LOCUS       NM_001144887             814 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens Cbp/p300 interacting transactivator with Glu/Asp rich
            carboxy-terminal domain 1 (CITED1), transcript variant 4, mRNA.
ACCESSION   NM_001144887
VERSION     NM_001144887.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 814)
  AUTHORS   Asir,F., Ozalp,Z., Yulek,O.U., Erdemci,F., Korak,T. and Tas,F.
  TITLE     CITED1 expression in odontogenic cysts
  JOURNAL   BMC Oral Health 24 (1), 782 (2024)
   PUBMED   38997708
  REMARK    GeneRIF: CITED1 expression in odontogenic cysts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 814)
  AUTHORS   Chen,W., Jiang,J., Gao,J., Wang,G., Wang,R., Lv,J. and Ben,J.
  TITLE     Roles and signaling pathways of CITED1 in tumors: overview and
            novel insights
  JOURNAL   J Int Med Res 52 (1), 3000605231220890 (2024)
   PUBMED   38190845
  REMARK    GeneRIF: Roles and signaling pathways of CITED1 in tumors: overview
            and novel insights.
            Review article
REFERENCE   3  (bases 1 to 814)
  AUTHORS   Chen,W., Yu,J., Xie,R., Zhang,S., Zhou,T., Xiong,C., Huang,D. and
            Zhong,M.
  TITLE     Effect of silencing CITED1 gene to regulate PI3K/AKT pathway on the
            biological function of PTC cells and its mechanism
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (9), 113-117 (2023)
   PUBMED   37807325
  REMARK    GeneRIF: Effect of silencing CITED1 gene to regulate PI3K/AKT
            pathway on the biological function of PTC cells and its mechanism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 814)
  AUTHORS   Dahlgren,M., Lettiero,B., Dalal,H., Martensson,K., Gaber,A.,
            Nodin,B., Gruvberger-Saal,S.K., Saal,L.H. and Howlin,J.
  TITLE     CITED1 as a marker of favourable outcome in anti-endocrine treated,
            estrogen-receptor positive, lymph-node negative breast cancer
  JOURNAL   BMC Res Notes 16 (1), 105 (2023)
   PUBMED   37322548
  REMARK    GeneRIF: CITED1 as a marker of favourable outcome in anti-endocrine
            treated, estrogen-receptor positive, lymph-node negative breast
            cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 814)
  AUTHORS   Duyndam,M.C., van Dam,H., Smits,P.H., Verlaan,M., van der Eb,A.J.
            and Zantema,A.
  TITLE     The N-terminal transactivation domain of ATF2 is a target for the
            co-operative activation of the c-jun promoter by p300 and 12S E1A
  JOURNAL   Oncogene 18 (14), 2311-2321 (1999)
   PUBMED   10327051
REFERENCE   6  (bases 1 to 814)
  AUTHORS   Shioda,T., Lechleider,R.J., Dunwoodie,S.L., Li,H., Yahata,T., de
            Caestecker,M.P., Fenner,M.H., Roberts,A.B. and Isselbacher,K.J.
  TITLE     Transcriptional activating activity of Smad4: roles of SMAD
            hetero-oligomerization and enhancement by an associating
            transactivator
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 9785-9790 (1998)
   PUBMED   9707553
REFERENCE   7  (bases 1 to 814)
  AUTHORS   Fenner,M.H., Parrish,J.E., Boyd,Y., Reed,V., MacDonald,M.,
            Nelson,D.L., Isselbacher,K.J. and Shioda,T.
  TITLE     MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1,
            genomic organization, and promoter analysis
  JOURNAL   Genomics 51 (3), 401-407 (1998)
   PUBMED   9721210
REFERENCE   8  (bases 1 to 814)
  AUTHORS   Li,H., Ahmed,N.U., Fenner,M.H., Ueda,M., Isselbacher,K.J. and
            Shioda,T.
  TITLE     Regulation of expression of MSG1 melanocyte-specific nuclear
            protein in human melanocytes and melanoma cells
  JOURNAL   Exp Cell Res 242 (2), 478-486 (1998)
   PUBMED   9683535
REFERENCE   9  (bases 1 to 814)
  AUTHORS   Shioda,T., Fenner,M.H. and Isselbacher,K.J.
  TITLE     MSG1 and its related protein MRG1 share a transcription activating
            domain
  JOURNAL   Gene 204 (1-2), 235-241 (1997)
   PUBMED   9434189
REFERENCE   10 (bases 1 to 814)
  AUTHORS   Shioda,T., Fenner,M.H. and Isselbacher,K.J.
  TITLE     msg1, a novel melanocyte-specific gene, encodes a nuclear protein
            and is associated with pigmentation
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12298-12303 (1996)
   PUBMED   8901575
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP247232.1, AL135749.3,
            BC004240.1 and AI217516.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001144887.1.
            
            Summary: This gene encodes a member of the CREB-binding
            protein/p300-interacting transactivator with Asp/Glu-rich
            C-terminal domain (CITED) family of proteins. The encoded protein,
            also known as melanocyte-specific gene 1, may function as a
            transcriptional coactivator and may play a role in pigmentation of
            melanocytes. Alternatively spliced transcript variants have been
            described. [provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL544337.3, SRR5189667.346236.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149178 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651998.1/ ENSP00000499148.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-442               BP247232.1         1-442
            443-443             AL135749.3         115906-115906       c
            444-810             BC004240.1         818-1184
            811-814             AI217516.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..814
                     /gene="CITED1"
                     /gene_synonym="MSG1"
                     /note="Cbp/p300 interacting transactivator with Glu/Asp
                     rich carboxy-terminal domain 1"
                     /db_xref="GeneID:4435"
                     /db_xref="HGNC:HGNC:1986"
                     /db_xref="MIM:300149"
     exon            1..90
                     /gene="CITED1"
                     /gene_synonym="MSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            91..215
                     /gene="CITED1"
                     /gene_synonym="MSG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..737
                     /gene="CITED1"
                     /gene_synonym="MSG1"
                     /EC_number="3.5.1.98"
                     /note="isoform 1 is encoded by transcript variant 4;
                     melanocyte-specific gene 1; melanocyte-specific protein 1"
                     /codon_start=1
                     /product="cbp/p300-interacting transactivator 1 isoform 1"
                     /protein_id="NP_001138359.1"
                     /db_xref="CCDS:CCDS14419.1"
                     /db_xref="GeneID:4435"
                     /db_xref="HGNC:HGNC:1986"
                     /db_xref="MIM:300149"
                     /translation="MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAI
                     LHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNS
                     QYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMS
                     LVVELGLDRANELPELWLGQNEFDFTADFPSSC"
     exon            216..814
                     /gene="CITED1"
                     /gene_synonym="MSG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      793..798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CITED1"
                     /gene_synonym="MSG1"
                     /note="hexamer: AATAAA"
     polyA_site      814
                     /gene="CITED1"
                     /gene_synonym="MSG1"
                     /note="major polyA site"
ORIGIN      
        1 gagtccctgc ttcgcagagc accggacttg gagtcagaga gacctggctg cgaatcccgg
       61 ctccgccact ttctagcgct gtgaccttgg cacaacagct ccagctggca gcatcacttc
      121 ccgccaattt atccaacttc tgccaaggct ctgaaatgcc aacaacgtcg aggcctgcac
      181 ttgatgtcaa gggtggcacc tcacctgcga aggaggatgc caaccaagag atgagctccg
      241 tggcctactc caaccttgcg gtgaaagatc gcaaagcagt ggccattctg cactaccctg
      301 gggtagcctc aaatggaacc aaggccagtg gggctcccac tagttcctcg ggatctccaa
      361 taggctctcc tacaaccacc cctcccacta aacccccatc cttcaacctg caccccgccc
      421 ctcacttgct ggctagtatg cacctgcaga aacttaatag ccagtatcag gggatggctg
      481 ctgccactcc aggccaaccc ggggaggcag gacccctgca aaactgggac tttggggccc
      541 aggcgggagg ggcagaatca ctctctcctt ctgctggtgc ccagagccct gctatcatcg
      601 attcggaccc agtggatgag gaagtgctga tgtcgctggt ggtggaactg gggttggacc
      661 gagccaatga gcttccggag ctgtggctgg ggcagaatga gtttgacttc actgcggact
      721 ttccatctag ctgctaatgc caagtgtccc taaagatgga ggaataaagc caccaattct
      781 gttgtaaata aaaataaagt tacttacaaa gaga
//
