LOCUS       NM_001823               1420 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens creatine kinase B (CKB), transcript variant 1, mRNA.
ACCESSION   NM_001823 XM_003119579 XM_003119580 XM_003119581 XM_003119586
VERSION     NM_001823.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Wu,K., Yan,M., Liu,T., Wang,Z., Duan,Y., Xia,Y., Ji,G., Shen,Y.,
            Wang,L., Li,L., Zheng,P., Dong,B., Wu,Q., Xiao,L., Yang,X.,
            Shen,H., Wen,T., Zhang,J., Yi,J., Deng,Y., Qian,X., Ma,L., Fang,J.,
            Zhou,Q., Lu,Z. and Xu,D.
  TITLE     Creatine kinase B suppresses ferroptosis by phosphorylating GPX4
            through a moonlighting function
  JOURNAL   Nat Cell Biol 25 (5), 714-725 (2023)
   PUBMED   37156912
  REMARK    GeneRIF: Creatine kinase B suppresses ferroptosis by
            phosphorylating GPX4 through a moonlighting function.
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Wang,Z., Hulsurkar,M., Zhuo,L., Xu,J., Yang,H., Naderinezhad,S.,
            Wang,L., Zhang,G., Ai,N., Li,L., Chang,J.T., Zhang,S., Fazli,L.,
            Creighton,C.J., Bai,F., Ittmann,M.M., Gleave,M.E. and Li,W.
  TITLE     CKB inhibits epithelial-mesenchymal transition and prostate cancer
            progression by sequestering and inhibiting AKT activation
  JOURNAL   Neoplasia 23 (11), 1147-1165 (2021)
   PUBMED   34706306
  REMARK    GeneRIF: CKB inhibits epithelial-mesenchymal transition and
            prostate cancer progression by sequestering and inhibiting AKT
            activation.
REFERENCE   5  (bases 1 to 1420)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1420)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   7  (bases 1 to 1420)
  AUTHORS   Mariman,E. and Wieringa,B.
  TITLE     Expression of the gene encoding human brain creatine kinase depends
            on sequences immediately following the transcription start point
  JOURNAL   Gene 102 (2), 205-212 (1991)
   PUBMED   1840537
REFERENCE   8  (bases 1 to 1420)
  AUTHORS   Mariman,E.C., Schepens,J.T. and Wieringa,B.
  TITLE     Complete nucleotide sequence of the human creatine kinase B gene
  JOURNAL   Nucleic Acids Res 17 (15), 6385 (1989)
   PUBMED   2771648
REFERENCE   9  (bases 1 to 1420)
  AUTHORS   Tarkkanen,P., Komor,S., Cornely,C., Hacke,W. and Greiling,H.
  TITLE     Bioluminescence assay of creatine kinase and its isoenzymes in
            serum and cerebrospinal fluid
  JOURNAL   Clin Chem 25 (9), 1644-1648 (1979)
   PUBMED   466791
REFERENCE   10 (bases 1 to 1420)
  AUTHORS   Foxall,C.D. and Emery,A.E.
  TITLE     Changes in creatine kinase and its isoenzymes in human fetal muscle
            during development
  JOURNAL   J Neurol Sci 24 (4), 483-492 (1975)
   PUBMED   1117316
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP213119.1, AK312282.1 and
            BM684665.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001823.4.
            
            Summary: The protein encoded by this gene is a cytoplasmic enzyme
            involved in energy homeostasis. The encoded protein reversibly
            catalyzes the transfer of phosphate between ATP and various
            phosphogens such as creatine phosphate. It acts as a homodimer in
            brain as well as in other tissues, and as a heterodimer with a
            similar muscle isozyme in heart. The encoded protein is a member of
            the ATP:guanido phosphotransferase protein family. A pseudogene of
            this gene has been characterized. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290101.1, SRR3476690.102196.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348956.7/ ENSP00000299198.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-551               BP213119.1         30-580
            552-1147            AK312282.1         553-1148
            1148-1420           BM684665.1         27-299              c
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..1420
                     /gene="CKB"
                     /gene_synonym="B-CK; BCK; CKBB; CPK-B; HEL-211; HEL-S-29"
                     /note="creatine kinase B"
                     /db_xref="GeneID:1152"
                     /db_xref="HGNC:HGNC:1991"
                     /db_xref="MIM:123280"
     exon            1..65
                     /gene="CKB"
                     /gene_synonym="B-CK; BCK; CKBB; CPK-B; HEL-211; HEL-S-29"
                     /inference="alignment:Splign:2.1.0"
     exon            66..270
                     /gene="CKB"
                     /gene_synonym="B-CK; BCK; CKBB; CPK-B; HEL-211; HEL-S-29"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1223
                     /gene="CKB"
                     /gene_synonym="B-CK; BCK; CKBB; CPK-B; HEL-211; HEL-S-29"
                     /EC_number="2.7.3.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     creatine kinase B-type; creatine kinase B chain;
                     epididymis secretory protein Li 29; epididymis luminal
                     protein 211; creatine kinase brain; creatine kinase
                     brain-type; brain creatine kinase; creatine phosphokinase
                     B-type"
                     /codon_start=1
                     /product="creatine kinase B-type isoform 1"
                     /protein_id="NP_001814.2"
                     /db_xref="CCDS:CCDS9981.1"
                     /db_xref="GeneID:1152"
                     /db_xref="HGNC:HGNC:1991"
                     /db_xref="MIM:123280"
                     /translation="MPFSNSHNALKLRFPAEDEFPDLSAHNNHMAKVLTPELYAELRA
                     KSTPSGFTLDDVIQTGVDNPGHPYIMTVGCVAGDEESYEVFKDLFDPIIEDRHGGYKP
                     SDEHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVE
                     ALSSLDGDLAGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIW
                     HNDNKTFLVWVNEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKDYEFMWNPH
                     LGYILTCPSNLGTGLRAGVHIKLPNLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVF
                     DVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQAIDDLMPAQK"
     exon            271..425
                     /gene="CKB"
                     /gene_synonym="B-CK; BCK; CKBB; CPK-B; HEL-211; HEL-S-29"
                     /inference="alignment:Splign:2.1.0"
     exon            426..558
                     /gene="CKB"
                     /gene_synonym="B-CK; BCK; CKBB; CPK-B; HEL-211; HEL-S-29"
                     /inference="alignment:Splign:2.1.0"
     exon            559..730
                     /gene="CKB"
                     /gene_synonym="B-CK; BCK; CKBB; CPK-B; HEL-211; HEL-S-29"
                     /inference="alignment:Splign:2.1.0"
     exon            731..854
                     /gene="CKB"
                     /gene_synonym="B-CK; BCK; CKBB; CPK-B; HEL-211; HEL-S-29"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1044
                     /gene="CKB"
                     /gene_synonym="B-CK; BCK; CKBB; CPK-B; HEL-211; HEL-S-29"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1420
                     /gene="CKB"
                     /gene_synonym="B-CK; BCK; CKBB; CPK-B; HEL-211; HEL-S-29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1397..1402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CKB"
                     /gene_synonym="B-CK; BCK; CKBB; CPK-B; HEL-211; HEL-S-29"
                     /note="hexamer: AATAAA"
     polyA_site      1420
                     /gene="CKB"
                     /gene_synonym="B-CK; BCK; CKBB; CPK-B; HEL-211; HEL-S-29"
                     /note="major polyA site"
ORIGIN      
        1 gttcgcctgc gtcgctccgg gagctgccga cggacggagc gcccccgccc ccgcccggcc
       61 gcccgcccgc cgccgccatg cccttctcca acagccacaa cgcactgaag ctgcgcttcc
      121 cggccgagga cgagttcccc gacctgagcg cccacaacaa ccacatggcc aaggtgctga
      181 cccccgagct gtacgcggag ctgcgcgcca agagcacgcc gagcggcttc acgctggacg
      241 acgtcatcca gacaggcgtg gacaacccgg gccacccgta catcatgacc gtgggctgcg
      301 tggcgggcga cgaggagtcc tacgaagtgt tcaaggatct cttcgacccc atcatcgagg
      361 accggcacgg cggctacaag cccagcgatg agcacaagac cgacctcaac cccgacaacc
      421 tgcagggcgg cgacgacctg gaccccaact acgtgctgag ctcgcgggtg cgcacgggcc
      481 gcagcatccg tggcttctgc ctccccccgc actgcagccg cggggagcgc cgcgccatcg
      541 agaagctcgc ggtggaagcc ctgtccagcc tggacggcga cctggcgggc cgatactacg
      601 cgctcaagag catgacggag gcggagcagc agcagctcat cgacgaccac ttcctcttcg
      661 acaagcccgt gtcgcccctg ctgctggcct cgggcatggc ccgcgactgg cccgacgccc
      721 gcggtatctg gcacaatgac aataagacct tcctggtgtg ggtcaacgag gaggaccacc
      781 tgcgggtcat ctccatgcag aaggggggca acatgaagga ggtgttcacc cgcttctgca
      841 ccggcctcac ccagattgaa actctcttca agtctaagga ctatgagttc atgtggaacc
      901 ctcacctggg ctacatcctc acctgcccat ccaacctggg caccgggctg cgggcaggtg
      961 tgcatatcaa gctgcccaac ctgggcaagc atgagaagtt ctcggaggtg cttaagcggc
     1021 tgcgacttca gaagcgaggc acaggcggtg tggacacggc tgcggtgggc ggggtcttcg
     1081 acgtctccaa cgctgaccgc ctgggcttct cagaggtgga gctggtgcag atggtggtgg
     1141 acggagtgaa gctgctcatc gagatggagc agcggctgga gcagggccag gccatcgacg
     1201 acctcatgcc tgcccagaaa tgaagcccgg cccacacccg acaccagccc tgctgcttcc
     1261 taacttattg cctgggcagt gcccaccatg cacccctgat gttcgccgtc tggcgagccc
     1321 ttagccttgc tgtagagact tccgtcaccc ttggtagagt ttattttttt gatggctaag
     1381 atactgctga tgctgaaata aactagggtt ttggcctgcc
//
