LOCUS       XM_011512401            6968 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens chloride voltage-gated channel 2 (CLCN2),
            transcript variant X2, mRNA.
ACCESSION   XM_011512401
VERSION     XM_011512401.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011512401.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6968
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..6968
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /note="chloride voltage-gated channel 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 29 ESTs, 39 long SRA reads, and 90% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     9 samples with support for all annotated introns"
                     /db_xref="GeneID:1181"
                     /db_xref="HGNC:HGNC:2020"
                     /db_xref="MIM:600570"
     CDS             127..2634
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /codon_start=1
                     /product="chloride channel protein 2 isoform X2"
                     /protein_id="XP_011510703.1"
                     /db_xref="GeneID:1181"
                     /db_xref="HGNC:HGNC:2020"
                     /db_xref="MIM:600570"
                     /translation="MAAAAAEEGMEPRALQYEQTLMYGRYTQDLGAFAKEEAARIRLG
                     GPEPWKGPPSSRAAPELLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMA
                     LVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAV
                     GSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAAL
                     LSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYW
                     RGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFG
                     GALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLS
                     QKETLVTLFDNRTWVRQGLVEELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALAT
                     TIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALA
                     GAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLP
                     ELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILL
                     GSIERSQVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDS
                     AFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESAGIALRSLFCGSPPPEAASEK
                     LESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLV
                     ERTSLHKPCPRGNSGPTKQQRQGLSWVEARRPGQGQS"
     polyA_site      6968
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gcactctgct ctcggcctcc cgggctgcgg ggacgggacg gctgccggcg cggactttgc
       61 gggccgggag ccgagtccag gacagagccg gaaccgccga gggaggcgag agggcagtgc
      121 gcggagatgg cggccgcggc ggcggaggaa gggatggagc cacgggcgct gcagtacgag
      181 cagaccctga tgtatggccg gtacactcag gaccttgggg cctttgccaa agaggaagct
      241 gctcggattc gcctgggagg gcctgaaccc tggaaaggtc ccccttcctc tcgggctgcc
      301 ccagagctct tggaatatgg acggagccgt tgcgcccgat gccgcgtctg ttctgtccgc
      361 tgccacaagt tcctagtatc cagggttggt gaagattgga tcttcctggt cctgctgggg
      421 cttctcatgg cattggtcag ctgggtcatg gactatgcca ttgctgcctg tctgcaagcc
      481 cagcagtgga tgtcccgggg cttgaacacc agcatcttgc tccagtacct ggcctgggtc
      541 acctaccctg ttgtcctcat cactttctca gccggattca cacagatcct ggcccctcag
      601 gctgtcggct ctggcatccc tgagatgaag accatcttgc ggggagtggt gctgaaagaa
      661 tacctcacac tcaagacctt tatagctaag gtcattgggc tgacctgcgc cctaggcagc
      721 gggatgccgc ttggcaaaga gggccctttt gtgcatatcg caagcatgtg tgctgccctt
      781 ctcagcaagt tcctctccct ctttgggggt atctatgaga atgaatcccg gaacacagag
      841 atgctggctg ccgcctgtgc cgtgggggtg ggctgctgct tcgcggcacc tattggaggc
      901 gtcctcttca gcatcgaggt cacctccacc ttctttgcag tgcggaacta ctggcggggc
      961 ttcttcgctg ccaccttcag tgccttcatc ttccgggtct tggcagtctg gaaccgggat
     1021 gaagagacta ttacagccct cttcaaaacc cgattccggc tcgacttccc ctttgacctg
     1081 caggagctgc cagcctttgc tgtcattggt attgctagtg gcttcggtgg agccctcttt
     1141 gtctacctga accggaagat tgtccaggtg atgcggaagc agaaaaccat caatcgcttc
     1201 ctcatgagga aacgcctgct cttcccggct ctggtgaccc tgctcatctc cacgctgacc
     1261 ttcccccctg gctttggaca gttcatggct ggacagctct cacagaaaga gacgctggtc
     1321 accctgtttg acaatcggac gtgggtccgc cagggcctgg tggaggagct agaaccaccc
     1381 agcacctcac aggcctggaa cccaccacgt gccaacgtct tcctcaccct ggtcatcttc
     1441 attctcatga agttctggat gtctgcactg gccaccacca tcccagttcc ctgtggggcc
     1501 ttcatgcctg tctttgtcat tggagcagca tttgggcgtc tggtgggtga aagcatggct
     1561 gcctggttcc cagatggaat tcatacggac agcagcacct accggattgt gcctgggggc
     1621 tacgctgtgg tcggggcagc tgcgctggca ggagcggtga cacacacagt gtccacggct
     1681 gtgatcgtgt tcgagctcac aggccagatt gcccacatcc tgcctgtcat gatcgccgtc
     1741 atcctggcca acgctgtcgc ccagagtctg cagccctccc tctatgacag catcatccga
     1801 atcaagaaac tgccctacct gcctgagctc ggctggggcc gccaccagca gtaccgggtg
     1861 cgtgtggagg acatcatggt gcgggatgtt ccccatgtgg ccctcagctg caccttccgg
     1921 gacctgcgtt tggcactgca caggaccaag ggccgaatgc tggccctagt ggagtcccct
     1981 gagtccatga ttctgctggg ctccatcgag cgttcacagg tggtggcatt gttgggggcc
     2041 cagctgagcc cagcccgccg gcggcagcac atgcaggagc gcagagccac ccagacctct
     2101 ccactatctg atcaggaggg tccccctacc cctgaggctt ctgtctgctt ccaggtgaac
     2161 acagaagact cagccttccc agcagcccgg ggggagaccc acaagcccct aaagcctgca
     2221 ctcaagaggg ggcccagtgt caccaggaac ctcggagaga gtcccacagg gagcgcagag
     2281 tcggcaggca tcgccctccg gagcctcttc tgtggcagtc caccccctga ggctgcttcg
     2341 gagaagttgg aatcctgtga gaagcgcaag ctgaagcgtg tccgaatctc cctggcaagt
     2401 gacgcggacc tggaaggcga gatgagccct gaagagattc tggagtggga ggagcagcaa
     2461 ctagatgaac ctgtcaactt cagtgactgc aaaattgatc ctgctccctt ccagctggtg
     2521 gagcggacct ctttgcacaa gccttgccct cgagggaact ctggaccaac gaagcaacaa
     2581 agacagggat tgagctgggt ggaagccaga aggccaggcc agggtcagag ctaggcggga
     2641 ggccaccaca gcccagcaag gttgatacgc ccatgcggaa aaaaacgggt gagaaacagg
     2701 caggataaga aaatgcaata aacaagccaa caaacatcca agtaggggtg gggagactgc
     2761 agagtagaga taaacaaaga tgagaaacac ccagtggggg gcttggaatg ccagacccca
     2821 gaaagtctgc cttaatgtgg gccgaaggaa aactggtacg gacgcgggaa gatggctcag
     2881 cagaactgca aagcagcctg cagaaatgcg gcgaggaact gagcagactg cctggggtgg
     2941 gcgaggcaga ccccagagga ggccaggagc tctctgcgtc caggactcct aaggggggca
     3001 gcctgcattg gtaaaatggc tcctgggacc agcagaagcc aaggggtgtt ttagctaaac
     3061 ttttgacagg cataatgtac aagccttgaa gcgttggggg gtttggggga ggggataagc
     3121 agcaggtaga tgtacccaaa acctgcagct tgggcattca gcttacacac aagctctgcc
     3181 taagagccag tatagcatgg acaagcggag actgaggcag gaagcatagg ggacaaaaga
     3241 gaaacaaaaa ggcaaaaata aaggaactta gaagtccttg gatgagtggc aaactgcagt
     3301 gcagttgcaa gaaaaaaggt aataggcctg agagggcttt tatctaaagc ccttcttccc
     3361 aaaacctctg aggcctttcc acaatgatct tactcctcaa acatccatga tgatgatcat
     3421 gctgacattt ttcgagtgct tgctatgtgc gagacactgt gctaagctct tcaactgttt
     3481 aatcatcaca agcacgcact tagatattgc gatcctccag tttttataga taagaaaact
     3541 gagattcaga gaggttgagc aagttgcaca aggacacaca gctaataagt agcagaactg
     3601 gcgcagtggc ttacacctgt aatcccagca ctttgggagg ctgcagcagg tggatcactt
     3661 gaggtcagca gttcgagacc agcctggcca acatggtgaa actccatctc tactaaaaat
     3721 acaaaaaatt agccaggcgt ggtggcaggc acctgtaatc ccagctacat gggaggctga
     3781 ggcaggagaa ttgcttgaac atgggaggtg gacgttgcag tgagccgaga tcatgacact
     3841 gcactccagc atgggtgaca aaagcgaaac tccatctcaa aaaaataata ataagtagca
     3901 gaactgggcc tggaatctag gatggtctga ctcaaaagcc tgtggcctta accatattaa
     3961 tacacaggga aactgaggca tgcagcgagg aggtcacgtg cctgagtcag cacagcagag
     4021 tcaggcccag agcccagatt tcctggccct gctcccagga ttctttcaga aggccatgtt
     4081 gtccctctcc atgtcagttc actgttccca ggcccaagaa gtatgggccc tccaatgggt
     4141 tccatgatgt ctaattgaat taaatgaaaa agaacaaagt agatatttgt tacaaactta
     4201 aaaatcagaa gagaagaagt ctttgaggaa ccaactaaca aaagtacaaa gaactagaag
     4261 tgataagaac ataaaagatt agaattcaaa atgtccttac aggcctgagg aatcaatagg
     4321 tagtcgccca attaagttca ggaggggaac attcagataa gagagagaaa acactggaga
     4381 ctacttagga acccgtgcaa ctggagatcg ctgtgccggc taataagtaa ttcattcaga
     4441 ggccacccac ggagaagcaa tggtaaaggc cagagtggcg gccacagcta gggccagacc
     4501 aactgaaccc aaatccttac tctgccacat gctggcttgc tgtgtacctt ggtaagtttc
     4561 ttagcctctc tgtgcttcac tttcccgatc tgtaaaatgg ggatcacacc tcactgggtt
     4621 ttctaagaat taaaggactt gaaacatgtg aagcacttac aatagggcct agcacacagt
     4681 aaatactcaa tatatgttag gaattactgt tactactcct actacttata ctgagagatg
     4741 aattttaaaa gatagcatat gctgggcatg gtggtgggca cctgtagtcc aagctactca
     4801 ggaggctgag gtgggaggac tgcacgagcc caggagttca agtccaacct gggcaacata
     4861 gtgagactgt cttctaacac aaaaatttta tttatttatt tatttttaga cggagtctca
     4921 ctctgtcacc aggctggagt gcaatggtgc gatcttggct cactgcaacc tccacctccc
     4981 aggttcaagt gattctcctg cctcagccct cccgagtagc cgggattaca ggagcgtgcc
     5041 accacgtctg actaattttt tatattttta gtagagacag ggttttacca tgttggccag
     5101 gcatgagcca ctgcgcccgg cccagaaaat ttttttaact aaaaaaaatt gtttaaaaaa
     5161 aatactgtaa tgagagaaga gctgaagtgt ggaagaaatg aatgttttca gaaaaagaag
     5221 agtgattatg tgaagctgca ggctggaagc tggagtacac agtagaatgt gaggctataa
     5281 agacaggctg gggttggctt gggaagggtc tcatgggcct tctagggagt ctgggctgta
     5341 ctcaagtttg acaaagggca taggataagc agggccagac tggagggaag ggaggcagaa
     5401 agaacccatc aggctgttgc agccccagtc ttagtgagga tagtgaggct acagtcagta
     5461 atggccagga tgtttaggaa gtgaattggt aaggcttggt gactgtcagg ggcaagtggt
     5521 ttgcaaacct gaaaggcata tcgcccgcca gaagctcacc tggttaggat tgtggagaaa
     5581 aagaaaattc aagggaacta tttaataggc tccttgggag aagatgagag gggttatttg
     5641 accataagaa gacaaggcta agggattagt aacataggaa gccttataat aaaagcgttt
     5701 ccctctgaag tcagacaagg aaattaaagc taacttgtag cacgtaggac tccagttagc
     5761 cagaaggaat cgctaaccac atgacaactg tgttataggt attcaagaaa cacagaagaa
     5821 cttttttttt tttttttttt tgagacgaca gcgtctcact ctgtcaccca ggctggagtg
     5881 cagtggcacg atcatggctc actatagcct ctgcctcctg ggctcaggtg atcctcacaa
     5941 ctcagcgccc ccaagtagct gggactgcag gcatgcacca ctatgtctgg ctttttgtgg
     6001 agacagggtt tcgcatattg caggctagtc tcaaactcct gggctcaagc attctacccg
     6061 ccttggcctc ccagagtgct aggattacag gcatgagcca tcgcgcccag aagagcttat
     6121 tctaaaattg aacttcttgc ccctctaagt actgtcatgc catgggtgga gaaatttagg
     6181 aaagttctgg aaatccctcc ctaaagaatt tcaaatgtgt aagaacattt aaaaagtgtt
     6241 aaggcaattt aagtgagttc tgagtaattg gtacacaaga agctgttatt actgctcatc
     6301 ttgattcaaa cattaagcga agaggcttac aagtaaactc agaacagtga gataaatgat
     6361 aggccaaaaa ttccaggaac tgctgagtca ggagagcgtt tttcaagaca tctggcccca
     6421 agaaaatcta cttaaagcat aaggagaact ggctgacaat ttctgaaccc ctggtgatta
     6481 tatgtgaaag cttaggggag ggcttaaagc aagaaaaaca tgggaagatg ggggtgaccg
     6541 ttgtcctcct ggactgcaag ctgcatctca acagaacttg ggatgctgct tggaccctag
     6601 aaaaggcaga ctgtatgaga ggcatagcgt gcttcaggcc aagactggaa tgccagagca
     6661 ggggagagag actccaaacc tggccagcca ggtaggaggg caactgagaa gcagtggaac
     6721 gagaggcata ggattcaggg cccaagtgcc cttaaggtcg gtgtgggctc tcccttctcg
     6781 gtatatctgc aactaaacag gactggggtt gtgcgtccct ctccggtgtg atgaaaagtg
     6841 actggggctg cacagccact cctgaggacc cgcctggaac aagtcacttc actgttgagc
     6901 cccatgctgc ttctcctaat gcttagttct caggacagta ctggaattaa atgataatgt
     6961 aagaccta
//
