LOCUS       NM_001377458            4994 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens chloride channel CLIC like 1 (CLCC1), transcript
            variant 5, mRNA.
ACCESSION   NM_001377458
VERSION     NM_001377458.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4994)
  AUTHORS   D'Atri,I., Martin,E.R., Yang,L., Sears,E., Baple,E., Crosby,A.H.,
            Chilton,J.K. and Oguro-Ando,A.
  TITLE     Unraveling the CLCC1 interactome: Impact of the Asp25Glu variant
            and its interaction with SigmaR1 at the Mitochondrial-Associated ER
            Membrane (MAM)
  JOURNAL   Neurosci Lett 830, 137778 (2024)
   PUBMED   38621504
  REMARK    GeneRIF: Unraveling the CLCC1 interactome: Impact of the Asp25Glu
            variant and its interaction with SigmaR1 at the
            Mitochondrial-Associated ER Membrane (MAM).
REFERENCE   2  (bases 1 to 4994)
  AUTHORS   Tang,L., Tang,X., Zhao,Q., Li,Y., Bu,Y., Liu,Z., Li,J., Guo,J.,
            Shen,L., Jiang,H., Tang,B., Xu,R., Cao,W., Yuan,Y. and Wang,J.
  TITLE     Mutation and clinical analysis of the CLCC1 gene in amyotrophic
            lateral sclerosis patients from Central South China
  JOURNAL   Ann Clin Transl Neurol 11 (1), 79-88 (2024)
   PUBMED   37916886
  REMARK    GeneRIF: Mutation and clinical analysis of the CLCC1 gene in
            amyotrophic lateral sclerosis patients from Central South China.
REFERENCE   3  (bases 1 to 4994)
  AUTHORS   Guo,L., Mao,Q., He,J., Liu,X., Piao,X., Luo,L., Hao,X., Yu,H.,
            Song,Q., Xiao,B., Fan,D., Gao,Z. and Jia,Y.
  TITLE     Disruption of ER ion homeostasis maintained by an ER anion channel
            CLCC1 contributes to ALS-like pathologies
  JOURNAL   Cell Res 33 (7), 497-515 (2023)
   PUBMED   37142673
REFERENCE   4  (bases 1 to 4994)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4994)
  AUTHORS   Chu,Q., Martinez,T.F., Novak,S.W., Donaldson,C.J., Tan,D.,
            Vaughan,J.M., Chang,T., Diedrich,J.K., Andrade,L., Kim,A.,
            Zhang,T., Manor,U. and Saghatelian,A.
  TITLE     Regulation of the ER stress response by a mitochondrial
            microprotein
  JOURNAL   Nat Commun 10 (1), 4883 (2019)
   PUBMED   31653868
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4994)
  AUTHORS   Irvin,M.R., Shrestha,S., Chen,Y.D., Wiener,H.W., Haritunians,T.,
            Vaughan,L.K., Tiwari,H.K., Taylor,K.D., Scherzer,R., Saag,M.S.,
            Grunfeld,C., Rotter,J.I. and Arnett,D.K.
  TITLE     Genes linked to energy metabolism and immunoregulatory mechanisms
            are associated with subcutaneous adipose tissue distribution in
            HIV-infected men
  JOURNAL   Pharmacogenet Genomics 21 (12), 798-807 (2011)
   PUBMED   21897333
REFERENCE   7  (bases 1 to 4994)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 4994)
  AUTHORS   Zhang,Q., Zulfiqar,F., Xiao,X., Riazuddin,S.A., Ayyagari,R.,
            Sabar,F., Caruso,R., Sieving,P.A., Riazuddin,S. and Hejtmancik,J.F.
  TITLE     Severe autosomal recessive retinitis pigmentosa maps to chromosome
            1p13.3-p21.2 between D1S2896 and D1S457 but outside ABCA4
  JOURNAL   Hum Genet 118 (3-4), 356-365 (2005)
   PUBMED   16189710
REFERENCE   9  (bases 1 to 4994)
  AUTHORS   Li,X. and Weinman,S.A.
  TITLE     Chloride channels and hepatocellular function: prospects for
            molecular identification
  JOURNAL   Annu Rev Physiol 64, 609-633 (2002)
   PUBMED   11826282
  REMARK    Review article
REFERENCE   10 (bases 1 to 4994)
  AUTHORS   Nagasawa,M., Kanzaki,M., Iino,Y., Morishita,Y. and Kojima,I.
  TITLE     Identification of a novel chloride channel expressed in the
            endoplasmic reticulum, golgi apparatus, and nucleus
  JOURNAL   J Biol Chem 276 (23), 20413-20418 (2001)
   PUBMED   11279057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL449266.17.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.1486.1,
                                           SRR1803612.111590.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369969.7/ ENSP00000358986.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AL449266.17        172235-172358       c
            125-285             AL449266.17        171183-171343       c
            286-425             AL449266.17        159183-159322       c
            426-527             AL449266.17        158694-158795       c
            528-635             AL449266.17        156485-156592       c
            636-857             AL449266.17        152710-152931       c
            858-998             AL449266.17        152349-152489       c
            999-1092            AL449266.17        150279-150372       c
            1093-1190           AL449266.17        148919-149016       c
            1191-1337           AL449266.17        148510-148656       c
            1338-1679           AL449266.17        145951-146292       c
            1680-1997           AL449266.17        143499-143816       c
            1998-4994           AL449266.17        138379-141375       c
FEATURES             Location/Qualifiers
     source          1..4994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..4994
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /note="chloride channel CLIC like 1"
                     /db_xref="GeneID:23155"
                     /db_xref="HGNC:HGNC:29675"
                     /db_xref="MIM:617539"
     exon            1..124
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /inference="alignment:Splign:2.1.0"
     exon            125..285
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /inference="alignment:Splign:2.1.0"
     exon            286..425
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1952
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 5; chloride channel CLIC-like protein 1;
                     Mid-1-related chloride channel protein 1; retinitis
                     pigmentosa 32 (autosomal recessive); ER anion channel 1"
                     /codon_start=1
                     /product="chloride channel CLIC-like protein 1 isoform 1
                     precursor"
                     /protein_id="NP_001364387.1"
                     /db_xref="CCDS:CCDS41362.1"
                     /db_xref="GeneID:23155"
                     /db_xref="HGNC:HGNC:29675"
                     /db_xref="MIM:617539"
                     /translation="MLCSLLLCECLLLVAGYAHDDDWIDPTDMLNYDAASGTMRKSQA
                     KYGISGEKDVSPDLSCADEISECYHKLDSLTYKIDECEKKKREDYESQSNPVFRRYLN
                     KILIEAGKLGLPDENKGDMHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILI
                     NFKFHDFETWKWRFEDSFGVDPYNVLMVLLCLLCIVVLVATELWTYVRWYTQLRRVLI
                     ISFLFSLGWNWMYLYKLAFAQHQAEVAKMEPLNNVCAKKMDWTGSIWEWFRSSWTYKD
                     DPCQKYYELLLVNPIWLVPPTKALAVTFTTFVTEPLKHIGKGTGEFIKALMKEIPALL
                     HLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDGG
                     AGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDA
                     EAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQSAKPVSGQDTSGNTEG
                     SPAAEKAQLKSEAAGSPDQGSTYSPARGVAGPRGQDPVSSPCG"
     exon            426..527
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /inference="alignment:Splign:2.1.0"
     exon            528..635
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /inference="alignment:Splign:2.1.0"
     exon            636..857
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /inference="alignment:Splign:2.1.0"
     exon            858..998
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1092
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1190
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1337
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1679
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1997
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..4994
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2178..2183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /note="hexamer: ATTAAA"
     polyA_site      2203
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /note="major polyA site"
     regulatory      2682..2687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /note="hexamer: AATACA"
     polyA_site      2706
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
     regulatory      4543..4548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /note="hexamer: AATAAA"
     polyA_site      4562
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
     regulatory      4839..4844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /note="hexamer: AAGAAA"
     polyA_site      4876
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
     regulatory      4975..4980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
                     /note="hexamer: AATAAT"
     polyA_site      4994
                     /gene="CLCC1"
                     /gene_synonym="ERAC1; MCLC; RP32"
ORIGIN      
        1 gaacaattcg atgacgaggc ccaggaagca cgctgaaacc ctgggcggcg gcaagctgtg
       61 cgacctcttc tgcggccggc ctgggcaggt gtcttcctcg agaggcaggc aggggatccc
      121 ggacactagc tttatcgtca tctgggaaat tgttaaaaat gcaaattcgc aagtttgaga
      181 gccatggttc caagaaactg cataagcata cgaaataagt tgcagcctcc cgacttatac
      241 cctggtactt ctagtctaaa acaggatttg actctactaa tccagcctta tacaggatgc
      301 tgtgttcttt gctcctttgt gaatgtctgt tgctggtagc tggttatgct catgatgatg
      361 actggattga ccccacagac atgcttaact atgatgctgc ttcaggaaca atgagaaaat
      421 ctcaggcaaa atatggtatt tcaggggaaa aggatgtcag tcctgacttg tcatgtgctg
      481 atgaaatatc agaatgttat cacaaacttg attctttaac ttataagatt gatgagtgtg
      541 aaaagaaaaa gagggaagac tatgaaagtc aaagcaatcc tgtttttagg agatacttaa
      601 ataagatttt aattgaagct ggaaagcttg gacttcctga tgaaaacaaa ggcgatatgc
      661 attatgatgc tgagattatc cttaaaagag aaactttgtt agaaatacag aagtttctca
      721 atggagaaga ctggaaacca ggtgccttgg atgatgcact aagtgatatt ttaattaatt
      781 ttaagtttca tgattttgaa acatggaagt ggcgattcga agattccttt ggagtggatc
      841 catataatgt gttaatggta cttctttgtc tgctctgcat cgtggtttta gtggctactg
      901 agctgtggac atatgtacgt tggtacactc agttgagacg tgttttaatc atcagctttc
      961 tgttcagttt gggatggaat tggatgtatt tatataagct agcttttgca cagcatcagg
     1021 ctgaagtcgc caagatggag ccattaaaca atgtgtgtgc caaaaagatg gactggactg
     1081 gaagtatctg ggaatggttt agaagttcat ggacctataa ggatgaccca tgccaaaaat
     1141 actatgagct cttactagtc aaccctattt ggttggtccc accaacaaag gcacttgcag
     1201 ttacattcac cacatttgta acggagccat tgaagcatat tggaaaagga actggggaat
     1261 ttattaaagc actcatgaag gaaattccag cgctgcttca tcttccagtg ctgataatta
     1321 tggcattagc catcctgagt ttctgctatg gtgctggaaa atcagttcat gtgctgagac
     1381 atataggcgg tcctgagagc gaacctcccc aggcacttcg gccacgggat agaagacggc
     1441 aggaggaaat tgattataga cctgatggtg gagcaggtga tgccgatttc cattataggg
     1501 gccaaatggg ccccactgag caaggccctt atgccaaaac gtatgagggt agaagagaga
     1561 ttttgagaga gagagatgtt gacttgagat ttcagactgg caacaagagc cctgaagtgc
     1621 tccgggcatt tgatgtacca gacgcagagg cacgagagca tcccacggtg gtacccagtc
     1681 ataaatcacc tgttttggat acaaagccca aggagacagg tggaatcctg ggggaaggca
     1741 caccgaaaga aagcagtact gaaagcagcc agtcggccaa gcctgtctct ggccaagaca
     1801 catcagggaa tacagaaggt tcacccgcag cggaaaaggc ccagctcaag tctgaagccg
     1861 caggcagccc agaccaaggc agcacataca gccccgcaag aggtgtggct ggaccacgtg
     1921 gacaggatcc ggtcagcagc ccctgtggct agaggaacac cagcacaaac gacagcctca
     1981 agtctccttc gagctttata tccatttggg gatgaagtct actttgacag ctagcaaggc
     2041 gacatgcaac tgttgttgaa tgatgacagc aattcaggaa agacttaaat atgaaagcaa
     2101 attgaacaca tcgggtgttt gttatcagaa aagagatgag atgagataag acttgtttat
     2161 tgactagcca atatgtcatt aaaattaagg tttatattgt gaagcttttt tgaaatttta
     2221 cttttttttg agagttttgc tctgtcaccc aggctggagt gaggtggtac aatctcggct
     2281 cactgcaacc tccacctccc aggttcaaga gattctcctg cctcagtctc ccgagtagct
     2341 aggattacag atgtgcatca ccatgcctgg ctaatttttg tattttttag tagagatggg
     2401 gtttcaccat gttggtcagg ctggtctcga actcctgacc tcaagtgacc cgcccttgtc
     2461 ggcctcccaa agtgctggga ttacaggcat gagccattgt gcccagccta tatagtgtga
     2521 agcttttagg aaaatcagaa cagggtagac agctgttaaa aacaatgttt aaatggaata
     2581 atgttgaatg tttacaggct gtaagaacta ttgtatacac aaaataatac acaaagtttg
     2641 tactttgtgt acaaatacaa atttgtactt tgtgtacaaa taatacaaaa agtttgtata
     2701 cacaaacttt ttacgttgtg gtttggtata ttgtcttaac tgaattttct tataagaacc
     2761 ccatgaaact tacctgagtt tttaaaatgc tatccaggac atcatacctt atagtataca
     2821 tgaaacataa tgtaatccag gttgtaattt agaacttttt tttttttttt agctgagcac
     2881 ttaatgtaat taattccagg ttatgactct taaaaaacat tggccattag agaaatagtt
     2941 ctatttgccc atccaaatca cctgaatgac tttttgaaag aataggggtc cacatcccca
     3001 gatcccatcc cagctgtgca cagtctgaag caagcagagt gaaacaagtt ggcaacttgt
     3061 tccaagcgtg ggcctttgca gtctgtgatc cagtgttact ccaggtccca gtctgtccca
     3121 tacttgtctt ttgctacagt tagttagtta ctttgttatc atccccttgt aaactgcctt
     3181 caatatctgg gataaggaag acaaagctta atgacaacta aggttctagc tgacatcttt
     3241 ctttcatatt taatttttgt gagttttcat ctgttttctg tttgtttatg tgtcctaggt
     3301 tcttgaccta accacatggg ttttgttttt tgtttttata ttagaactta gaaaagtttg
     3361 ttttacagca gtattatgga acagaagaga ccattttaaa taattttttt aaacagccca
     3421 aaacacacaa aagatacttg ttttctagag acagggtctt gctctgtcac ccaggctgga
     3481 gtgcagtggc acgatcatag ctcagtgcag cctccacctc ctgggctcaa gtggtcctcc
     3541 tgcctcagcc tcttaagcag ttgggactac aggtgtgtgc cagcatgctt gctgtttttt
     3601 ttttttttga gacagagtct tgctctgtca ctcaggctgg agtccagtgg cttggtctca
     3661 gctcactgca atctctgcct cccaggggtt caagtgattc tcctgcctca gcctcccaag
     3721 tagctgaaac tacaggcgca tgccaccatg cccagctaat ttttgtattt ttagtagaga
     3781 cagggtttca ctatgttggc caggctggtc tcaaactccc gacctcaagt gatccgcccg
     3841 cttcggcctc ccaaagtgct gggattacag gtgtgagcca ctgcgcctgg ctgctgattt
     3901 atttttcata gacacggggg tctatgttgc ccaggttggt cttgaactcc tagcctcaag
     3961 cgatcctcct gcctcagcct cccaatgtgc tgggattaca ggaatgagcc accatgccca
     4021 gcccaagaag tagagtttct tttatactga ctttggccta aaaaaacaga ttttcatgga
     4081 ggaaaaaaaa acctagattt ttagtaagac tattttatat acttttttac attgatcaag
     4141 tacattattt ttaccaaaca acattgtttc ccactacatc catggttatg tataaaaaaa
     4201 cgccattgtc aattaagatg ttaaaaaatt atttccataa gagtattaaa ttctaatcta
     4261 tgattcactt aacttcctac tttataaaca ctaggtaaag taatctcaca agctgccaaa
     4321 gaacacatcc caagcagtaa tcacagacga tgaagcacct tacaggaccc ctccaccctc
     4381 aaacgcgcat gtccagagaa gtattaatgc cttaatagac tactgaaggt taactattta
     4441 catcattcta aaaatatttt aagctgtatt acagtgctat aaattctcct tttaaggaaa
     4501 aaagtaatag attgtttcct taccgtgttt gaaaggaaaa aaaataaatc catagtaact
     4561 aatggtctgc cgattttttc cctgaatttt taaactccaa caaagcatta ttttgcaaaa
     4621 agtcctttag cccaaagtca gtgtctctgt tttgatctct ttgtaaaaga actctctgtt
     4681 catccattct ctttccctgg gaccgtaaaa taaggctgaa aaagtcttca tctggtactg
     4741 tcggaccctt tgtggtagca ggtggtggag cacatctttg atcatctaat ctggatccct
     4801 agaagtttat gagagagatt aaaagacata ctgtgggaaa gaaagcacca agctatgtta
     4861 aatctctcag tcacaacaag aaaacgcagt tgtaaacttt tatttggggc ttctcagaaa
     4921 ttaatctttg tttttatatt gttctcttta gttcccagcc tgatttctga aagaaataat
     4981 ctttaaacct gaaa
//
