LOCUS       NM_001285               3004 bp    mRNA    linear   PRI 14-AUG-2024
DEFINITION  Homo sapiens chloride channel accessory 1 (CLCA1), mRNA.
ACCESSION   NM_001285
VERSION     NM_001285.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3004)
  AUTHORS   Gaur,P., Rajendran,Y., Srivastava,B., Markandey,M.,
            Fishbain-Yoskovitz,V., Mohapatra,G., Suhail,A., Chaudhary,S.,
            Tyagi,S., Yadav,S.C., Pandey,A.K., Merbl,Y., Bajaj,A., Ahuja,V. and
            Srikanth,C.
  TITLE     Rab7-dependent regulation of goblet cell protein CLCA1 modulates
            gastrointestinal homeostasis
  JOURNAL   Elife 12, 89776 (2024)
   PUBMED   38593125
  REMARK    GeneRIF: Rab7-dependent regulation of goblet cell protein CLCA1
            modulates gastrointestinal homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3004)
  AUTHORS   Lv,X., Zheng,L., Zhang,T., Wang,W., Chen,Y., Li,J., Cai,Z., Guo,X.
            and Song,L.
  TITLE     CLCA1 exacerbates lung inflammation via p38 MAPK pathway in acute
            respiratory distress syndrome
  JOURNAL   Exp Lung Res 50 (1), 85-95 (2024)
   PUBMED   38597420
  REMARK    GeneRIF: CLCA1 exacerbates lung inflammation via p38 MAPK pathway
            in acute respiratory distress syndrome.
REFERENCE   3  (bases 1 to 3004)
  AUTHORS   Berry,K.N. and Brett,T.J.
  TITLE     Structural and Biophysical Analysis of the CLCA1 VWA Domain
            Suggests Mode of TMEM16A Engagement
  JOURNAL   Cell Rep 30 (4), 1141-1151 (2020)
   PUBMED   31995732
  REMARK    GeneRIF: Structural and Biophysical Analysis of the CLCA1 VWA
            Domain Suggests Mode of TMEM16A Engagement.
REFERENCE   4  (bases 1 to 3004)
  AUTHORS   Nystrom,E.E.L., Arike,L., Ehrencrona,E., Hansson,G.C. and
            Johansson,M.E.V.
  TITLE     Calcium-activated chloride channel regulator 1 (CLCA1) forms
            non-covalent oligomers in colonic mucus and has mucin 2-processing
            properties
  JOURNAL   J Biol Chem 294 (45), 17075-17089 (2019)
   PUBMED   31570526
  REMARK    GeneRIF: SDR16C5 and SDR16C6 enzymes are not critical for survival
            but are responsible for most of the retinol dehydrogenase activity
            in skin, essential for the regulation of the hair-follicle cycle,
            and required for the maintenance of both sebaceous and meibomian
            glands
REFERENCE   5  (bases 1 to 3004)
  AUTHORS   Nystrom,E.E.L., Birchenough,G.M.H., van der Post,S., Arike,L.,
            Gruber,A.D., Hansson,G.C. and Johansson,M.E.V.
  TITLE     Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls
            Mucus Expansion in Colon by Proteolytic Activity
  JOURNAL   EBioMedicine 33, 134-143 (2018)
   PUBMED   29885864
  REMARK    GeneRIF: Results suggest that CLCA1 is involved in intestinal mucus
            homeostasis by facilitating processing and removal of mucus to
            prevent stagnation.
REFERENCE   6  (bases 1 to 3004)
  AUTHORS   Toda,M., Tulic,M.K., Levitt,R.C. and Hamid,Q.
  TITLE     A calcium-activated chloride channel (HCLCA1) is strongly related
            to IL-9 expression and mucus production in bronchial epithelium of
            patients with asthma
  JOURNAL   J Allergy Clin Immunol 109 (2), 246-250 (2002)
   PUBMED   11842292
  REMARK    GeneRIF: upregulation in the IL-9- responsive mucus-producing
            epithelium of asthmatic subjects supports the hypothesis that this
            channel may be responsible, in part, for the overproduction of
            mucus in asthmatic subjects
REFERENCE   7  (bases 1 to 3004)
  AUTHORS   Pauli,B.U., Abdel-Ghany,M., Cheng,H.C., Gruber,A.D., Archibald,H.A.
            and Elble,R.C.
  TITLE     Molecular characteristics and functional diversity of CLCA family
            members
  JOURNAL   Clin Exp Pharmacol Physiol 27 (11), 901-905 (2000)
   PUBMED   11071307
  REMARK    Review article
REFERENCE   8  (bases 1 to 3004)
  AUTHORS   Hume,J.R., Duan,D., Collier,M.L., Yamazaki,J. and Horowitz,B.
  TITLE     Anion transport in heart
  JOURNAL   Physiol Rev 80 (1), 31-81 (2000)
   PUBMED   10617765
  REMARK    Review article
REFERENCE   9  (bases 1 to 3004)
  AUTHORS   Agnel,M., Vermat,T. and Culouscou,J.M.
  TITLE     Identification of three novel members of the calcium-dependent
            chloride channel (CaCC) family predominantly expressed in the
            digestive tract and trachea
  JOURNAL   FEBS Lett 455 (3), 295-301 (1999)
   PUBMED   10437792
REFERENCE   10 (bases 1 to 3004)
  AUTHORS   Gruber,A.D., Elble,R.C., Ji,H.L., Schreur,K.D., Fuller,C.M. and
            Pauli,B.U.
  TITLE     Genomic cloning, molecular characterization, and functional
            analysis of human CLCA1, the first human member of the family of
            Ca2+-activated Cl- channel proteins
  JOURNAL   Genomics 54 (2), 200-214 (1998)
   PUBMED   9828122
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA428844.1, AL122002.16 and
            AF127036.1.
            
            On Jun 28, 2019 this sequence version replaced NM_001285.3.
            
            Summary: This gene encodes a member of the calcium sensitive
            chloride conductance protein family. To date, all members of this
            gene family map to the same region on chromosome 1p31-p22 and share
            a high degree of homology in size, sequence, and predicted
            structure, but differ significantly in their tissue distributions.
            The encoded protein is expressed as a precursor protein that is
            processed into two cell-surface-associated subunits, although the
            site at which the precursor is cleaved has not been precisely
            determined. The encoded protein may be involved in mediating
            calcium-activated chloride conductance in the intestine. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291999.1, AF127036.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394711.2/ ENSP00000378200.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               DA428844.1         85-321
            238-238             AL122002.16        6417-6417
            239-482             DA428844.1         323-566
            483-689             AF127036.1         442-648
            690-780             AL122002.16        15262-15352
            781-1114            AF127036.1         740-1073
            1115-1227           AL122002.16        19611-19723
            1228-1615           AF127036.1         1187-1574
            1616-1725           AL122002.16        26460-26569
            1726-2849           AF127036.1         1685-2808
            2850-3004           AL122002.16        33075-33229
FEATURES             Location/Qualifiers
     source          1..3004
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..3004
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /note="chloride channel accessory 1"
                     /db_xref="GeneID:1179"
                     /db_xref="HGNC:HGNC:2015"
                     /db_xref="MIM:603906"
     exon            1..207
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..2790
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /note="chloride channel regulator 1; CLCA family member 1,
                     chloride channel regulator; chloride channel, calcium
                     activated, family member 1; calcium-activated chloride
                     channel regulator 1; calcium-dependent chloride channel-1;
                     calcium-activated chloride channel protein 1;
                     calcium-activated chloride channel family member 1"
                     /codon_start=1
                     /product="calcium-activated chloride channel regulator 1
                     precursor"
                     /protein_id="NP_001276.3"
                     /db_xref="CCDS:CCDS709.1"
                     /db_xref="GeneID:1179"
                     /db_xref="HGNC:HGNC:2015"
                     /db_xref="MIM:603906"
                     /translation="MGPFKSSVFILILHLLEGALSNSLIQLNNNGYEGIVVAIDPNVP
                     EDETLIQQIKDMVTQASLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNA
                     DVLVAESTPPGNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAH
                     LRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKKCQGGSCYTKRCTFNKVTGL
                     YEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVI
                     RDSEDFKKTTPMTTQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFL
                     LQTVELGSWVGMVTFDSAAHVQNELIQINSGSDRDTLAKRLPAAASGGTSICSGLRSA
                     FTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSK
                     MTGGLQTYASDQVQNNGLIDAFGALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIV
                     DSTVGKDTLFLITWTMQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIAKVGTWKY
                     SLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRA
                     SVTALIESVNGKTVTLELLDNGAGADATKDDGVYSRYFTTYDTNGRYSVKVRALGGVN
                     AARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVAS
                     DVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILD
                     LRDKFNESLQVNTTALIPKEANSEEVFLFKPENITFENGTDLFIAIQAVDKVDLKSEI
                     SNIARVSLFIPPQTPPETPSPDETSAPCPNIHINSTIPGIHILKIMWKWIGELQLSIA
                     "
     exon            208..348
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..496
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..602
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..780
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..999
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1227
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1402
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1509
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1725
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1987
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2158
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2398
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..3004
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2811..2816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /note="hexamer: AATAAA"
     polyA_site      2833
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
     regulatory      2981..2986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /note="hexamer: AATAAA"
     polyA_site      3004
                     /gene="CLCA1"
                     /gene_synonym="CACC; CaCC-1; CACC1; CLCRG1; GOB5; hCaCC-1;
                     hCLCA1"
                     /note="major polyA site"
ORIGIN      
        1 aacccgcatt ttccaaagag agaaatcaca gggagatgta cagcaatggg gccatttaag
       61 agttctgtgt tcatcttgat tcttcacctt ctagaagggg ccctgagtaa ttcactcatt
      121 cagctgaaca acaatggcta tgaaggcatt gtcgttgcaa tcgaccccaa tgtgccagaa
      181 gatgaaacac tcattcaaca aataaaggac atggtgaccc aggcatctct gtatctgctt
      241 gaagctacag gaaagcgatt ttatttcaaa aatgttgcca ttttgattcc tgaaacatgg
      301 aagacaaagg ctgactatgt gagaccaaaa cttgagacct acaaaaatgc tgatgttctg
      361 gttgctgagt ctactcctcc aggtaatgat gaaccctaca ctgagcagat gggcaactgt
      421 ggagagaagg gtgaaaggat ccacctcact cctgatttca ttgcaggaaa aaagttagct
      481 gaatatggac cacaaggtag ggcatttgtc catgagtggg ctcatctacg atggggagta
      541 tttgacgagt acaataatga tgagaaattc tacttatcca atggaagaat acaagcagta
      601 agatgttcag caggtattac tggtacaaat gtagtaaaga agtgtcaggg aggcagctgt
      661 tacaccaaaa gatgcacatt caataaagta acaggactct atgaaaaagg atgtgagttt
      721 gttctccaat cccgccagac ggagaaggct tctataatgt ttgcacaaca tgttgattct
      781 atagttgaat tctgtacaga acaaaaccac aacaaagaag ctccaaacaa gcaaaatcaa
      841 aaatgcaatc tccgaagcac atgggaagtg atccgtgatt ctgaggactt taagaaaacc
      901 actcctatga caacacagcc accaaatccc accttctcat tgctgcagat tggacaaaga
      961 attgtgtgtt tagtccttga caaatctgga agcatggcga ctggtaaccg cctcaatcga
     1021 ctgaatcaag caggccagct tttcctgctg cagacagttg agctggggtc ctgggttggg
     1081 atggtgacat ttgacagtgc tgcccatgta caaaatgaac tcatacagat aaacagtggc
     1141 agtgacaggg acacactcgc caaaagatta cctgcagcag cttcaggagg gacgtccatc
     1201 tgcagcgggc ttcgatcggc atttactgtg attaggaaga aatatccaac tgatggatct
     1261 gaaattgtgc tgctgacgga tggggaagac aacactataa gtgggtgctt taacgaggtc
     1321 aaacaaagtg gtgccatcat ccacacagtc gctttggggc cctctgcagc tcaagaacta
     1381 gaggagctgt ccaaaatgac aggaggttta cagacatatg cttcagatca agttcagaac
     1441 aatggcctca ttgatgcttt tggggccctt tcatcaggaa atggagctgt ctctcagcgc
     1501 tccatccagc ttgagagtaa gggattaacc ctccagaaca gccagtggat gaatggcaca
     1561 gtgatcgtgg acagcaccgt gggaaaggac actttgtttc ttatcacctg gacaatgcag
     1621 cctccccaaa tccttctctg ggatcccagt ggacagaagc aaggtggctt tgtagtggac
     1681 aaaaacacca aaatggccta cctccaaatc ccaggcattg ctaaggttgg cacttggaaa
     1741 tacagtctgc aagcaagctc acaaaccttg accctgactg tcacgtcccg tgcgtccaat
     1801 gctaccctgc ctccaattac agtgacttcc aaaacgaaca aggacaccag caaattcccc
     1861 agccctctgg tagtttatgc aaatattcgc caaggagcct ccccaattct cagggccagt
     1921 gtcacagccc tgattgaatc agtgaatgga aaaacagtta ccttggaact actggataat
     1981 ggagcaggtg ctgatgctac taaggatgac ggtgtctact caaggtattt cacaacttat
     2041 gacacgaatg gtagatacag tgtaaaagtg cgggctctgg gaggagttaa cgcagccaga
     2101 cggagagtga taccccagca gagtggagca ctgtacatac ctggctggat tgagaatgat
     2161 gaaatacaat ggaatccacc aagacctgaa attaataagg atgatgttca acacaagcaa
     2221 gtgtgtttca gcagaacatc ctcgggaggc tcatttgtgg cttctgatgt cccaaatgct
     2281 cccatacctg atctcttccc acctggccaa atcaccgacc tgaaggcgga aattcacggg
     2341 ggcagtctca ttaatctgac ttggacagct cctggggatg attatgacca tggaacagct
     2401 cacaagtata tcattcgaat aagtacaagt attcttgatc tcagagacaa gttcaatgaa
     2461 tctcttcaag tgaatactac tgctctcatc ccaaaggaag ccaactctga ggaagtcttt
     2521 ttgtttaaac cagaaaacat tacttttgaa aatggcacag atcttttcat tgctattcag
     2581 gctgttgata aggtcgatct gaaatcagaa atatccaaca ttgcacgagt atctttgttt
     2641 attcctccac agactccgcc agagacacct agtcctgatg aaacgtctgc tccttgtcct
     2701 aatattcata tcaacagcac cattcctggc attcacattt taaaaattat gtggaagtgg
     2761 ataggagaac tgcagctgtc aatagcctag ggctgaattt ttgtcagata aataaaataa
     2821 atcattcatc cttttttttg attataaaat tttctaaaat gtattttaga cttcctgtag
     2881 ggggcgatat actaaatgta tatagtacat ttatactaaa tgtattcctg tagggggcga
     2941 tatactaaat gtattttaga cttcctgtag ggggcgataa aataaaatgc taaacaactg
     3001 ggta
//
