LOCUS       NM_001828                631 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Charcot-Leyden crystal galectin (CLC), mRNA.
ACCESSION   NM_001828
VERSION     NM_001828.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 631)
  AUTHORS   Sato,T., Chiba,T., Nakahara,T., Watanabe,K., Sakai,S., Noguchi,N.,
            Noto,M., Ueki,S. and Kono,M.
  TITLE     Eosinophil-derived galectin-10 upregulates matrix metalloproteinase
            expression in bullous pemphigoid blisters
  JOURNAL   J Dermatol Sci 112 (1), 6-14 (2023)
   PUBMED   37640566
  REMARK    GeneRIF: Eosinophil-derived galectin-10 upregulates matrix
            metalloproteinase expression in bullous pemphigoid blisters.
REFERENCE   2  (bases 1 to 631)
  AUTHORS   Oguz,A.K., Oygur,C.S., Tasir,S., Ozdag,H. and Akar,M.N.
  TITLE     Behcet syndrome: The disturbed balance between anti- (CLEC12A, CLC)
            and proinflammatory (IFI27) gene expressions
  JOURNAL   Immun Inflamm Dis 11 (4), e836 (2023)
   PUBMED   37102643
  REMARK    GeneRIF: Behcet syndrome: The disturbed balance between anti-
            (CLEC12A, CLC) and proinflammatory (IFI27) gene expressions.
REFERENCE   3  (bases 1 to 631)
  AUTHORS   Na,H., Sayed,H., Ayala,G.J., Wang,X., Liu,Y., Yu,J., Liu,T.,
            Mayo,K.H. and Su,J.
  TITLE     Glutathione disrupts galectin-10 Charcot-Leyden crystal formation
            to possibly ameliorate eosinophil-based diseases such as asthma
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (4), 613-622 (2023)
   PUBMED   36988350
  REMARK    GeneRIF: Glutathione disrupts galectin-10 Charcot-Leyden crystal
            formation to possibly ameliorate eosinophil-based diseases such as
            asthma.
REFERENCE   4  (bases 1 to 631)
  AUTHORS   Tomizawa,H., Yamada,Y., Arima,M., Miyabe,Y., Fukuchi,M.,
            Hikichi,H., Melo,R.C.N., Yamada,T. and Ueki,S.
  TITLE     Galectin-10 as a Potential Biomarker for Eosinophilic Diseases
  JOURNAL   Biomolecules 12 (10), 1385 (2022)
   PUBMED   36291593
  REMARK    GeneRIF: Galectin-10 as a Potential Biomarker for Eosinophilic
            Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 631)
  AUTHORS   Zhao,Y., Mo,S., Yu,L., Li,X., Hao,Y., Zhang,W., Zhang,Q., Wang,P.,
            Wang,X., Wang,C. and Zhang,L.
  TITLE     Crystalline State Determines the Potency of Galectin-10 Protein
            Assembly to Induce Inflammation
  JOURNAL   Nano Lett 22 (6), 2350-2357 (2022)
   PUBMED   35274950
  REMARK    GeneRIF: Crystalline State Determines the Potency of Galectin-10
            Protein Assembly to Induce Inflammation.
REFERENCE   6  (bases 1 to 631)
  AUTHORS   Mastrianni,D.M., Eddy,R.L., Rosenberg,H.F., Corrette,S.E.,
            Shows,T.B., Tenen,D.G. and Ackerman,S.J.
  TITLE     Localization of the human eosinophil Charcot-Leyden crystal protein
            (lysophospholipase) gene (CLC) to chromosome 19 and the human
            ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3
            (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome
            14
  JOURNAL   Genomics 13 (1), 240-242 (1992)
   PUBMED   1577491
REFERENCE   7  (bases 1 to 631)
  AUTHORS   Golightly,L.M., Thomas,L.L., Dvorak,A.M. and Ackerman,S.J.
  TITLE     Charcot-Leyden crystal protein in the degranulation and recovery of
            activated basophils
  JOURNAL   J Leukoc Biol 51 (4), 386-392 (1992)
   PUBMED   1373430
REFERENCE   8  (bases 1 to 631)
  AUTHORS   Dvorak,A.M., Letourneau,L., Weller,P.F. and Ackerman,S.J.
  TITLE     Ultrastructural localization of Charcot-Leyden crystal protein
            (lysophospholipase) to intracytoplasmic crystals in tumor cells of
            primary solid and papillary epithelial neoplasm of the pancreas
  JOURNAL   Lab Invest 62 (5), 608-615 (1990)
   PUBMED   2160563
REFERENCE   9  (bases 1 to 631)
  AUTHORS   Dvorak,A.M., Weller,P.F., Monahan-Earley,R.A., Letourneau,L. and
            Ackerman,S.J.
  TITLE     Ultrastructural localization of Charcot-Leyden crystal protein
            (lysophospholipase) and peroxidase in macrophages, eosinophils, and
            extracellular matrix of the skin in the hypereosinophilic syndrome
  JOURNAL   Lab Invest 62 (5), 590-607 (1990)
   PUBMED   2160562
REFERENCE   10 (bases 1 to 631)
  AUTHORS   Gleich,G.J., Loegering,D.A., Mann,K.G. and Maldonado,J.E.
  TITLE     Comparative properties of the Charcot-Leyden crystal protein and
            the major basic protein from human eosinophils
  JOURNAL   J Clin Invest 57 (3), 633-640 (1976)
   PUBMED   942977
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AV762486.1, AV715261.1 and
            AW292557.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001828.5.
            
            Summary: Lysophospholipases are enzymes that act on biological
            membranes to regulate the multifunctional lysophospholipids. The
            protein encoded by this gene is a lysophospholipase expressed in
            eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to
            glycerophosphocholine and a free fatty acid. This protein may
            possess carbohydrate or IgE-binding activities. It is both
            structurally and functionally related to the galectin family of
            beta-galactoside binding proteins. It may be associated with
            inflammation and some myeloid leukemias. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV715152.1, AV714984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221804.5/ ENSP00000221804.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AV762486.1         1-143
            144-628             AV715261.1         143-627
            629-631             AW292557.1         19-21               c
FEATURES             Location/Qualifiers
     source          1..631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..631
                     /gene="CLC"
                     /gene_synonym="Gal-10; GAL10; LGALS10; LGALS10A;
                     LPPL_HUMAN"
                     /note="Charcot-Leyden crystal galectin"
                     /db_xref="GeneID:1178"
                     /db_xref="HGNC:HGNC:2014"
                     /db_xref="MIM:153310"
     exon            1..92
                     /gene="CLC"
                     /gene_synonym="Gal-10; GAL10; LGALS10; LGALS10A;
                     LPPL_HUMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..506
                     /gene="CLC"
                     /gene_synonym="Gal-10; GAL10; LGALS10; LGALS10A;
                     LPPL_HUMAN"
                     /EC_number="3.1.1.5"
                     /note="eosinophil lysophospholipase; lysolecithin
                     acylhydrolase; Charcot-Leyden crystal protein; lectin,
                     galactoside-binding, soluble, 10"
                     /codon_start=1
                     /product="galectin-10"
                     /protein_id="NP_001819.2"
                     /db_xref="CCDS:CCDS33025.1"
                     /db_xref="GeneID:1178"
                     /db_xref="HGNC:HGNC:2014"
                     /db_xref="MIM:153310"
                     /translation="MSLLPVPYTEAASLSTGSTVTIKGRPLACFLNEPYLQVDFHTEM
                     KEESDIVFHFQVCFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQV
                     MVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR"
     exon            93..169
                     /gene="CLC"
                     /gene_synonym="Gal-10; GAL10; LGALS10; LGALS10A;
                     LPPL_HUMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            170..380
                     /gene="CLC"
                     /gene_synonym="Gal-10; GAL10; LGALS10; LGALS10A;
                     LPPL_HUMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            381..631
                     /gene="CLC"
                     /gene_synonym="Gal-10; GAL10; LGALS10; LGALS10A;
                     LPPL_HUMAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      610..615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLC"
                     /gene_synonym="Gal-10; GAL10; LGALS10; LGALS10A;
                     LPPL_HUMAN"
                     /note="hexamer: ATTAAA"
     polyA_site      631
                     /gene="CLC"
                     /gene_synonym="Gal-10; GAL10; LGALS10; LGALS10A;
                     LPPL_HUMAN"
                     /note="major polyA site"
ORIGIN      
        1 catttaaatt ctgcagctca gagattcaca cagaagtctg gacacaattc agaagagcca
       61 cccagaagga gacaacaatg tccctgctac ccgtgccata cacagaggct gcctctttgt
      121 ctactggttc tactgtgaca atcaaagggc gaccacttgc ctgtttcttg aatgaaccat
      181 atctgcaggt ggatttccac actgagatga aggaggaatc agacattgtc ttccatttcc
      241 aagtgtgctt tggtcgtcgt gtggtcatga acagccgtga gtatggggcc tggaagcagc
      301 aggtggaatc caagaatatg ccctttcagg atggccaaga atttgaactg agcatctcag
      361 tgctgccaga taagtaccag gtaatggtca atggccaatc ctcttacacc tttgaccata
      421 gaatcaagcc tgaggctgtg aagatggtgc aagtgtggag agatatctcc ctgaccaaat
      481 ttaatgtcag ctatttaaag agataaccag acttcatgtt gccaaggaat ccctgtctct
      541 acgtgaactt gggattccaa agccagctaa cagcatgatc ttttctcact tcaatcctta
      601 ctcctgctca ttaaaactta atcaaacttc a
//
