LOCUS       NM_001824               1556 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens creatine kinase, M-type (CKM), mRNA.
ACCESSION   NM_001824
VERSION     NM_001824.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1556)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1556)
  AUTHORS   Sang,P., Ma,Y., Chen,B. and Zhang,M.
  TITLE     The role of serum creatine kinase levels in anterior cervical
            spinal surgery: Change trends and risk factors
  JOURNAL   Medicine (Baltimore) 100 (51), e28300 (2021)
   PUBMED   34941118
  REMARK    GeneRIF: The role of serum creatine kinase levels in anterior
            cervical spinal surgery: Change trends and risk factors.
REFERENCE   3  (bases 1 to 1556)
  AUTHORS   Gineviciene,V., Jakaitiene,A., Utkus,A., Hall,E.C.R.,
            Semenova,E.A., Andryushchenko,L.B., Larin,A.K., Moreland,E.,
            Generozov,E.V. and Ahmetov,I.I.
  TITLE     CKM Gene rs8111989 Polymorphism and Power Athlete Status
  JOURNAL   Genes (Basel) 12 (10), 1499 (2021)
   PUBMED   34680894
  REMARK    GeneRIF: CKM Gene rs8111989 Polymorphism and Power Athlete Status.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1556)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1556)
  AUTHORS   Walker,M.A., Chavez,J., Villet,O., Tang,X., Keller,A., Bruce,J.E.
            and Tian,R.
  TITLE     Acetylation of muscle creatine kinase negatively impacts
            high-energy phosphotransfer in heart failure
  JOURNAL   JCI Insight 6 (3), 144301 (2021)
   PUBMED   33554956
  REMARK    GeneRIF: Acetylation of muscle creatine kinase negatively impacts
            high-energy phosphotransfer in heart failure.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1556)
  AUTHORS   Hamburg,R.J., Friedman,D.L., Olson,E.N., Ma,T.S., Cortez,M.D.,
            Goodman,C., Puleo,P.R. and Perryman,M.B.
  TITLE     Muscle creatine kinase isoenzyme expression in adult human brain
  JOURNAL   J Biol Chem 265 (11), 6403-6409 (1990)
   PUBMED   1690725
REFERENCE   7  (bases 1 to 1556)
  AUTHORS   Huszar,G. and Vigue,L.
  TITLE     Spermatogenesis-related change in the synthesis of the creatine
            kinase B-type and M-type isoforms in human spermatozoa
  JOURNAL   Mol Reprod Dev 25 (3), 258-262 (1990)
   PUBMED   2331374
REFERENCE   8  (bases 1 to 1556)
  AUTHORS   Smeets,H., Bachinski,L., Coerwinkel,M., Schepens,J.,
            Hoeijmakers,J., van Duin,M., Grzeschik,K.H., Weber,C.A., de
            Jong,P., Siciliano,M.J. et al.
  TITLE     A long-range restriction map of the human chromosome 19q13 region:
            close physical linkage between CKMM and the ERCC1 and ERCC2 genes
  JOURNAL   Am J Hum Genet 46 (3), 492-501 (1990)
   PUBMED   2309701
REFERENCE   9  (bases 1 to 1556)
  AUTHORS   Trask,R.V., Strauss,A.W. and Billadello,J.J.
  TITLE     Developmental regulation and tissue-specific expression of the
            human muscle creatine kinase gene
  JOURNAL   J Biol Chem 263 (32), 17142-17149 (1988)
   PUBMED   2903158
REFERENCE   10 (bases 1 to 1556)
  AUTHORS   Nigro,J.M., Schweinfest,C.W., Rajkovic,A., Pavlovic,J., Jamal,S.,
            Dottin,R.P., Hart,J.T., Kamarck,M.E., Rae,P.M., Carty,M.D. et al.
  TITLE     cDNA cloning and mapping of the human creatine kinase M gene to
            19q13
  JOURNAL   Am J Hum Genet 40 (2), 115-125 (1987)
   PUBMED   3031982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA896166.1, AK313281.1 and
            AJ572902.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001824.4.
            
            Summary: The protein encoded by this gene is a cytoplasmic enzyme
            involved in energy homeostasis and is an important serum marker for
            myocardial infarction. The encoded protein reversibly catalyzes the
            transfer of phosphate between ATP and various phosphogens such as
            creatine phosphate. It acts as a homodimer in striated muscle as
            well as in other tissues, and as a heterodimer with a similar brain
            isozyme in heart. The encoded protein is a member of the
            ATP:guanido phosphotransferase protein family. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007462.1, SRR5189655.101838.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800, SAMEA2159607
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221476.4/ ENSP00000221476.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-453               DA896166.1         101-553
            454-1219            AK313281.1         454-1219
            1220-1556           AJ572902.1         84-420
FEATURES             Location/Qualifiers
     source          1..1556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..1556
                     /gene="CKM"
                     /gene_synonym="CKMM; CPK-M; M-CK"
                     /note="creatine kinase, M-type"
                     /db_xref="GeneID:1158"
                     /db_xref="HGNC:HGNC:1994"
                     /db_xref="MIM:123310"
     exon            1..55
                     /gene="CKM"
                     /gene_synonym="CKMM; CPK-M; M-CK"
                     /inference="alignment:Splign:2.1.0"
     exon            56..266
                     /gene="CKM"
                     /gene_synonym="CKMM; CPK-M; M-CK"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1219
                     /gene="CKM"
                     /gene_synonym="CKMM; CPK-M; M-CK"
                     /EC_number="2.7.3.2"
                     /note="creatine kinase M chain; creatine kinase, muscle;
                     creatine phosphokinase M-type"
                     /codon_start=1
                     /product="creatine kinase M-type"
                     /protein_id="NP_001815.2"
                     /db_xref="CCDS:CCDS12659.1"
                     /db_xref="GeneID:1158"
                     /db_xref="HGNC:HGNC:1994"
                     /db_xref="MIM:123310"
                     /translation="MPFGNTHNKFKLNYKPEEEYPDLSKHNNHMAKVLTLELYKKLRD
                     KETPSGFTVDDVIQTGVDNPGHPFIMTVGCVAGDEESYEVFKELFDPIISDRHGGYKP
                     TDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVE
                     ALNSLTGEFKGKYYPLKSMTEKEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIW
                     HNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNQH
                     LGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVF
                     DVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK"
     exon            267..421
                     /gene="CKM"
                     /gene_synonym="CKMM; CPK-M; M-CK"
                     /inference="alignment:Splign:2.1.0"
     exon            422..554
                     /gene="CKM"
                     /gene_synonym="CKMM; CPK-M; M-CK"
                     /inference="alignment:Splign:2.1.0"
     exon            555..726
                     /gene="CKM"
                     /gene_synonym="CKMM; CPK-M; M-CK"
                     /inference="alignment:Splign:2.1.0"
     exon            727..850
                     /gene="CKM"
                     /gene_synonym="CKMM; CPK-M; M-CK"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1040
                     /gene="CKM"
                     /gene_synonym="CKMM; CPK-M; M-CK"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1556
                     /gene="CKM"
                     /gene_synonym="CKMM; CPK-M; M-CK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1535..1540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CKM"
                     /gene_synonym="CKMM; CPK-M; M-CK"
                     /note="hexamer: AATAAA"
     polyA_site      1556
                     /gene="CKM"
                     /gene_synonym="CKMM; CPK-M; M-CK"
                     /note="major polyA site"
ORIGIN      
        1 gggtcagtgt cacctccagg atacagacag ccccccttca gcccagccca gccaggtctc
       61 ctacaccgcc accatgccat tcggtaacac ccacaacaag ttcaagctga attacaagcc
      121 tgaggaggag taccccgacc tcagcaaaca taacaaccac atggccaagg tactgaccct
      181 tgaactctac aagaagctgc gggacaagga gactccatct ggcttcactg tagacgatgt
      241 catccagaca ggagtggaca acccaggtca ccccttcatc atgaccgtgg gctgcgtggc
      301 tggtgatgag gagtcctacg aagttttcaa ggaactcttt gaccccatca tctcggatcg
      361 ccacgggggc tacaaaccca ctgacaagca caagactgac ctcaaccatg aaaacctcaa
      421 gggtggagac gacctggacc ctaactacgt gctcagcagc cgcgtccgca ctggccgcag
      481 catcaagggc tacacgttgc ccccacactg ctcccgtggc gagcgccggg cggtggagaa
      541 gctctctgtg gaagctctca acagcctgac gggcgagttc aaagggaagt actaccctct
      601 gaagagcatg acggagaagg agcagcagca gctcatcgat gaccacttcc tgttcgacaa
      661 gcccgtgtcc ccgctgctgc tggcctcagg catggcccgc gactggcccg acgcccgtgg
      721 catctggcac aatgacaaca agagcttcct ggtgtgggtg aacgaggagg atcacctccg
      781 ggtcatctcc atggagaagg ggggcaacat gaaggaggtt ttccgccgct tctgcgtagg
      841 gctgcagaag attgaggaga tctttaagaa agctggccac cccttcatgt ggaaccagca
      901 cctgggctac gtgctcacct gcccatccaa cctgggcact gggctgcgtg gaggcgtgca
      961 tgtgaagctg gcgcacctga gcaagcaccc caagttcgag gagatcctca cccgcctgcg
     1021 tctgcagaag aggggtacag gtggcgtgga cacagctgcc gtgggctcag tatttgacgt
     1081 gtccaacgct gatcggctgg gctcgtccga agtagaacag gtgcagctgg tggtggatgg
     1141 tgtgaagctc atggtggaaa tggagaagaa gttggagaaa ggccagtcca ttgacgacat
     1201 gatccccgcc cagaagtagg cgcctgccca cctgccaccg actgctggaa cccagccagt
     1261 gggagggcct ggcccaccag agtcctgctc cctcactcct cgccccgccc cctgtcccag
     1321 agtcccacct gggggctctc tccacccttc tcagagttcc agtttcaacc agagttccaa
     1381 ccaatgggct ccatcctctg gattctggcc aatgaaatat ctccctggca gggtcctctt
     1441 cttttcccag agctccaccc caaccaggag ctctagttaa tggagagctc ccagcacact
     1501 cggagcttgt gctttgtctc cacgcaaagc gataaataaa agcattggtg gcctta
//
