LOCUS       NM_033426               4325 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens CLOCK interacting pacemaker (CIPC), mRNA.
ACCESSION   NM_033426
VERSION     NM_033426.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4325)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4325)
  AUTHORS   Matsunaga,R., Nishino,T., Yokoyama,A., Nakashima,A., Kikkawa,U. and
            Konishi,H.
  TITLE     Versatile function of the circadian protein CIPC as a regulator of
            Erk activation
  JOURNAL   Biochem Biophys Res Commun 469 (3), 377-383 (2016)
   PUBMED   26657846
  REMARK    GeneRIF: Since CAD and Erk have significant roles in cell
            proliferation and cell cycle, CIPC may work as a cell cycle
            regulator by interacting with these binding proteins.
REFERENCE   3  (bases 1 to 4325)
  AUTHORS   Yoshitane,H., Takao,T., Satomi,Y., Du,N.H., Okano,T. and Fukada,Y.
  TITLE     Roles of CLOCK phosphorylation in suppression of E-box-dependent
            transcription
  JOURNAL   Mol Cell Biol 29 (13), 3675-3686 (2009)
   PUBMED   19414601
REFERENCE   4  (bases 1 to 4325)
  AUTHORS   Zhao,W.N., Malinin,N., Yang,F.C., Staknis,D., Gekakis,N., Maier,B.,
            Reischl,S., Kramer,A. and Weitz,C.J.
  TITLE     CIPC is a mammalian circadian clock protein without invertebrate
            homologues
  JOURNAL   Nat Cell Biol 9 (3), 268-275 (2007)
   PUBMED   17310242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007686.5 and AC007375.6.
            
            On Nov 23, 2018 this sequence version replaced NM_033426.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.80029.1,
                                           SRR1660805.91665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361786.7/ ENSP00000355319.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC007686.5         160682-160785
            105-292             AC007686.5         168081-168268
            293-462             AC007686.5         172236-172405
            463-4242            AC007686.5         175849-179628
            4243-4325           AC007375.6         2-84
FEATURES             Location/Qualifiers
     source          1..4325
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..4325
                     /gene="CIPC"
                     /gene_synonym="KIAA1737"
                     /note="CLOCK interacting pacemaker"
                     /db_xref="GeneID:85457"
                     /db_xref="HGNC:HGNC:20365"
                     /db_xref="MIM:616995"
     exon            1..104
                     /gene="CIPC"
                     /gene_synonym="KIAA1737"
                     /inference="alignment:Splign:2.1.0"
     exon            105..292
                     /gene="CIPC"
                     /gene_synonym="KIAA1737"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1356
                     /gene="CIPC"
                     /gene_synonym="KIAA1737"
                     /note="CLOCK-interacting protein, circadian;
                     CLOCK-interacting circadian protein"
                     /codon_start=1
                     /product="CLOCK-interacting pacemaker"
                     /protein_id="NP_219494.2"
                     /db_xref="CCDS:CCDS9855.1"
                     /db_xref="GeneID:85457"
                     /db_xref="HGNC:HGNC:20365"
                     /db_xref="MIM:616995"
                     /translation="MERKNPSRESPRRLSAKVGKGTEMKKVARQLGMAAAESDKDSGF
                     SDGSSECLSSAEQMESEDMLSALGWSREDRPRQNSKTAKNAFPTLSPMVVMKNVLVKQ
                     GSSSSQLQSWTVQPSFEVISAQPQLLFLHPPVPSPVSPCHTGEKKSDSRNYLPILNSY
                     TKIAPHPGKRGLSLGPEEKGTSGVQKKICTERLGPSLSSSEPTKAGAVPSSPSTPAPP
                     SAKLAEDSALQGVPSLVAGGSPQTLQPVSSSHVAKAPSLTFASPASPVCASDSTLHGL
                     ESNSPLSPLSANYSSPLWAAEHLCRSPDIFSEQRQSKHRRFQNTLVVLHKSGLLEITL
                     KTKELIRQNQATQVELDQLKEQTQLFIEATKSRAPQAWAKLQASLTPGSSNTGSDLEA
                     FSDHPAI"
     exon            293..462
                     /gene="CIPC"
                     /gene_synonym="KIAA1737"
                     /inference="alignment:Splign:2.1.0"
     exon            463..4325
                     /gene="CIPC"
                     /gene_synonym="KIAA1737"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4300..4305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIPC"
                     /gene_synonym="KIAA1737"
                     /note="hexamer: AATAAA"
     polyA_site      4325
                     /gene="CIPC"
                     /gene_synonym="KIAA1737"
                     /note="major polyA site"
ORIGIN      
        1 gagacaccca gcgacgacga ggttgtcatg gtgccgcggg gccgtgctcg cgcatgcgcc
       61 acctgaccca caggccggtc gtggagctgc gaccccggcc ctagggcagt ccagatgaaa
      121 agagtaccaa tgaatctgcc tccagctgaa taaaccatgg agaggaaaaa cccatccaga
      181 gagagcccca gaagactctc tgccaaagta ggcaaaggca cagagatgaa gaaagtggct
      241 cgtcagcttg ggatggctgc tgctgagtca gacaaggact ctggcttttc agatgggagc
      301 tcggaatgtc tgagctctgc agagcagatg gagtccgagg acatgctgag cgccttaggc
      361 tggagcagag aagacaggcc gaggcagaac tccaaaactg caaagaatgc cttccctacc
      421 ctgtctccca tggtcgtcat gaagaatgtg cttgtcaaac agggcagcag ctcatcccag
      481 ctccagtcgt ggactgtcca gccctccttt gaagtgatct cagcacagcc acagctctta
      541 ttccttcatc cacctgtacc atctcctgtc agtccatgtc acactggtga gaaaaagtcc
      601 gactccagga actacttgcc cattctgaat tcttacacca aaatagcccc acatccaggc
      661 aaaaggggcc tttcccttgg cccagaagaa aaaggaacaa gtggagtgca gaagaaaatc
      721 tgtactgaga gacttgggcc tagcttgtct tccagtgagc caaccaaggc tggtgctgtc
      781 ccatccagtc cctcgacgcc agcaccaccc agcgccaaac ttgccgagga ctcagctctg
      841 cagggtgtgc cctctctggt ggcaggtgga agtccacaga ctcttcagcc ggtatccagc
      901 agtcacgtgg ctaaagctcc cagtctgacc ttcgcttccc ccgccagtcc tgtctgcgca
      961 tcagacagca ctctccatgg gttagagagc aactctcccc tttcaccact gtccgctaat
     1021 tatagctcac ctttatgggc tgcagagcac ctctgccgca gcccagatat cttttcagag
     1081 cagcggcaga gcaaacatag gcgctttcag aataccctag tagtcctaca taaatctggt
     1141 ttgctggaga tcactttgaa aaccaaggag ttgattcgtc agaatcaggc aactcaggta
     1201 gaactagacc agctaaagga gcaaacccag ctgtttatag aagccaccaa gagcagggcc
     1261 cctcaggctt gggccaagct gcaggcatct ttaacacctg ggtccagtaa tacaggcagt
     1321 gacctagaag cattctctga tcacccagcc atatagcaca gaggcatatt ttcctgttac
     1381 ttgagtggtt cttttagctc atttgctgtt acctactcct gtttcccaaa gcttatgtaa
     1441 gagcttttcc ttctaaactt aaactgtgtt gtggttcact taggaagcca cgtgccaata
     1501 cctggctgct gtcttaactc gtagtctggg cacaggatac atatgtcccc gtcccactga
     1561 ggacctcagt ttgggagtgc ccttgagccc cttttcctta gcctgcaggt gcttcaatgg
     1621 atcatggggc aaagcaggag atgattgtgt ggggctcttc ctgctgtcac ctcccatcat
     1681 cccactctct caccaggatc aagggtacag taacacgaat gagcatacag agcaacacct
     1741 gttgagccag ggagtaggtg acacaaggaa accttcatgg atcttccctt gcctgtctta
     1801 gtcacagaga gaaataagag gaggttgttt gcatcccaca aggcatcgta ctagttgggc
     1861 gagacctaaa attccctggg cacaggttgc acctgggtgt gagcacttaa tcactcaacg
     1921 ctttgttttc ttacacttga aaatcaaggg aaagagtagt accatctgac tcctacactt
     1981 tcattacaag tcagattttt cttaaactag caggcaaaaa cagtacttcc aaattttaag
     2041 gtatggaatg aatgcagtac atctggaatt gtagtcgatg aattgctttt ttgacttaga
     2101 agctgaagaa aatagacata gccggcatat ctcatggtca ggagctggac gattctggta
     2161 acttaggctt tttttctctc ttcttttgaa acagtgtaac ctgttttatg tctaaaaatc
     2221 ttaaggatag tttcagtggt tcctgggatg tagtataagt taactctgct gccatcttgt
     2281 tttttttttt tttcctttat tttgataagt gattattatg cttgataaac tttgaattaa
     2341 atacagttgt cttgagggta tgataagtcc acaaaaaatt ggaaagcatc ttacccattt
     2401 tcttcacatc ccaaattttt atttgttcca tgtcatagtg atgggaagca gttacagagc
     2461 agcgtcttct gtgtttcctt catgtgttag atattggcaa caaagccaga ggtgtaatgt
     2521 tggttatatg aagttcatct caaaatggag accatgacca gagtttccag atgatacacg
     2581 ttcttttcag cttcattaaa taggcaacta tgtttctaaa tagtaaagtt tcaaaatatt
     2641 ctctcaattt aaaatttcat cctcttgaaa atctttgttc tttacaaaat tatcttaata
     2701 agttctatat ggtcagcttc atcttccttt tttttttttt tgagatggag tttcgctctt
     2761 gttgcccagg cggagtacaa tggtgggatc tcggctcact gcaacctccg cctcctgggt
     2821 tcaagtgatt ctcctgccac agcctcccaa gtagctggga ttacaggtgc ctgccaccat
     2881 gcccagctaa tttttgtatt tttagtagaa atggggtttt accgtgttgg ccaggctggt
     2941 ctcgaactcc tgacctcagt tgatccgcct gcctcagcct cccaaagtgc tgggcttaca
     3001 ggcctgagcc accacgctca gctcagcttc accctgtctg caaagaaaag ttttaccaag
     3061 accagaagtt aaatatgaca tttcctaggt agttgtaact ctaacatagt ttaaaaagta
     3121 tgtggcttca gattgcctat actttgttca caaacgtgtg atttagatat gactgatgta
     3181 gaagtgaaca acttggtaac atccctagac tccactcatg aacgcagaat tattacctgc
     3241 tgtttgcttt ctgaaagaat ttcagaaatc agagcaaatg tgtctttagg cagattcagc
     3301 tccttttaat atttttctct tggcccactc tctttgcttc ccctgaatct gtgtggtact
     3361 atagcagctc tactctgtgc accatgctag gaagcttcct ttttggcaga atatgtttgg
     3421 cagcaaagct atagagacag gtgcattcag aacatcctgg gcaccagtca tgagtcttac
     3481 tgtgtcaaaa atctgaaaac acttgctgag aaccaaattt attccattgg aaaaaccctc
     3541 tgtggagcta taagcctctt ggactcttct tcctagatta aggcttgcat ttccctccct
     3601 gtttcagtaa aagatgatga aagccactat caatcctcac tgctgagtgg cagggagaag
     3661 cagcaccact ctcagctctt ttctaatctt gtaacttagt gctagaagtc tctccaggct
     3721 attaccatgg gcatttgttc tctgttggag ctgtaagcag atgaacccaa gtagagaaga
     3781 tagatcttgg aaggagagat ccattgagtc cagaagccag atcagcaaat ggaggaacct
     3841 cggaggtgac cagaaagatc tccatcggtt gcccaaggct gtaagtagtg atggttttag
     3901 cgatgaataa cgtaattggc tatgaagtac tgtggcagag ctgctgtttt ctgaaggtga
     3961 gaagccattt ttagctcaga gcaaccctta agagaacttt tggcagattt tgttggcatt
     4021 attgaaatat atatagaaaa gttgctgatt gcaatggtta tgggaatgga atttaatgac
     4081 atttgtaatt tattacactc attggttttt attgattata gtattgtctg actttttatt
     4141 ttctactatg gttcctttag cagaaaagta acttttgtgc atatattgaa gtggtttttc
     4201 agctatgaat tctttagggt agaaatttat ttagcaaatg tgaattcttt tgagaaagta
     4261 tgaagttttg cagaaattga ctgtgaaatg tcagagaaaa ataaaagtca cttacttgaa
     4321 accta
//
