LOCUS       NM_001206999            8736 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens citron rho-interacting serine/threonine kinase (CIT),
            transcript variant 1, mRNA.
ACCESSION   NM_001206999
VERSION     NM_001206999.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8736)
  AUTHORS   Rawat,C., Ben-Salem,S., Singh,N., Chauhan,G., Rabljenovic,A.,
            Vaghela,V., Venkadakrishnan,V.B., Macdonald,J.D., Dahiya,U.R.,
            Ghanem,Y., Bachour,S., Su,Y., DePriest,A.D., Lee,S., Muldong,M.,
            Kim,H.T., Kumari,S., Valenzuela,M.M., Zhang,D., Hu,Q., Cortes
            Gomez,E., Dehm,S.M., Zoubeidi,A., Jamieson,C.A.M., Nicolas,M.,
            McKenney,J., Willard,B., Klein,E.A., Magi-Galluzzi,C.,
            Stauffer,S.R., Liu,S. and Heemers,H.V.
  TITLE     Prostate Cancer Progression Relies on the Mitotic Kinase Citron
            Kinase
  JOURNAL   Cancer Res 83 (24), 4142-4160 (2023)
   PUBMED   37801613
  REMARK    GeneRIF: Prostate Cancer Progression Relies on the Mitotic Kinase
            Citron Kinase.
REFERENCE   2  (bases 1 to 8736)
  AUTHORS   Liu,Z., Yang,Y., Yang,Z., Xia,S., Lin,D., Xiao,B. and Xiu,Y.
  TITLE     Novel circRNA_0071196/miRNA-19b-3p/CIT axis is associated with
            proliferation and migration of bladder cancer
  JOURNAL   Int J Oncol 57 (3), 767-779 (2020)
   PUBMED   32705161
  REMARK    GeneRIF: Novel circRNA_0071196/miRNA19b3p/CIT axis is associated
            with proliferation and migration of bladder cancer.
REFERENCE   3  (bases 1 to 8736)
  AUTHORS   Liu,Z., Yan,H., Yang,Y., Wei,L., Xia,S. and Xiu,Y.
  TITLE     Down-regulation of CIT can inhibit the growth of human bladder
            cancer cells
  JOURNAL   Biomed Pharmacother 124, 109830 (2020)
   PUBMED   31972359
  REMARK    GeneRIF: Down-regulation of CIT can inhibit the growth of human
            bladder cancer cells.
REFERENCE   4  (bases 1 to 8736)
  AUTHORS   Fu,Y., Huang,J., Wang,K.S., Zhang,X. and Han,Z.G.
  TITLE     RNA interference targeting CITRON can significantly inhibit the
            proliferation of hepatocellular carcinoma cells
  JOURNAL   Mol Biol Rep 38 (2), 693-702 (2011)
   PUBMED   20369383
  REMARK    GeneRIF: CITRON has a role in proliferation of hepatocellular
            carcinoma cells
REFERENCE   5  (bases 1 to 8736)
  AUTHORS   Nicodemus,K.K., Callicott,J.H., Higier,R.G., Luna,A., Nixon,D.C.,
            Lipska,B.K., Vakkalanka,R., Giegling,I., Rujescu,D., St Clair,D.,
            Muglia,P., Shugart,Y.Y. and Weinberger,D.R.
  TITLE     Evidence of statistical epistasis between DISC1, CIT and NDEL1
            impacting risk for schizophrenia: biological validation with
            functional neuroimaging
  JOURNAL   Hum Genet 127 (4), 441-452 (2010)
   PUBMED   20084519
  REMARK    GeneRIF: Evidence of statistical epistasis between DISC1, CIT and
            NDEL1 impacting risk for schizophrenia: biological validation with
            functional neuroimaging.
            GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
            Erratum:[Hum Genet. 2010 Apr;127(4):453-4]
REFERENCE   6  (bases 1 to 8736)
  AUTHORS   Gruneberg,U., Neef,R., Li,X., Chan,E.H., Chalamalasetty,R.B.,
            Nigg,E.A. and Barr,F.A.
  TITLE     KIF14 and citron kinase act together to promote efficient
            cytokinesis
  JOURNAL   J Cell Biol 172 (3), 363-372 (2006)
   PUBMED   16431929
  REMARK    GeneRIF: During cytokinesis, the localization of KIF14 and citron
            kinase to the central spindle and midbody is codependent, and they
            form a complex depending on the activation state of citron kinase.
REFERENCE   7  (bases 1 to 8736)
  AUTHORS   Lyons-Warren,A., Chang,J.J., Balkissoon,R., Kamiya,A., Garant,M.,
            Nurnberger,J., Scheftner,W., Reich,T., McMahon,F., Kelsoe,J.,
            Gershon,E., Coryell,W., Byerley,W., Berrettini,W., Depaulo,R.,
            McInnis,M. and Sawa,A.
  TITLE     Evidence of association between bipolar disorder and Citron on
            chromosome 12q24
  JOURNAL   Mol Psychiatry 10 (9), 807-809 (2005)
   PUBMED   15983625
  REMARK    GeneRIF: Single nucleotide polymorphisms associated with bipolar
            disorder.
            Erratum:[Mol Psychiatry. 2006 Jun;11(6):612]
REFERENCE   8  (bases 1 to 8736)
  AUTHORS   Husi,H., Ward,M.A., Choudhary,J.S., Blackstock,W.P. and Grant,S.G.
  TITLE     Proteomic analysis of NMDA receptor-adhesion protein signaling
            complexes
  JOURNAL   Nat Neurosci 3 (7), 661-669 (2000)
   PUBMED   10862698
REFERENCE   9  (bases 1 to 8736)
  AUTHORS   Zhang,W., Vazquez,L., Apperson,M. and Kennedy,M.B.
  TITLE     Citron binds to PSD-95 at glutamatergic synapses on inhibitory
            neurons in the hippocampus
  JOURNAL   J Neurosci 19 (1), 96-108 (1999)
   PUBMED   9870942
REFERENCE   10 (bases 1 to 8736)
  AUTHORS   Madaule,P., Furuyashiki,T., Reid,T., Ishizaki,T., Watanabe,G.,
            Morii,N. and Narumiya,S.
  TITLE     A novel partner for the GTP-bound forms of rho and rac
  JOURNAL   FEBS Lett 377 (2), 243-248 (1995)
   PUBMED   8543060
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004813.2, AY681966.1 and
            AY257469.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001206999.1.
            
            Summary: This gene encodes a serine/threonine-protein kinase that
            functions in cell division. Together with the kinesin KIF14, this
            protein localizes to the central spindle and midbody, and functions
            to promote efficient cytokinesis. This protein is involved in
            central nervous system development. Polymorphisms in this gene are
            associated with bipolar disorder and risk for schizophrenia.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY681966.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392521.7/ ENSP00000376306.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC004813.2         52451-52479         c
            30-3408             AY681966.1         1-3379
            3409-6732           AY257469.1         3251-6574
            6733-8736           AY681966.1         6703-8706
FEATURES             Location/Qualifiers
     source          1..8736
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.23"
     gene            1..8736
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /note="citron rho-interacting serine/threonine kinase"
                     /db_xref="GeneID:11113"
                     /db_xref="HGNC:HGNC:1985"
                     /db_xref="MIM:605629"
     exon            1..72
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            73..181
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..6295
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase 21; citron
                     (rho-interacting, serine/threonine kinase 21)"
                     /codon_start=1
                     /product="citron Rho-interacting kinase isoform 1"
                     /protein_id="NP_001193928.1"
                     /db_xref="CCDS:CCDS55891.1"
                     /db_xref="GeneID:11113"
                     /db_xref="HGNC:HGNC:1985"
                     /db_xref="MIM:605629"
                     /translation="MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMS
                     PLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSL
                     VGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQL
                     QYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYV
                     HRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDG
                     KGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDF
                     LDLIQSLLCGQKERLKFEGLCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPE
                     KNSWVSSSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKK
                     LLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLA
                     TYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRL
                     MMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEY
                     AKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDS
                     SEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEE
                     KHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEK
                     GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQ
                     QKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLEL
                     KRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD
                     EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLR
                     SEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAW
                     RSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQ
                     QALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ
                     MDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQT
                     KLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEA
                     LQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPP
                     SSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLE
                     CQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKV
                     PRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGA
                     SELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVS
                     REKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHV
                     PGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEA
                     VKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNY
                     SILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEY
                     LLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSA
                     GTPARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPST
                     SRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGR
                     PLEREKSPGRMLSTRRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV"
     exon            182..323
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            324..499
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            500..601
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            602..744
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            745..838
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1042
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1196
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1380
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1486
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1630
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1750
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1921
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..1972
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2026
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2167
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2293
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2389
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2506
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2616
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2791
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2989
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3043
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3241
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3435
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3571
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            3572..3676
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..3817
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            3818..3925
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            3926..4088
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            4089..4253
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4391
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            4392..4572
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            4573..4664
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            4665..4769
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            4770..4939
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            4940..5020
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            5021..5156
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            5157..5296
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            5297..5389
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            5390..5498
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            5499..5627
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            5628..5708
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            5709..5787
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            5788..5967
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            5968..6271
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     exon            6272..8736
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8714..8719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /note="hexamer: AATAAA"
     polyA_site      8736
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /note="major polyA site"
ORIGIN      
        1 gttcctcggg ttcaaacgcg gcggcgggag gcgcggggcg gaacagatcg cagacctggg
       61 ggttcgcaga gccgccagtg gggagatgtt gaagttcaaa tatggagcgc ggaatccttt
      121 ggatgctggt gctgctgaac ccattgccag ccgggcctcc aggctgaatc tgttcttcca
      181 ggggaaacca ccctttatga ctcaacagca gatgtctcct ctttcccgag aagggatatt
      241 agatgccctc tttgttctct ttgaagaatg cagtcagcct gctctgatga agattaagca
      301 cgtgagcaac tttgtccgga agtattccga caccatagct gagttacagg agctccagcc
      361 ttcggcaaag gacttcgaag tcagaagtct tgtaggttgt ggtcactttg ctgaagtgca
      421 ggtggtaaga gagaaagcaa ccggggacat ctatgctatg aaagtgatga agaagaaggc
      481 tttattggcc caggagcagg tttcattttt tgaggaagag cggaacatat tatctcgaag
      541 cacaagcccg tggatccccc aattacagta tgcctttcag gacaaaaatc acctttatct
      601 ggtcatggaa tatcagcctg gaggggactt gctgtcactt ttgaatagat atgaggacca
      661 gttagatgaa aacctgatac agttttacct agctgagctg attttggctg ttcacagcgt
      721 tcatctgatg ggatacgtgc atcgagacat caagcctgag aacattctcg ttgaccgcac
      781 aggacacatc aagctggtgg attttggatc tgccgcgaaa atgaattcaa acaagatggt
      841 gaatgccaaa ctcccgattg ggaccccaga ttacatggct cctgaagtgc tgactgtgat
      901 gaacggggat ggaaaaggca cctacggcct ggactgtgac tggtggtcag tgggcgtgat
      961 tgcctatgag atgatttatg ggagatcccc cttcgcagag ggaacctctg ccagaacctt
     1021 caataacatt atgaatttcc agcggttttt gaaatttcca gatgacccca aagtgagcag
     1081 tgactttctt gatctgattc aaagcttgtt gtgcggccag aaagagagac tgaagtttga
     1141 aggtctttgc tgccatcctt tcttctctaa aattgactgg aacaacattc gtaactctcc
     1201 tccccccttc gttcccaccc tcaagtctga cgatgacacc tccaattttg atgaaccaga
     1261 gaagaattcg tgggtttcat cctctccgtg ccagctgagc ccctcaggct tctcgggtga
     1321 agaactgccg tttgtggggt tttcgtacag caaggcactg gggattcttg gtagatctga
     1381 gtctgttgtg tcgggtctgg actcccctgc caagactagc tccatggaaa agaaacttct
     1441 catcaaaagc aaagagctac aagactctca ggacaagtgt cacaagatgg agcaggaaat
     1501 gacccggtta catcggagag tgtcagaggt ggaggctgtg cttagtcaga aggaggtgga
     1561 gctgaaggcc tctgagactc agagatccct cctggagcag gaccttgcta cctacatcac
     1621 agaatgcagt agcttaaagc gaagtttgga gcaagcacgg atggaggtgt cccaggagga
     1681 tgacaaagca ctgcagcttc tccatgatat cagagagcag agccggaagc tccaagaaat
     1741 caaagagcag gagtaccagg ctcaagtgga agaaatgagg ttgatgatga atcagttgga
     1801 agaggatctt gtctcagcaa gaagacggag tgatctctac gaatctgagc tgagagagtc
     1861 tcggcttgct gctgaagaat tcaagcggaa agcgacagaa tgtcagcata aactgttgaa
     1921 ggctaaggat caagggaagc ctgaagtggg agaatatgcg aaactggaga agatcaatgc
     1981 tgagcagcag ctcaaaattc aggagctcca agagaaactg gagaaggctg taaaagccag
     2041 cacggaggcc accgagctgc tgcagaatat ccgccaggca aaggagcgag ccgagaggga
     2101 gctggagaag ctgcagaacc gagaggattc ttctgaaggc atcagaaaga agctggtgga
     2161 agctgaggaa cgccgccatt ctctggagaa caaggtaaag agactagaga ccatggagcg
     2221 tagagaaaac agactgaagg atgacatcca gacaaaatcc caacagatcc agcagatggc
     2281 tgataaaatt ctggagctcg aagagaaaca tcgggaggcc caagtctcag cccagcacct
     2341 agaagtgcac ctgaaacaga aagagcagca ctatgaggaa aagattaaag tgttggacaa
     2401 tcagataaag aaagacctgg ctgacaagga gacactggag aacatgatgc agagacacga
     2461 ggaggaggcc catgagaagg gcaaaattct cagcgaacag aaggcgatga tcaatgctat
     2521 ggattccaag atcagatccc tggaacagag gattgtggaa ctgtctgaag ccaataaact
     2581 tgcagcaaat agcagtcttt ttacccaaag gaacatgaag gcccaagaag agatgatttc
     2641 tgaactcagg caacagaaat tttacctgga gacacaggct gggaagttgg aggcccagaa
     2701 ccgaaaactg gaggagcagc tggagaagat cagccaccaa gaccacagtg acaagaatcg
     2761 gctgctggaa ctggagacaa gattgcggga ggtcagtcta gagcacgagg agcagaaact
     2821 ggagctcaag cgccagctca cagagctaca gctctccctg caggagcgcg agtcacagtt
     2881 gacagccctg caggctgcac gggcggccct ggagagccag cttcgccagg cgaagacaga
     2941 gctggaagag accacagcag aagctgaaga ggagatccag gcactcacgg cacatagaga
     3001 tgaaatccag cgcaaatttg atgctcttcg taacagctgt actgtaatca cagacctgga
     3061 ggagcagcta aaccagctga ccgaggacaa cgctgaactc aacaaccaaa acttctactt
     3121 gtccaaacaa ctcgatgagg cttctggcgc caacgacgag attgtacaac tgcgaagtga
     3181 agtggaccat ctccgccggg agatcacgga acgagagatg cagcttacca gccagaagca
     3241 aacgatggag gctctgaaga ccacgtgcac catgctggag gaacaggtca tggatttgga
     3301 ggccctaaac gatgagctgc tagaaaaaga gcggcagtgg gaggcctgga ggagcgtcct
     3361 gggtgatgag aaatcccagt ttgagtgtcg ggttcgagag ctgcagagaa tgctggacac
     3421 cgagaaacag agcagggcga gagccgatca gcggatcacc gagtctcgcc aggtggtgga
     3481 gctggcagtg aaggagcaca aggctgagat tctcgctctg cagcaggctc tcaaagagca
     3541 gaagctgaag gccgagagcc tctctgacaa gctcaatgac ctggagaaga agcatgctat
     3601 gcttgaaatg aatgcccgaa gcttacagca gaagctggag actgaacgag agctcaaaca
     3661 gaggcttctg gaagagcaag ccaaattaca gcagcagatg gacctgcaga aaaatcacat
     3721 tttccgtctg actcaaggac tgcaagaagc tctagatcgg gctgatctac tgaagacaga
     3781 aagaagtgac ttggagtatc agctggaaaa cattcaggtt ctctattctc atgaaaaggt
     3841 gaaaatggaa ggcactattt ctcaacaaac caaactcatt gattttctgc aagccaaaat
     3901 ggaccaacct gctaaaaaga aaaagggttt atttagtcga cggaaagagg accctgcttt
     3961 acccacacag gttcctctgc agtacaatga gctgaagctg gccctggaga aggagaaagc
     4021 tcgctgtgca gagctagagg aagcccttca gaagacccgc atcgagctcc ggtccgcccg
     4081 ggaggaagct gcccaccgca aagcaacgga ccacccacac ccatccacgc cagccaccgc
     4141 gaggcagcag atcgccatgt ccgccatcgt gcggtcgcca gagcaccagc ccagtgccat
     4201 gagcctgctg gccccgccat ccagccgcag aaaggagtct tcaactccag aggaatttag
     4261 tcggcgtctt aaggaacgca tgcaccacaa tattcctcac cgattcaacg taggactgaa
     4321 catgcgagcc acaaagtgtg ctgtgtgtct ggataccgtg cactttggac gccaggcatc
     4381 caaatgtctc gaatgtcagg tgatgtgtca ccccaagtgc tccacgtgct tgccagccac
     4441 ctgcggcttg cctgctgaat atgccacaca cttcaccgag gccttctgcc gtgacaaaat
     4501 gaactcccca ggtctccaga ccaaggagcc cagcagcagc ttgcacctgg aagggtggat
     4561 gaaggtgccc aggaataaca aacgaggaca gcaaggctgg gacaggaagt acattgtcct
     4621 ggagggatca aaagtcctca tttatgacaa tgaagccaga gaagctggac agaggccggt
     4681 ggaagaattt gagctgtgcc ttcccgacgg ggatgtatct attcatggtg ccgttggtgc
     4741 ttccgaactc gcaaatacag ccaaagcaga tgtcccatac atactgaaga tggaatctca
     4801 cccgcacacc acctgctggc ccgggagaac cctctacttg ctagctccca gcttccctga
     4861 caaacagcgc tgggtcaccg ccttagaatc agttgtcgca ggtgggagag tttctaggga
     4921 aaaagcagaa gctgatgcta aactgcttgg aaactccctg ctgaaactgg aaggtgatga
     4981 ccgtctagac atgaactgca cgctgccctt cagtgaccag gtggtgttgg tgggcaccga
     5041 ggaagggctc tacgccctga atgtcttgaa aaactcccta acccatgtcc caggaattgg
     5101 agcagtcttc caaatttata ttatcaagga cctggagaag ctactcatga tagcaggaga
     5161 agagcgggca ctgtgtcttg tggacgtgaa gaaagtgaaa cagtccctgg cccagtccca
     5221 cctgcctgcc cagcccgaca tctcacccaa catttttgaa gctgtcaagg gctgccactt
     5281 gtttggggca ggcaagattg agaacgggct ctgcatctgt gcagccatgc ccagcaaagt
     5341 cgtcattctc cgctacaacg aaaacctcag caaatactgc atccggaaag agatagagac
     5401 ctcagagccc tgcagctgta tccacttcac caattacagt atcctcattg gaaccaataa
     5461 attctacgaa atcgacatga agcagtacac gctcgaggaa ttcctggata agaatgacca
     5521 ttccttggca cctgctgtgt ttgccgcctc ttccaacagc ttccctgtct caatcgtgca
     5581 ggtgaacagc gcagggcagc gagaggagta cttgctgtgt ttccacgaat ttggagtgtt
     5641 cgtggattct tacggaagac gtagccgcac agacgatctc aagtggagtc gcttaccttt
     5701 ggcctttgcc tacagagaac cctatctgtt tgtgacccac ttcaactcac tcgaagtaat
     5761 tgagatccag gcacgctcct cagcagggac ccctgcccga gcgtacctgg acatcccgaa
     5821 cccgcgctac ctgggccctg ccatttcctc aggagcgatt tacttggcgt cctcatacca
     5881 ggataaatta agggtcattt gctgcaaggg aaacctcgtg aaggagtccg gcactgaaca
     5941 ccaccggggc ccgtccacct cccgcagcag ccccaacaag cgaggcccac ccacgtacaa
     6001 cgagcacatc accaagcgcg tggcctccag cccagcgccg cccgaaggcc ccagccaccc
     6061 gcgagagcca agcacacccc accgctaccg cgaggggcgg accgagctgc gcagggacaa
     6121 gtctcctggc cgccccctgg agcgagagaa gtcccccggc cggatgctca gcacgcggag
     6181 agagcggtcc cccgggaggc tgtttgaaga cagcagcagg ggccggctgc ctgcgggagc
     6241 cgtgaggacc ccgctgtccc aggtgaacaa ggtctgggac cagtcttcag tataaatctc
     6301 agccagaaaa accaactcct catcttgatc tgcaggaaaa caccaaacac actatggaac
     6361 tctgctgatg gggacccaag cgcccacgtg ctcagccacc ctctggctca gcggggccca
     6421 gacccacctc ggcacggaca cccctgtctc caggaggggc aggtggctga ggctcttcgg
     6481 agctgtcagc gcccggtgcc tgccctgggc acctccctgc agtcatctct ttgcactttg
     6541 ttactctttc aaagcattca caaacttttg tacctagctc tagcctgtac cagttagttc
     6601 atcaaaggaa accaaccggg atgctaacta caacatggtt agaatcctaa ttagctactt
     6661 taagatccta ggattggttg gtttttcttt tttttttctc tttgtttctt tccttttttt
     6721 tttttttttt ttaagacaac agaattctta atagatttga atagcgacgt atttcctgtt
     6781 gtagtcattt ttagctcgac cacatcatca ggtctttgcc accgaggcat agtgtagaac
     6841 agtcccggtc agttggccaa cctcccgcag ccaagtaggt tcatccttgt tcctgttcat
     6901 tctcatagat ggccctgctt tccccagggt gacatcgtag ccaaatgttt actgttttca
     6961 ttgcctttta tggccttgac gacttcccct cccaccagct gagaatgtat ggaggtcatc
     7021 ggggcctcag ctcggaggca gtgacttggg gccaagggac ctcgagacgc tttccttccc
     7081 caccccccag cgtcatctcc ccagcctgct gttcccgctt tccatatagc tttggccagg
     7141 aaagcatgca atagacttgc tcggagccca gcactcctgg gtctcggggt cggggagggg
     7201 acgggggcac ccacttcctt gtctgtgacg gcgtgttgtt ccccactctg ggatggggaa
     7261 gaggcccgtc gggagttctg catggcagtt cactgcatgt gctgccccct tgggttgctc
     7321 tgccaatgta ttaataccat cccatagctc ctgccaaatc gagaccctct gacgacttgc
     7381 cgactaactg gccaccacaa gctgcagtct gtagcactga acaaacaaaa aacaaaacgc
     7441 tcaagcctta cgaccagaga aggatttcag caaaccacca cctcccactc agtgtcccct
     7501 ccaaacttca cacttccctg cctgcagagg atgactctgt tcacacccaa tccagcgcgg
     7561 ttctacccca cgaaactgtg actttccaaa tgagcctttc cctagggcta gacctaagac
     7621 caggaagttt gagaaagcag ccgcagctca actcttccag ctccgccagg gttgggaagt
     7681 ccttaggtgc agtgcggctc ccactgggtc tgcggaccct cctattagag tacgaaattc
     7741 ctggcaactg gtacagaacc aacctagagg ctttgcagtt ggcaagctaa ctcgcggcct
     7801 tatttctgcc tttaatctcc cacaaggcat ctgttgcttt gggtcctcca cgactcttag
     7861 gcccgcctca acaacccagg cacctcctag gtaggctcaa aggtagaccc gtttccaccg
     7921 cagcaggtga acatgaccgt gttttcaact gtgtccacag ttcagatccc tttccagatt
     7981 gcaacctggc ctgcatccca gctccttcct gctcgtgtct taacctaagt gctttcttgt
     8041 ttgaaacgcc tacaaacctc catgtggtag ctcctttggc aaatgtcctg ctgtggcgtt
     8101 ttatgtgttg cttggagtct gtggggtcgt actccctccc ctcccgtccc cagggcagat
     8161 ttgattgaat gtttgctgaa gttttgtctc ttggtccaca gtatttggaa aggtcactga
     8221 aaatgggtct ttcagtcttg gcatttcatt taggatctcc atgagaaatg ggcttcttga
     8281 gccctgaaaa tgtatattgt gtgtctcatc tgtgaactgc tttctgctat atagaactag
     8341 ctcaaaagac tgtacatatt tacaagaaac tttatattcg taaaaaaaaa aagaggaaat
     8401 tgaattggtt tctacttttt tattgtaaaa ggtgcatttt tcaacactta cttttggttt
     8461 caatggtggt agttgtggac agccatcttc actggagggt ggggagctcc gtgtgaccac
     8521 caagatgcca gcaggatata ccgtaacacg aaattgctgt caaaagctta ttagcatcaa
     8581 tcaagattct aggtctccaa aagtacaggc tttttcttca ttaccttttt tattcagaac
     8641 gaggaagaga acacaaggaa tgattcaaga tccaccttga gaggaatgaa ctttgttgtt
     8701 gaacaattag tgaaataaag caatgatcta aactaa
//
