LOCUS       NM_001100396            1975 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens ciliary microtubule inner protein 6 (CIMIP6),
            transcript variant 1, mRNA.
ACCESSION   NM_001100396
VERSION     NM_001100396.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1975)
  AUTHORS   Andersen,J.S., Vijayakumaran,A., Godbehere,C., Lorentzen,E.,
            Mennella,V. and Schou,K.B.
  TITLE     Uncovering structural themes across cilia microtubule inner
            proteins with implications for human cilia function
  JOURNAL   Nat Commun 15 (1), 2687 (2024)
   PUBMED   38538594
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108929.4, AK097617.1, BC031669.1 and BC126246.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001100396.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.303943.1, BC031669.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398634.7/ ENSP00000381631.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC108929.4         63589-63638
            51-87               AK097617.1         1-37
            88-852              BC031669.1         1-765
            853-1781            BC126246.1         564-1492
            1782-1971           AK097617.1         1524-1713
            1972-1975           AC108929.4         94283-94286
FEATURES             Location/Qualifiers
     source          1..1975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.2"
     gene            1..1975
                     /gene="CIMIP6"
                     /gene_synonym="C2orf73"
                     /note="ciliary microtubule inner protein 6"
                     /db_xref="GeneID:129852"
                     /db_xref="HGNC:HGNC:26861"
     exon            1..118
                     /gene="CIMIP6"
                     /gene_synonym="C2orf73"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..956
                     /gene="CIMIP6"
                     /gene_synonym="C2orf73"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C2orf73"
                     /codon_start=1
                     /product="ciliary microtubule inner protein 6 isoform 1"
                     /protein_id="NP_001093866.1"
                     /db_xref="CCDS:CCDS46285.1"
                     /db_xref="GeneID:129852"
                     /db_xref="HGNC:HGNC:26861"
                     /translation="MEEKEDKHQQHKIEDAAITYVSENEEIKHEEKPGKSIHHSKSHV
                     GRGRIYYAKFINTNARTYNEPFPYIDPKKGPEIQGDWWSHGKALEPVFLPPYDSKSTQ
                     RSDFQKPSCPLVLPVKHSKMQKPSCGIVPLASPGTSAELQNNFIEYISFIHQYDARKT
                     PNEPLQGKRHGAFVQREIKPGSRPTVPKGAEVLLNTPGSRSSEQSKKTEKGNSAESRM
                     ISPGLCQQNSQELLEPKTHLSETDVRQAAKACPSTPESREKTSGATQTTVGDALFTRH
                     KPLNPPIKKSE"
     exon            119..326
                     /gene="CIMIP6"
                     /gene_synonym="C2orf73"
                     /inference="alignment:Splign:2.1.0"
     exon            327..480
                     /gene="CIMIP6"
                     /gene_synonym="C2orf73"
                     /inference="alignment:Splign:2.1.0"
     exon            481..596
                     /gene="CIMIP6"
                     /gene_synonym="C2orf73"
                     /inference="alignment:Splign:2.1.0"
     exon            597..1975
                     /gene="CIMIP6"
                     /gene_synonym="C2orf73"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1103..1108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIMIP6"
                     /gene_synonym="C2orf73"
                     /note="hexamer: AATACA"
     polyA_site      1126
                     /gene="CIMIP6"
                     /gene_synonym="C2orf73"
                     /note="major polyA site"
     regulatory      1952..1957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIMIP6"
                     /gene_synonym="C2orf73"
                     /note="hexamer: AAGAAA"
     polyA_site      1975
                     /gene="CIMIP6"
                     /gene_synonym="C2orf73"
ORIGIN      
        1 acagtcgccg cgctttgcgc acccttttcc tggcagggct gcgtccctgt tcttcccagg
       61 aggctcctcg ctgcctggtg ccgtagaggc ccatggagga aaaggaagat aagcatcaac
      121 agcataaaat agaggatgct gctataacat atgtaagtga aaatgaagaa attaaacacg
      181 aagaaaaacc tggaaaaagc atacatcatt caaaatcaca tgttggaaga ggacgtatat
      241 attatgctaa attcattaac acaaatgcaa gaacatacaa tgaaccattt ccctacatag
      301 atcccaaaaa agggccagaa atacagggtg actggtggtc acatggtaaa gcactggaac
      361 ctgtcttcct accaccttac gactctaaga gcacccagag gagtgacttc caaaaaccat
      421 cgtgtccact ggttttgcca gtcaaacaca gcaagatgca aaagccttct tgtggaatag
      481 taccacttgc ctctcctggt acatcagcag aacttcaaaa caattttata gaatacatct
      541 cttttataca tcaatatgat gccagaaaaa ctccgaatga gcctctccag ggaaagagac
      601 acggagcttt tgtacagaga gagataaaac caggcagtag gccaacagtt cctaaaggag
      661 cagaggtatt actgaacact ccagggtcac gttcatcaga acagtccaaa aaaacagaga
      721 aaggaaactc agcggaaagc agaatgatct caccaggtct ctgccaacaa aattctcagg
      781 agctgttaga gcctaaaact cacttatcag aaacagacgt cagacaggca gccaaggcat
      841 gccccagcac tcctgagagc agagaaaaga cctcaggcgc cactcaaaca actgtaggag
      901 atgctctttt cactaggcac aagcctttaa atccaccaat taaaaaatca gaataaatta
      961 ccttcttcag ataaaaatct aatccctgga atatagggaa atttcacaat catcatcttg
     1021 gccctcacat ttacttttct gttatcagta acttcagaac atacaattta tgtaaatgga
     1081 aaaagagaaa aaagacaatt aaaatacaac caaatgttat taataagagt ggtctccaat
     1141 aagtggagtg agacattatt tctatgtcac attctttatg aacacaactt tgttttgcac
     1201 aacacatgat cgtaattaac aaatataata cttttagaag agaggccctg ttagacatga
     1261 gtggacagct ttggaatcaa acaaactaga gttggaatgt tggcttcact tcattccttg
     1321 agctgtgtga ccttgggtaa gtaacttaac ctctctagac ttcagttttc tcaactgtaa
     1381 aattaggaaa atagcaactt cgtaagatta ttgaggatgt gattatgcac attgatcagt
     1441 aagtggtcaa tgtaatcata tcatcactgc tactataatt caattttcaa tttaaggata
     1501 atgttctctt atatatttaa tttttcctca ttattctaaa acttagaact cctccatata
     1561 taattaaaag tgtgaaaatc taaaaatact tctgccagta caagatgcac agacacatac
     1621 acacttaatt caaagacata tgggtactta gaatattgaa gtattttcta aattgttttc
     1681 tattttactc agatcatttc tagcaccaac tcaacctttg ctttttggat gagtttggta
     1741 aggattaatt ctacttccaa tttggtgtgt ttggtgtgcc aaaatgtatc tattataaga
     1801 tatgttatat tgcatacaag tggaagtagg tggagtattc ctctgttata aagagtattt
     1861 acaaatttcc attgggaaat atcagctgct cactattatc tgcagtattg ataagactac
     1921 agctatatct ttatccattt attctccatt aaagaaattg tgataaactg caaaa
//
