LOCUS       NM_013246               1705 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens cardiotrophin like cytokine factor 1 (CLCF1),
            transcript variant 1, mRNA.
ACCESSION   NM_013246
VERSION     NM_013246.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1705)
  AUTHORS   Liu,T., Wang,Q., Zhou,L., Zhang,P., Mi,L., Qiu,X., Chen,Z.,
            Kuang,H., Li,S. and Lin,J.D.
  TITLE     Intrahepatic paracrine signaling by cardiotrophin-like cytokine
            factor 1 ameliorates diet-induced NASH in mice
  JOURNAL   Hepatology 78 (5), 1478-1491 (2023)
   PUBMED   35950514
  REMARK    GeneRIF: Intrahepatic paracrine signaling by cardiotrophin-like
            cytokine factor 1 ameliorates diet-induced NASH in mice.
REFERENCE   2  (bases 1 to 1705)
  AUTHORS   Jiang,Y., Ji,Q., Long,X., Wang,P., Tu,Z., Zhang,X., Zhu,X.,
            Huang,K. and Li,J.
  TITLE     CLCF1 Is a Novel Potential Immune-Related Target With Predictive
            Value for Prognosis and Immunotherapy Response in Glioma
  JOURNAL   Front Immunol 13, 810832 (2022)
   PUBMED   35265072
  REMARK    GeneRIF: CLCF1 Is a Novel Potential Immune-Related Target With
            Predictive Value for Prognosis and Immunotherapy Response in
            Glioma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1705)
  AUTHORS   Crisponi,L., Buers,I. and Rutsch,F.
  TITLE     CRLF1 and CLCF1 in Development, Health and Disease
  JOURNAL   Int J Mol Sci 23 (2), 992 (2022)
   PUBMED   35055176
  REMARK    GeneRIF: CRLF1 and CLCF1 in Development, Health and Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1705)
  AUTHORS   Yokota,S., Matsumae,G., Shimizu,T., Hasegawa,T., Ebata,T.,
            Takahashi,D., Heguo,C., Tian,Y., Alhasan,H., Takahata,M.,
            Kadoya,K., Terkawi,M.A. and Iwasaki,N.
  TITLE     Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates bone loss
            in osteoporosis mouse models by suppressing osteoclast
            differentiation through activating interferon signaling and
            repressing the nuclear factor-kappaB signaling pathway
  JOURNAL   Bone 153, 116140 (2021)
   PUBMED   34364014
  REMARK    GeneRIF: Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates
            bone loss in osteoporosis mouse models by suppressing osteoclast
            differentiation through activating interferon signaling and
            repressing the nuclear factor-kappaB signaling pathway.
REFERENCE   5  (bases 1 to 1705)
  AUTHORS   Chen,X., Li,J., Ye,Y., Huang,J., Xie,L., Chen,J., Li,S., Chen,S.
            and Ge,J.
  TITLE     Association of cardiotrophin-like cytokine factor 1 levels in
            peripheral blood mononuclear cells with bone mineral density and
            osteoporosis in postmenopausal women
  JOURNAL   BMC Musculoskelet Disord 22 (1), 62 (2021)
   PUBMED   33430863
  REMARK    GeneRIF: Association of cardiotrophin-like cytokine factor 1 levels
            in peripheral blood mononuclear cells with bone mineral density and
            osteoporosis in postmenopausal women.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1705)
  AUTHORS   Plun-Favreau,H., Elson,G., Chabbert,M., Froger,J., deLapeyriere,O.,
            Lelievre,E., Guillet,C., Hermann,J., Gauchat,J.F., Gascan,H. and
            Chevalier,S.
  TITLE     The ciliary neurotrophic factor receptor alpha component induces
            the secretion of and is required for functional responses to
            cardiotrophin-like cytokine
  JOURNAL   EMBO J 20 (7), 1692-1703 (2001)
   PUBMED   11285233
REFERENCE   7  (bases 1 to 1705)
  AUTHORS   Elson,G.C., Lelievre,E., Guillet,C., Chevalier,S., Plun-Favreau,H.,
            Froger,J., Suard,I., de Coignac,A.B., Delneste,Y., Bonnefoy,J.Y.,
            Gauchat,J.F. and Gascan,H.
  TITLE     CLF associates with CLC to form a functional heteromeric ligand for
            the CNTF receptor complex
  JOURNAL   Nat Neurosci 3 (9), 867-872 (2000)
   PUBMED   10966616
REFERENCE   8  (bases 1 to 1705)
  AUTHORS   Senaldi,G., Varnum,B.C., Sarmiento,U., Starnes,C., Lile,J.,
            Scully,S., Guo,J., Elliott,G., McNinch,J., Shaklee,C.L.,
            Freeman,D., Manu,F., Simonet,W.S., Boone,T. and Chang,M.S.
  TITLE     Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the
            IL-6 family
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11458-11463 (1999)
   PUBMED   10500198
REFERENCE   9  (bases 1 to 1705)
  AUTHORS   Shi,Y., Wang,W., Yourey,P.A., Gohari,S., Zukauskas,D., Zhang,J.,
            Ruben,S. and Alderson,R.F.
  TITLE     Computational EST database analysis identifies a novel member of
            the neuropoietic cytokine family
  JOURNAL   Biochem Biophys Res Commun 262 (1), 132-138 (1999)
   PUBMED   10448081
REFERENCE   10 (bases 1 to 1705)
  AUTHORS   Hahn,A.F. and Knappskog,P.M.
  TITLE     Cold-Induced Sweating Syndrome Including Crisponi Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   21370513
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM846622.1 and BC012939.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_013246.2.
            
            Summary: This gene is a member of the glycoprotein (gp)130 cytokine
            family and encodes cardiotrophin-like cytokine factor 1 (CLCF1).
            CLCF1 forms a heterodimer complex with cytokine receptor-like
            factor 1 (CRLF1). This dimer competes with ciliary neurotrophic
            factor (CNTF) for binding to the ciliary neurotrophic factor
            receptor (CNTFR) complex, and activates the Jak-STAT signaling
            cascade. CLCF1 can be actively secreted from cells by forming a
            complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a
            potent neurotrophic factor, B-cell stimulatory agent and
            neuroendocrine modulator of pituitary corticotroph function.
            Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2).
            This syndrome is characterized by a profuse sweating after exposure
            to cold as well as congenital physical abnormalities of the head
            and spine. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Though this isoform has a predicted signal peptide at amino
            acids 1-27, experiments show it is retained within the cell.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012939.1, AF172854.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2153427
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312438.8/ ENSP00000309338.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               BM846622.1         140-482
            344-1705            BC012939.1         357-1718
FEATURES             Location/Qualifiers
     source          1..1705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1705
                     /gene="CLCF1"
                     /gene_synonym="BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6"
                     /note="cardiotrophin like cytokine factor 1"
                     /db_xref="GeneID:23529"
                     /db_xref="HGNC:HGNC:17412"
                     /db_xref="MIM:607672"
     exon            1..75
                     /gene="CLCF1"
                     /gene_synonym="BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..737
                     /gene="CLCF1"
                     /gene_synonym="BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CRLF1 associated cytokine-like factor 1;
                     neurotrophin-1/B-cell stimulating factor-3; novel
                     neurotrophin-1; B-cell stimulatory factor 3;
                     B-cell-stimulating factor 3"
                     /codon_start=1
                     /product="cardiotrophin-like cytokine factor 1 isoform 1
                     precursor"
                     /protein_id="NP_037378.1"
                     /db_xref="CCDS:CCDS31617.1"
                     /db_xref="GeneID:23529"
                     /db_xref="HGNC:HGNC:17412"
                     /db_xref="MIM:607672"
                     /translation="MDLRAGDSWGMLACLCTVLWHLPAVPALNRTGDPGPGPSIQKTY
                     DLTRYLEHQLRSLAGTYLNYLGPPFNEPDFNPPRLGAETLPRATVDLEVWRSLNDKLR
                     LTQNYEAYSHLLCYLRGLNRQAATAELRRSLAHFCTSLQGLLGSIAGVMAALGYPLPQ
                     PLPGTEPTWTPGPAHSDFLQKMDDFWLLKELQTWLWRSAKDFNRLKKKMQPPAAAVTL
                     HLGAHGF"
     exon            76..242
                     /gene="CLCF1"
                     /gene_synonym="BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6"
                     /inference="alignment:Splign:2.1.0"
     exon            243..1705
                     /gene="CLCF1"
                     /gene_synonym="BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1685..1690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLCF1"
                     /gene_synonym="BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6"
                     /note="hexamer: AATAAA"
     polyA_site      1705
                     /gene="CLCF1"
                     /gene_synonym="BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6"
                     /note="major polyA site"
ORIGIN      
        1 ctcccactcc gccagcctcc gggagaggag ccgcacccgg ccggcccggc cccagcccca
       61 tggacctccg agcaggggac tcgtggggga tgttagcgtg cctgtgcacg gtgctctggc
      121 acctccctgc agtgccagct ctcaatcgca caggggaccc agggcctggc ccctccatcc
      181 agaaaaccta tgacctcacc cgctacctgg agcaccaact ccgcagcttg gctgggacct
      241 atctgaacta cctgggcccc cctttcaacg agccagactt caaccctccc cgcctggggg
      301 cagagactct gcccagggcc actgttgact tggaggtgtg gcgaagcctc aatgacaaac
      361 tgcggctgac ccagaactac gaggcctaca gccaccttct gtgttacttg cgtggcctca
      421 accgtcaggc tgccactgct gagctgcgcc gcagcctggc ccacttctgc accagcctcc
      481 agggcctgct gggcagcatt gcgggcgtca tggcagctct gggctaccca ctgccccagc
      541 cgctgcctgg gactgaaccc acttggactc ctggccctgc ccacagtgac ttcctccaga
      601 agatggacga cttctggctg ctgaaggagc tgcagacctg gctgtggcgc tcggccaagg
      661 acttcaaccg gctcaagaag aagatgcagc ctccagcagc tgcagtcacc ctgcacctgg
      721 gggctcatgg cttctgactt ctgaccttct cctcttcgct cccccttcaa accctgctcc
      781 cactttgtga gagccagccc tgtatgccaa cacctgttga gccaggagac agaagctgtg
      841 agcctctggc cctttcctgg accggctggg cgtgtgatgc gatcagccct gtctcctccc
      901 cacctcccaa aggtctaccg agctggggag gaggtacagt aggccctgtc ctgtcctgtt
      961 tctacaggaa gtcatgctcg agggagtgtg aagtggttca ggttggtgca gaggcgctca
     1021 tggcctcctg cttcttgcct accacttggc cagtgcccac ccagcccctc aggtggcaca
     1081 tctggagggc aggggttgag gggccaccac cacacatgcc tttctggggt gaagcccttt
     1141 ggctgcccca ctctccttgg atgggtgttg ctcccttatc cccaaatcac tctatacatc
     1201 caattcagga aacaaacatg gtggcaattc tacacaaaaa gagatgagat taacagtgca
     1261 gggttggggt ctgcattgga ggtgccctat aaaccagaag agaaaatact gaaagcacag
     1321 gggcagggac agaccagacc agacccagga gtctccaaag cacagagtgg caaacaaaac
     1381 ccgagctgag catcaggacc ttgcctcgaa ttgtcttcca gtattacggt gcctcttctc
     1441 tgcccccttt cccagggtat ctgtgggttg ccaggctggg gagggcaacc atagccacac
     1501 cacaggattt cctgaaagtt tacaatgcag tagcattttg gggtgtaggg tggcagctcc
     1561 ccaaggccct gccccccagc cccacccact catgactcta agtgtgttgt attaatattt
     1621 atttatttgg agatgttatt tattagatga tatttattgc agaatttcta ttcttgtatt
     1681 aacaaataaa atgcttgccc cagaa
//
