LOCUS       NM_004366               3244 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens chloride voltage-gated channel 2 (CLCN2), transcript
            variant 1, mRNA.
ACCESSION   NM_004366
VERSION     NM_004366.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3244)
  AUTHORS   Xu,M., Neelands,T., Powers,A.S., Liu,Y., Miller,S.D.,
            Pintilie,G.D., Bois,J.D., Dror,R.O., Chiu,W. and Maduke,M.
  TITLE     CryoEM structures of the human CLC-2 voltage-gated chloride channel
            reveal a ball-and-chain gating mechanism
  JOURNAL   Elife 12, 90648 (2024)
   PUBMED   38345841
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3244)
  AUTHORS   Xu,P., Chen,Z., Ma,J., Shan,Y., Wang,Y., Xie,B., Zheng,D., Guo,F.,
            Song,X., Gao,G., Ye,K., Liu,Y., Pan,G., Jiang,B., Peng,F. and
            Zhong,X.
  TITLE     Biallelic CLCN2 mutations cause retinal degeneration by impairing
            retinal pigment epithelium phagocytosis and chloride channel
            function
  JOURNAL   Hum Genet 142 (4), 577-593 (2023)
   PUBMED   36964785
  REMARK    GeneRIF: Biallelic CLCN2 mutations cause retinal degeneration by
            impairing retinal pigment epithelium phagocytosis and chloride
            channel function.
REFERENCE   3  (bases 1 to 3244)
  AUTHORS   Jeworutzki,E., Tuttelmann,F., Rothenberg,I., Pusch,M.,
            Schreiber,J.A., Kliesch,S., Wunsch,B., Strutz-Seebohm,N. and
            Seebohm,G.
  TITLE     Can Unlikely Neanderthal Chloride Channel CLC-2 Gene Variants
            Provide Insights in Modern Human Infertility?
  JOURNAL   Cell Physiol Biochem 55 (3), 301-310 (2021)
   PUBMED   34148308
  REMARK    GeneRIF: Can Unlikely Neanderthal Chloride Channel CLC-2 Gene
            Variants Provide Insights in Modern Human Infertility?
REFERENCE   4  (bases 1 to 3244)
  AUTHORS   Fu,S.J., Hu,M.C., Hsiao,C.T., Cheng,A.T., Chen,T.Y., Jeng,C.J. and
            Tang,C.Y.
  TITLE     Regulation of ClC-2 Chloride Channel Proteostasis by Molecular
            Chaperones: Correction of Leukodystrophy-Associated Defect
  JOURNAL   Int J Mol Sci 22 (11), 5859 (2021)
   PUBMED   34070744
  REMARK    GeneRIF: Regulation of ClC-2 Chloride Channel Proteostasis by
            Molecular Chaperones: Correction of Leukodystrophy-Associated
            Defect.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3244)
  AUTHORS   Lamb,F.S., Graeff,R.W., Clayton,G.H., Smith,R.L., Schutte,B.C. and
            McCray,P.B. Jr.
  TITLE     Ontogeny of CLCN3 chloride channel gene expression in human
            pulmonary epithelium
  JOURNAL   Am J Respir Cell Mol Biol 24 (4), 376-381 (2001)
   PUBMED   11306429
REFERENCE   6  (bases 1 to 3244)
  AUTHORS   Lafferty,A.R., Torpy,D.J., Stowasser,M., Taymans,S.E., Lin,J.P.,
            Huggard,P., Gordon,R.D. and Stratakis,C.A.
  TITLE     A novel genetic locus for low renin hypertension: familial
            hyperaldosteronism type II maps to chromosome 7 (7p22)
  JOURNAL   J Med Genet 37 (11), 831-835 (2000)
   PUBMED   11073536
REFERENCE   7  (bases 1 to 3244)
  AUTHORS   Sander,T., Schulz,H., Saar,K., Gennaro,E., Riggio,M.C., Bianchi,A.,
            Zara,F., Luna,D., Bulteau,C., Kaminska,A., Ville,D., Cieuta,C.,
            Picard,F., Prud'homme,J.F., Bate,L., Sundquist,A., Gardiner,R.M.,
            Janssen,G.A., de Haan,G.J., Kasteleijn-Nolst-Trenite,D.G.,
            Bader,A., Lindhout,D., Riess,O., Wienker,T.F., Janz,D. and Reis,A.
  TITLE     Genome search for susceptibility loci of common idiopathic
            generalised epilepsies
  JOURNAL   Hum Mol Genet 9 (10), 1465-1472 (2000)
   PUBMED   10888596
REFERENCE   8  (bases 1 to 3244)
  AUTHORS   Lamb,F.S., Clayton,G.H., Liu,B.X., Smith,R.L., Barna,T.J. and
            Schutte,B.C.
  TITLE     Expression of CLCN voltage-gated chloride channel genes in human
            blood vessels
  JOURNAL   J Mol Cell Cardiol 31 (3), 657-666 (1999)
   PUBMED   10198195
REFERENCE   9  (bases 1 to 3244)
  AUTHORS   Cid,L.P., Montrose-Rafizadeh,C., Smith,D.I., Guggino,W.B. and
            Cutting,G.R.
  TITLE     Cloning of a putative human voltage-gated chloride channel (CIC-2)
            cDNA widely expressed in human tissues
  JOURNAL   Hum Mol Genet 4 (3), 407-413 (1995)
   PUBMED   7795595
REFERENCE   10 (bases 1 to 3244)
  AUTHORS   Min,R., Depienne,C., Sedel,F., Abbink,T.E.M. and van der Knaap,M.S.
  TITLE     CLCN2-Related Leukoencephalopathy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   26539602
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC403930.1, AF026004.1,
            AC078797.20 and AA524434.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004366.5.
            
            Summary: This gene encodes a voltage-gated chloride channel. The
            encoded protein is a transmembrane protein that maintains chloride
            ion homeostasis in various cells. Defects in this gene may be a
            cause of certain epilepsies. Four transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S77770.1, SRR1803611.176946.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265593.9/ ENSP00000265593.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               DC403930.1         47-172
            127-2823            AF026004.1         1-2697
            2824-3241           AC078797.20        87553-87970         c
            3242-3244           AA524434.1         10-12               c
FEATURES             Location/Qualifiers
     source          1..3244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..3244
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /note="chloride voltage-gated channel 2"
                     /db_xref="GeneID:1181"
                     /db_xref="HGNC:HGNC:2020"
                     /db_xref="MIM:600570"
     exon            1..189
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2823
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chloride channel protein 2; chloride channel 2; chloride
                     channel, voltage-sensitive 2"
                     /codon_start=1
                     /product="chloride channel protein 2 isoform 1"
                     /protein_id="NP_004357.3"
                     /db_xref="CCDS:CCDS3263.1"
                     /db_xref="GeneID:1181"
                     /db_xref="HGNC:HGNC:2020"
                     /db_xref="MIM:600570"
                     /translation="MAAAAAEEGMEPRALQYEQTLMYGRYTQDLGAFAKEEAARIRLG
                     GPEPWKGPPSSRAAPELLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMA
                     LVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAV
                     GSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAAL
                     LSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYW
                     RGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFG
                     GALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLS
                     QKETLVTLFDNRTWVRQGLVEELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALAT
                     TIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALA
                     GAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLP
                     ELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILL
                     GSIERSQVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDS
                     AFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESAGIALRSLFCGSPPPEAASEK
                     LESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLV
                     ERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGVKVRPPLAS
                     FRDSATSSSDTETTEVHALWGPHSRHGLPREGSPSDSDDKCQ"
     exon            190..346
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            347..478
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            479..607
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            608..741
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            742..819
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            820..898
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1024
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1109
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1211
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1296
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1452
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1522
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1633
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1847
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1981
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2154
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2269
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2343
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2397
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2436
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2541
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2628
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..3244
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3190..3195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /note="hexamer: AACAAA"
     regulatory      3212..3217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /note="hexamer: AATAAA"
     polyA_site      3213
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /note="major polyA site"
     polyA_site      3244
                     /gene="CLCN2"
                     /gene_synonym="CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11;
                     EGI3; EGMA; EJM6; EJM8; FHA2; FHII; HALD2; LKPAT"
                     /note="major polyA site"
ORIGIN      
        1 gcactctgct ctcggcctcc cgggctgcgg ggacgggacg gctgccggcg cggactttgc
       61 gggccgggag ccgagtccag gacagagccg gaaccgccga gggaggcgag agggcagtgc
      121 gcggagatgg cggccgcggc ggcggaggaa gggatggagc cacgggcgct gcagtacgag
      181 cagaccctga tgtatggccg gtacactcag gaccttgggg cctttgccaa agaggaagct
      241 gctcggattc gcctgggagg gcctgaaccc tggaaaggtc ccccttcctc tcgggctgcc
      301 ccagagctct tggaatatgg acggagccgt tgcgcccgat gccgcgtctg ttctgtccgc
      361 tgccacaagt tcctagtatc cagggttggt gaagattgga tcttcctggt cctgctgggg
      421 cttctcatgg cattggtcag ctgggtcatg gactatgcca ttgctgcctg tctgcaagcc
      481 cagcagtgga tgtcccgggg cttgaacacc agcatcttgc tccagtacct ggcctgggtc
      541 acctaccctg ttgtcctcat cactttctca gccggattca cacagatcct ggcccctcag
      601 gctgtcggct ctggcatccc tgagatgaag accatcttgc ggggagtggt gctgaaagaa
      661 tacctcacac tcaagacctt tatagctaag gtcattgggc tgacctgcgc cctaggcagc
      721 gggatgccgc ttggcaaaga gggccctttt gtgcatatcg caagcatgtg tgctgccctt
      781 ctcagcaagt tcctctccct ctttgggggt atctatgaga atgaatcccg gaacacagag
      841 atgctggctg ccgcctgtgc cgtgggggtg ggctgctgct tcgcggcacc tattggaggc
      901 gtcctcttca gcatcgaggt cacctccacc ttctttgcag tgcggaacta ctggcggggc
      961 ttcttcgctg ccaccttcag tgccttcatc ttccgggtct tggcagtctg gaaccgggat
     1021 gaagagacta ttacagccct cttcaaaacc cgattccggc tcgacttccc ctttgacctg
     1081 caggagctgc cagcctttgc tgtcattggt attgctagtg gcttcggtgg agccctcttt
     1141 gtctacctga accggaagat tgtccaggtg atgcggaagc agaaaaccat caatcgcttc
     1201 ctcatgagga aacgcctgct cttcccggct ctggtgaccc tgctcatctc cacgctgacc
     1261 ttcccccctg gctttggaca gttcatggct ggacagctct cacagaaaga gacgctggtc
     1321 accctgtttg acaatcggac gtgggtccgc cagggcctgg tggaggagct agaaccaccc
     1381 agcacctcac aggcctggaa cccaccacgt gccaacgtct tcctcaccct ggtcatcttc
     1441 attctcatga agttctggat gtctgcactg gccaccacca tcccagttcc ctgtggggcc
     1501 ttcatgcctg tctttgtcat tggagcagca tttgggcgtc tggtgggtga aagcatggct
     1561 gcctggttcc cagatggaat tcatacggac agcagcacct accggattgt gcctgggggc
     1621 tacgctgtgg tcggggcagc tgcgctggca ggagcggtga cacacacagt gtccacggct
     1681 gtgatcgtgt tcgagctcac aggccagatt gcccacatcc tgcctgtcat gatcgccgtc
     1741 atcctggcca acgctgtcgc ccagagtctg cagccctccc tctatgacag catcatccga
     1801 atcaagaaac tgccctacct gcctgagctc ggctggggcc gccaccagca gtaccgggtg
     1861 cgtgtggagg acatcatggt gcgggatgtt ccccatgtgg ccctcagctg caccttccgg
     1921 gacctgcgtt tggcactgca caggaccaag ggccgaatgc tggccctagt ggagtcccct
     1981 gagtccatga ttctgctggg ctccatcgag cgttcacagg tggtggcatt gttgggggcc
     2041 cagctgagcc cagcccgccg gcggcagcac atgcaggagc gcagagccac ccagacctct
     2101 ccactatctg atcaggaggg tccccctacc cctgaggctt ctgtctgctt ccaggtgaac
     2161 acagaagact cagccttccc agcagcccgg ggggagaccc acaagcccct aaagcctgca
     2221 ctcaagaggg ggcccagtgt caccaggaac ctcggagaga gtcccacagg gagcgcagag
     2281 tcggcaggca tcgccctccg gagcctcttc tgtggcagtc caccccctga ggctgcttcg
     2341 gagaagttgg aatcctgtga gaagcgcaag ctgaagcgtg tccgaatctc cctggcaagt
     2401 gacgcggacc tggaaggcga gatgagccct gaagagattc tggagtggga ggagcagcaa
     2461 ctagatgaac ctgtcaactt cagtgactgc aaaattgatc ctgctccctt ccagctggtg
     2521 gagcggacct ctttgcacaa gactcacact atcttctcac tgctgggagt ggaccatgct
     2581 tatgtcacca gtattggcag actcattgga atcgttactc taaaggagct ccggaaggcc
     2641 atcgagggct ctgtcacagc acagggtgtg aaagtccggc cgcccctcgc cagcttccga
     2701 gacagtgcca ccagcagcag tgacacggag accactgagg tgcatgcact ctgggggccc
     2761 cactcccgtc atggcctccc ccgggagggc agcccttccg acagcgacga caaatgccaa
     2821 tgagcccctc gtgggtggcc taggatggtg ctagccatgc ccgtcagccc agaatgtgca
     2881 tctttcattc cttctgcctt cggaaggcag gaggcagcta cagctggagg ctgcacccca
     2941 gccccctcca gacctggggt gccagcttct cccagttcat cctacctgga atctgaccca
     3001 ctacccacct gcaacaagtc ttccagaggc aggaagatag gccctgccct ggcaggatgg
     3061 gttggggtca cttgacccct gctccccctt tgaggggaaa ggggtggaac taagatgggt
     3121 ttataactgg aacctccaat gaccagatgt atatagagat ttacaaagat ttttatatta
     3181 atttaataaa acaaattctt aaatagaaca aaataaacac ctaatgagcc acttatatat
     3241 agaa
//
