LOCUS       NM_001300829            3346 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens cold inducible RNA binding protein (CIRBP), transcript
            variant 3, mRNA.
ACCESSION   NM_001300829 XM_006722636
VERSION     NM_001300829.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3346)
  AUTHORS   Gong,E.Y., Jung,D., Woo,H., Song,J., Choi,E., Jo,S.G., Eyun,S.I.,
            Kim,S. and Park,Y.Y.
  TITLE     Genomic analysis uncovers that cold-inducible RNA binding protein
            is associated with estrogen receptor in breast cancer
  JOURNAL   Genes Genomics 46 (8), 899-907 (2024)
   PUBMED   38847971
  REMARK    GeneRIF: Genomic analysis uncovers that cold-inducible RNA binding
            protein is associated with estrogen receptor in breast cancer.
REFERENCE   2  (bases 1 to 3346)
  AUTHORS   Zhou,M., Aziz,M., Li,J., Jha,A., Ma,G., Murao,A. and Wang,P.
  TITLE     BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance
  JOURNAL   Front Immunol 15, 1426682 (2024)
   PUBMED   38938563
  REMARK    GeneRIF: BMAL2 promotes eCIRP-induced macrophage endotoxin
            tolerance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3346)
  AUTHORS   Lei,H., Li,D., Duan,M., Zhang,Y., Sun,Y., She,J., Zhang,X.,
            Reinke,P., Volk,H.D., Zhang,Y., Lv,Y. and Wu,R.
  TITLE     Extracellular CIRP co-stimulated T cells through IL6R/STAT3 in
            pediatric IgA vasculitis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167151 (2024)
   PUBMED   38565387
  REMARK    GeneRIF: Extracellular CIRP co-stimulated T cells through
            IL6R/STAT3 in pediatric IgA vasculitis.
REFERENCE   4  (bases 1 to 3346)
  AUTHORS   Yao,F., Zhao,Y., Yu,Q., Hu,W., Lin,Y., Chen,Y., Li,L., Sun,C.,
            Li,S., Wang,K., Yang,M., Zhou,R. and Hu,W.
  TITLE     Extracellular CIRP induces abnormal activation of fibroblast-like
            synoviocytes from patients with RA via the TLR4-mediated HDAC3
            pathways
  JOURNAL   Int Immunopharmacol 128, 111525 (2024)
   PUBMED   38218010
  REMARK    GeneRIF: Extracellular CIRP induces abnormal activation of
            fibroblast-like synoviocytes from patients with RA via the
            TLR4-mediated HDAC3 pathways.
REFERENCE   5  (bases 1 to 3346)
  AUTHORS   Lee,J. and Bedford,M.T.
  TITLE     PABP1 identified as an arginine methyltransferase substrate using
            high-density protein arrays
  JOURNAL   EMBO Rep 3 (3), 268-273 (2002)
   PUBMED   11850402
REFERENCE   6  (bases 1 to 3346)
  AUTHORS   Yang,C. and Carrier,F.
  TITLE     The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a
            protective role in the genotoxic stress response
  JOURNAL   J Biol Chem 276 (50), 47277-47284 (2001)
   PUBMED   11574538
REFERENCE   7  (bases 1 to 3346)
  AUTHORS   Nishiyama,H., Danno,S., Kaneko,Y., Itoh,K., Yokoi,H., Fukumoto,M.,
            Okuno,H., Millan,J.L., Matsuda,T., Yoshida,O. and Fujita,J.
  TITLE     Decreased expression of cold-inducible RNA-binding protein (CIRP)
            in male germ cells at elevated temperature
  JOURNAL   Am J Pathol 152 (1), 289-296 (1998)
   PUBMED   9422546
REFERENCE   8  (bases 1 to 3346)
  AUTHORS   Nishiyama,H., Higashitsuji,H., Yokoi,H., Itoh,K., Danno,S.,
            Matsuda,T. and Fujita,J.
  TITLE     Cloning and characterization of human CIRP (cold-inducible
            RNA-binding protein) cDNA and chromosomal assignment of the gene
  JOURNAL   Gene 204 (1-2), 115-120 (1997)
   PUBMED   9434172
REFERENCE   9  (bases 1 to 3346)
  AUTHORS   Sheikh,M.S., Carrier,F., Papathanasiou,M.A., Hollander,M.C.,
            Zhan,Q., Yu,K. and Fornace,A.J. Jr.
  TITLE     Identification of several human homologs of hamster DNA
            damage-inducible transcripts. Cloning and characterization of a
            novel UV-inducible cDNA that codes for a putative RNA-binding
            protein
  JOURNAL   J Biol Chem 272 (42), 26720-26726 (1997)
   PUBMED   9334257
REFERENCE   10 (bases 1 to 3346)
  AUTHORS   Nishiyama,H., Itoh,K., Kaneko,Y., Kishishita,M., Yoshida,O. and
            Fujita,J.
  TITLE     A glycine-rich RNA-binding protein mediating cold-inducible
            suppression of mammalian cell growth
  JOURNAL   J Cell Biol 137 (4), 899-908 (1997)
   PUBMED   9151692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA433715.1, AK094781.1, BC000403.2 and AC004258.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001300829.1.
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA931250.1, SRR3476690.308960.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000587896.6/ ENSP00000466025.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-576               DA433715.1         2-577
            577-979             AK094781.1         467-869
            980-1708            BC000403.2         581-1309
            1709-3346           AC004258.1         7412-9049
FEATURES             Location/Qualifiers
     source          1..3346
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3346
                     /gene="CIRBP"
                     /gene_synonym="CIRP"
                     /note="cold inducible RNA binding protein"
                     /db_xref="GeneID:1153"
                     /db_xref="HGNC:HGNC:1982"
                     /db_xref="MIM:602649"
     exon            1..79
                     /gene="CIRBP"
                     /gene_synonym="CIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            80..188
                     /gene="CIRBP"
                     /gene_synonym="CIRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..979
                     /gene="CIRBP"
                     /gene_synonym="CIRP"
                     /note="isoform 3 is encoded by transcript variant 3;
                     glycine-rich RNA binding protein; A18 hnRNP; testicular
                     tissue protein Li 39"
                     /codon_start=1
                     /product="cold-inducible RNA-binding protein isoform 3"
                     /protein_id="NP_001287758.1"
                     /db_xref="CCDS:CCDS74245.1"
                     /db_xref="GeneID:1153"
                     /db_xref="HGNC:HGNC:1982"
                     /db_xref="MIM:602649"
                     /translation="MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQ
                     RSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRG
                     FFRGGRGRGRGFSRGGGDRGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSY
                     RDSYDSYGKSHSEGATLLWPAVGARFTLVPSPSTLGWTLRPCHCACPEEAHLSSQSHF
                     YRRTQKPNETDQKGKGERGPAGQSARCMCGRRPASLGCGGWLLPGRRPRPGLASGVKL
                     PLVASVPLHCACFLSSATHNE"
     exon            189..295
                     /gene="CIRBP"
                     /gene_synonym="CIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            296..434
                     /gene="CIRBP"
                     /gene_synonym="CIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            435..516
                     /gene="CIRBP"
                     /gene_synonym="CIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            517..3346
                     /gene="CIRBP"
                     /gene_synonym="CIRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1686..1691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIRBP"
                     /gene_synonym="CIRP"
                     /note="hexamer: ATTAAA"
     polyA_site      1708
                     /gene="CIRBP"
                     /gene_synonym="CIRP"
                     /note="major polyA site"
     regulatory      3319..3324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIRBP"
                     /gene_synonym="CIRP"
                     /note="hexamer: AATAAA"
     polyA_site      3346
                     /gene="CIRBP"
                     /gene_synonym="CIRP"
ORIGIN      
        1 ctcactcgcg cgttaggagg ctcgggtcgt tgtggtgcgc tgtcttcccg cttgcgtcag
       61 ggacctgccc gactcagtgg ccgccatggc atcagatgaa ggcaaacttt ttgttggagg
      121 gctgagtttt gacaccaatg agcagtcgct ggagcaggtc ttctcaaagt acggacagat
      181 ctctgaagtg gtggttgtga aagacaggga gacccagaga tctcggggat ttgggtttgt
      241 cacctttgag aacattgacg acgctaagga tgccatgatg gccatgaatg ggaagtctgt
      301 agatggacgg cagatccgag tagaccaggc aggcaagtcg tcagacaacc gatcccgtgg
      361 gtaccgtggt ggctctgccg ggggccgggg cttcttccgt gggggccgag gacggggccg
      421 tgggttctct agaggaggag gggaccgagg ctatgggggg aaccggttcg agtccaggag
      481 tgggggctac ggaggctcca gagactacta tagcagccgg agtcagagtg gtggctacag
      541 tgaccggagc tcgggcgggt cctacagaga cagttatgac agttacggta agtcacactc
      601 cgagggcgcc acgctgctgt ggcctgcggt gggagctcgg ttcaccttgg tgccctctcc
      661 aagcacttta ggctggacac tcagaccttg tcactgtgct tgcccagaag aggcgcatct
      721 gtcctctcag agccatttct atcgcaggac gcaaaagcca aatgagactg accaaaaagg
      781 caagggagag cgagggcccg ctgggcagtc agctaggtgc atgtgtggcc gcaggccagc
      841 ctccctcggc tgtggggggt ggttgctccc cggccgcagg ccgcgccctg gtctggcctc
      901 tggggtgaag ctgcctcttg ttgcttcggt gcctttacac tgtgcctgct tcttgtcctc
      961 agctacacac aacgagtaaa aacccttcct gctcaagatc gtccttccaa tggctgtgtg
     1021 tttaaagatt gtgggagctt cgctgaacgt taatgtgtag taaatgcacc tccttgtatt
     1081 cccactttcg tagtcatttc ggttctgatc ttgtcaaacc cagcctgacc gcttctgacg
     1141 ccgggatggc ctcgttacta gacttttctt tttaaggaag tgctgttttt ttttgagggt
     1201 tttcaaaaca ttttgaaaag catttacttt tttgaccacg agccatgagt tttcaaaaaa
     1261 atcgggggtt gtgtgggttt ttggtttttg ttttagtttt tggttgcgtt gccttttttt
     1321 ttttagtggg gttggcccca tgaagtgggt gccccactca cttctctgag atcgaacgga
     1381 ctgtgaatcc gctctttgtc ggaagctgag caagctgtgg cttttttcca actccgtgtg
     1441 acgtttctga gtgtagtgtg gtaggacccc ggcgggtgtg gcagcaactg ccctggagcc
     1501 ccagcccctg cgtccatctg tgctgtgcgc cccacagtag acgtgcagac gtccctgaga
     1561 ggttcttgaa gatgtttatt tatattgtcc ttttttactg gaagacgtac gcatactcca
     1621 tcgatgttgt atttgcagtg gctgaggaat tcttgtacgc agttttcttt ggctttacga
     1681 agccgattaa aagaccgtgt gaaatgaacc ttgctctgac aattcccttg cattgcacca
     1741 cacactcctt gctgcgggct cctgcagcca gacctgagca gagagagaag gtggagaagc
     1801 agcgggtctg caagccttcc ctggggcctg cagagctaga aagggaggcc cagcagactg
     1861 gcgctggtca gggtagggga gccaggcggg ggacgggagc gggcagctca ggcctcaggg
     1921 cagccctggg aggcttctgg cagtggtggc cagagggctg gactgtgcgg gcagcttagc
     1981 agggacagtg gacgtgcacc tgacgctgac ctggactgcc tcagtctaga agcaggccag
     2041 agagcagagg cacgtggcat cccagggcga cctcagacgg ccagccggtt agctagttct
     2101 gctgttgctt cacgagttct gagcattctc tgctagccta tggaagctgc agccctcgga
     2161 ggacagaagt gttgtgcgcc caacagaacc ctctgagacg caagctgctc ccttggctag
     2221 ctcatatgtg gaaatagccc tgtaattcga ggtaactcct tccgctcgtg tccacatccc
     2281 tcttgttgag agctcactga aagtcatgtg cccggggaat gttcctgtga ctgttttttg
     2341 tttttccttt tttttttaac tttgtttttg tttttttcaa ttaagctgga actaaagtca
     2401 ggcccagcca ttacgctccc cacgtgcagc caggtgcagc ctgggcccag tcatgcctgg
     2461 ctcatagatg aaatccctta agcaggattg aagaccagtg aacgcccccg ccttttggat
     2521 tttttgctca attgaccgtc ttttccagac ctctttaagt cacactctta acttagcttt
     2581 ctctgatgtc tgttgccgcc attagttttt ttctagagcc cacactggcc cacatagctc
     2641 catcccatac gggtagctgg ctccagctgc gccaaggtgc agacccgccc tgggcatgct
     2701 ggcctgtgac ggagcctgag gtcacagccc cctgactagc ctgagacctt cctaggggct
     2761 gtggctgttt ccggggaggc cgggaggggc agctgtgagc cctgtggagg acgttgggag
     2821 taacgctgct ttgctttggc aggttgaagg ggcccggcca ggactcgggg aagggtggcc
     2881 tgagagcagc gatgacctct ggggtcactg tcccaggagg gacttcacct ggaacaagag
     2941 ctggaggcag ccgcttgccc aggaggcttg tcccctgtaa gtgctttcgg gaagagtggc
     3001 atgtggcgct gagccctgtc ccgggcggca cctgggcgtt tcagtgagtc ctgctctccc
     3061 gcacctatgg ccccatggcg ggcgcctttc ggtgtgtgtt gggtgcaggg cagcgcctcc
     3121 cgggagcgcc gggtcccccg cctggagccc gcgcctgttc tccctccctt cctcctcctt
     3181 ccaggaggcg cttcgccagt gaggtgcggg ctcagggcct cgagtctctc ctggagcacg
     3241 ggctgcggtg cgccggcagc ttacggggcg gccagtcctt gcccacaacg atgtggagcc
     3301 ctgtgaaagt cggattcgaa taaagggcca cgtgtgcacc cagaaa
//
