LOCUS       NM_032630                953 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens cyclin dependent kinase 2 interacting protein (CINP),
            transcript variant 1, mRNA.
ACCESSION   NM_032630 NM_016550
VERSION     NM_032630.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 953)
  AUTHORS   Krishnamoorthy,V., Foglizzo,M., Dilley,R.L., Wu,A., Datta,A.,
            Dutta,P., Campbell,L.J., Degtjarik,O., Musgrove,L.J.,
            Calabrese,A.N., Zeqiraj,E. and Greenberg,R.A.
  TITLE     The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis
            to ensure genome integrity
  JOURNAL   Cell 187 (9), 2250-2268 (2024)
   PUBMED   38554706
REFERENCE   2  (bases 1 to 953)
  AUTHORS   Ni,C., Schmitz,D.A., Lee,J., Pawlowski,K., Wu,J. and Buszczak,M.
  TITLE     Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5
            control a late step in human ribosome assembly
  JOURNAL   Cell Rep 38 (13), 110597 (2022)
   PUBMED   35354024
REFERENCE   3  (bases 1 to 953)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 953)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 953)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 953)
  AUTHORS   Wang,Y., Wang,Y., Xu,Y., Tong,W., Pan,T., Li,J., Sun,S., Shao,J.,
            Ding,H., Toyoda,T. and Yuan,Z.
  TITLE     Hepatitis C virus NS5B protein delays s phase progression in human
            hepatocyte-derived cells by relocalizing cyclin-dependent kinase
            2-interacting protein (CINP)
  JOURNAL   J Biol Chem 286 (30), 26603-26615 (2011)
   PUBMED   21628470
  REMARK    GeneRIF: NS5B delays cells in S phase through interaction with CINP
            and relocalization of the protein from the nucleus to the cytoplasm
REFERENCE   7  (bases 1 to 953)
  AUTHORS   Kalay,E., Yigit,G., Aslan,Y., Brown,K.E., Pohl,E., Bicknell,L.S.,
            Kayserili,H., Li,Y., Tuysuz,B., Nurnberg,G., Kiess,W., Koegl,M.,
            Baessmann,I., Buruk,K., Toraman,B., Kayipmaz,S., Kul,S., Ikbal,M.,
            Turner,D.J., Taylor,M.S., Aerts,J., Scott,C., Milstein,K.,
            Dollfus,H., Wieczorek,D., Brunner,H.G., Hurles,M., Jackson,A.P.,
            Rauch,A., Nurnberg,P., Karaguzel,A. and Wollnik,B.
  TITLE     CEP152 is a genome maintenance protein disrupted in Seckel syndrome
  JOURNAL   Nat Genet 43 (1), 23-26 (2011)
   PUBMED   21131973
REFERENCE   8  (bases 1 to 953)
  AUTHORS   Lovejoy,C.A., Xu,X., Bansbach,C.E., Glick,G.G., Zhao,R., Ye,F.,
            Sirbu,B.M., Titus,L.C., Shyr,Y. and Cortez,D.
  TITLE     Functional genomic screens identify CINP as a genome maintenance
            protein
  JOURNAL   Proc Natl Acad Sci U S A 106 (46), 19304-19309 (2009)
   PUBMED   19889979
  REMARK    GeneRIF: CINP interacts with ATR-interacting protein and regulates
            ATR-dependent signaling, resistance to replication stress, and G2
            checkpoint integrity.
REFERENCE   9  (bases 1 to 953)
  AUTHORS   Cho,J.W., Kim,C.W. and Lee,K.S.
  TITLE     Modification of gene expression by melatonin in UVB-irradiated
            HaCaT keratinocyte cell lines using a cDNA microarray
  JOURNAL   Oncol Rep 17 (3), 573-577 (2007)
   PUBMED   17273735
REFERENCE   10 (bases 1 to 953)
  AUTHORS   Grishina,I. and Lattes,B.
  TITLE     A novel Cdk2 interactor is phosphorylated by Cdc7 and associates
            with components of the replication complexes
  JOURNAL   Cell Cycle 4 (8), 1120-1126 (2005)
   PUBMED   16082200
  REMARK    GeneRIF: CINP is part of the Cdc7-dependent mechanism of origin
            firing and a functional and physical link between Cdk2 and Cdc7
            complexes at the origins
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA351468.1, BC000600.2 and
            EL951117.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032630.2.
            
            Summary: The protein encoded by this gene is reported to be a
            component of the DNA replication complex as well as a
            genome-maintenance protein. It may interact with proteins important
            for replication initiation and has been shown to bind chromatin at
            the G1 phase of the cell cycle and dissociate from chromatin with
            replication initiation. It may also serve to regulate checkpoint
            signaling as part of the DNA damage response. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Feb
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.143715.1,
                                           SRR1660803.130635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216756.11/ ENSP00000216756.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DA351468.1         27-41
            16-626              BC000600.2         1-611
            627-880             EL951117.1         418-671
            881-953             BC000600.2         869-941
FEATURES             Location/Qualifiers
     source          1..953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.31"
     gene            1..953
                     /gene="CINP"
                     /note="cyclin dependent kinase 2 interacting protein"
                     /db_xref="GeneID:51550"
                     /db_xref="HGNC:HGNC:23789"
                     /db_xref="MIM:613362"
     exon            1..46
                     /gene="CINP"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..678
                     /gene="CINP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CDK2-interacting protein"
                     /codon_start=1
                     /product="cyclin-dependent kinase 2-interacting protein
                     isoform 1"
                     /protein_id="NP_116019.1"
                     /db_xref="CCDS:CCDS9972.1"
                     /db_xref="GeneID:51550"
                     /db_xref="HGNC:HGNC:23789"
                     /db_xref="MIM:613362"
                     /translation="MEAKTLGTVTPRKPVLSVSARKIKDNAADWHNLILKWETLNDAG
                     FTTANNIANLKISLLNKDKIELDSSSPASKENEEKVCLEYNEELEKLCEELQATLDGL
                     TKIQVKMEKLSSTTKGICELENYHYGEESKRPPLFHTWPTTHFYEVSHKLLEMYRKEL
                     LLKRTVAKELAHTGDPDLTLSYLSMWLHQPYVESDSRLHLESMLLETGHRAL"
     exon            47..215
                     /gene="CINP"
                     /inference="alignment:Splign:2.1.0"
     exon            216..345
                     /gene="CINP"
                     /inference="alignment:Splign:2.1.0"
     exon            346..475
                     /gene="CINP"
                     /inference="alignment:Splign:2.1.0"
     exon            476..953
                     /gene="CINP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      926..931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CINP"
                     /note="hexamer: AGTAAA"
     polyA_site      953
                     /gene="CINP"
                     /note="major polyA site"
ORIGIN      
        1 ggggcttcgc gtctccttct acggatatct gtggacctta tggaagcaaa gactcttgga
       61 actgtaacgc ccagaaaacc tgtcttatct gtcagtgcaa gaaaaattaa ggacaatgcg
      121 gctgattggc acaatttaat cctgaagtgg gaaaccctca atgatgcagg ttttaccact
      181 gcaaataata ttgccaactt gaaaatcagt ttattgaata aagacaagat agaactagac
      241 agcagcagcc cagcctcgaa ggaaaatgaa gaaaaggtgt gtctggaata taacgaggaa
      301 ctggagaagc tgtgtgagga actgcaggcc accttggatg ggttgaccaa aatacaggtg
      361 aaaatggaaa agctgtcttc aactaccaag ggaatttgtg aactagaaaa ctaccattat
      421 ggggaggaga gtaaacgacc ccctctgttc cacacgtggc ctacaaccca tttctatgag
      481 gtttcgcata agctcttgga gatgtacagg aaggagctgc tcctgaagcg cacggtggcc
      541 aaggagcttg cccacaccgg ggatcccgac ctcaccctga gctacctgtc catgtggctg
      601 caccagccct atgtggagag cgacagcagg ctgcatctgg agagcatgct gctggagaca
      661 ggccaccgag ctctctgacg tcctgagacg gctgcggaca ctggctcctt ccacgtctca
      721 ccaggcagac agtctgccta ggacccagtg ccgcaggcct ggatcagacc ccaggatcag
      781 accttggggt cttctggcca gagcttgtca ccagccccat ggcctctcca ggcgtgctca
      841 tgcccacaac ccgcggccag ccccacgtgg tgctgctcag ccttctctgc ccctcctggg
      901 aatctgtcat tcgtgggtgc ttcagagtaa aatcaatgag tttctgagca gaa
//
