LOCUS       NM_001131016            2975 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens CDKN1A interacting zinc finger protein 1 (CIZ1),
            transcript variant 5, mRNA.
ACCESSION   NM_001131016
VERSION     NM_001131016.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2975)
  AUTHORS   Chen,Y.R., Wu,Y.S., Wang,W.S., Zhang,J.S. and Wu,Q.G.
  TITLE     Upregulation of lncRNA DANCR functions as an oncogenic role in
            non-small lung cancer by regulating miR-214-5p/CIZ1 axis
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2539-2547 (2020)
   PUBMED   32196604
  REMARK    GeneRIF: Upregulation of lncRNA DANCR functions as an oncogenic
            role in non-small lung cancer by regulating miR-214-5p/CIZ1 axis.
REFERENCE   2  (bases 1 to 2975)
  AUTHORS   Chen,X., Wang,P., Wang,S., Li,J., Ou,T. and Zeng,X.
  TITLE     CIZ1 knockdown suppresses the proliferation of bladder cancer cells
            by inducing apoptosis
  JOURNAL   Gene 719, 143946 (2019)
   PUBMED   31252164
  REMARK    GeneRIF: silencing of CIZ1 suppressed bladder cancer cell
            proliferation through inducing apoptosis and reducing cell cycle
            progression
REFERENCE   3  (bases 1 to 2975)
  AUTHORS   Wang,Y., Li,X., Zhang,J., Liu,Q., Gao,P., Li,D., Zhang,S. and
            Liu,J.
  TITLE     CIZ1 Expression Is Upregulated in Hemangioma of the Tongue
  JOURNAL   Pathol Oncol Res 25 (4), 1653-1658 (2019)
   PUBMED   30456533
  REMARK    GeneRIF: High CIZ1 expression is associated with Hemangioma of the
            Tongue.
REFERENCE   4  (bases 1 to 2975)
  AUTHORS   Sunwoo,H., Colognori,D., Froberg,J.E., Jeon,Y. and Lee,J.T.
  TITLE     Repeat E anchors Xist RNA to the inactive X chromosomal compartment
            through CDKN1A-interacting protein (CIZ1)
  JOURNAL   Proc Natl Acad Sci U S A 114 (40), 10654-10659 (2017)
   PUBMED   28923964
  REMARK    GeneRIF: data reveal that CIZ1 plays a major role in ensuring
            stable association of Xist RNA within the Xi territory.
REFERENCE   5  (bases 1 to 2975)
  AUTHORS   Lei,L., Wu,J., Gu,D., Liu,H. and Wang,S.
  TITLE     CIZ1 interacts with YAP and activates its transcriptional activity
            in hepatocellular carcinoma cells
  JOURNAL   Tumour Biol 37 (8), 11073-11079 (2016)
   PUBMED   26906552
  REMARK    GeneRIF: our study demonstrated that CIZ1 is a positive regulator
            of YAP signaling, and CIZ1 might be a therapeutic target for
            hepatocellular carcinoma
REFERENCE   6  (bases 1 to 2975)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 2975)
  AUTHORS   Coverley,D., Marr,J. and Ainscough,J.
  TITLE     Ciz1 promotes mammalian DNA replication
  JOURNAL   J Cell Sci 118 (Pt 1), 101-112 (2005)
   PUBMED   15585571
REFERENCE   8  (bases 1 to 2975)
  AUTHORS   Warder,D.E. and Keherly,M.J.
  TITLE     Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus
            DNA sequence ARYSR(0-2)YYAC
  JOURNAL   J Biomed Sci 10 (4), 406-417 (2003)
   PUBMED   12824700
  REMARK    GeneRIF: data indicate that Ciz1 is localized in the nucleus and is
            expressed in a wide range of tissues, especially the pancreas and
            the brain; formulated a consensus DNA sequence, ARYSR(0-2)YYAC,
            recognized by Ciz1
REFERENCE   9  (bases 1 to 2975)
  AUTHORS   Mitsui,K., Matsumoto,A., Ohtsuka,S., Ohtsubo,M. and Yoshimura,A.
  TITLE     Cloning and characterization of a novel p21(Cip1/Waf1)-interacting
            zinc finger protein, ciz1
  JOURNAL   Biochem Biophys Res Commun 264 (2), 457-464 (1999)
   PUBMED   10529385
REFERENCE   10 (bases 1 to 2975)
  AUTHORS   Gilley,J. and Fried,M.
  TITLE     Extensive gene order differences within regions of conserved
            synteny between the Fugu and human genomes: implications for
            chromosomal evolution and the cloning of disease genes
  JOURNAL   Hum Mol Genet 8 (7), 1313-1320 (1999)
   PUBMED   10369878
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292713.1, AK303636.1 and
            BC021163.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001131016.1.
            
            Summary: The protein encoded by this gene is a zinc finger DNA
            binding protein that interacts with CIP1, part of a complex with
            cyclin E. The encoded protein may regulate the cellular
            localization of CIP1. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Apr 2012].
            
            Transcript Variant: This variant (5) has an alternate exon in place
            of the first exon and lacks an alternate in-frame exon compared to
            variant 6. The resulting isoform (1) is shorter at the N-terminus
            and lacks an alternate internal segment compared to isoform 5.
            Variants 1 and 5 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292713.1, AB030835.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372938.10/ ENSP00000362029.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-472               AK292713.1         9-480
            473-1790            AK303636.1         357-1674
            1791-2975           BC021163.2         1547-2731
FEATURES             Location/Qualifiers
     source          1..2975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..2975
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /note="CDKN1A interacting zinc finger protein 1"
                     /db_xref="GeneID:25792"
                     /db_xref="HGNC:HGNC:16744"
                     /db_xref="MIM:611420"
     exon            1..141
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            142..316
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..2843
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /note="isoform 1 is encoded by transcript variant 5; zinc
                     finger protein 356; nuclear protein NP94; Cip1-interacting
                     zinc finger protein"
                     /codon_start=1
                     /product="cip1-interacting zinc finger protein isoform 1"
                     /protein_id="NP_001124488.1"
                     /db_xref="CCDS:CCDS6894.1"
                     /db_xref="GeneID:25792"
                     /db_xref="HGNC:HGNC:16744"
                     /db_xref="MIM:611420"
                     /translation="MFSQQQQQQLQQQQQQLQQLQQQQLQQQQLQQQQLLQLQQLLQQ
                     SPPQAPLPMAVSRGLPPQQPQQPLLNLQGTNSASLLNGSMLQRALLLQQLQGLDQFAM
                     PPATYDTAGLTMPTATLGNLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLL
                     GPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEEA
                     AEPRMDTPEDQDLPPCPEDIAKEKRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQ
                     LQVKAQPQARMTVPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPSTD
                     TQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVQPQAHSQGPRQVQ
                     LQQEAEPLKQVQPQVQPQAHSQPPRQVQLQLQKQVQTQTYPQVHTQAQPSVQPQEHPP
                     AQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGGMEKTLPEP
                     VGTQVSMEEIQNESACGLDVGECENRAREMPGVWGAGGSLKVTILQSSDSRAFSTVPL
                     TPVPRPSDSVSSTPAATSTPSKQALQFFCYICKASCSSQQEFQDHMSEPQHQQRLGEI
                     QHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQLYYMGDLIQHRRTQDHKIAKQS
                     LRPFCTVCNRYFKTPRKFVEHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCF
                     EGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSETYSPNTAYGVDFLVPVMG
                     YICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTRPVSRRCAINARNAL
                     TALFTSSGRPPSQPNTQDKTPSKVTARPSQPPLPRRSTRLKT"
     exon            317..432
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            433..504
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            505..734
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            735..828
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            829..937
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1644
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1766
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1964
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2089
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2177
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2291
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2441
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2511
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2633
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2975
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2949..2954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /note="hexamer: AATAAA"
     polyA_site      2975
                     /gene="CIZ1"
                     /gene_synonym="LSFR1; NP94; ZNF356"
                     /note="major polyA site"
ORIGIN      
        1 cttacgagcc cacaggcccc ggagtagcag cggggaggcc gggagcccgc gggccggagc
       61 cgcccggccg aggcgtgggg gctgcggggc cggcccatcc gtgggggcga cttgagcgtt
      121 gagggcgcgc ggggaggcga gccaccatgt tcagccagca gcagcagcag cagctccagc
      181 aacagcagca gcagctccag cagttacagc agcagcagct ccagcagcag caattgcagc
      241 agcagcagtt actgcagctc cagcagctgc tccagcagtc cccaccacag gccccgttgc
      301 ccatggctgt cagccggggg ctccccccgc agcagccaca gcagccgctt ctgaatctcc
      361 agggcaccaa ctcagcctcc ctcctcaacg gctccatgct gcagagagct ttgcttttac
      421 agcagttgca aggactggac cagtttgcaa tgccaccagc cacgtatgac actgccggtc
      481 tcaccatgcc cacagcaaca ctgggtaacc tccgaggcta tggcatggca tccccaggcc
      541 tcgcagcccc cagcctcaca cccccacaac tggccactcc aaatttgcaa cagttctttc
      601 cccaggccac tcgccagtcc ttgctgggac ctcctcctgt tggggtcccc atgaaccctt
      661 cccagttcaa cctttcagga cggaaccccc agaaacaggc ccggacctcc tcctctacca
      721 cccccaatcg aaaggattct tcttctcaga caatgcctgt ggaagacaag tcagaccccc
      781 cagaggggtc tgaggaagcc gcagagcccc ggatggacac accagaagac caagatttac
      841 cgccctgccc agaggacatc gccaaggaaa aacgcactcc agcacctgag cctgagcctt
      901 gtgaggcgtc cgagctgcca gcaaagagat tgaggagctc agaagagccc acagagaagg
      961 aacctccagg gcagttacag gtgaaggccc agccgcaggc ccggatgaca gtaccgaaac
     1021 agacacagac accagacctg ctgcctgagg ccctggaagc ccaagtgctg ccacgattcc
     1081 agccacgggt cctgcaggtc caggcccagg tgcagtcaca gactcagccg cggataccat
     1141 ccacagacac ccaggtgcag ccaaagctgc agaagcaggc gcaaacacag acctctccag
     1201 agcacttagt gctgcaacag aagcaggtgc agccacagct gcagcaggag gcagagccac
     1261 agaagcaggt gcagccacag gtacagccac aggcacattc acagggccca aggcaggtgc
     1321 agctgcagca ggaggcagag ccgctgaagc aggtgcagcc acaggtgcag ccccaggcac
     1381 attcacagcc cccaaggcag gtgcagctgc agctgcagaa gcaggtccag acacagacat
     1441 atccacaggt ccacacacag gcacagccaa gcgtccagcc acaggagcat cctccagcgc
     1501 aggtgtcagt acagccacca gagcagaccc atgagcagcc tcacacccag ccgcaggtgt
     1561 cgttgctggc tccagagcaa acaccagttg tggttcatgt ctgcgggctg gagatgccac
     1621 ctgatgcagt agaagctggt ggaggcatgg aaaagacctt gccagagcct gtgggcaccc
     1681 aagtcagcat ggaagagatt cagaatgagt cggcctgtgg cctagatgtg ggagaatgtg
     1741 aaaacagagc gagagagatg ccaggggtat ggggcgccgg gggctccctg aaggtcacca
     1801 ttctgcagag cagtgacagc cgggccttta gcactgtacc cctgacacct gtcccccgcc
     1861 ccagtgactc cgtctcctcc acccctgcgg ctaccagcac tccctctaag caggccctcc
     1921 agttcttctg ctacatctgc aaggccagct gctccagcca gcaggagttc caggaccaca
     1981 tgtcggagcc tcagcaccag cagcggctag gggagatcca gcacatgagc caagcctgcc
     2041 tcctgtccct gctgcccgtg ccccgggacg tcctggagac agaggatgag gagcctccac
     2101 caaggcgctg gtgcaacacc tgccagctct actacatggg ggacctgatc caacaccgca
     2161 ggacacagga ccacaagatt gccaaacaat ccttgcgacc cttctgcacc gtttgcaacc
     2221 gctacttcaa aacccctcgc aagtttgtgg agcacgtgaa gtcccagggg cataaggaca
     2281 aagccaagga gctgaagtcg cttgagaaag aaattgctgg ccaagatgag gaccacttca
     2341 ttacagtgga cgctgtgggt tgcttcgagg gtgatgaaga agaggaagag gatgatgagg
     2401 atgaagaaga gatcgaggtt gaggaggaac tctgcaagca ggtgaggtcc agagatatat
     2461 ccagagagga gtggaagggc tcggagacct acagccccaa tactgcatat ggtgtggact
     2521 tcctggtgcc cgtgatgggc tatatctgcc gcatctgcca caagttctat cacagcaact
     2581 caggggcaca gctctcccac tgcaagtccc tgggccactt tgagaacctg cagaaataca
     2641 aggcggccaa gaaccccagc cccaccaccc gacctgtgag ccgccggtgc gcaatcaacg
     2701 cccggaacgc tttgacagcc ctgttcacct ccagcggccg cccaccctcc cagcccaaca
     2761 cccaggacaa aacacccagc aaggtgacgg ctcgaccctc ccagccccca ctacctcggc
     2821 gctcaacccg cctcaaaacc tgatagaggg acctccctgt ccctggcctg cctgggtcca
     2881 gatctgctaa tgctttttag gagtctgcct ggaaactttg acatggttca tgtttttact
     2941 caaaatccaa taaaacaagg tagtttggct gtgca
//
