagatggat tttgcaaagc tgtggttaac gattagaaat cctttatcac ctcagcccgt
       61 ggccccttgt acttcgctcc cctccctcag gatccctttc tccctctcca ggggcatctc
      121 cccctccaag gctctgcaaa gaactgccct gtcttctaga tgccttcttg aggctgcttg
      181 tggccaccca cagacacttg taaggaggag agaagtcagc ctggcagaga gactctgaaa
      241 tgagggatta gaggtgttca aggagcaaga gcttcagcct gaagacaagg gagcagtccc
      301 tgaagacgct tctactgaga ggtctgccat ggcctctctt ggcctccaac ttgtgggcta
      361 catcctaggc cttctggggc ttttgggcac actggttgcc atgctgctcc ccagctggaa
      421 aacaagttct tatgtcggtg ccagcattgt gacagcagtt ggcttctcca agggcctctg
      481 gatggaatgt gccacacaca gcacaggcat cacccagtgt gacatctata gcacccttct
      541 gggcctgccc gctgacatcc aggctgccca ggccatgatg gtgacatcca gtgcaatctc
      601 ctccctggcc tgcattatct ctgtggtggg catgagatgc acagtcttct gccaggaatc
      661 ccgagccaaa gacagagtgg cggtagcagg tggagtcttt ttcatccttg gaggcctcct
      721 gggattcatt cctgttgcct ggaatcttca tgggatccta cgggacttct actcaccact
      781 ggtgcctgac agcatgaaat ttgagattgg agaggctctt tacttgggca ttatttcttc
      841 cctgttctcc ctgatagctg gaatcatcct ctgcttttcc tgctcatccc agagaaatcg
      901 ctccaactac tacgatgcct accaagccca acctcttgcc acaaggagct ctccaaggcc
      961 tggtcaacct cccaaagtca agagtgagtt caattcctac agcctgacag ggtatgtgtg
     1021 aagaaccagg ggccagagct ggggggtggc tgggtctgtg aaaaacagtg gacagcaccc
     1081 cgagggccac aggtgaggga cactaccact ggatcgtgtc agaaggtgct gctgaggata
     1141 gactgacttt ggccattgga ttgagcaaag gcagaaatgg gggctagtgt aacagcatgc
     1201 aggttgaatt gccaaggatg ctcgccatgc cagcctttct gttttcctca ccttgctgct
     1261 cccctgccct aagtccccaa ccctcaactt gaaaccccat tcccttaagc caggactcag
     1321 aggatccctt tgccctctgg tttacctggg actccatccc caaacccact aatcacatcc
     1381 cactgactga ccctctgtga tcaaagaccc tctctctggc tgaggttggc tcttagctca
     1441 ttgctgggga tgggaaggag aagcagtggc ttttgtgggc attgctctaa cctacttctc
     1501 aagcttccct ccaaagaaac tgattggccc tggaacctcc atcccactct tgttatgact
     1561 ccacagtgtc cagactaatt tgtgcatgaa ctgaaataaa accatcctac ggtatccagg
     1621 gaacagaaag caggatgcag gatgggagga caggaaggca gcctgggaca tttaaaaaaa
     1681 taaaaatgaa aaaaaaaccc agaacccatt tctcagggca ctttccagaa ttctctcata
     1741 tttgtgggct gggatcaagc ctgcagcttg aggaaagcac aaggaaagga aagaagatct
     1801 ggtggaaagc tcaggtggca gcggactctg actccactga ggaactgcct cagaagctgc
     1861 gatcacaact ttggctgaag cccctgcctc actctagggc acctgacctg gcctcttgcc
     1921 taaaccacaa ggctaagggc tatagacaat ggtttcctta ggaacagtaa accagttttt
     1981 ctagggatgg cccttggctg ggggatgaca gtgtgggagc tgtggggtac tgaggaagac
     2041 accattcctt gacggtgtct aagaagccag gtggatgtgt gtggtggctc cagtgggtgt
     2101 ttctactctg ccagtgagag gcagccccct agaaactctt caggcgtaat ggaaaatcag
     2161 ctcaaatgag atcaggcccc cccagggtcc acccacagag cactacagag cctctgaaag
     2221 accatagcac caagcgagcc ccttcagatt cccccactgt ccatcggaag atgctccaga
     2281 gtggctagag ggcatctaag ggctccagca tggcatatcc atgcccacgg tgctgtgtcc
     2341 atgatctgag tgatagctgc actgctgcct gggattgcag ctgaggtggg agtggagaat
     2401 ggttcccagg aagacagttc cacctctaag gtccgaaaat gttcccttta ccctggagtg
     2461 ggagtgaggg gtcatacacc aaaggtattt tccctcacca gtctaggcat gactggcttc
     2521 tgaaaaattc cagcacacct cctcgaacct cattgtcagc agagagggcc catctgttgt
     2581 ctgtaacatg cctttcacat gtccaccttc ttgccatgtt ccagctgctc tcccaacctg
     2641 gaaggccgtc tccccttagc caagtcctcc tcaggcttgg agaacttcct cagcgtcacc
     2701 tccttcattg agccttctct gatcactcca tccctctcct acccctccct cccccaaccc
     2761 tcaatgtata aattgcttct tgatgcttag cattcacaat ttttgattga tcgttatttg
     2821 tgtgtgtgtg tccgatctca caagtatatt gtaaaccctt cggtgggtgg gggccatatc
     2881 ctagacctct ctgtatcccc cagactatct gtaacagtgc caggcacaca gtaggtgatc
     2941 aataaacact tgttgattga g
//
