LOCUS       NM_001136498            2552 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens CDGSH iron sulfur domain 3 (CISD3), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_001136498 XM_001714917 XM_001716624 XM_001718346
VERSION     NM_001136498.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2552)
  AUTHORS   Grifagni,D., Silva,J.M., Querci,L., Lepoivre,M., Vallieres,C.,
            Louro,R.O., Banci,L., Piccioli,M., Golinelli-Cohen,M.P. and
            Cantini,F.
  TITLE     Biochemical and cellular characterization of the CISD3 protein:
            Molecular bases of cluster release and destabilizing effects of
            nitric oxide
  JOURNAL   J Biol Chem 300 (3), 105745 (2024)
   PUBMED   38354784
  REMARK    GeneRIF: Biochemical and cellular characterization of the CISD3
            protein: Molecular bases of cluster release and destabilizing
            effects of nitric oxide.
REFERENCE   2  (bases 1 to 2552)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2552)
  AUTHORS   Li,Y., Wang,X., Huang,Z., Zhou,Y., Xia,J., Hu,W., Wang,X., Du,J.,
            Tong,X. and Wang,Y.
  TITLE     CISD3 inhibition drives cystine-deprivation induced ferroptosis
  JOURNAL   Cell Death Dis 12 (9), 839 (2021)
   PUBMED   34497268
  REMARK    GeneRIF: CISD3 inhibition drives cystine-deprivation induced
            ferroptosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2552)
  AUTHORS   Lipper,C.H., Karmi,O., Sohn,Y.S., Darash-Yahana,M., Lammert,H.,
            Song,L., Liu,A., Mittler,R., Nechushtai,R., Onuchic,J.N. and
            Jennings,P.A.
  TITLE     Structure of the human monomeric NEET protein MiNT and its role in
            regulating iron and reactive oxygen species in cancer cells
  JOURNAL   Proc Natl Acad Sci U S A 115 (2), 272-277 (2018)
   PUBMED   29259115
  REMARK    GeneRIF: Data indicate that mitochondrial inner NEET protein
            (MiNT)functions within the mitochondria to regulate levels of toxic
            iron and reactive oxygen species (ROS).
REFERENCE   5  (bases 1 to 2552)
  AUTHORS   Wiley,S.E., Paddock,M.L., Abresch,E.C., Gross,L., van der Geer,P.,
            Nechushtai,R., Murphy,A.N., Jennings,P.A. and Dixon,J.E.
  TITLE     The outer mitochondrial membrane protein mitoNEET contains a novel
            redox-active 2Fe-2S cluster
  JOURNAL   J Biol Chem 282 (33), 23745-23749 (2007)
   PUBMED   17584744
REFERENCE   6  (bases 1 to 2552)
  AUTHORS   Wiley,S.E., Murphy,A.N., Ross,S.A., van der Geer,P. and Dixon,J.E.
  TITLE     MitoNEET is an iron-containing outer mitochondrial membrane protein
            that regulates oxidative capacity
  JOURNAL   Proc Natl Acad Sci U S A 104 (13), 5318-5323 (2007)
   PUBMED   17376863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006449.19.
            
            On May 17, 2019 this sequence version replaced NM_001136498.1.
            
            Summary: CISD3 is a member of the CDGSH domain-containing family,
            which may play a role in regulating electron transport and
            oxidative phosphorylation (Wiley et al., 2007 [PubMed
            17376863]).[supplied by OMIM, Apr 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.998108.1,
                                           SRR1660805.314775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000613478.2/ ENSP00000483781.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC006449.19        175344-175409
            67-102              AC006449.19        175763-175798
            103-222             AC006449.19        176323-176442
            223-2552            AC006449.19        178279-180608
FEATURES             Location/Qualifiers
     source          1..2552
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2552
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
                     /note="CDGSH iron sulfur domain 3"
                     /db_xref="GeneID:284106"
                     /db_xref="HGNC:HGNC:27578"
                     /db_xref="MIM:611933"
     exon            1..66
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..402
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
                     /note="mitoNEET related 2; CDGSH iron-sulfur
                     domain-containing protein 3, mitochondrial;
                     mitoNEET-related protein 2; mitochondrial inner NEET
                     protein"
                     /codon_start=1
                     /product="CDGSH iron-sulfur domain-containing protein 3,
                     mitochondrial precursor"
                     /protein_id="NP_001129970.1"
                     /db_xref="CCDS:CCDS45662.1"
                     /db_xref="GeneID:284106"
                     /db_xref="HGNC:HGNC:27578"
                     /db_xref="MIM:611933"
                     /translation="MRGAGAILRPAARGARDLNPRRDISSWLAQWFPRTPARSVVALK
                     TPIKVELVAGKTYRWCVCGRSKKQPFCDGSHFFQRTGLSPLKFKAQETRMVALCTCKA
                     TQRPPYCDGTHRSERVQKAEVGSPL"
     exon            67..102
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
                     /inference="alignment:Splign:2.1.0"
     exon            103..222
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
                     /inference="alignment:Splign:2.1.0"
     exon            223..2552
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      620..625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
                     /note="hexamer: AACAAG"
     polyA_site      639
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
                     /note="major polyA site"
     regulatory      1586..1591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
                     /note="hexamer: GATAAA"
     polyA_site      1609
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
     regulatory      1940..1945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
                     /note="hexamer: CATAAA"
     polyA_site      1968
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
     regulatory      1991..1996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
                     /note="hexamer: AATAAG"
     polyA_site      1992
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
     polyA_site      2022
                     /gene="CISD3"
                     /gene_synonym="Miner2; MiNT"
ORIGIN      
        1 gcggcgcggg aggcgaccat gcgcggcgcg ggggcgatcc tgcggccggc ggcgcgtggt
       61 gcccgggacc tgaacccgcg gcgggacatc tcctcctggc tggcccagtg gttccctaga
      121 accccagcca ggtccgtggt ggccctgaag acccccatca aggtggagct ggtggcaggg
      181 aaaacctaca ggtggtgtgt gtgtggccgc agcaagaagc agcccttctg tgacggctcc
      241 cacttcttcc aacgcactgg cctatctcca ctcaagttca aggcccaaga gacccgcatg
      301 gtggcactct gtacctgcaa ggccactcag aggcccccgt actgcgatgg cacccacagg
      361 agtgagcgcg tgcagaaggc agaagtgggc tccccactct gagggggctg ctgctgtcca
      421 gccacaggtg gccttggctc caggcctctg acaggcaccc ccttctgtgg gaaaggaaac
      481 aggtgctgag cccaagagac tctggtaccc actgctggct catgaaggaa gaattattcc
      541 ttataaccta aaagtctcca gtctggggca ggcgggagtg ggccctggtt caatgtttgc
      601 tgatggggaa gatggcaaaa acaagcctgc ccaaccagac tggtagtcct gcagtcactg
      661 ctatgaggcc cacgtgctgc ctcctgctcc agattttaac ctctctgtgg gctgggggca
      721 cctgaccagc cacaggagag ggcagttcag attcattctg tatggggtcc ccaagccagg
      781 ctaaacccag agatgagagg cacccttccc ttcttccctc caccccaaag aactacaggc
      841 tccagaaagt atgcagcatt tattacaaag ccaagagata cagatgtccc agggcaaagg
      901 agggtacagt cacaggacct cagacacagg acaaggtgca aacacagaca agcccatcag
      961 ggggctccca accccacaca cctacgctat gatggaatct cgagtctcga ctcccgactc
     1021 ctctcagatc tatgcacact tgaggaaatc tcggtgggca gcgacctgcc agggtctgtc
     1081 cctaaggagg tggtccgctg acctctcaag gggtgggggt ggggtcagag cttacaggtt
     1141 tctgtcttct tgtgctttta gatgcagttg ctctgtcctg accaggtgac cgggcctcag
     1201 ctgggggtgg aggggcaatt ggaaggctgt ttgcctctgg caaagtctgg gatctgtgct
     1261 tgtgtgaggt taacccaccc ccacttccac tctaggcccc aggtgagact ccaccaccag
     1321 tcctgctagt gagggttccc cggtgagggt aaggttggtg ggggtgcagc gcttcacaat
     1381 gctaaagcct tagccctcct ccaagagctg agacctctca gggcctgaat cttcttttcc
     1441 acaagataaa tgatgcaaag gccacacaca caggaaaaaa aaaaaaagag gcagaactat
     1501 ctattctttg cacaaagttt ccactgcaag aggaggaggt gatgcaggtg ccacctccac
     1561 cctgcacttg ctcctcagaa ccagggataa actgcatttg taaaaggcac tgttcttagc
     1621 aatttctgga cattcaacaa cgtggggggc ggccactggt cagaggcagg acagcagcca
     1681 agatggggag agaaacgggg agagaaagaa acgattctaa ctgactccta tatgcagcca
     1741 gttggaatca tgcctaaagc tttgggtctg aaggggcccc caacacacca cctgccttgg
     1801 gaaacagcga ggatggtgca gagctttatt gagactccag tggcccatcc agttcatctc
     1861 caggcacccc caaaaacagc aaattacaca agaccccccc caaaaaaaat gaacaccatt
     1921 ttccacacat acacacacac ataaagtttg tttcctgtgg catttaaatt aatctggttg
     1981 gtccatagaa aataagtatg tatatttggt ttttcctatg tacatatata tatatattta
     2041 tttataaaac ccgcccccca cccccaaggt gggaagagct ggggaaagta gaagaggtgg
     2101 aaaaaagggc ccagaaaaag tggaaggagt ggagaggctt ggctggaaga agggagaggg
     2161 tccctggcct caagttaagg ggggcacggg agcgccgttg acagtcatct tgcgccccct
     2221 gctggtggag gatggtgtct gcaggcagtt caagctaccc ccgttggcag ctgtggtggc
     2281 cccactggct gtcgaagggg gagtggggga ggtagggtgg gtggctggag gcccatggga
     2341 actgggagag ccatgggatg gggtggctgg gctgggcagg gaggaggagg tggctggcag
     2401 ggtggcaggg ctgggagcct tgtcgctgac tgactcacac tcggacgccc cgctggtgtt
     2461 ggtgccctcg gagggggtgg gcaccgtggc tagggtgagc cgcttgcagg ctggctggac
     2521 acggtacttg agggggagag gcccgttctg cg
//
