LOCUS       NM_014343               1224 bp    mRNA    linear   PRI 28-OCT-2024
DEFINITION  Homo sapiens claudin 15 (CLDN15), transcript variant 2, mRNA.
ACCESSION   NM_014343
VERSION     NM_014343.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1224)
  AUTHORS   Rajagopal,N. and Nangia,S.
  TITLE     Unique structural features of claudin-5 and claudin-15 lead to
            functionally distinct tight junction strand architecture
  JOURNAL   Ann N Y Acad Sci 1517 (1), 225-233 (2022)
   PUBMED   36114674
  REMARK    GeneRIF: Unique structural features of claudin-5 and claudin-15
            lead to functionally distinct tight junction strand architecture.
REFERENCE   2  (bases 1 to 1224)
  AUTHORS   Hempel,C., Rosenthal,R., Fromm,A., Krug,S.M., Fromm,M., Gunzel,D.
            and Piontek,J.
  TITLE     Tight junction channels claudin-10b and claudin-15: Functional
            mapping of pore-lining residues
  JOURNAL   Ann N Y Acad Sci 1515 (1), 129-142 (2022)
   PUBMED   35650657
  REMARK    GeneRIF: Tight junction channels claudin-10b and claudin-15:
            Functional mapping of pore-lining residues.
REFERENCE   3  (bases 1 to 1224)
  AUTHORS   Gonschior,H., Schmied,C., Van der Veen,R.E., Eichhorst,J.,
            Himmerkus,N., Piontek,J., Gunzel,D., Bleich,M., Furuse,M.,
            Haucke,V. and Lehmann,M.
  TITLE     Nanoscale segregation of channel and barrier claudins enables
            paracellular ion flux
  JOURNAL   Nat Commun 13 (1), 4985 (2022)
   PUBMED   36008380
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1224)
  AUTHORS   Watanabe,M., Higashi,T., Ozeki,K., Higashi,A.Y., Sugimoto,K.,
            Mine,H., Takagi,H., Ozaki,Y., Muto,S., Okabe,N., Matsumura,Y.,
            Hasegawa,T., Shio,Y., Suzuki,H. and Chiba,H.
  TITLE     CLDN15 is a novel diagnostic marker for malignant pleural
            mesothelioma
  JOURNAL   Sci Rep 11 (1), 12554 (2021)
   PUBMED   34131154
  REMARK    GeneRIF: CLDN15 is a novel diagnostic marker for malignant pleural
            mesothelioma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1224)
  AUTHORS   Ong,M.L.D.M., Yeruva,S., Sailer,A., Nilsen,S.P. and Turner,J.R.
  TITLE     Differential regulation of claudin-2 and claudin-15 expression in
            children and adults with malabsorptive disease
  JOURNAL   Lab Invest 100 (3), 483-490 (2020)
   PUBMED   31605016
  REMARK    GeneRIF: Differential regulation of claudin-2 and claudin-15
            expression in children and adults with malabsorptive disease.
REFERENCE   6  (bases 1 to 1224)
  AUTHORS   Kiuchi-Saishin,Y., Gotoh,S., Furuse,M., Takasuga,A., Tano,Y. and
            Tsukita,S.
  TITLE     Differential expression patterns of claudins, tight junction
            membrane proteins, in mouse nephron segments
  JOURNAL   J Am Soc Nephrol 13 (4), 875-886 (2002)
   PUBMED   11912246
REFERENCE   7  (bases 1 to 1224)
  AUTHORS   Tsukita,S., Furuse,M. and Itoh,M.
  TITLE     Multifunctional strands in tight junctions
  JOURNAL   Nat Rev Mol Cell Biol 2 (4), 285-293 (2001)
   PUBMED   11283726
  REMARK    Review article
REFERENCE   8  (bases 1 to 1224)
  AUTHORS   Heiskala,M., Peterson,P.A. and Yang,Y.
  TITLE     The roles of claudin superfamily proteins in paracellular transport
  JOURNAL   Traffic 2 (2), 93-98 (2001)
   PUBMED   11247307
  REMARK    Review article
REFERENCE   9  (bases 1 to 1224)
  AUTHORS   Yi,X., Wang,Y. and Yu,F.S.
  TITLE     Corneal epithelial tight junctions and their response to
            lipopolysaccharide challenge
  JOURNAL   Invest Ophthalmol Vis Sci 41 (13), 4093-4100 (2000)
   PUBMED   11095601
REFERENCE   10 (bases 1 to 1224)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell Mol Neurobiol 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ245738.1 and AK056103.1.
            
            On Jun 2, 2019 this sequence version replaced NM_014343.2.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. Alternatively spliced transcript variants
            encoding the same protein have been found for this gene. [provided
            by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (2) has a shorter and alternate 5'
            UTR, as compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279859.229.1, DRR138528.254063.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153946, SAMEA2159764
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308344.10/ ENSP00000308870.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-826               AJ245738.1         34-859
            827-1224            AK056103.1         1732-2129
FEATURES             Location/Qualifiers
     source          1..1224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1224
                     /gene="CLDN15"
                     /note="claudin 15"
                     /db_xref="GeneID:24146"
                     /db_xref="HGNC:HGNC:2036"
                     /db_xref="MIM:615778"
     exon            1..438
                     /gene="CLDN15"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..908
                     /gene="CLDN15"
                     /codon_start=1
                     /product="claudin-15"
                     /protein_id="NP_055158.1"
                     /db_xref="CCDS:CCDS5717.1"
                     /db_xref="GeneID:24146"
                     /db_xref="HGNC:HGNC:2036"
                     /db_xref="MIM:615778"
                     /translation="MSMAVETFGFFMATVGLLMLGVTLPNSYWRVSTVHGNVITTNTI
                     FENLWFSCATDSLGVYNCWEFPSMLALSGYIQACRALMITAILLGFLGLLLGIAGLRC
                     TNIGGLELSRKAKLAATAGALHILAGICGMVAISWYAFNITRDFFDPLYPGTKYELGP
                     ALYLGWSASLISILGGLCLCSACCCGSDEDPAASARRPYQAPVSVMPVATSDQEGDSS
                     FGKYGRNAYV"
     exon            439..603
                     /gene="CLDN15"
                     /inference="alignment:Splign:2.1.0"
     exon            604..685
                     /gene="CLDN15"
                     /inference="alignment:Splign:2.1.0"
     exon            686..802
                     /gene="CLDN15"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1224
                     /gene="CLDN15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1202..1207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN15"
                     /note="hexamer: AATAAA"
     polyA_site      1224
                     /gene="CLDN15"
                     /note="major polyA site"
ORIGIN      
        1 attcctctga cctgccagga agcagagaga cccacagagc aggagggagg cagaaagtgg
       61 agacggacct gagcccgagg aagaggcagg cagaggctga ggctgattcc accccagcct
      121 gcctggacaa ccctccttag ccgcagcccc ttccagttcc ctaggggttc tgcccctccc
      181 cctctctggg gcaccagccc cccagggtcc tgcatcccac catgtcgatg gctgtggaaa
      241 cctttggctt cttcatggca actgtggggc tgctgatgct gggggtgact ctgccaaaca
      301 gctactggcg agtgtccact gtgcacggga acgtcatcac caccaacacc atcttcgaga
      361 acctctggtt tagctgtgcc accgactccc tgggcgtcta caactgctgg gagttcccgt
      421 ccatgctggc cctctctggg tatattcagg cctgccgggc actcatgatc accgccatcc
      481 tcctgggctt cctcggcctc ttgctaggca tagcgggcct gcgctgcacc aacattgggg
      541 gcctggagct ctccaggaaa gccaagctgg cggccaccgc aggggccctc cacattctgg
      601 ccggtatctg cgggatggtg gccatctcct ggtacgcctt caacatcacc cgggacttct
      661 tcgacccctt gtaccccgga accaagtacg agctgggccc cgccctctac ctggggtgga
      721 gcgcctcact gatctccatc ctgggtggcc tctgcctctg ctccgcctgc tgctgcggct
      781 ctgacgagga cccagccgcc agcgcccggc ggccctacca ggctccagtg tccgtgatgc
      841 ccgtcgccac ctcggaccaa gaaggcgaca gcagctttgg caaatacggc agaaacgcct
      901 acgtgtagca gctctggccc gtgggccccg ctgtcttccc actgccccaa ggagagggga
      961 cctggccggg gcccattccc ctatagtaac ctcaggggcc ggccacgccc cgctcccgta
     1021 gccccgcccc ggccacggcc ccgtgtcttg cactctcatg gcccctccag gccaagaact
     1081 gctcttggga agtcgcatat ctcccctctg aggctggatc cctcatcttc tgaccctggg
     1141 ttctgggctg tgaaggggac ggtgtccccg cacgtttgta ttgtgtataa atacattcat
     1201 taataaatgc atattgtgac cgtt
//
