LOCUS       NM_145071               2019 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens cytokine inducible SH2 containing protein (CISH),
            transcript variant 2, mRNA.
ACCESSION   NM_145071
VERSION     NM_145071.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2019)
  AUTHORS   Nakazawa,T., Morimoto,T., Maeoka,R., Matsuda,R., Nakamura,M.,
            Nishimura,F., Ouji,N., Yamada,S., Nakagawa,I., Park,Y.S., Ito,T.,
            Nakase,H. and Tsujimura,T.
  TITLE     CIS deletion by CRISPR/Cas9 enhances human primary natural killer
            cell functions against allogeneic glioblastoma
  JOURNAL   J Exp Clin Cancer Res 42 (1), 205 (2023)
   PUBMED   37563692
  REMARK    GeneRIF: CIS deletion by CRISPR/Cas9 enhances human primary natural
            killer cell functions against allogeneic glioblastoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2019)
  AUTHORS   Jin,J., Mu,Y., Zhang,H., Sturmlechner,I., Wang,C., Jadhav,R.R.,
            Xia,Q., Weyand,C.M. and Goronzy,J.J.
  TITLE     CISH impairs lysosomal function in activated T cells resulting in
            mitochondrial DNA release and inflammaging
  JOURNAL   Nat Aging 3 (5), 600-616 (2023)
   PUBMED   37118554
  REMARK    GeneRIF: CISH impairs lysosomal function in activated T cells
            resulting in mitochondrial DNA release and inflammaging.
REFERENCE   3  (bases 1 to 2019)
  AUTHORS   Rosier,F., Brisebarre,A., Dupuis,C., Baaklini,S., Puthier,D.,
            Brun,C., Pradel,L.C., Rihet,P. and Payen,D.
  TITLE     Genetic Predisposition to the Mortality in Septic Shock Patients:
            From GWAS to the Identification of a Regulatory Variant Modulating
            the Activity of a CISH Enhancer
  JOURNAL   Int J Mol Sci 22 (11), 5852 (2021)
   PUBMED   34072601
  REMARK    GeneRIF: Genetic Predisposition to the Mortality in Septic Shock
            Patients: From GWAS to the Identification of a Regulatory Variant
            Modulating the Activity of a CISH Enhancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2019)
  AUTHORS   Peng,H.Y., Hsiao,J.R., Chou,S.T., Hsu,Y.M., Wu,G.H., Shieh,Y.S. and
            Shiah,S.G.
  TITLE     MiR-944/CISH mediated inflammation via STAT3 is involved in oral
            cancer malignance by cigarette smoking
  JOURNAL   Neoplasia 22 (11), 554-565 (2020)
   PUBMED   32961483
  REMARK    GeneRIF: MiR-944/CISH mediated inflammation via STAT3 is involved
            in oral cancer malignance by cigarette smoking.
REFERENCE   5  (bases 1 to 2019)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2019)
  AUTHORS   Aman,M.J., Migone,T.S., Sasaki,A., Ascherman,D.P., Zhu,Mh.,
            Soldaini,E., Imada,K., Miyajima,A., Yoshimura,A. and Leonard,W.J.
  TITLE     CIS associates with the interleukin-2 receptor beta chain and
            inhibits interleukin-2-dependent signaling
  JOURNAL   J Biol Chem 274 (42), 30266-30272 (1999)
   PUBMED   10514520
REFERENCE   7  (bases 1 to 2019)
  AUTHORS   Okabe,S., Tauchi,T., Morita,H., Ohashi,H., Yoshimura,A. and
            Ohyashiki,K.
  TITLE     Thrombopoietin induces an SH2-containing protein, CIS1, which binds
            to Mpl: involvement of the ubiquitin proteosome pathway
  JOURNAL   Exp Hematol 27 (10), 1542-1547 (1999)
   PUBMED   10517496
REFERENCE   8  (bases 1 to 2019)
  AUTHORS   Verdier,F., Chretien,S., Muller,O., Varlet,P., Yoshimura,A.,
            Gisselbrecht,S., Lacombe,C. and Mayeux,P.
  TITLE     Proteasomes regulate erythropoietin receptor and signal transducer
            and activator of transcription 5 (STAT5) activation. Possible
            involvement of the ubiquitinated Cis protein
  JOURNAL   J Biol Chem 273 (43), 28185-28190 (1998)
   PUBMED   9774439
REFERENCE   9  (bases 1 to 2019)
  AUTHORS   Uchida,K., Yoshimura,A., Inazawa,J., Yanagisawa,K., Osada,H.,
            Masuda,A., Saito,T., Takahashi,T., Miyajima,A. and Takahashi,T.
  TITLE     Molecular cloning of CISH, chromosome assignment to 3p21.3, and
            analysis of expression in fetal and adult tissues
  JOURNAL   Cytogenet Cell Genet 78 (3-4), 209-212 (1997)
   PUBMED   9465889
REFERENCE   10 (bases 1 to 2019)
  AUTHORS   Yoshimura,A., Ohkubo,T., Kiguchi,T., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., Hara,T. and Miyajima,A.
  TITLE     A novel cytokine-inducible gene CIS encodes an SH2-containing
            protein that binds to tyrosine-phosphorylated interleukin 3 and
            erythropoietin receptors
  JOURNAL   EMBO J 14 (12), 2816-2826 (1995)
   PUBMED   7796808
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA957793.1, BC064354.1 and
            BC031590.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_145071.3.
            
            Summary: The protein encoded by this gene contains a SH2 domain and
            a SOCS box domain. The protein thus belongs to the cytokine-induced
            STAT inhibitor (CIS), also known as suppressor of cytokine
            signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein
            family. CIS family members are known to be cytokine-inducible
            negative regulators of cytokine signaling. The expression of this
            gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic
            cells. Proteasome-mediated degradation of this protein has been
            shown to be involved in the inactivation of the erythropoietin
            receptor. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (2) lacks a segment in the 5' UTR
            and coding region compared to variant 1. The translation begins at
            an in-frame upstream start codon, and results in an isoform (2)
            with a different N-terminus, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031590.1, D83532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348721.4/ ENSP00000294173.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               DA957793.1         58-163
            107-1804            BC064354.1         1-1698
            1805-2019           BC031590.1         1794-2008
FEATURES             Location/Qualifiers
     source          1..2019
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..2019
                     /gene="CISH"
                     /gene_synonym="BACTS2; CIS; CIS-1; G18; SOCS"
                     /note="cytokine inducible SH2 containing protein"
                     /db_xref="GeneID:1154"
                     /db_xref="HGNC:HGNC:1984"
                     /db_xref="MIM:602441"
     exon            1..144
                     /gene="CISH"
                     /gene_synonym="BACTS2; CIS; CIS-1; G18; SOCS"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..901
                     /gene="CISH"
                     /gene_synonym="BACTS2; CIS; CIS-1; G18; SOCS"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cytokine-inducible inhibitor of signaling type 1B;
                     suppressor of cytokine signaling"
                     /codon_start=1
                     /product="cytokine-inducible SH2-containing protein
                     isoform 2"
                     /protein_id="NP_659508.1"
                     /db_xref="CCDS:CCDS2831.1"
                     /db_xref="GeneID:1154"
                     /db_xref="HGNC:HGNC:1984"
                     /db_xref="MIM:602441"
                     /translation="MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLE
                     EVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEG
                     TFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLV
                     QHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRS
                     SARSLQHLCRLVINRLVADVDCLPLPRRMADYLRQYPFQL"
     exon            145..365
                     /gene="CISH"
                     /gene_synonym="BACTS2; CIS; CIS-1; G18; SOCS"
                     /inference="alignment:Splign:2.1.0"
     exon            366..2019
                     /gene="CISH"
                     /gene_synonym="BACTS2; CIS; CIS-1; G18; SOCS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1997..2002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CISH"
                     /gene_synonym="BACTS2; CIS; CIS-1; G18; SOCS"
                     /note="hexamer: AATAAA"
     polyA_site      2019
                     /gene="CISH"
                     /gene_synonym="BACTS2; CIS; CIS-1; G18; SOCS"
                     /note="major polyA site"
ORIGIN      
        1 agtccctgtc ctgcgcccgc gcgccccggg agcctaccca gcacgcgctc cgcgcccact
       61 ggttccctcc agccgccgcc gtccagccga gtccccactc cggagtcgcc gctgccgcgg
      121 ggacatggtc ctctgcgttc agggacctcg tcctttgctg gctgtggagc ggactgggca
      181 gcggcccctg tgggccccgt ccctggaact gcccaagcca gtcatgcagc ccttgcctgc
      241 tggggccttc ctcgaggagg tggcagaggg taccccagcc cagacagaga gtgagccaaa
      301 ggtgctggac ccagaggagg atctgctgtg catagccaag accttctcct accttcggga
      361 atctggctgg tattggggtt ccattacggc cagcgaggcc cgacaacacc tgcagaagat
      421 gccagaaggc acgttcttag tacgtgacag cacgcacccc agctacctgt tcacgctgtc
      481 agtgaaaacc actcgtggcc ccaccaatgt acgcattgag tatgccgact ccagcttccg
      541 tctggactcc aactgcttgt ccaggccacg catcctggcc tttccggatg tggtcagcct
      601 tgtgcagcac tatgtggcct cctgcactgc tgatacccga agcgacagcc ccgatcctgc
      661 tcccaccccg gccctgccta tgcctaagga ggatgcgcct agtgacccag cactgcctgc
      721 tcctccacca gccactgctg tacacctaaa actggtgcag ccctttgtac gcagaagcag
      781 tgcccgcagc ctgcaacacc tgtgccgcct tgtcatcaac cgtctggtgg ccgacgtgga
      841 ctgcctgcca ctgccccggc gcatggccga ctacctccga cagtacccct tccagctctg
      901 actgtacggg gcaatctgcc caccctcacc cagtcgcacc ctggagggga catcagcccc
      961 agctggactt gggcccccac tgtccctcct ccaggcatcc tggtgcctgc atacctctgg
     1021 cagctggccc aggaagagcc agcaagagca aggcatggga gaggggaggt gtcacacaac
     1081 ttggaggtaa atgcccccag gccgcatgtg gcttcattat actgagccat gtgtcagagg
     1141 atggggagac aggcaggacc ttgtctcacc tgtgggctgg gcccagacct ccactcgctt
     1201 gcctgccctg gccacctgaa ctgtatgggc actctcagcc ctggtttttc aatccccagg
     1261 gtcgggtagg acccctactg gcagccagcc tctgtttctg ggaggatgac atgcagagga
     1321 actgagatcg acagtgacta gtgacccctt gttgaggggt aagccaggct aggggactgc
     1381 acaattatac actatttatt tatttattct ccttggggtt ggtgtcaggg gcgagccaac
     1441 cccacctcta tgccctgagc cctggtagtc cagagacccc aactctgccc tggcttctct
     1501 ggttcttccc tgtggaaagc ccatcctgag acatcttgct ggaaccaagg caatcctgga
     1561 tgtcctggta ctgacccacc cgtctgtgaa tgtgtccact ctcttctgcc cccagccata
     1621 tttggggagg atggacaact acaataggta agaaaatgca gccggagcct cagtccccag
     1681 cagagcctgt gtctcacccc ctcacaggac agagctgtat ctgcatagag ctggtctcac
     1741 tgtggcgcag gccccggggg gagtgcctgt gctgtcagga agagggggtg ctggtttgag
     1801 ggccgccact gcagttctgc taggtctgct tcctgcccag gaaggtgcct gcacatgaga
     1861 ggagagaaat acacgtctga taagacttca tgaaataata attatagcaa agaacagttt
     1921 ggtggtcttt tctcttccac tgatttttct gtaatgacat tataccttta ttacctcttt
     1981 attttattac ctctataata aaatgatacc tttcatgta
//
