LOCUS       NM_001286               5589 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens chloride voltage-gated channel 6 (CLCN6), transcript
            variant 1, mRNA.
ACCESSION   NM_001286
VERSION     NM_001286.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5589)
  AUTHORS   Zhang,B., Zhang,S., Polovitskaya,M.M., Yi,J., Ye,B., Li,R.,
            Huang,X., Yin,J., Neuens,S., Balfroid,T., Soblet,J., Vens,D.,
            Aeby,A., Li,X., Cai,J., Song,Y., Li,Y., Tartaglia,M., Li,Y.,
            Jentsch,T.J., Yang,M. and Liu,Z.
  TITLE     Molecular basis of ClC-6 function and its impairment in human
            disease
  JOURNAL   Sci Adv 9 (41), eadg4479 (2023)
   PUBMED   37831762
  REMARK    GeneRIF: Molecular basis of ClC-6 function and its impairment in
            human disease.
REFERENCE   2  (bases 1 to 5589)
  AUTHORS   Sassi,C., Capozzo,R., Hammer,M., Zecca,C., Federoff,M.,
            Blauwendraat,C., Bernstein,N., Ding,J., Gibbs,J.R., Price,T.,
            Singleton,A. and Logroscino,G.
  TITLE     Exploring dementia and neuronal ceroid lipofuscinosis genes in 100
            FTD-like patients from 6 towns and rural villages on the Adriatic
            Sea cost of Apulia
  JOURNAL   Sci Rep 11 (1), 6353 (2021)
   PUBMED   33737586
  REMARK    GeneRIF: Exploring dementia and neuronal ceroid lipofuscinosis
            genes in 100 FTD-like patients from 6 towns and rural villages on
            the Adriatic Sea cost of Apulia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5589)
  AUTHORS   Polovitskaya,M.M., Barbini,C., Martinelli,D., Harms,F.L.,
            Cole,F.S., Calligari,P., Bocchinfuso,G., Stella,L., Ciolfi,A.,
            Niceta,M., Rizza,T., Shinawi,M., Sisco,K., Johannsen,J.,
            Denecke,J., Carrozzo,R., Wegner,D.J., Kutsche,K., Tartaglia,M. and
            Jentsch,T.J.
  TITLE     A Recurrent Gain-of-Function Mutation in CLCN6, Encoding the ClC-6
            Cl-/H+-Exchanger, Causes Early-Onset Neurodegeneration
  JOURNAL   Am J Hum Genet 107 (6), 1062-1077 (2020)
   PUBMED   33217309
  REMARK    GeneRIF: A Recurrent Gain-of-Function Mutation in CLCN6, Encoding
            the ClC-6 Cl(-)/H(+)-Exchanger, Causes Early-Onset
            Neurodegeneration.
REFERENCE   4  (bases 1 to 5589)
  AUTHORS   Yu,B., Pulit,S.L., Hwang,S.J., Brody,J.A., Amin,N., Auer,P.L.,
            Bis,J.C., Boerwinkle,E., Burke,G.L., Chakravarti,A., Correa,A.,
            Dreisbach,A.W., Franco,O.H., Ehret,G.B., Franceschini,N.,
            Hofman,A., Lin,D.Y., Metcalf,G.A., Musani,S.K., Muzny,D.,
            Palmas,W., Raffel,L., Reiner,A., Rice,K., Rotter,J.I.,
            Veeraraghavan,N., Fox,E., Guo,X., North,K.E., Gibbs,R.A., van
            Duijn,C.M., Psaty,B.M., Levy,D., Newton-Cheh,C. and Morrison,A.C.
  CONSRTM   CHARGE Consortium and the National Heart, Lung, and Blood Institute
            GO ESP*
  TITLE     Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels
            and Hypertension Risk
  JOURNAL   Circ Cardiovasc Genet 9 (1), 64-70 (2016)
   PUBMED   26658788
  REMARK    GeneRIF: These findings implicate the effect of rare coding
            variants in CLCN6 in Blood Pressure variation and offer new
            insights into Blood Pressure regulation.
REFERENCE   5  (bases 1 to 5589)
  AUTHORS   Lamb,F.S., Graeff,R.W., Clayton,G.H., Smith,R.L., Schutte,B.C. and
            McCray,P.B. Jr.
  TITLE     Ontogeny of CLCN3 chloride channel gene expression in human
            pulmonary epithelium
  JOURNAL   Am J Respir Cell Mol Biol 24 (4), 376-381 (2001)
   PUBMED   11306429
REFERENCE   6  (bases 1 to 5589)
  AUTHORS   Kornak,U., Bosl,M.R. and Kubisch,C.
  TITLE     Complete genomic structure of the CLCN6 and CLCN7 putative chloride
            channel genes(1)
  JOURNAL   Biochim Biophys Acta 1447 (1), 100-106 (1999)
   PUBMED   10500249
REFERENCE   7  (bases 1 to 5589)
  AUTHORS   Lamb,F.S., Clayton,G.H., Liu,B.X., Smith,R.L., Barna,T.J. and
            Schutte,B.C.
  TITLE     Expression of CLCN voltage-gated chloride channel genes in human
            blood vessels
  JOURNAL   J Mol Cell Cardiol 31 (3), 657-666 (1999)
   PUBMED   10198195
REFERENCE   8  (bases 1 to 5589)
  AUTHORS   Eggermont,J.
  TITLE     The exon-intron architecture of human chloride channel genes is not
            conserved
  JOURNAL   Biochim Biophys Acta 1397 (2), 156-160 (1998)
   PUBMED   9565675
REFERENCE   9  (bases 1 to 5589)
  AUTHORS   Eggermont,J., Buyse,G., Voets,T., Tytgat,J., De Smedt,H.,
            Droogmans,G. and Nilius,B.
  TITLE     Alternative splicing of ClC-6 (a member of the CIC chloride-channel
            family) transcripts generates three truncated isoforms one of
            which, ClC-6c, is kidney-specific
  JOURNAL   Biochem J 325 (Pt 1) (Pt 1), 269-276 (1997)
   PUBMED   9224655
REFERENCE   10 (bases 1 to 5589)
  AUTHORS   Brandt,S. and Jentsch,T.J.
  TITLE     ClC-6 and ClC-7 are two novel broadly expressed members of the CLC
            chloride channel family
  JOURNAL   FEBS Lett 377 (1), 15-20 (1995)
   PUBMED   8543009
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL953897.6 and AL021155.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_001286.4.
            
            Summary: This gene encodes a member of the voltage-dependent
            chloride channel protein family. Members of this family can
            function as either chloride channels or antiporters. This protein
            is primarily localized to late endosomes and functions as a
            chloride/proton antiporter. Alternate splicing results in both
            coding and non-coding variants. Additional alternately spliced
            variants have been described but their full-length structure is
            unknown. [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) is the longest transcript and
            encodes the longer isoform (1). This isoform is also known as
            CLC-6a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289999.1, D28475.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000346436.11/ ENSP00000234488.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AL953897.6         92215-92373
            160-219             AL953897.6         93155-93214
            220-285             AL953897.6         101870-101935
            286-351             AL021155.1         2129-2194
            352-418             AL021155.1         5002-5068
            419-525             AL021155.1         8209-8315
            526-652             AL021155.1         9221-9347
            653-720             AL021155.1         10000-10067
            721-779             AL021155.1         11670-11728
            780-912             AL021155.1         12603-12735
            913-1026            AL021155.1         13620-13733
            1027-1193           AL021155.1         13972-14138
            1194-1320           AL021155.1         14710-14836
            1321-1444           AL021155.1         19029-19152
            1445-1598           AL021155.1         19391-19544
            1599-1758           AL021155.1         19750-19909
            1759-1865           AL021155.1         19998-20104
            1866-2052           AL021155.1         21481-21667
            2053-2210           AL021155.1         22513-22670
            2211-2367           AL021155.1         22857-23013
            2368-2475           AL021155.1         23849-23956
            2476-2601           AL021155.1         24049-24174
            2602-5589           AL021155.1         25657-28644
FEATURES             Location/Qualifiers
     source          1..5589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..5589
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /note="chloride voltage-gated channel 6"
                     /db_xref="GeneID:1185"
                     /db_xref="HGNC:HGNC:2024"
                     /db_xref="MIM:602726"
     exon            1..159
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..2682
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chloride transport protein 6; H(+)/Cl(-) exchange
                     transporter 6; chloride channel, voltage-sensitive 6"
                     /codon_start=1
                     /product="H(+)/Cl(-) exchange transporter 6 isoform 1"
                     /protein_id="NP_001277.2"
                     /db_xref="CCDS:CCDS138.1"
                     /db_xref="GeneID:1185"
                     /db_xref="HGNC:HGNC:2024"
                     /db_xref="MIM:602726"
                     /translation="MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILP
                     RKDYESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFV
                     RLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIP
                     EVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVEKEGPMIHSGSVVGAGLPQFQ
                     SISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGL
                     TWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDL
                     GFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVA
                     SMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAI
                     LQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLK
                     SYIGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKW
                     TGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSI
                     LRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRSQSMKSYP
                     SSELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLT
                     FHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPR
                     MIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYE
                     FLQARLRQHYQTI"
     exon            160..219
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            220..285
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            286..351
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            352..418
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            419..525
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            526..652
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            653..720
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            721..779
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            780..912
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1026
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1193
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1320
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1444
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1598
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1758
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1865
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2052
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2210
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2367
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2475
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2601
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..5589
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5570..5575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /note="hexamer: AATAAA"
     polyA_site      5589
                     /gene="CLCN6"
                     /gene_synonym="CLC-6; CONRIBA"
                     /note="major polyA site"
ORIGIN      
        1 agtcacgtga ggcgcagatc ctggctggga gggggttggt agaggggtcc agagtggcag
       61 taaaggagga agatggcggg gtgcaggggg tctctgtgct gctgctgcag gtggtgctgc
      121 tgctgcggtg agcgtgagac ccgcaccccc gaggagctga ccatccttgg agaaacacag
      181 gaggaggagg atgagattct tccaaggaaa gactatgaga gtttggatta tgatcgctgt
      241 atcaatgacc cttacctgga agttttggag accatggata ataagaaagg tcgaagatat
      301 gaggcggtga agtggatggt ggtgtttgcc attggagtct gcactggcct ggtgggtctc
      361 tttgtggact tttttgtgcg actcttcacc caactcaagt tcggagtggt acagacatcg
      421 gtggaggagt gcagccagaa aggctgcctc gctctgtctc tccttgaact cctgggtttt
      481 aacctcacct ttgtcttcct ggcaagcctc cttgttctca ttgagccggt ggcagcaggt
      541 tccgggatac ccgaggtcaa atgctatctg aatggcgtaa aggtgccagg aatcgtccgt
      601 ctccggaccc tgctctgcaa ggtccttgga gtgctgttca gtgtggctgg agggctcttc
      661 gtggagaagg aaggccccat gatccacagt ggttcggtgg tgggagctgg cctccctcag
      721 tttcagagca tctccttacg gaagatccag tttaacttcc cctatttccg aagcgacaga
      781 gacaagagag actttgtatc agcaggagcg gctgctggag ttgctgcagc tttcggggcg
      841 ccaatcgggg gtaccttgtt cagtctagag gagggttcgt ccttctggaa ccaagggctc
      901 acgtggaaag tgctcttttg ttccatgtct gccaccttca ccctcaactt cttccgttct
      961 gggattcagt ttggaagctg gggttccttc cagctccctg gattgctgaa ctttggcgag
     1021 tttaagtgct ctgactctga taaaaaatgt catctctgga cagctatgga tttgggtttc
     1081 ttcgtcgtga tgggggtcat tgggggcctc ctgggagcca cattcaactg tctgaacaag
     1141 aggcttgcaa agtaccgtat gcgaaacgtg cacccgaaac ctaagctcgt cagagtctta
     1201 gagagcctcc ttgtgtctct ggtaaccacc gtggtggtgt ttgtggcctc gatggtgtta
     1261 ggagaatgcc gacagatgtc ctcttcgagt caaatcggta atgactcatt ccagctccag
     1321 gtcacagaag atgtgaattc aagtatcaag acattttttt gtcccaatga tacctacaat
     1381 gacatggcca cactcttctt caacccgcag gagtctgcca tcctccagct cttccaccag
     1441 gatggtactt tcagccccgt cactctggcc ttgttcttcg ttctctattt cttgcttgca
     1501 tgttggactt acggcatttc tgttccaagt ggcctttttg tgccttctct gctgtgtgga
     1561 gctgcttttg gacgtttagt tgccaatgtc ctaaaaagct acattggatt gggccacatc
     1621 tattcgggga cctttgccct gattggtgca gcggctttct tgggcggggt ggtccgcatg
     1681 accatcagcc tcacggtcat cctgatcgag tccaccaatg agatcaccta cgggctcccc
     1741 atcatggtca cactgatggt ggccaaatgg acaggggact ttttcaataa gggcatttat
     1801 gatatccacg tgggcctgcg aggcgtgccg cttctggaat gggagacaga ggtggaaatg
     1861 gacaagctga gagccagcga catcatggag cccaacctga cctacgtcta cccgcacacc
     1921 cgcatccagt ctctggtgag catcctgcgc accacggtcc accatgcctt cccggtggtc
     1981 acagagaacc gcggtaacga gaaggagttc atgaagggca accagctcat cagcaacaac
     2041 atcaagttca agaaatccag catcctcacc cgggctggcg agcagcgcaa acggagccag
     2101 tccatgaagt cctacccatc cagcgagcta cggaacatgt gtgatgagca catcgcctct
     2161 gaggagccag ccgagaagga ggacctcctg cagcagatgc tggaaaggag atacactccc
     2221 taccccaacc tataccctga ccagtcccca agtgaagact ggaccatgga ggagcggttc
     2281 cgccctctga ccttccacgg cctgatcctt cggtcgcagc ttgtcaccct gcttgtccga
     2341 ggagtttgtt actctgaaag ccagtcgagc gccagccagc cgcgcctctc ctatgccgag
     2401 atggccgagg actacccgcg gtaccccgac atccacgacc tggacctgac gctgctcaac
     2461 ccgcgcatga tcgtggatgt caccccatac atgaaccctt cgcctttcac cgtctcgccc
     2521 aacacccacg tctcccaagt cttcaacctg ttcagaacga tgggcctgcg ccacctgccc
     2581 gtggtgaacg ctgtgggaga gatcgtgggg atcatcacac ggcacaacct cacctatgaa
     2641 tttctgcagg cccggctgag gcagcactac cagaccatct gacagcccag cccaccctct
     2701 cctggtgctg cctggggagg caaatcatgc tcactccggc gggcacagct ggctggggct
     2761 gttccggggc atggaagatt cccagtcacc cactcactca gaaagccggg agtcatcgga
     2821 caccttgctg gtcagaggtc ctgggggtgg ttttgaacca tcagagcttg gacttttctg
     2881 acttccccag caaggatctt cccacttcct gctccctgtg ttcccaccct ccagtgttgg
     2941 cacaggccca cccctggctc caccagagcc agaagcagag gtagaatcag gcgggccccg
     3001 ggctgcactc cgagcagtgt tcctggccat ctttgctact ttcctagaga acccggctgt
     3061 tgccttaaat gtgtgagagg gacttggcca aggcaaaagc tggggagatg ccagtgacaa
     3121 catacagttc atgactaggt ttaggaattg ggcactgaga aaattctcaa tatttcagag
     3181 agtccttccc ttatttggga ctcttaacac ggtatcctcg ctagttggtt ttaagggaaa
     3241 cactctgctc ctgggtgtga gcagaggctc tggtcttgcc ctgtggtttg actctcctta
     3301 gaaccaccgc ccaccagaaa cataaaggat taaaatcaca ctaataaccc ctggatggtc
     3361 aatctgataa taggatcaga tttacgtcta ccctaattct taacattgca gctttctctc
     3421 catctgcaga ttattcccag tctcccagta acacgtttct acccagatcc tttttcattt
     3481 ccttaagttt tgatctccgt cttcctgatg aagcaggcag agctcagagg atcttggcat
     3541 cacccaccaa agttagctga aagcagggca ctcctggata aagcagcttc actcaactct
     3601 ggggaatgct accatttttt ttccaaagta gaaaggaagc acttctgagc cagtgaccac
     3661 tgaaaggtat gtgctatgat aaagcagatg gcctatttga ggaagagggt gtctgccctt
     3721 cacaaacacc tctctctccc ctgcactagc tgtcccaagc ttacatacag aggcccttca
     3781 ggagggcctc ctgtgccgca gggagggtgc gtggggaaga tgcttcctgc cagcacgtgc
     3841 ctgaaggttt cacatgaagc atgggaagcg caccctgtcg ttcagtgacg tcattcttct
     3901 ccaggctggc ccgccccctc tgactaggca cccaaagtga gcatctgggc attgggcatt
     3961 catgcttatc ttcccccacc ttctacatgg tattagtccc agcaggcatc cctggggcag
     4021 acgtgctttg gctcaagatg gccttcattt acgtttagtt ttttttaaaa ccgtggaggt
     4081 tgcccacggg cctcggcacc tggccctggc agcacagctc tcaggcccag ccctgggcga
     4141 cctccttggc caagtctgcc tttcaccctg gggtgagcat cagtcctggc tctgctggtc
     4201 cagatcttgc gctcagcaca ctctagggaa taattccact ccagagatgg ggctgcttca
     4261 aggtcttttc tagctgattg tggcccctcc attttcccca ttttcttatc tccctgacca
     4321 aaattgcttt gacttctaaa tgtttctgct tcccagaatg cacctgactt atgaaatggg
     4381 gataatactc ccaggaaata gcgcaggaca tcacaaggac caaaaaggca attcttattt
     4441 aaatgttact atttggccag ctgctgctgt gttttatggc agtgttcaga gcttgatcac
     4501 gttatttctt ccttttatta agaaggaagc caattgtcca agtcaggaga atggtgtgat
     4561 cacctgtcac agacactttg tcccctctcc ccgccccttc ctggagctgg cagagctaac
     4621 gccctgcagg aggaccccgg cctctcgagg gctggatcag cagccgcctg ccctgaggct
     4681 gccccggtga atgttattgg aattcatccc tcgtgcacat cctgttgtgt ttaagtcacc
     4741 agatattttg ttcccatcag tttagcccag agatagacag tagaatgcaa atacctccct
     4801 cccctaaact gactggacgg ctgccaagga ggccccaaac ccaggcccca tgcaaaggca
     4861 cgtggtttcc ttttctcctc tctctgcatc tgcgctttcc agataagccc aaagacagca
     4921 acttctccac tcatgacaaa tcaactgtga ccctcgctcc ttccatttct gtccattaga
     4981 aaccagcctt ttcagcatct cacccattag cagccccatc acccagtgat cagtcgcctc
     5041 agtaaagcag atctgtggat ggggagccta cgggtggtaa gaagtggtgt tttgtgtttc
     5101 atctccagct tggtgttcca tggcccctag gcgaggtgat cagggagtgg ggccaatggg
     5161 cccccggccc tggctttggg accttgtgct gagggatgat ttgctcctga ccttgattaa
     5221 cttaacagtt cccagctgga agggacactt tcaggaccca gtccactgta tggcatttgt
     5281 gatgcagaat tatgcactga catgaccctg ggtgacagga aagcctttcg agaggcccaa
     5341 ggtggcctcg ccagccctgc agtattgatg tgcagtattg caccacagct ctgcggacct
     5401 tggccattgc cgcagtcgca gcttcctttt ttctgtttgc actgtttgtt tgtatgatgt
     5461 tagctaattc cactgtgtat ataaattgta ttttttttaa tttgtaaaat gctattttta
     5521 tttgaacctt tggaacttgg gagttctcat tgtaacccta acatgtgaga ataaaatgtc
     5581 ttctgtctc
//
