LOCUS       NM_001287               4168 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens chloride voltage-gated channel 7 (CLCN7), transcript
            variant 1, mRNA.
ACCESSION   NM_001287
VERSION     NM_001287.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4168)
  AUTHORS   Lee,C.L., Chang,Y.W., Lin,H.Y., Lee,H.C., Yeh,T.C., Fang,L.C.,
            Lee,N.C., Tsai,J.D. and Lin,S.P.
  TITLE     Multisystem disorder associated with a pathogenic variant in CLCN7
            in the absence of osteopetrosis
  JOURNAL   Mol Genet Genomic Med 12 (7), e2494 (2024)
   PUBMED   39056574
  REMARK    GeneRIF: Multisystem disorder associated with a pathogenic variant
            in CLCN7 in the absence of osteopetrosis.
REFERENCE   2  (bases 1 to 4168)
  AUTHORS   Polovitskaya,M.M., Rana,T., Ullrich,K., Murko,S., Bierhals,T.,
            Vogt,G., Stauber,T., Kubisch,C., Santer,R. and Jentsch,T.J.
  TITLE     Gain-of-function variants in CLCN7 cause hypopigmentation and
            lysosomal storage disease
  JOURNAL   J Biol Chem 300 (7), 107437 (2024)
   PUBMED   38838776
  REMARK    GeneRIF: Gain-of-function variants in CLCN7 cause hypopigmentation
            and lysosomal storage disease.
REFERENCE   3  (bases 1 to 4168)
  AUTHORS   Bose,S., de Heus,C., Kennedy,M.E., Wang,F., Jentsch,T.J.,
            Klumperman,J. and Stauber,T.
  TITLE     Impaired Autophagic Clearance with a Gain-of-Function Variant of
            the Lysosomal Cl-/H+ Exchanger ClC-7
  JOURNAL   Biomolecules 13 (12), 1799 (2023)
   PUBMED   38136669
  REMARK    GeneRIF: Impaired Autophagic Clearance with a Gain-of-Function
            Variant of the Lysosomal Cl[-]/H[+] Exchanger ClC-7.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4168)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 4168)
  AUTHORS   White,K.E., Koller,D.L., Takacs,I., Buckwalter,K.A., Foroud,T. and
            Econs,M.J.
  TITLE     Locus heterogeneity of autosomal dominant osteopetrosis (ADO)
  JOURNAL   J Clin Endocrinol Metab 84 (3), 1047-1051 (1999)
   PUBMED   10084593
REFERENCE   6  (bases 1 to 4168)
  AUTHORS   Eggermont,J.
  TITLE     The exon-intron architecture of human chloride channel genes is not
            conserved
  JOURNAL   Biochim Biophys Acta 1397 (2), 156-160 (1998)
   PUBMED   9565675
REFERENCE   7  (bases 1 to 4168)
  AUTHORS   Lennon,G., Auffray,C., Polymeropoulos,M. and Soares,M.B.
  TITLE     The I.M.A.G.E. Consortium: an integrated molecular analysis of
            genomes and their expression
  JOURNAL   Genomics 33 (1), 151-152 (1996)
   PUBMED   8617505
REFERENCE   8  (bases 1 to 4168)
  AUTHORS   Heon,E., Piguet,B., Munier,F., Sneed,S.R., Morgan,C.M., Forni,S.,
            Pescia,G., Schorderet,D., Taylor,C.M., Streb,L.M., Wiles,C.D.,
            Nishimura,D.Y., Sheffield,V.C. and Stone,E.M.
  TITLE     Linkage of autosomal dominant radial drusen (malattia leventinese)
            to chromosome 2p16-21
  JOURNAL   Arch Ophthalmol 114 (2), 193-198 (1996)
   PUBMED   8573024
REFERENCE   9  (bases 1 to 4168)
  AUTHORS   Brandt,S. and Jentsch,T.J.
  TITLE     ClC-6 and ClC-7 are two novel broadly expressed members of the CLC
            chloride channel family
  JOURNAL   FEBS Lett 377 (1), 15-20 (1995)
   PUBMED   8543009
REFERENCE   10 (bases 1 to 4168)
  AUTHORS   Sobacchi,C., Villa,A., Schulz,A. and Kornak,U.
  TITLE     CLCN7-Related Osteopetrosis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301306
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031705.25, BC012737.2,
            AL031600.4 and AA741117.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001287.5.
            
            Summary: The product of this gene belongs to the CLC chloride
            channel family of proteins. Chloride channels play important roles
            in the plasma membrane and in intracellular organelles. This gene
            encodes chloride channel 7. Defects in this gene are the cause of
            osteopetrosis autosomal recessive type 4 (OPTB4), also called
            infantile malignant osteopetrosis type 2 as well as the cause of
            autosomal dominant osteopetrosis type 2 (OPTA2), also called
            autosomal dominant Albers-Schonberg disease or marble disease
            autosoml dominant. Osteopetrosis is a rare genetic disease
            characterized by abnormally dense bone, due to defective resorption
            of immature bone. OPTA2 is the most common form of osteopetrosis,
            occurring in adolescence or adulthood. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript, and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122944.1, BC012737.2 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382745.9/ ENSP00000372193.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL031705.25        3017-3033           c
            18-3098             BC012737.2         1-3081
            3099-3359           AL031600.4         5162-5422           c
            3360-3760           BC012737.2         3343-3743
            3761-4098           AL031600.4         4423-4760           c
            4099-4168           AA741117.1         13-82               c
FEATURES             Location/Qualifiers
     source          1..4168
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..4168
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /note="chloride voltage-gated channel 7"
                     /db_xref="GeneID:1186"
                     /db_xref="HGNC:HGNC:2025"
                     /db_xref="MIM:602727"
     exon            1..195
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2472
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /note="isoform a is encoded by transcript variant 1;
                     h(+)/Cl(-) exchange transporter 7; chloride channel
                     protein 7; protein phosphatase 1, regulatory subunit 63;
                     chloride channel 7 alpha subunit; chloride channel,
                     voltage-sensitive 7"
                     /codon_start=1
                     /product="H(+)/Cl(-) exchange transporter 7 isoform a"
                     /protein_id="NP_001278.1"
                     /db_xref="CCDS:CCDS32361.1"
                     /db_xref="GeneID:1186"
                     /db_xref="HGNC:HGNC:2025"
                     /db_xref="MIM:602727"
                     /translation="MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGA
                     ARQSPRSALFRVGHMSSVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNS
                     ENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIK
                     GNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKI
                     PHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIF
                     EYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMIS
                     TFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVF
                     NALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPL
                     QLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLT
                     VSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSL
                     TVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHS
                     LTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRS
                     QLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEF
                     MNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLE
                     ELSLAQT"
     exon            196..267
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            268..339
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            340..405
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            406..538
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            539..648
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            649..729
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            730..792
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            793..876
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            877..970
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1035
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1152
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1207
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1268
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1407
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1501
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1671
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1723
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1851
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1937
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2067
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2127
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2304
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2385
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..4168
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3743..3748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /note="hexamer: AATAAA"
     polyA_site      3763
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /note="major polyA site"
     regulatory      4145..4150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /note="hexamer: AATAAA"
     polyA_site      4168
                     /gene="CLCN7"
                     /gene_synonym="CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63"
                     /note="major polyA site"
ORIGIN      
        1 aacaaacacg ggggcagccg gcgcttcccg gccggtgtcg ctccgcggcg ggccatggcc
       61 aacgtctcta agaaggtgtc ctggtccggc cgggaccggg acgacgagga ggcggcgccg
      121 ctgctgcgga ggacggcgcg gcccggcggg gggacgccgc tgctgaacgg ggctgggcct
      181 ggggctgcgc gccagtcacc acgttctgcg cttttccgag tcggacatat gagcagcgtg
      241 gagctggatg atgaactttt ggacccggat atggaccctc cacatccctt ccccaaggag
      301 atcccacaca acgagaagct cctgtccctc aagtatgaga gcttggacta tgacaacagt
      361 gagaaccagc tgttcctgga ggaggagcgg cggatcaatc acacggcctt ccggacggtg
      421 gagatcaagc gctgggtcat ctgcgccctc attgggatcc tcacgggcct cgtggcctgc
      481 ttcattgaca tcgtggtgga aaacctggct ggcctcaagt acagggtcat caagggcaat
      541 atcgacaagt tcacagagaa gggcggactg tccttctccc tgttgctgtg ggccacgctg
      601 aacgccgcct tcgtgctcgt gggctctgtg attgtggctt tcatagagcc ggtggctgct
      661 ggcagcggaa tcccccagat caagtgcttc ctcaacgggg tgaagatccc ccacgtggtg
      721 cggctcaaga cgttggtgat caaagtgtcc ggtgtgatcc tgtccgtggt cgggggcctg
      781 gccgtgggaa aggaagggcc gatgatccac tcaggttcag tgattgccgc cgggatctct
      841 cagggaaggt caacgtcact gaaacgagat ttcaagatct tcgagtactt ccgcagagac
      901 acagagaagc gggacttcgt ctccgcaggg gctgcggccg gagtgtcagc ggcgtttgga
      961 gcccccgtgg gtggggtcct gttcagcttg gaggagggtg cgtccttctg gaaccagttc
     1021 ctgacctgga ggatcttctt tgcttccatg atctccacgt tcaccctgaa ttttgttctg
     1081 agcatttacc acgggaacat gtgggacctg tccagcccag gcctcatcaa cttcggaagg
     1141 tttgactcgg agaaaatggc ctacacgatc cacgagatcc cggtcttcat cgccatgggc
     1201 gtggtgggcg gtgtgcttgg agcagtgttc aatgccttga actactggct gaccatgttt
     1261 cgaatcaggt acatccaccg gccctgcctg caggtgattg aggccgtgct ggtggccgcc
     1321 gtcacggcca cagttgcctt cgtgctgatc tactcgtcgc gggattgcca gcccctgcag
     1381 gggggctcca tgtcctaccc gctgcagctc ttttgtgcag atggcgagta caactccatg
     1441 gctgcggcct tcttcaacac cccggagaag agcgtggtga gcctcttcca cgacccgcca
     1501 ggctcctaca accccctgac cctcggcctg ttcacgctgg tctacttctt cctggcctgc
     1561 tggacctacg ggctcacggt gtctgccggg gtcttcatcc cgtccctgct catcggggct
     1621 gcctggggcc ggctctttgg gatctccctg tcctacctca cgggggcggc gatctgggcg
     1681 gaccccggca aatacgccct gatgggagct gctgcccagc tgggcgggat tgtgcggatg
     1741 acactgagcc tgaccgtcat catgatggag gccaccagca acgtgaccta cggcttcccc
     1801 atcatgctgg tgctcatgac cgccaagatc gtgggcgacg tcttcattga gggcctgtac
     1861 gacatgcaca ttcagctgca gagtgtgccc ttcctgcact gggaggcccc ggtcacctca
     1921 cactcactca ctgccaggga ggtgatgagc acaccagtga cctgcctgag gcggcgtgag
     1981 aaggtcggcg tcattgtgga cgtgctgagc gacacggcgt ccaatcacaa cggcttcccc
     2041 gtggtggagc atgccgatga cacccagcct gcccggctcc agggcctgat cctgcgctcc
     2101 cagctcatcg ttctcctaaa gcacaaggtg tttgtggagc ggtccaacct gggcctggta
     2161 cagcggcgcc tgaggctgaa ggacttccga gacgcctacc cgcgcttccc acccatccag
     2221 tccatccacg tgtcccagga cgagcgggag tgcaccatgg acctctccga gttcatgaac
     2281 ccctccccct acacggtgcc ccaggaggcg tcgctcccac gggtgttcaa gctgttccgg
     2341 gccctgggcc tgcggcacct ggtggtggtg gacaaccgca atcaggttgt cgggttggtg
     2401 accaggaagg acctcgccag gtaccgcctg ggaaagagag gcttggagga gctctcgctg
     2461 gcccagacgt gaggcccagc cctgcccata atgggcactg gcgctggcac cccggccctt
     2521 ctgcatttcc tcccggagtc actggtttct cggcccaaac catgctcccc agcagtggca
     2581 atggcgagca ccctgcagct gggcgggcag gcggcaggcg cggaactgac cctctcgcgg
     2641 gactgaccct gttgtgggca gtggtctccc cccttggcgc ctccttgcgc aggcccagcc
     2701 tccactctcc tcgtctaggt ttctttacct ccagggatca gctgtgtgtg tgtgacctcc
     2761 ctaccgggct atcggcctct tgggagccag cggcagggcc ggcacctgcg tgcctgtgcc
     2821 cgtgtgcgtg agacagagcc cttgcccctg ctgctgcccc gagggctgcc ctgccctgga
     2881 agggcccctc tgcctccaca ccagtggagt cttcgagact tgggagctgc ttggcctcat
     2941 tttcagccat gagcagacgg cctgtggtcc ctgggcctga ggcacggact cgtagcacca
     3001 gggtttggag gctgcgaccg ccccggagag cagcttcaca ctggcgccac agaggagccc
     3061 cacgtgcact ccccggcctg catccggctt gggtacacag gcccagagga ctggggtgac
     3121 tcacgggccc tgtgctgtga tgttgagagc tgagaaaaac ctccaaggcc ctgagcccca
     3181 tgcccagccc tgccttggtc ccccaacccc cagagcttgg agtctgggcc ccacacccag
     3241 ccctgccttg gtccctgagc ctcagagcgt ggaattgctg ccctgtggac actggctggg
     3301 aaggcaggtc ttcccctagc acatggggac cccggcctcg agggtgacct ccctaccccg
     3361 cccctgccag ccaccaagcg caggtgcagc gggggccaga ctcctgccgg cctcagagga
     3421 cacctggccc agcacaggca gctagaaggg ccggtgggca ccggggccgg gaagccccca
     3481 cctcaccacc tgagggcccc tgggaggctc ctctggcctg gctgggctgg gtctggggcc
     3541 gccacaggcc cctcacgggg cggcagaggc aacttcagtg tccctgttag agcaacacgg
     3601 gtccctccgt ggggggctgg gtgcggcccc ctgccgtgta tttcctcccc agggagtggg
     3661 gcctccccgg gagctgacgc caccaccctg cttagccctc acagggcccc aaggtgtccg
     3721 agtgtgttgg gtctgaacgc gaaataaaga aatcctctca gcccgccttt gccagcgtcg
     3781 tccctcccac cccacccaga ccacgtccaa cagcctggga ctttcgggac cctggggtcg
     3841 gggcaccgtg tggagtgaga aaggcgtgaa agacagcggc tgcggccacc cagggcacca
     3901 gccacatcct cttcctcgtc cccgcccctc agcctccctc ctctggctcc tggctggtgg
     3961 gtctgggggc aaggcagagg cgctccaggt ggaggggggc gggccggggt gcccacgctg
     4021 gggtgacgca agaagaaaac tcccgggcct cagagtcggc gccggaaacc taggtctggg
     4081 tttccctcgt ggtggttgtg tactgaggac ctggaagtga tcatattttg gatatattcg
     4141 gttaaataaa atcagcggtt aggattca
//
