LOCUS       NM_021101               3446 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens claudin 1 (CLDN1), mRNA.
ACCESSION   NM_021101
VERSION     NM_021101.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3446)
  AUTHORS   Arnold,K.A., Moran,M.C., Shi,H., van Vlijmen-Willems,I.M.J.J.,
            Rodijk-Olthuis,D., Smits,J.P.H. and Brewer,M.G.
  TITLE     CLDN1 knock out keratinocytes as a model to investigate multiple
            skin disorders
  JOURNAL   Exp Dermatol 33 (5), e15084 (2024)
   PUBMED   38711223
  REMARK    GeneRIF: CLDN1 knock out keratinocytes as a model to investigate
            multiple skin disorders.
REFERENCE   2  (bases 1 to 3446)
  AUTHORS   Fernandez-Garcia,P., Taxeras,S.D., Reyes-Farias,M., Gonzalez,L.,
            Soria-Gondek,A., Pellitero,S., Tarasco,J., Moreno,P., Sumoy,L.,
            Stephens,J.M., Yoo,L.G., Galan,M., Izquierdo,A., Medina-Gomez,G.,
            Herrero,L., Corrales,P., Villarroya,F., Cereijo,R. and
            Sanchez-Infantes,D.
  TITLE     Claudin-1 as a novel target gene induced in obesity and associated
            to inflammation, fibrosis, and cell differentiation
  JOURNAL   Eur J Endocrinol 190 (3), 201-210 (2024)
   PUBMED   38375549
  REMARK    GeneRIF: Claudin-1 as a novel target gene induced in obesity and
            associated to inflammation, fibrosis, and cell differentiation.
REFERENCE   3  (bases 1 to 3446)
  AUTHORS   Wu,Q., Qiu,Y., Guo,J., Yuan,Z., Yang,Y., Zhu,Q., Zhang,Z., Guo,J.,
            Wu,Y., Zhang,J., Huang,D., Tu,K. and Hu,X.
  TITLE     USP40 promotes hepatocellular carcinoma cell proliferation,
            migration and stemness by deubiquitinating and stabilizing Claudin1
  JOURNAL   Biol Direct 19 (1), 13 (2024)
   PUBMED   38308285
  REMARK    GeneRIF: USP40 promotes hepatocellular carcinoma cell
            proliferation, migration and stemness by deubiquitinating and
            stabilizing Claudin1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3446)
  AUTHORS   Elsayed,A.M., Mahmoud,E.I., Salem,M.M. and Khairy,R.A.
  TITLE     Immunohistochemical Expression of Claudin-1 and Claudin-4 in
            Urothelial Carcinoma of the Urinary Bladder
  JOURNAL   Asian Pac J Cancer Prev 25 (2), 637-646 (2024)
   PUBMED   38415551
  REMARK    GeneRIF: Immunohistochemical Expression of Claudin-1 and Claudin-4
            in Urothelial Carcinoma of the Urinary Bladder.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3446)
  AUTHORS   So,C.W., Sourisseau,M., Sarwar,S., Evans,M.J. and Randall,G.
  TITLE     Roles of epidermal growth factor receptor, claudin-1 and occludin
            in multi-step entry of hepatitis C virus into polarized hepatoma
            spheroids
  JOURNAL   PLoS Pathog 19 (12), e1011887 (2023)
   PUBMED   38157366
  REMARK    GeneRIF: Roles of epidermal growth factor receptor, claudin-1 and
            occludin in multi-step entry of hepatitis C virus into polarized
            hepatoma spheroids.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3446)
  AUTHORS   Itoh,M., Furuse,M., Morita,K., Kubota,K., Saitou,M. and Tsukita,S.
  TITLE     Direct binding of three tight junction-associated MAGUKs, ZO-1,
            ZO-2, and ZO-3, with the COOH termini of claudins
  JOURNAL   J Cell Biol 147 (6), 1351-1363 (1999)
   PUBMED   10601346
REFERENCE   7  (bases 1 to 3446)
  AUTHORS   Furuse,M., Sasaki,H. and Tsukita,S.
  TITLE     Manner of interaction of heterogeneous claudin species within and
            between tight junction strands
  JOURNAL   J Cell Biol 147 (4), 891-903 (1999)
   PUBMED   10562289
REFERENCE   8  (bases 1 to 3446)
  AUTHORS   Swisshelm,K., Machl,A., Planitzer,S., Robertson,R., Kubbies,M. and
            Hosier,S.
  TITLE     SEMP1, a senescence-associated cDNA isolated from human mammary
            epithelial cells, is a member of an epithelial membrane protein
            superfamily
  JOURNAL   Gene 226 (2), 285-295 (1999)
   PUBMED   9931503
REFERENCE   9  (bases 1 to 3446)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
REFERENCE   10 (bases 1 to 3446)
  AUTHORS   Furuse,M., Fujita,K., Hiiragi,T., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin-1 and -2: novel integral membrane proteins localizing at
            tight junctions with no sequence similarity to occludin
  JOURNAL   J Cell Biol 141 (7), 1539-1550 (1998)
   PUBMED   9647647
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA907275.1, AY358652.1 and
            AC009520.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_021101.4.
            
            Summary: Tight junctions represent one mode of cell-to-cell
            adhesion in epithelial or endothelial cell sheets, forming
            continuous seals around cells and serving as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space. These junctions are comprised of sets of
            continuous networking strands in the outwardly facing cytoplasmic
            leaflet, with complementary grooves in the inwardly facing
            extracytoplasmic leaflet. The protein encoded by this gene, a
            member of the claudin family, is an integral membrane protein and a
            component of tight junction strands. Loss of function mutations
            result in neonatal ichthyosis-sclerosing cholangitis syndrome.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.53301.1, AF101051.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295522.4/ ENSP00000295522.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               DA907275.1         1-228
            229-1136            AY358652.1         207-1114
            1137-3446           AC009520.16        10696-13005         c
FEATURES             Location/Qualifiers
     source          1..3446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q28"
     gene            1..3446
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /note="claudin 1"
                     /db_xref="GeneID:9076"
                     /db_xref="HGNC:HGNC:2032"
                     /db_xref="MIM:603718"
     exon            1..463
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..876
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /note="senescence-associated epithelial membrane protein
                     1"
                     /codon_start=1
                     /product="claudin-1"
                     /protein_id="NP_066924.1"
                     /db_xref="CCDS:CCDS3295.1"
                     /db_xref="GeneID:9076"
                     /db_xref="HGNC:HGNC:2032"
                     /db_xref="MIM:603718"
                     /translation="MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQ
                     AMYEGLWMSCVSQSTGQIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGM
                     KCMKCLEDDEVQKMRMAVIGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYE
                     FGQALFTGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPAPSSGKDYV"
     exon            464..628
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..713
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /inference="alignment:Splign:2.1.0"
     exon            714..3446
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3420..3425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /note="hexamer: AATAAA"
     polyA_site      3446
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /note="major polyA site"
ORIGIN      
        1 gtctcagttc ccgagcctgg gagcaaccgc agcttctagt atccagactc cagcgccgcc
       61 ccgggcgcgg accccaaccc cgacccagag cttctccagc ggcggcgcag cgagcagggc
      121 tccccgcctt aacttcctcc gcggggccca gccaccttcg ggagtccggg ttgcccacct
      181 gcaaactctc cgccttctgc acctgccacc cctgagccag cgcgggcgcc cgagcgagtc
      241 atggccaacg cggggctgca gctgttgggc ttcattctcg ccttcctggg atggatcggc
      301 gccatcgtca gcactgccct gccccagtgg aggatttact cctatgccgg cgacaacatc
      361 gtgaccgccc aggccatgta cgaggggctg tggatgtcct gcgtgtcgca gagcaccggg
      421 cagatccagt gcaaagtctt tgactccttg ctgaatctga gcagcacatt gcaagcaacc
      481 cgtgccttga tggtggttgg catcctcctg ggagtgatag caatctttgt ggccaccgtt
      541 ggcatgaagt gtatgaagtg cttggaagac gatgaggtgc agaagatgag gatggctgtc
      601 attgggggtg cgatatttct tcttgcaggt ctggctattt tagttgccac agcatggtat
      661 ggcaatagaa tcgttcaaga attctatgac cctatgaccc cagtcaatgc caggtacgaa
      721 tttggtcagg ctctcttcac tggctgggct gctgcttctc tctgccttct gggaggtgcc
      781 ctactttgct gttcctgtcc ccgaaaaaca acctcttacc caacaccaag gccctatcca
      841 aaacctgcac cttccagcgg gaaagactac gtgtgacaca gaggcaaaag gagaaaatca
      901 tgttgaaaca aaccgaaaat ggacattgag atactatcat taacattagg accttagaat
      961 tttgggtatt gtaatctgaa gtatggtatt acaaaacaaa caaacaaaca aaaaacccat
     1021 gtgttaaaat actcagtgct aaacatggct taatcttatt ttatcttctt tcctcaatat
     1081 aggagggaag atttttccat ttgtattact gcttcccatt gagtaatcat actcaactgg
     1141 gggaaggggt gctccttaaa tatatataga tatgtatata tacatgtttt tctattaaaa
     1201 atagacagta aaatactatt ctcattatgt tgatactagc atacttaaaa tatctctaaa
     1261 ataggtaaat gtatttaatt ccatattgat gaagatgttt attggtatat tttctttttc
     1321 gtctatatat acatatgtaa cagtcaaata tcatttactc ttcttcatta gctttgggtg
     1381 cctttgccac aagacctagc ctaatttacc aaggatgaat tctttcaatt cttcatgcgt
     1441 gcccttttca tatacttatt ttatttttta ccataatctt atagcacttg catcgttatt
     1501 aagcccttat ttgttttgtg tttcattggt ctctatctcc tgaatctaac acatttcata
     1561 gcctacattt tagtttctaa agccaagaag aatttattac aaatcagaac tttggaggca
     1621 aatctttctg catgaccaaa gtgataaatt cctgttgacc ttcccacaca atccctgtac
     1681 tctgacccat agcactcttg tttgctttga aaatatttgt ccaattgagt agctgcatgc
     1741 tgttccccca ggtgttgtaa cacaacttta ttgattgaat ttttaagcta cttattcata
     1801 gttttatatc cccctaaact acctttttgt tccccattcc ttaattgtat tgttttccca
     1861 agtgtaatta tcatgcgttt tatatcttcc taataaggtg tggtctgttt gtctgaacaa
     1921 agtgctagac tttctggagt gataatctgg tgacaaatat tctctctgta gctgtaagca
     1981 agtcacttaa tctttctacc tcttttttct atctgccaaa ttgagataat gatacttaac
     2041 cagttagaag aggtagtgtg aatattaatt agtttatatt actctcattc tttgaacatg
     2101 aactatgcct atgtagtgtc tttatttgct cagctggctg agacactgaa gaagtcactg
     2161 aacaaaacct acacacgtac cttcatgtga ttcactgcct tcctctctct accagtctat
     2221 ttccactgaa caaaacctac acacatacct tcatgtggtt cagtgccttc ctctctctac
     2281 cagtctattt ccactgaaca aaacctacgc acataccttc atgtggctca gtgccttcct
     2341 ctctctacca gtctatttcc attctttcag ctgtgtctga catgtttgtg ctctgttcca
     2401 ttttaacaac tgctcttact tttccagtct gtacagaatg ctatttcact tgagcaagat
     2461 gatgtaatgg aaagggtgtt ggcattggtg tctggagacc tggatttgag tcttggtgct
     2521 atcaatcacc gtctgtgttt gagcaaggca tttggctgct gtaagcttat tgcttcatct
     2581 gtaagcggtg gtttgtaatt cctgatcttc ccacctcaca gtgatgttgt ggggatccag
     2641 tgagatagaa tacatgtaag tgtggttttg taatttaaaa agtgctatac taagggaaag
     2701 aattgaggaa ttaactgcat acgttttggt gttgcttttc aaatgtttga aaacaaaaaa
     2761 aatgttaaga aatgggtttc ttgccttaac cagtctctca agtgatgaga cagtgaagta
     2821 aaattgagtg cactaaacaa ataagattct gaggaagtct tatcttctgc agtgagtatg
     2881 gcccgatgct ttctgtggct aaacagatgt aatgggaaga aataaaagcc tacgtgttgg
     2941 taaatccaac agcaagggag atttttgaat cataataact cataaggtgc tatctgttca
     3001 gtgatgccct cagagctctt gctgttagct ggcagctgac gctgctagga tagttagttt
     3061 ggaaatggta cttcataata aactacacaa ggaaagtcag ccactgtgtc ttatgaggaa
     3121 ttggacctaa taaattttag tgtgccttcc aaacctgaga atatatgctt ttggaagtta
     3181 aaatttaaat ggcttttgcc acatacatag atcttcatga tgtgtgagtg taattccatg
     3241 tggatatcag ttaccaaaca ttacaaaaaa attttatggc ccaaaatgac caacgaaatt
     3301 gttacaatag aatttatcca attttgatct ttttatattc ttctaccaca cctggaaaca
     3361 gaccaataga cattttgggg ttttataata ggaatttgta taaagcatta ctctttttca
     3421 ataaattgtt ttttaattta aaaaaa
//
