LOCUS       NM_007056               2229 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens CLK4 associating serine/arginine rich protein
            (CLASRP), transcript variant 1, mRNA.
ACCESSION   NM_007056
VERSION     NM_007056.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2229)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2229)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2229)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 2229)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2229)
  AUTHORS   Xu,Z., Lie,R.T., Wilcox,A.J., Saugstad,O.D. and Taylor,J.A.
  TITLE     A comparison of DNA methylation in newborn blood samples from
            infants with and without orofacial clefts
  JOURNAL   Clin Epigenetics 11 (1), 40 (2019)
   PUBMED   30832715
  REMARK    GeneRIF: Data identified a significantly differentially methylated
            cg26985354 near gene CLASRP to be associated with cleft lip and
            cleft palate.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2229)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   7  (bases 1 to 2229)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   8  (bases 1 to 2229)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 2229)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 2229)
  AUTHORS   Katsu,R., Onogi,H., Wada,K., Kawaguchi,Y. and Hagiwara,M.
  TITLE     Novel SR-rich-related protein clasp specifically interacts with
            inactivated Clk4 and induces the exon EB inclusion of Clk
  JOURNAL   J Biol Chem 277 (46), 44220-44228 (2002)
   PUBMED   12169693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF042800.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007056.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF042800.1, SRR3476690.1148120.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221455.8/ ENSP00000221455.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2229              AF042800.1         6-2234
FEATURES             Location/Qualifiers
     source          1..2229
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2229
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /note="CLK4 associating serine/arginine rich protein"
                     /db_xref="GeneID:11129"
                     /db_xref="HGNC:HGNC:17731"
                     /db_xref="MIM:618532"
     exon            1..64
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            65..192
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..2118
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     suppressor of white apricot homolog 2; Clk4 associating
                     SR-related protein; splicing factor, arginine/serine-rich
                     16 (suppressor-of-white-apricot homolog, Drosophila)"
                     /codon_start=1
                     /product="CLK4-associating serine/arginine rich protein
                     isoform 1"
                     /protein_id="NP_008987.2"
                     /db_xref="CCDS:CCDS12652.2"
                     /db_xref="GeneID:11129"
                     /db_xref="HGNC:HGNC:17731"
                     /db_xref="MIM:618532"
                     /translation="MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQVH
                     GRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIPDYTPPLLTTISP
                     EQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDEKKKLAEKK
                     ASIGYTYEDSTVAEVEKAAEKPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQV
                     ADLNKQATTYGMADGDFVRMLRKDKEEAEAIKHAKALEEEKAMYSGRRSRRQRREFRE
                     KRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPTPGREEKITFITSFGG
                     SDEEAAAAAAAAAASGVTTGKPPAPPQPGGPAPGRNASARRRSSSSSSSSSASRTSSS
                     RSSSRSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGSRDG
                     HRYSRSPARRGGYGPRRRSRSRSHSGDRYRRGGRGLRHHSSSRSRSSWSLSPSRSRSL
                     TRSRSHSPSPSQSRSRSRSRSQSPSPSPAREKLTRPAASPAVGEKLKKTEPAAGKETG
                     AAKPKLTPQEKLKLRMQKALNRQFKADKKAAQEKMIQQEHERQEREDELRAMARKIRM
                     KERERREKEREEWERQYSRQSRSPSPRYSREYSSSRRRSRSRSRSPHYRH"
     exon            193..290
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            291..392
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..472
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..557
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..706
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..803
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            804..882
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            883..956
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..998
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1214
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1502
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1760
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1800
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1861
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1920
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..1967
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2050
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2075
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2229
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2199..2204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /note="hexamer: AATAAA"
     polyA_site      2229
                     /gene="CLASRP"
                     /gene_synonym="CLASP; SFRS16; SWAP2"
                     /note="major polyA site"
ORIGIN      
        1 ctttcatttc cgcttccggt gcgggccgcg cgcgagcgca gcggtgggag gcggcgacca
       61 gccggttgag gccccaggct tggcctcacc acaatgtggc acgaggctcg gaagcatgag
      121 cggaagcttc gaggcatgat ggtcgactac aagaagaggg cggagcggag acgggagtat
      181 tatgaaaaga tcaagaagga cccagcccag ttcctgcagg tacatggccg agcttgcaag
      241 gtgcacctgg attctgcagt cgccctggcc gctgagagcc ctgttaatat gatgccctgg
      301 cagggggaca ccaacaacat gattgaccga ttcgatgtcc gtgcccacct ggaccacatc
      361 cccgactaca ccccccctct gctcaccacc atctccccag aacaggagtc ggacgaacgg
      421 aagtgtaact acgagcgcta cagaggcctg gtgcagaacg actttgccgg catctcagag
      481 gagcagtgcc tgtaccagat ctacattgat gagttgtacg gaggcctcca gagacccagc
      541 gaagatgaga agaagaagct ggcagagaag aaggcttcca tcggttatac ctacgaggac
      601 agcacggtgg ccgaggtaga gaaggcggca gaaaagccag aggaggagga gtcagcggcc
      661 gaggaggaga gcaactcgga cgaagatgag gtcatccccg acatcgacgt ggaggtggac
      721 gtggatgaat tgaaccagga gcaggtggca gatctcaaca aacaggccac gacttatggc
      781 atggccgacg gtgacttcgt caggatgctc cggaaagaca aggaggaggc agaggccatc
      841 aagcatgcca aggctcttga ggaggagaag gccatgtact cgggacgccg ctctcgacgc
      901 cagcggagag agtttcggga gaagcggctg aggggtcgca agatcagccc acccagctat
      961 gcccgccgag acagccccac ctatgacccc tataagcggt caccctcgga gtccagctca
     1021 gagtcccgct cccgctcccg ctccccgacc ccgggccgcg aggagaagat cacgttcatc
     1081 accagttttg ggggcagcga tgaggaggca gccgcagccg ctgctgccgc agcagcatca
     1141 ggagtcacca cagggaagcc ccccgcacct ccccagcctg gcggccccgc cccgggacgt
     1201 aatgccagcg cccgccgccg ctcctcctcc tcctcctcct cctcttctgc ctcgaggacc
     1261 tccagctccc gctccagctc tcgctccagc tcccgctctc gccgtggtgg gggctactac
     1321 cgttccggcc gccacgcccg ctcccggtcc cgctcctggt cccgctcccg ctcccgctcc
     1381 cggcgctatt cccggtcccg tagccgtggc cggcggcact caggtggggg ctcccgagac
     1441 ggacaccggt actcccgctc gcccgcccgg cgtggtggtt acgggccccg gcgcagaagc
     1501 aggagccgct cccactcagg ggaccgctac aggcggggcg gccggggcct caggcaccac
     1561 agcagtagcc gcagccgcag cagctggtcc ctcagcccgt cccgcagtcg cagcctgact
     1621 cgcagccgca gccatagccc cagccccagc cagagccgca gccgcagccg cagccgcagc
     1681 cagagcccct cgccatcacc cgcaagagag aagctgacca ggccggccgc gtcccctgct
     1741 gtgggcgaga agctgaaaaa gaccgaacct gccgctggta aagagacagg agctgccaaa
     1801 cccaagctga cgcctcagga gaagctgaaa ctgaggatgc agaaggcgct gaacaggcag
     1861 ttcaaggcgg ataagaaggc ggcacaagaa aagatgatcc agcaggagca tgagcggcag
     1921 gagcgggaag acgagcttcg agccatggcc cgcaagatcc gcatgaagga gcgggaacgc
     1981 cgagagaagg agagagaaga gtgggaacgc cagtacagcc ggcagagccg ctcaccctcc
     2041 ccccgataca gtcgagaata cagctcttct cgaaggcgct caaggtcccg atcccgaagc
     2101 ccccattacc gacattaggc agaagagtgg ggggtgggga ggacaagggg gtgggtaagg
     2161 ggctcaagct gtgatgctgc tggttttatc tctagtgaaa taaagtcaaa agttatttaa
     2221 ttcccgtca
//
