LOCUS       NM_004882               1918 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens corepressor interacting with RBPJ, CIR1 (CIR1), mRNA.
ACCESSION   NM_004882
VERSION     NM_004882.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1918)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1918)
  AUTHORS   Lee,S.Y., Kang,H.G., Choi,J.E., Jung,D.K., Lee,W.K., Lee,H.C.,
            Lee,S.Y., Yoo,S.S., Lee,J., Seok,Y., Lee,E.B., Cha,S.I., Cho,S.,
            Kim,C.H., Lee,M.H. and Park,J.Y.
  TITLE     Polymorphisms in cancer-related pathway genes and lung cancer
  JOURNAL   Eur Respir J 48 (4), 1184-1191 (2016)
   PUBMED   27587543
  REMARK    GeneRIF: three SNPs (corepressor interacting with RBPJ 1 (CIR1)
            rs13009079T>C, ribonucleotide reductase M1 (RRM1) rs1465952T>C and
            solute carrier family 38, member 4 (SLC38A4) rs2429467C>T), may
            play a role in the pathogenesis of lung cancer
REFERENCE   3  (bases 1 to 1918)
  AUTHORS   Vaz Meirelles,G., Ferreira Lanza,D.C., da Silva,J.C., Santana
            Bernachi,J., Paes Leme,A.F. and Kobarg,J.
  TITLE     Characterization of hNek6 interactome reveals an important role for
            its short N-terminal domain and colocalization with proteins at the
            centrosome
  JOURNAL   J Proteome Res 9 (12), 6298-6316 (2010)
   PUBMED   20873783
REFERENCE   4  (bases 1 to 1918)
  AUTHORS   Pajerowski,A.G., Nguyen,C., Aghajanian,H., Shapiro,M.J. and
            Shapiro,V.S.
  TITLE     NKAP is a transcriptional repressor of notch signaling and is
            required for T cell development
  JOURNAL   Immunity 30 (5), 696-707 (2009)
   PUBMED   19409814
REFERENCE   5  (bases 1 to 1918)
  AUTHORS   Niessen,K., Fu,Y., Chang,L., Hoodless,P.A., McFadden,D. and
            Karsan,A.
  TITLE     Slug is a direct Notch target required for initiation of cardiac
            cushion cellularization
  JOURNAL   J Cell Biol 182 (2), 315-325 (2008)
   PUBMED   18663143
REFERENCE   6  (bases 1 to 1918)
  AUTHORS   Zhou,S. and Hayward,S.D.
  TITLE     Nuclear localization of CBF1 is regulated by interactions with the
            SMRT corepressor complex
  JOURNAL   Mol Cell Biol 21 (18), 6222-6232 (2001)
   PUBMED   11509665
REFERENCE   7  (bases 1 to 1918)
  AUTHORS   Zhang,J., Chen,H., Weinmaster,G. and Hayward,S.D.
  TITLE     Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS
            protein interacts with the CBF1-associated corepressor CIR to
            negatively regulate the activity of EBNA2 and NotchIC
  JOURNAL   J Virol 75 (6), 2946-2956 (2001)
   PUBMED   11222720
REFERENCE   8  (bases 1 to 1918)
  AUTHORS   Zhou,S., Fujimuro,M., Hsieh,J.J., Chen,L. and Hayward,S.D.
  TITLE     A role for SKIP in EBNA2 activation of CBF1-repressed promoters
  JOURNAL   J Virol 74 (4), 1939-1947 (2000)
   PUBMED   10644367
REFERENCE   9  (bases 1 to 1918)
  AUTHORS   Hsieh,J.J., Zhou,S., Chen,L., Young,D.B. and Hayward,S.D.
  TITLE     CIR, a corepressor linking the DNA binding factor CBF1 to the
            histone deacetylase complex
  JOURNAL   Proc Natl Acad Sci U S A 96 (1), 23-28 (1999)
   PUBMED   9874765
REFERENCE   10 (bases 1 to 1918)
  AUTHORS   DuBridge,R.B., Tang,P., Hsia,H.C., Leong,P.M., Miller,J.H. and
            Calos,M.P.
  TITLE     Analysis of mutation in human cells by using an Epstein-Barr virus
            shuttle system
  JOURNAL   Mol Cell Biol 7 (1), 379-387 (1987)
   PUBMED   3031469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU596189.1, BC046098.2, BC015040.1 and AC018470.11.
            
            On Nov 23, 2018 this sequence version replaced NM_004882.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.7939.1,
                                           SRR1803613.130520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342016.8/ ENSP00000339723.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               BU596189.1         7-548
            543-1576            BC046098.2         497-1530
            1577-1790           BC015040.1         1562-1775
            1791-1918           AC018470.11        43667-43794         c
FEATURES             Location/Qualifiers
     source          1..1918
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..1918
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /note="corepressor interacting with RBPJ, CIR1"
                     /db_xref="GeneID:9541"
                     /db_xref="HGNC:HGNC:24217"
                     /db_xref="MIM:605228"
     exon            1..162
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1443
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /note="recepin; corepressor interacting with RBPJ, 1; CBF1
                     (RBPJ) interacting corepressor 1; CBF1-interacting
                     corepressor"
                     /codon_start=1
                     /product="corepressor interacting with RBPJ 1"
                     /protein_id="NP_004873.3"
                     /db_xref="CCDS:CCDS2256.1"
                     /db_xref="GeneID:9541"
                     /db_xref="HGNC:HGNC:24217"
                     /db_xref="MIM:605228"
                     /translation="MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQ
                     QYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGA
                     PREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDG
                     SGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTT
                     KQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSES
                     SSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKE
                     KPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRS
                     RSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGTHTKVTQRE
                     "
     exon            163..257
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            258..331
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            332..342
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..407
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..456
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..574
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..681
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..767
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..1918
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1556..1561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /note="hexamer: AATAAA"
     polyA_site      1576
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /note="major polyA site"
     regulatory      1766..1771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /note="hexamer: ATTAAA"
     polyA_site      1790
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /note="major polyA site"
     regulatory      1897..1902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
                     /note="hexamer: AATAAA"
     polyA_site      1918
                     /gene="CIR1"
                     /gene_synonym="CIR; THE1B/CIR1"
ORIGIN      
        1 gctgctggaa acgcagttcc ggttaggcgg ctgagtttgt ttacgttgct aacagatcta
       61 gcccctgctt tccctagttc cagttccaag atggggaaat ccttcgccaa cttcatgtgc
      121 aagaaagact ttcatcctgc ctccaaatcc aatatcaaaa aagtatggat ggcagaacag
      181 aaaatatcat atgataagaa gaaacaagaa gaattgatgc agcaatatct taaagaacaa
      241 gaatcatatg ataatagatt gcttatggga gatgaacgtg taaagaatgg ccttaatttc
      301 atgtatgaag ccccaccagg agctaaaaaa gaaaacaaag agaaagaaga aacagaagga
      361 gagaccgaat acaaatttga atggcagaaa ggagccccac gagaaaaata tgccaaagat
      421 gacatgaaca tcagagatca gccctttggt attcaggttc gaaatgtgag gtgcattaaa
      481 tgtcacaaat ggggtcatgt caacacagat cgagaatgtc ctttgtttgg tctttctgga
      541 atcaatgcaa gttcggttcc cactgatggc tcagggccat cgatgcaccc ctcggagcta
      601 atagcggaga tgagaaacag tgggtttgca ctgaaacgaa atgtactggg gagaaacttg
      661 accgcaaatg atccatcaca ggagtatgtt gcaagtgagg gtgaagaaga tccagaagtt
      721 gaatttttaa agtcactaac aaccaaacaa aaacagaaac ttctcaggaa attagatcga
      781 ctggagaaga aaaaaaagaa aaaagataga aaaaagaaaa agtttcagaa gagcagaagt
      841 aaacacaaaa aacataagtc ctcttcttcc tcatcttcct cctcctcctc ctcttcctct
      901 actgagactt cagaaagcag tagtgagagt gagagtaaca ataaagaaaa aaaaatacaa
      961 aggaagaaaa gaaagaaaaa caagtgttca gggcataaca acagtgattc tgaagagaag
     1021 gacaagtcta agaagagaaa gcttcatgaa gaactttcta gcagtcacca taaccgggaa
     1081 aaagccaagg aaaagcccag gttcttaaaa cacgagagtt ctagggagga cagcaaatgg
     1141 agccattctg attctgacaa aaagtccaga acccataaac atagcccaga gaagagaggc
     1201 tctgaaagaa aggaggggag cagcagaagc cacggcaggg aggaaaggag ccggagaagc
     1261 cggagcagaa gtcctggtag ttacaagcaa agggagacaa ggaaacgggc acagcgaaat
     1321 cctggtgaag agcaaagcag aagaaatgac agcagaagcc atggcacaga cttgtataga
     1381 ggagaaaaaa tgtacagaga gcacccagga ggtacacata ctaaagtgac acaaagagaa
     1441 tgaagcagaa gtagagaaga aagactgtat gtgacaatta cctgggaata aaaatatctc
     1501 cactttttta ttgaatacct ttagcaaggg gtaaattatg tactgttgtc tttctaataa
     1561 aaaagctcaa ttttaatttt tcatctctag actgtcaatt caagtacaaa actacatgag
     1621 tactataaga atgaattttg caaatatttg taagtaagct attttggggc tgtggaaata
     1681 ttttctgttg gtaactgttt cttgttcccc ataccagata aaaaccgcat ataactctgt
     1741 gacattttct ttgttctgaa acatcattaa aagaatgaca gtacattgaa tgggtataat
     1801 ttactttttt caattcaaat ttgttattct aggatttgaa tttgcttgaa gtgaattgta
     1861 ataattattc aaattcatta gtataaatta aggattaata aatctttaag acttttaa
//
