LOCUS       NM_001826                779 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens CDC28 protein kinase regulatory subunit 1B (CKS1B),
            transcript variant 1, mRNA.
ACCESSION   NM_001826
VERSION     NM_001826.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 779)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 779)
  AUTHORS   Deng,T., Liu,Y., Yang,Y., Yuan,L., Liu,F., Wang,X., Zhang,Q. and
            Xie,M.
  TITLE     Regulation of microRNA miR-197-3p/CDC28 protein kinase regulatory
            subunit 1B (CKS1B) axis by Circular RNA hsa_circ_0000285 promotes
            glioma progression
  JOURNAL   Bioengineered 13 (3), 4757-4772 (2022)
   PUBMED   35174774
  REMARK    GeneRIF: Regulation of microRNA miR-197-3p/CDC28 protein kinase
            regulatory subunit 1B (CKS1B) axis by Circular RNA hsa_circ_0000285
            promotes glioma progression.
REFERENCE   3  (bases 1 to 779)
  AUTHORS   Alerasool,N., Leng,H., Lin,Z.Y., Gingras,A.C. and Taipale,M.
  TITLE     Identification and functional characterization of transcriptional
            activators in human cells
  JOURNAL   Mol Cell 82 (3), 677-695 (2022)
   PUBMED   35016035
REFERENCE   4  (bases 1 to 779)
  AUTHORS   Jia,Y., Tian,Q., Yang,K., Liu,Y. and Liu,Y.
  TITLE     A Pan-Cancer Analysis of Clinical Prognosis and Immune Infiltration
            of CKS1B in Human Tumors
  JOURNAL   Biomed Res Int 2021, 5862941 (2021)
   PUBMED   34845438
  REMARK    GeneRIF: A Pan-Cancer Analysis of Clinical Prognosis and Immune
            Infiltration of CKS1B in Human Tumors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 779)
  AUTHORS   Hu,K., Li,X.J., Asmamaw,M.D., Shi,X.J. and Liu,H.M.
  TITLE     Establishment of high-throughput screening HTRF assay for
            identification small molecule inhibitors of Skp2-Cks1
  JOURNAL   Sci Rep 11 (1), 21105 (2021)
   PUBMED   34702937
  REMARK    GeneRIF: Establishment of high-throughput screening HTRF assay for
            identification small molecule inhibitors of Skp2-Cks1.
            Erratum:[Sci Rep. 2021 Nov 10;11(1):22338. doi:
            10.1038/s41598-021-01776-4.. PMID: 34759370]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 779)
  AUTHORS   De Veylder,L., Segers,G., Glab,N., Casteels,P., Van Montagu,M. and
            Inze,D.
  TITLE     The Arabidopsis Cks1At protein binds the cyclin-dependent kinases
            Cdc2aAt and Cdc2bAt
  JOURNAL   FEBS Lett 412 (3), 446-452 (1997)
   PUBMED   9276444
REFERENCE   7  (bases 1 to 779)
  AUTHORS   Bourne,Y., Watson,M.H., Hickey,M.J., Holmes,W., Rocque,W.,
            Reed,S.I. and Tainer,J.A.
  TITLE     Crystal structure and mutational analysis of the human CDK2 kinase
            complex with cell cycle-regulatory protein CksHs1
  JOURNAL   Cell 84 (6), 863-874 (1996)
   PUBMED   8601310
REFERENCE   8  (bases 1 to 779)
  AUTHORS   Demetrick,D.J., Zhang,H. and Beach,D.H.
  TITLE     Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to
            9q22
  JOURNAL   Cytogenet Cell Genet 73 (3), 250-254 (1996)
   PUBMED   8697818
REFERENCE   9  (bases 1 to 779)
  AUTHORS   Arvai,A.S., Bourne,Y., Hickey,M.J. and Tainer,J.A.
  TITLE     Crystal structure of the human cell cycle protein CksHs1: single
            domain fold with similarity to kinase N-lobe domain
  JOURNAL   J Mol Biol 249 (5), 835-842 (1995)
   PUBMED   7791211
REFERENCE   10 (bases 1 to 779)
  AUTHORS   Richardson,H.E., Stueland,C.S., Thomas,J., Russell,P. and Reed,S.I.
  TITLE     Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated
            protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe
  JOURNAL   Genes Dev 4 (8), 1332-1344 (1990)
   PUBMED   2227411
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN347951.1, BQ883992.1 and
            AL451085.20.
            
            On Nov 23, 2018 this sequence version replaced NM_001826.2.
            
            Summary: CKS1B protein binds to the catalytic subunit of the cyclin
            dependent kinases and is essential for their biological function.
            The CKS1B mRNA is found to be expressed in different patterns
            through the cell cycle in HeLa cells, which reflects a specialized
            role for the encoded protein. At least two transcript variants have
            been identified for this gene, and it appears that only one of them
            encodes a protein. [provided by RefSeq, Sep 2008].
            
            Transcript Variant: This variant (1) is the protein-coding variant.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070319.1, CD247130.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308987.6/ ENSP00000311083.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-529               CN347951.1         42-570
            530-777             BQ883992.1         508-755
            778-779             AL451085.20        107688-107689
FEATURES             Location/Qualifiers
     source          1..779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..779
                     /gene="CKS1B"
                     /gene_synonym="CKS1; ckshs1; PNAS-16; PNAS-18"
                     /note="CDC28 protein kinase regulatory subunit 1B"
                     /db_xref="GeneID:1163"
                     /db_xref="HGNC:HGNC:19083"
                     /db_xref="MIM:116900"
     exon            1..124
                     /gene="CKS1B"
                     /gene_synonym="CKS1; ckshs1; PNAS-16; PNAS-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..305
                     /gene="CKS1B"
                     /gene_synonym="CKS1; ckshs1; PNAS-16; PNAS-18"
                     /note="CDC28 protein kinase 1B; cell division control
                     protein CKS1; NB4 apoptosis/differentiation related
                     protein; CDC2-associated protein CKS1"
                     /codon_start=1
                     /product="cyclin-dependent kinases regulatory subunit 1"
                     /protein_id="NP_001817.1"
                     /db_xref="CCDS:CCDS1077.1"
                     /db_xref="GeneID:1163"
                     /db_xref="HGNC:HGNC:19083"
                     /db_xref="MIM:116900"
                     /translation="MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWR
                     NLGVQQSQGWVHYMIHEPEPHILLFRRPLPKKPKK"
     exon            125..252
                     /gene="CKS1B"
                     /gene_synonym="CKS1; ckshs1; PNAS-16; PNAS-18"
                     /inference="alignment:Splign:2.1.0"
     exon            253..779
                     /gene="CKS1B"
                     /gene_synonym="CKS1; ckshs1; PNAS-16; PNAS-18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      752..757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CKS1B"
                     /gene_synonym="CKS1; ckshs1; PNAS-16; PNAS-18"
                     /note="hexamer: ATTAAA"
     polyA_site      779
                     /gene="CKS1B"
                     /gene_synonym="CKS1; ckshs1; PNAS-16; PNAS-18"
                     /note="major polyA site"
ORIGIN      
        1 gcgtgctgtt gggagttgct tggaggttgg cggcgcgggg ctgaaggcta gcaaaccgag
       61 cgatcatgtc gcacaaacaa atttactatt cggacaaata cgacgacgag gagtttgagt
      121 atcgacatgt catgctgccc aaggacatag ccaagctggt ccctaaaacc catctgatgt
      181 ctgaatctga atggaggaat cttggcgttc agcagagtca gggatgggtc cattatatga
      241 tccatgaacc agaacctcac atcttgctgt tccggcgccc actacccaag aaaccaaaga
      301 aatgaagctg gcaagctact tttcagcctc aagctttaca cagctgtcct tacttcctaa
      361 catctttctg ataacattat tatgttgcct tcttgtttct cactttgata tttaaaagat
      421 gttcaataca ctgtttgaat gtgctggtaa ctgctttgct tcttgagtag agccaccacc
      481 accatagccc agccagatga gtgctctgtg gacccacagc ctaagctgag tgtgacccca
      541 gaagccacga tgtgctctgt atccagaaca cacttggcag atggaggaag catctgagtt
      601 tgagaccatg gctgttacag ggatcatgta aacttgctgt ttttgttttt tcctgccggg
      661 tgttgtatgt gtggtgactt gcggatttat gtttcagtgt actggaaact ttccatttta
      721 ttcaagaaat ctgttcatgt taaaagcctt gattaaagag gaagttttta taatctagt
//
