LOCUS       NM_018464               2375 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens CDGSH iron sulfur domain 1 (CISD1), mRNA.
ACCESSION   NM_018464
VERSION     NM_018464.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2375)
  AUTHORS   Mons,C., Salameh,M., Botzanowski,T., Clemancey,M., Dorlet,P.,
            Vallieres,C., Erb,S., Vernis,L., Guittet,O., Lepoivre,M.,
            Huang,M.E., Cianferani,S., Latour,J.M., Blondin,G. and
            Golinelli-Cohen,M.P.
  TITLE     Regulations of mitoNEET by the key redox homeostasis molecule
            glutathione
  JOURNAL   J Inorg Biochem 255, 112535 (2024)
   PUBMED   38527404
  REMARK    GeneRIF: Regulations of mitoNEET by the key redox homeostasis
            molecule glutathione.
REFERENCE   2  (bases 1 to 2375)
  AUTHORS   Zang,J., Cui,M., Xiao,L., Zhang,J. and Jing,R.
  TITLE     Overexpression of ferroptosis-related genes FSP1 and CISD1 is
            related to prognosis and tumor immune infiltration in gastric
            cancer
  JOURNAL   Clin Transl Oncol 25 (8), 2532-2544 (2023)
   PUBMED   36995520
  REMARK    GeneRIF: Overexpression of ferroptosis-related genes FSP1 and CISD1
            is related to prognosis and tumor immune infiltration in gastric
            cancer.
REFERENCE   3  (bases 1 to 2375)
  AUTHORS   Liu,F., Dong,Y., Zhong,F., Guo,H. and Dong,P.
  TITLE     CISD1 Is a Breast Cancer Prognostic Biomarker Associated with
            Diabetes Mellitus
  JOURNAL   Biomolecules 13 (1), 37 (2022)
   PUBMED   36671422
  REMARK    GeneRIF: CISD1 Is a Breast Cancer Prognostic Biomarker Associated
            with Diabetes Mellitus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2375)
  AUTHORS   Kunk,C., Kruger,J., Mendoza,G., Markitan,J., Bias,T., Mann,A.,
            Nath,A., Geldenhuys,W.J., Menze,M.A. and Konkle,M.E.
  TITLE     MitoNEET's Reactivity of Lys55 toward Pyridoxal Phosphate
            Demonstrates its Activity as a Transaminase Enzyme
  JOURNAL   ACS Chem Biol 17 (10), 2716-2722 (2022)
   PUBMED   36194135
REFERENCE   5  (bases 1 to 2375)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 2375)
  AUTHORS   Lin,J., Zhou,T., Ye,K. and Wang,J.
  TITLE     Crystal structure of human mitoNEET reveals distinct groups of iron
            sulfur proteins
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14640-14645 (2007)
   PUBMED   17766439
  REMARK    GeneRIF: Crystal structure of mitoNEET reveals distinct groups of
            iron sulfur proteins.
REFERENCE   7  (bases 1 to 2375)
  AUTHORS   Paddock,M.L., Wiley,S.E., Axelrod,H.L., Cohen,A.E., Roy,M.,
            Abresch,E.C., Capraro,D., Murphy,A.N., Nechushtai,R., Dixon,J.E.
            and Jennings,P.A.
  TITLE     MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane
            protein stabilized by pioglitazone
  JOURNAL   Proc Natl Acad Sci U S A 104 (36), 14342-14347 (2007)
   PUBMED   17766440
  REMARK    GeneRIF: biophysical properties of mitoNEET suggest that it may
            participate in a redox-sensitive signaling and/or in Fe-S cluster
            transfer
REFERENCE   8  (bases 1 to 2375)
  AUTHORS   Wiley,S.E., Paddock,M.L., Abresch,E.C., Gross,L., van der Geer,P.,
            Nechushtai,R., Murphy,A.N., Jennings,P.A. and Dixon,J.E.
  TITLE     The outer mitochondrial membrane protein mitoNEET contains a novel
            redox-active 2Fe-2S cluster
  JOURNAL   J Biol Chem 282 (33), 23745-23749 (2007)
   PUBMED   17584744
  REMARK    GeneRIF: Spectroscopic studies show that the 2Fe-2S cluster is
            coordinated by Cys-3 and His-1. The His ligand is shown to be
            involved in the observed pH lability of the cluster, indicating
            that loss of this ligand via protonation triggered release of the
            cluster.
REFERENCE   9  (bases 1 to 2375)
  AUTHORS   Wiley,S.E., Murphy,A.N., Ross,S.A., van der Geer,P. and Dixon,J.E.
  TITLE     MitoNEET is an iron-containing outer mitochondrial membrane protein
            that regulates oxidative capacity
  JOURNAL   Proc Natl Acad Sci U S A 104 (13), 5318-5323 (2007)
   PUBMED   17376863
  REMARK    GeneRIF: mito- NEET is an important iron-containing protein
            involved in the control of maximal mitochondrial respiratory rates
REFERENCE   10 (bases 1 to 2375)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA417986.1, AY960578.1, AC016396.6 and AI025360.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018464.4.
            
            Summary: This gene encodes a protein with a CDGSH iron-sulfur
            domain and has been shown to bind a redox-active [2Fe-2S] cluster.
            The encoded protein has been localized to the outer membrane of
            mitochondria and is thought to play a role in regulation of
            oxidation. Genes encoding similar proteins are located on
            chromosomes 4 and 17, and a pseudogene of this gene is located on
            chromosome 2. [provided by RefSeq, Feb 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG614903.1, SRR1660803.175955.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333926.6/ ENSP00000363041.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                DA417986.1         61-117
            58-534              AY960578.1         1-477
            535-1680            AC016396.6         89921-91066
            1681-2048           AI025360.1         8-375               c
            2049-2375           AC016396.6         91435-91761
FEATURES             Location/Qualifiers
     source          1..2375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.1"
     gene            1..2375
                     /gene="CISD1"
                     /gene_synonym="C10orf70; MDS029; mitoNEET; ZCD1"
                     /note="CDGSH iron sulfur domain 1"
                     /db_xref="GeneID:55847"
                     /db_xref="HGNC:HGNC:30880"
                     /db_xref="MIM:611932"
     exon            1..143
                     /gene="CISD1"
                     /gene_synonym="C10orf70; MDS029; mitoNEET; ZCD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..439
                     /gene="CISD1"
                     /gene_synonym="C10orf70; MDS029; mitoNEET; ZCD1"
                     /EC_number="2.6.1.3"
                     /note="zinc finger CDGSH-type domain 1; cysteine
                     transaminase CISD1"
                     /codon_start=1
                     /product="CDGSH iron-sulfur domain-containing protein 1"
                     /protein_id="NP_060934.1"
                     /db_xref="CCDS:CCDS7251.1"
                     /db_xref="GeneID:55847"
                     /db_xref="HGNC:HGNC:30880"
                     /db_xref="MIM:611932"
                     /translation="MSLTSSSSVRVEWIAAVTIAAGTAAIGYLAYKRFYVKDHRNKAM
                     INLHIQKDNPKIVHAFDMEDLGDKAVYCRCWRSKKFPFCDGAHTKHNEETGDNVGPLI
                     IKKKET"
     exon            144..349
                     /gene="CISD1"
                     /gene_synonym="C10orf70; MDS029; mitoNEET; ZCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..2375
                     /gene="CISD1"
                     /gene_synonym="C10orf70; MDS029; mitoNEET; ZCD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      759..764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CISD1"
                     /gene_synonym="C10orf70; MDS029; mitoNEET; ZCD1"
                     /note="hexamer: ATTAAA"
     polyA_site      779
                     /gene="CISD1"
                     /gene_synonym="C10orf70; MDS029; mitoNEET; ZCD1"
                     /note="major polyA site"
     regulatory      881..886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CISD1"
                     /gene_synonym="C10orf70; MDS029; mitoNEET; ZCD1"
                     /note="hexamer: AATACA"
     polyA_site      898
                     /gene="CISD1"
                     /gene_synonym="C10orf70; MDS029; mitoNEET; ZCD1"
     regulatory      2029..2034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CISD1"
                     /gene_synonym="C10orf70; MDS029; mitoNEET; ZCD1"
                     /note="hexamer: AATAAA"
     polyA_site      2048
                     /gene="CISD1"
                     /gene_synonym="C10orf70; MDS029; mitoNEET; ZCD1"
     regulatory      2337..2342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CISD1"
                     /gene_synonym="C10orf70; MDS029; mitoNEET; ZCD1"
                     /note="hexamer: ATTAAA"
     polyA_site      2375
                     /gene="CISD1"
                     /gene_synonym="C10orf70; MDS029; mitoNEET; ZCD1"
ORIGIN      
        1 agcatcgcgg agtcggtgct ttagtacgcc gctggcacct ttactctcgc cggccgcgcg
       61 aacccgtttg agctcggtat cctagtgcac acgccttgca agcgacggcg ccatgagtct
      121 gacttccagt tccagcgtac gagttgaatg gatcgcagca gttaccattg ctgctgggac
      181 agctgcaatt ggttatctag cttacaaaag attttatgtt aaagatcatc gaaataaagc
      241 tatgataaac cttcacatcc agaaagacaa ccccaagata gtacatgctt ttgacatgga
      301 ggatttggga gataaagctg tgtactgccg ttgttggagg tccaaaaagt tcccattctg
      361 tgatggggct cacacaaaac ataacgaaga gactggagac aatgtgggcc ctctgatcat
      421 caagaaaaaa gaaacttaaa tggacacttt tgatgctgca aatcagcttg tcgtgaagtt
      481 acctgattgt ttaattagaa tgactaccac ctctgtctga ttcaccttcg ctggattcta
      541 aatgtggtat attgcaaact gcagctttca catttatggc atttgtcttg ttgaaacatc
      601 gtggtgcaca tttgtttaaa caaaaaaaaa aaaaaaaagg aaaaaccaac ctgcatggcc
      661 tgtgggttat tttggtcttg taaggatcca tttctttaaa atactgacat atagagttgt
      721 accttatata gaatatagtt gtatcttgaa gtcaacatat taaattattc tcaaaattat
      781 gtatttgcag attgtacttg taagtttcaa agaaaaatta ccatcttttc atattgacct
      841 ggaaactaaa taggatgtga ttcagctaca ttaatttctt aatacaatct aggaaagacc
      901 tgttgtagcc ttgattttct tgacattggt aatgacactg agaaaatatg gcttctgttt
      961 ttcaccgttt tcaatcaaaa tgattgataa atgttattct gtttaatttc ataagtcagg
     1021 tcaataataa aggggtggta acttcctcat atttatcttc acagatattt aatgaagatg
     1081 gatccattaa aggagccaat agtgaaaatt tagttaaagg tgatattaga tttaaattag
     1141 tcatgaagaa tgtcttaaaa tctaatgttc cagaattctg gcccaaggaa tggtaagcac
     1201 ttgaactgag gattttgaag gaattggaac atataatgtc aagtcttttg atcactaagc
     1261 cacatatcct gacagaaata gtagtcacaa gattagatca aaggcgtggg aagatttttt
     1321 tttttcccac tctagctaat caagcacatg gcttttaaat tgtatgatct ttttcttaaa
     1381 agcaaaaatt tgaagacaag tgtttgttta tgtaatattc ttcaaagact ccgagcagaa
     1441 acattgcatt cattgttgat tcagaaaaaa gaaaatataa aaactgaaaa taattagcaa
     1501 taaaagattt aagacaaata gttcataaat atttttaaag agattaggtt tttgaatttc
     1561 ataggttaga aggaaaatca tggcaaaatt tacagaaaat tgggcaaaca attgaaattg
     1621 ataaagcagg taaacatcat catttatttt agtatacatg aattctcagt agtagtcaat
     1681 cacaaatttc tacttgctaa aatccattta ccttgacagg aatcaaacct gacagcagca
     1741 tatcctatgt aatatatgat catggctatt tttaaatatg tagttttgtg tattactgta
     1801 gataaaagtt ggtaacaaaa ttgtacagtg gttttaagaa gcccatgtaa ctaacttgga
     1861 catgtcttta agtcacatat tcatcataaa atctaaaatc ctacaaactg attctattag
     1921 attcttaggg taaatttttt ctttgcccac ctccttcttt ttaagataag tatgcatgtc
     1981 agcaaaacag agcaatcatg cttttaaaga tgaactgttt taaagaaaaa taaatgcatc
     2041 aactcccagt gtttctgata aagggacatc cttctaactt aacagactat tctttatctt
     2101 gaatttgaaa ttatattgtt agtcatgcat ttttgtaatg tcagggggaa cctggtacca
     2161 gttctcaaaa ctataggatt atatgagtgt gtgtatacat atggcaaaat tataaatgac
     2221 caccttactg tgaaatatag atcttgagca ttttgaaagg ccaaaataat taggtaaatg
     2281 tattttcaag gtcatgttaa aatgtttaca tgcttttgaa ctagcattca tttatgatta
     2341 aaaccctttt caggttattt gacctaaaaa ccaaa
//
