LOCUS       NM_133467               1310 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens Cbp/p300 interacting transactivator with Glu/Asp rich
            carboxy-terminal domain 4 (CITED4), mRNA.
ACCESSION   NM_133467
VERSION     NM_133467.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1310)
  AUTHORS   Zhang,L., Wang,Y., Sha,Y., Zhang,B., Zhang,R., Zhang,H., Xu,S.,
            Wang,H., Xu,Y., Chen,Y., Zhao,X., Zhu,J., Zhang,Z. and Wang,C.
  TITLE     CITED4 enhances the metastatic potential of lung adenocarcinoma
  JOURNAL   Thorac Cancer 12 (9), 1291-1302 (2021)
   PUBMED   33759374
  REMARK    GeneRIF: CITED4 enhances the metastatic potential of lung
            adenocarcinoma.
REFERENCE   2  (bases 1 to 1310)
  AUTHORS   Ding,S., Gan,T., Song,M., Dai,Q., Huang,H., Xu,Y. and Zhong,C.
  TITLE     C/EBPB-CITED4 in Exercised Heart
  JOURNAL   Adv Exp Med Biol 1000, 247-259 (2017)
   PUBMED   29098625
  REMARK    GeneRIF: Studies indicate that CCAAT enhancer binding protein beta
            (C/EBPB)-transcription factor CITED4 (CITED4) signaling is a
            pathway in cardioprotection mediating benefits of exercise in
            heart.
REFERENCE   3  (bases 1 to 1310)
  AUTHORS   Rogers,M.A., Kalter,V., Marcias,G., Zapatka,M., Barbus,S. and
            Lichter,P.
  TITLE     CITED4 gene silencing in colorectal cancer cells modulates
            adherens/tight junction gene expression and reduces cell
            proliferation
  JOURNAL   J Cancer Res Clin Oncol 142 (1), 225-237 (2016)
   PUBMED   26243458
  REMARK    GeneRIF: Upregulation of CITED4 is associated with colorectal
            cancer.
REFERENCE   4  (bases 1 to 1310)
  AUTHORS   Huang,K.T., Takano,E.A., Mikeska,T., Byrne,D.J., Dobrovic,A. and
            Fox,S.B.
  TITLE     Aberrant DNA methylation but not mutation of CITED4 is associated
            with alteration of HIF-regulated genes in breast cancer
  JOURNAL   Breast Cancer Res Treat 130 (1), 319-329 (2011)
   PUBMED   21755341
  REMARK    GeneRIF: Demethylation and histone modification can potentially
            reactivate CITED4 gene expression in some breast cancers and lead
            to changes in tumour behaviour.
REFERENCE   5  (bases 1 to 1310)
  AUTHORS   Torres-Martin,M., Franco-Hernandez,C., Martinez-Glez,V., de
            Campos,J.M., Isla,A., Casartelli,C. and Rey,J.A.
  TITLE     Mutational analysis of the CITED4 gene in glioblastomas
  JOURNAL   Cancer Genet Cytogenet 185 (2), 114-116 (2008)
   PUBMED   18722883
  REMARK    GeneRIF: mutational study of CITED4 in 24 glial tumors (22 primary
            glioblastomas, 1 low-grade astrocytoma & its recurrent secondary
            glioblastoma)
REFERENCE   6  (bases 1 to 1310)
  AUTHORS   Tews,B., Roerig,P., Hartmann,C., Hahn,M., Felsberg,J., Blaschke,B.,
            Sabel,M., Kunitz,A., Toedt,G., Neben,K., Benner,A., von
            Deimling,A., Reifenberger,G. and Lichter,P.
  TITLE     Hypermethylation and transcriptional downregulation of the CITED4
            gene at 1p34.2 in oligodendroglial tumours with allelic losses on
            1p and 19q
  JOURNAL   Oncogene 26 (34), 5010-5016 (2007)
   PUBMED   17311001
  REMARK    GeneRIF: CITED4 is epigenetically silenced in the vast majority of
            oligodendroglial tumours with 1p and 19q deletions.
REFERENCE   7  (bases 1 to 1310)
  AUTHORS   Labalette,C., Renard,C.A., Neuveut,C., Buendia,M.A. and Wei,Y.
  TITLE     Interaction and functional cooperation between the LIM protein
            FHL2, CBP/p300, and beta-catenin
  JOURNAL   Mol Cell Biol 24 (24), 10689-10702 (2004)
   PUBMED   15572674
  REMARK    GeneRIF: The interaction and functional cooperation between FHL2,
            CITED4, and CTNNB were studied.
REFERENCE   8  (bases 1 to 1310)
  AUTHORS   Fox,S.B., Braganca,J., Turley,H., Campo,L., Han,C., Gatter,K.C.,
            Bhattacharya,S. and Harris,A.L.
  TITLE     CITED4 inhibits hypoxia-activated transcription in cancer cells,
            and its cytoplasmic location in breast cancer is associated with
            elevated expression of tumor cell hypoxia-inducible factor 1alpha
  JOURNAL   Cancer Res 64 (17), 6075-6081 (2004)
   PUBMED   15342390
  REMARK    GeneRIF: Results show that breast cancer development is
            characterized by either nuclear loss or cytoplasmic translocation
            of CITED4, with consequent loss of hypoxia-inducible factor-1alpha
            transcriptional antagonist activity.
REFERENCE   9  (bases 1 to 1310)
  AUTHORS   Braganca,J., Swingler,T., Marques,F.I., Jones,T., Eloranta,J.J.,
            Hurst,H.C., Shioda,T. and Bhattacharya,S.
  TITLE     Human CREB-binding protein/p300-interacting transactivator with
            ED-rich tail (CITED) 4, a new member of the CITED family, functions
            as a co-activator for transcription factor AP-2
  JOURNAL   J Biol Chem 277 (10), 8559-8565 (2002)
   PUBMED   11744733
  REMARK    GeneRIF: CITED4 functions as a transactivator when artificially
            targeted to a promoter element. CITED4 physically interacts with
            all TFAP2 isoforms in vitro and strongly co-activates all TFAP2
            isoforms in Hep3B cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119677.2 and BC052559.1.
            
            On May 17, 2019 this sequence version replaced NM_133467.2.
            
            Summary: The protein encoded by this intronless gene belongs to the
            CITED family of transcriptional coactivators that bind to several
            proteins, including CREB-binding protein (CBP) and p300, via a
            conserved 32 aa C-terminal motif, and regulate gene transcription.
            This protein also interacts with transcription factor AP2 (TFAP2),
            and thus may function as a co-activator for TFAP2. Hypermethylation
            and transcriptional downregulation of this gene has been observed
            in oligodendroglial tumors with deletions of chromosomal arms 1p
            and 19q, and associated with longer recurrence-free and overall
            survival of patients with oligodendroglial tumors. [provided by
            RefSeq, Aug 2011].
            
            ##Evidence-Data-START##
            Transcript is intronless :: DRR138524.1067215.1, DRR138519.45024.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372638.4/ ENSP00000361721.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC119677.2         97311-97327         c
            18-1308             BC052559.1         1-1291
            1309-1310           AC119677.2         96018-96019         c
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..1310
                     /gene="CITED4"
                     /note="Cbp/p300 interacting transactivator with Glu/Asp
                     rich carboxy-terminal domain 4"
                     /db_xref="GeneID:163732"
                     /db_xref="HGNC:HGNC:18696"
                     /db_xref="MIM:606815"
     exon            1..1310
                     /gene="CITED4"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..791
                     /gene="CITED4"
                     /note="transcriptional co-activator 4; MRG-2; MSG1-related
                     protein 2"
                     /codon_start=1
                     /product="cbp/p300-interacting transactivator 4"
                     /protein_id="NP_597724.1"
                     /db_xref="CCDS:CCDS458.1"
                     /db_xref="GeneID:163732"
                     /db_xref="HGNC:HGNC:18696"
                     /db_xref="MIM:606815"
                     /translation="MADHLMLAEGYRLVQRPPSAAAAHGPHALRTLPPYAGPGLDSGL
                     RPRGAPLGPPPPRQPGALAYGAFGPPSSFQPFPAVPPPAAGIAHLQPVATPYPGRAAA
                     PPNAPGGPPGPQPAPSAAAPPPPAHALGGMDAELIDEEALTSLELELGLHRVRELPEL
                     FLGQSEFDCFSDLGSAPPAGSVSC"
     regulatory      1289..1294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CITED4"
                     /note="hexamer: AATAAA"
     polyA_site      1310
                     /gene="CITED4"
                     /note="major polyA site"
ORIGIN      
        1 gcggaggttt cggagcacta caggttgcgg gcctttgtga ccccaggctg cggccgcaag
       61 gtgcgcagta gtgggctggg ccggggcacc agtcgggttt ggttttgctc cgcccggccg
      121 agctgcaggg accgcacggt gcccgggtct cccgccgcag agcagccgct ggcccgggcc
      181 gggggagccg gcgctgacca ccgcgcgctg tccccgcagg cagccggcct gccgccatgg
      241 ccgaccacct gatgctcgcc gagggctacc gcctggtgca gaggccgccg tccgccgcgg
      301 ccgcccatgg ccctcatgcg ctccggactc tgccgccgta cgcgggcccg ggcctggaca
      361 gtgggctgag gccgcggggg gctccgctgg ggccgccgcc gccccgccaa cccggggccc
      421 tggcgtacgg ggccttcggg ccgccgtcct ccttccagcc ctttccggcc gtgcctccgc
      481 cggccgcggg catcgcgcac ctgcagcctg tggcgacgcc gtaccccggc cgcgcggccg
      541 cgccccccaa cgctccggga ggccccccgg gcccgcagcc ggcgccaagc gccgcagccc
      601 cgccgccgcc cgcgcacgcc ctgggcggca tggacgccga actcatcgac gaggaggcgc
      661 tgacgtcgct ggagctggag ctcgggctgc accgcgtgcg cgagctgccc gagctcttcc
      721 tgggccagag cgagttcgac tgcttctcgg acttggggtc cgcgccgccc gccggctccg
      781 tgagctgctg agggcggccg gcgcccgccc ggcgtgccgg agaggagaaa gggcccgact
      841 gcccgccgga ccctgcaccc agcgactggg ccccgcgcgc gccctccgcg agggtggagg
      901 cggcggctgt gtgcgcaggg cccggcaccg gactgggacc ctggcgtccc tccaggcctt
      961 gcctcctgcg ggaggacagt ttggcttcac ttctctgacc ccagcctcgg ccgtaaagtg
     1021 aaagagaccg gaccagcttc agctttcgga ctctggttct tggatcgtgt cctctccccc
     1081 tcgccgccct cttcccccaa tctgagccat tgcaggcctc tgcctgctgc cccctctctc
     1141 ctcgggatcg ggtccccaga gccaccatct cctgagcctc ccaccccgct gcctgggccc
     1201 tgtggttgct gggcctccca cctcaaggag gggaaggttg tacagcccga acccgtggag
     1261 caatgccctg tctggcctcc aaaaccaaaa taaaactggg tcactttaca
//
